Drug Development and Industrial Pharmacy最新文献

{"title":"Development and characterization of a <i>Vaccinium vitis-idaea</i> liposomal gel for the treatment of atopic dermatitis.","authors":"Zhuoqun Zhang, Jinhai Huo, Lina Feng, Jing Wang, Xinyu Fan, Weiming Wang","doi":"10.1080/03639045.2025.2467857","DOIUrl":"10.1080/03639045.2025.2467857","url":null,"abstract":"<p><strong>Objective: </strong>In this study, a liposomal gel with anti-inflammatory, antibacterial, and antioxidant effects and improving atopic dermatitis (AD) was prepared using <i>Vaccinium vitis-idaea</i> polyphenol as the main active ingredient, which is safe, effective, of stable quality and has anti-inflammatory and antimicrobial effects.</p><p><strong>Methods: </strong>The polyphenol extract from <i>Vaccinium vitis-idaea</i> was obtained through ultrasonic extraction and subsequently purified using macroporous resin. A liposome gel incorporating this extract was formulated using poloxamer 188 and poloxamer 407 as the base materials. The gel's physical characteristics, including appearance, vesicle size, and zeta potential, were systematically characterized. Furthermore, its anti-inflammatory, antioxidant, anti-aging, and anti-AD effects were assessed through both <i>ex vivo</i> and <i>in vivo</i> studies.</p><p><strong>Results: </strong>After process optimization, the yield of <i>Vaccinium vitis-idaea</i> polyphenol was 4.33%; the encapsulation rate of <i>Vaccinium vitis-idaea</i> liposome was 90.45%. The liposome gel prepared by the optimal process had a zeta potential of -33.67 mV, a particle size of 119 nm, a PDI of 0.147, and showed good stability under the conditions of 60 °C, 75% relative humidity, and light intensity of 4500 ± 500 Lux. The results of <i>in vitro</i> studies showed that <i>Vaccinium vitis-idaea</i> polyphenols have antibacterial and antioxidant effects, and the results of <i>in vivo</i> studies showed that the <i>Vaccinium vitis-idaea</i> liposome gel is safe for skin application, effectively reduces dandruff and erythema, reduces the degree of keratinization, reduces the degree of congestion and inflammatory infiltration of local tissues as well as increasing the content of collagen fibers in skin tissues, promotes the restoration of the structural integrity of the skin, and by reducing the inflammatory factors TNF-α, IL-4. By reducing the expression level of inflammatory factors TNF-α, IL-4, IL-13, and MDA, increasing the expression level of SOD, and reducing the diversity of bacterial flora in AD tissues, it can play the role of anti-inflammatory, anti-bacterial, and antioxidant effects and improve the symptoms of AD.</p><p><strong>Conclusion: </strong>The present study demonstrated that the prepared <i>Vaccinium vitis-idaea</i> liposome gel had an ameliorating effect on AD.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"273-283"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor microenvironment as a target for developing anticancer hydrogels.","authors":"Suman Khurana, Shrestha Sharma, Parveen Kumar Goyal","doi":"10.1080/03639045.2025.2455424","DOIUrl":"10.1080/03639045.2025.2455424","url":null,"abstract":"<p><strong>Objective: </strong>It has been reported that cancer cells get protected by a complex and rich multicellular environment i.e. the tumor microenvironment (TME) consisting of varying immune cells, endothelial cells, dendritic cells, fibroblasts, etc. This manuscript is aimed at the characteristic features of TME considered as potential target(s) for developing smart anticancer hydrogels.</p><p><strong>Significance: </strong>The stimuli-specific drug delivery systems especially hydrogels that can respond to the characteristic features of TME are fabricated for treating cancer. For developing anticancer formulations, TME targeting can be considered an alternative way as it enhances the cytotoxic potential and reduces the unwanted effects. This manuscript shall be of quite interest to academicians, researchers, and clinicians engaged in oncology.</p><p><strong>Methods: </strong>The manuscript was prepared by using the data available in the public domain in online resources such as Google Scholar, PubMed, Science Direct, Scopus, Web of Science, Research Gate, etc.</p><p><strong>Results: </strong>Smart hydrogels, sensitive to some specific features of TME such as low pH, high concentration of glutathione, specific enzymes, etc., are promising anticancer formulations as these improve the efficacy and lower the side effects of chemotherapy.</p><p><strong>Conclusion: </strong>The stimuli-responsive hydrogels have been gaining more attention for delivering cytotoxic drugs to the TME in response to specific stimuli. The stimuli-responsive hydrogels, comprising of cytotoxic drug(s) and specific polymers have some special features such as similarity with biological matrix, ability to respond to various internal as well as external stimuli, improved permeability, porosity, biocompatibility, resemblance with soft living tissues, etc.; and are considered as the promising anticancer candidates.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"157-168"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of oral pharmaceutical solution of fucoxanthin against paracetamol-induced liver injury: modulation of drug-metabolizing enzymes, oxidative stress, and apoptotic pathways in rats.","authors":"Safaa Y Eid, Maimonah F Koshak, Mohamed E Elzubier, Bassem Refaat, Riyad A Almaimani, Mohammad Althubiti, Essam Eldin M Nour Eldin, Nawaf H Alahmadi, Sameer H Fatani, Akhmed Aslam, Elshiekh Babiker Adam Khidir, Ahmed A H Abdellatif, Mahmoud Zaki El-Readi","doi":"10.1080/03639045.2025.2469808","DOIUrl":"10.1080/03639045.2025.2469808","url":null,"abstract":"<p><strong>Background: </strong>Paracetamol (PAC) overdose causes acute liver injury through oxidative stress, inflammation, and apoptosis. While N-acetyl cysteine (NAC) is the standard treatment, fucoxanthin (FUC), a carotenoid from brown seaweed, has shown hepatoprotective effects in animal studies, but its role in PAC toxicity is unclear.</p><p><strong>Objective: </strong>Compared to NAC, this study assessed the hepatoprotective potential of oral FUC solution toward PAC-induced injury to the rat's liver.</p><p><strong>Method: </strong>FUC was formulated as a pharmaceutical solution and characterized <i>via</i> UV-VIS spectroscopy. Six groups of male Wistar rats each contain five animal which are in total 30 rats: negative control (NC), positive control (PC, 2 g/kg PAC), NAC (1200 mg/kg), and three oral FUC doses (100, 200, and 500 mg/kg) for seven days, with PAC administered on day-8. Liver tissues were analyzed for oxidative stress, gene expression, and histology.</p><p><strong>Results: </strong>FUC solution was clear with absorbance at 433 nm. PAC caused 30% mortality (<i>p</i> < .01 vs. others). NAC reduced ALT (56%), AST (78%), ALP (28%), and increased TP by 25% (<i>p</i> < .001 vs. PC). FUC at 500 mg/kg (F500) was superior, reducing ALT (82%), AST (93%), ALP (40%), and increasing TP (35%) (<i>p</i> < .001 vs. NAC). PAC increased oxidative stress, CYP2E1/CYP3A2 expression, apoptosis markers, and suppressed Nrf2/AMPK/AKT1. F500 improved antioxidants, reduced oxidative stress, and apoptosis, enhanced the Nrf2/AMPK pathway, and downregulated CYP2E1/CYP3A2 (<i>p</i> < .01).</p><p><strong>Conclusion: </strong>FUC, particularly at 500 mg/kg, offers significant hepatoprotection against PAC-induced liver injury by modulating drug metabolizing enzymes and enhancing antioxidant defenses, warranting further research.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1-12"},"PeriodicalIF":2.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing quality-by-design through weighted goal programming: a case study on formulation of ultradeformable liposomes.","authors":"Sonia Valverde Cabeza, Pedro Luis González-R, María Luisa González-Rodríguez","doi":"10.1080/03639045.2025.2470397","DOIUrl":"10.1080/03639045.2025.2470397","url":null,"abstract":"<p><strong>Introduction: </strong>Optimization of pharmaceutical formulations requires advanced tools to ensure quality, safety, and efficacy. quality-by-design (QbD), introduced by the FDA, emphasizes understanding and controlling processes early in development. Advanced optimization methods, such as desirability, have surpassed traditional single-objective techniques. Others, such as weighted goal programming (WGP) offers unique advantages by integrating decision-maker preferences, enabling balanced solutions for complex drug delivery systems. This study applies WGP to optimize timolol (TM)-loaded nanoliposomes aligning with QbD principles.</p><p><strong>Methods: </strong>The optimization process followed six steps: identifying factors and responses, developing a Design of Experiments (DoE) plan, defining ideal and anti-ideal points, setting aspiration levels, assigning relative weights, and applying WGP compared to desirability function. Minimized and balanced deviations from aspiration levels served as criteria for selecting the most robust optimization results. Six responses were analyzed: vesicle size <math><mo>(</mo><mrow><msub><mrow><mi>z</mi></mrow><mrow><mn>1</mn></mrow></msub></mrow><mo>)</mo></math>, polydispersity index <math><mo>(</mo><mrow><msub><mrow><mi>z</mi></mrow><mrow><mn>2</mn></mrow></msub></mrow><mo>)</mo></math>, zeta potential <math><mo>(</mo><mrow><msub><mrow><mi>z</mi></mrow><mrow><mn>3</mn></mrow></msub></mrow><mo>)</mo></math>, deformability index <math><mo>(</mo><mrow><msub><mrow><mi>z</mi></mrow><mrow><mn>4</mn></mrow></msub></mrow><mo>)</mo></math>, phosphorus content <math><mo>(</mo><mrow><msub><mrow><mi>z</mi></mrow><mrow><mn>5</mn></mrow></msub></mrow><mo>)</mo></math>, and drug entrapment efficiency <math><mo>(</mo><mrow><msub><mrow><mi>z</mi></mrow><mrow><mn>6</mn></mrow></msub></mrow><mo>)</mo></math>.</p><p><strong>Results: </strong>WGP produced a more balanced formulation that simultaneously optimized multiple responses. By incorporating the importance of each response, the WGP approach improved control over size, colloidal stability, and drug entrapment, based on its mathematical formulation. Comparative analysis with the desirability function confirmed that WGP effectively addressed potential tradeoffs without oversimplifying conflicting objectives.</p><p><strong>Conclusions: </strong>This case-study demonstrates WGP potential as an advanced multi-objective optimization tool for pharmaceutical applications, improving upon traditional methods in complex formulations. Its ability to harmonize multiple critical attributes in line with QbD highlights its value in developing high-quality pharmaceutical products.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1-12"},"PeriodicalIF":2.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preformulation studies and <i>in vitro</i> cytotoxicity of naringin.","authors":"A Gaitán, S Ravetti, A G Garro, M Bonaterra, R V Alasino, S D Palma","doi":"10.1080/03639045.2025.2471912","DOIUrl":"10.1080/03639045.2025.2471912","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluates the chemical and enzymatic stability of naringin (NRG), identifies its degradation metabolites, assesses its <i>in vitro</i> cytotoxicity, and validates a high-performance liquid chromatography (HPLC) method for precise quantification.</p><p><strong>Significance: </strong>NRG, a flavonoid with antioxidant, anti-inflammatory, and anticancer properties, faces clinical limitations due to poor solubility, rapid degradation, and low bioavailability. While research efforts on this promising compound have largely focused on overcoming these limitations through formulation strategies, it is equally necessary and complementary to focus on preformulation studies to enhance NRG's therapeutic potential. These studies represent a fundamental step in drug development, providing key insights into the physicochemical and biological properties of NRG and serving as the basis for the rational design of safe and effective formulations in future research.</p><p><strong>Methods: </strong>NRG stability was analyzed under various temperature and pH conditions. Cytotoxicity was evaluated in 3T3 cells, and an HPLC method was developed and validated to quantify NRG and its primary metabolite, naringenin (NRGN).</p><p><strong>Results: </strong>NRG remained stable up to 100 °C and under physiological pH (1.2, 5.8, and 7.4) but degraded at extreme pH, forming NRGN. Cytotoxicity assays showed low toxicity at ≤1 mM (viability >80%), whereas 5 mM significantly reduced viability. The validated HPLC method exhibited high precision, specificity, and accuracy in distinguishing NRG from NRGN.</p><p><strong>Discussion: </strong>This study provides critical insights into NRG's stability, safety, and quantification, supporting its potential therapeutic development. These findings establish a foundation for future research aimed at enhancing NRG bioavailability and clinical applicability.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1-10"},"PeriodicalIF":2.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In vitro</i>, <i>ex vivo</i>, and <i>in vivo</i> studies of celecoxib topical platforms for antimicrobial activity and wound healing: a comparative assessment.","authors":"Priyanka Mundankar, Pankaj Neje, Shubhada Mangrulkar, Pranav Shah, Madhur Kulkarni","doi":"10.1080/03639045.2025.2469805","DOIUrl":"10.1080/03639045.2025.2469805","url":null,"abstract":"<p><strong>Background & rationale: </strong>Celecoxib (CXB), with its anti-inflammatory and recently discovered antibacterial activity, especially against sensitive and methicillin-resistant <i>Staphylococcus aureus (MRSA),</i> could be promising in treating local pain, superficial skin infections, wounds and infected wounds. The study aims to develop and compare commercially scalable topical formulations of CXB to explore their antimicrobial and wound-healing potential.</p><p><strong>Methods: </strong>Carbopol gel, o/w cream, polyethylene glycol (PEG) ointment, and paraffin ointment were selected as the vehicles for the preparation of 3% CXB topical formulations. Appearance, pH, viscosity, spreadability, drug content, stability, <i>in vitro</i> release and permeation, and skin retention studies were performed. Further, antimicrobial assay, <i>in vivo</i> wound-healing and histopathology studies were carried out for each formulation.</p><p><strong>Results: </strong>The formulations had an acceptable appearance, viscosity, spreadability, and drug content. The drug release at 6h was the highest from gel (2428.8ug/cm²), followed by PEG ointment (2230.1ug/cm²), cream (1897.8ug/cm²), and lastly, the paraffin ointment (1217.2ug/cm²). PEG ointment and gel showed the highest skin permeation, whereas cream and gel were better able to retain the drug in the skin. All the formulations exhibited appreciable zones of inhibition against sensitive and the resistant strains of <i>Staphylococcus aureus</i>. PEG ointment exerted a significantly greater (<i>p</i> < 0.001) wound-healing effect. Accelerated stability studies confirmed good physicochemical stability of the formulations.</p><p><strong>Conclusion: </strong>PEG ointment, with its optimal drug release profile, skin permeation ability, and greater wound-healing action, can be considered as a promising topical delivery vehicle for CXB. CXB's antimicrobial potential could further aid in the prevention as well as treatment of wound infection.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1-13"},"PeriodicalIF":2.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced intestinal permeation of novel sulpiride electrospun nanofibers: formulation, optimization, and <i>ex vivo</i> evaluation of drug absorption.","authors":"Safaa Khaled, Omar Mady, Asmaa Hedaya, Noorelhoda Abdine, Yusuf Haggag","doi":"10.1080/03639045.2025.2469140","DOIUrl":"10.1080/03639045.2025.2469140","url":null,"abstract":"<p><strong>Significance: </strong>Electrospinning presents a promising avenue for drug delivery applications by integrating traditional solid dispersion methods with nano-medicinal strategies. Electrospun nanofibers (NFs) can be tailored to control the composition, diameter, and orientation of the NFs based on the intended application.</p><p><strong>Objectives: </strong>Herein, we aim to fabricate novel polymeric NFs loaded with sulpiride (SUL) utilizing Eudragit L100-55 (EL100-55) polymers to improve the dissolution and permeability of a model class IV drug.</p><p><strong>Methods: </strong>Various factors were assessed to optimize the electrospun NF formulation, including polymer concentrations, flow rate, and drug amount.</p><p><strong>Results: </strong>The electrospinning process yielded defect-free SUL-loaded EL100-55 NFs. The physicochemical analysis demonstrated favorable attributes in all formulations, encompassing high drug loading, encapsulation efficiency, and rapid drug release. Nanofiber formulations exhibited superior dissolution due to their extensive surface area. Modified non-everted sac experiments revealed a twofold increase in SUL permeation through the intestinal membrane upon EL100-55 encapsulation, emphasizing its impact on tight junction modulation in both NF and solid dispersion formulations. Enhanced drug permeation in the NF formulation involved dual mechanisms: transcellular diffusion and widening of the paracellular pathway. In contrast, the solid dispersion formulation prepared via solvent evaporation predominantly widened the paracellular pathway. Visualization techniques illustrated the NFs' robust affinity for the transcellular pathway.</p><p><strong>Conclusion: </strong>Sulpiride encapsulation into EL100-55-NF is a promising solution for BCS class IV drugs facing solubility and permeability challenges.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1-14"},"PeriodicalIF":2.4,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An evaluation of the effect of aging on the quality attributes of orodispersible tablets prepared by the direct compression technique.","authors":"Amjad Khan, Abad Khan, Shabnam Nazir, Nauman Rahim Khan, Majeed Ullah, Naila Shahbaz, Noor Ul Ain Nawaz","doi":"10.1080/03639045.2025.2469800","DOIUrl":"10.1080/03639045.2025.2469800","url":null,"abstract":"<p><strong>Background: </strong>The presented study aimed to evaluate the effect of aging on the quality attributes of ODTs.</p><p><strong>Experimental: </strong>ODTs prepared in one of our previous studies, packed in standard blister packing, were stored at ambient conditions in a laboratory (protected from direct sunlight) for 5 years and evaluated for their quality attributes, including physical parameters, mechanical strength (crushing strength, specific crushing strength, tensile strength, and friability), disintegration behavior (<i>in vitro</i> disintegration time, oral disintegration time, and wetting time), assay and dissolution rates. Drug content of all the samples was determined by HPLC.</p><p><strong>Results: </strong>Physically, the ODTs were oval (10 mm), shallow, and convex with a bisection line, and their compression weight was 200 mg/tablet. With the passage of time, the moisture content of the ODTs increased from 2.4 ± 0.39% to 3.48 ± 0.62%. After 5 years, the drug content decreased to 92.38 ± 0.93%.</p><p><strong>Discussion: </strong>Initially, there was an increase in the crushing strength of the ODTs (up to 3 years), and then it gradually decreased. At the time of preparation, disintegration time of the ODTs was 53 s, which gradually increased up to 89 s, at the 4th year. After completion of the study, it slightly decreased to 85 s. The dissolution rate of domperidone from the ODTs remained unaffected by aging. The FTIR spectra of the ODTs showed insignificant cahnges, indicating absence of degradation during the study period.</p><p><strong>Conclusion: </strong>ODTs remained stable for five years and insignificant changes were observed in their quality attributes.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1-10"},"PeriodicalIF":2.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in nanotechnology for targeted drug delivery in idiopathic pulmonary fibrosis: a focus on solid lipid nanoparticles and nanostructured lipid carriers.","authors":"Suriya Prakaash K K, Damodharan Narayansamy","doi":"10.1080/03639045.2025.2468811","DOIUrl":"10.1080/03639045.2025.2468811","url":null,"abstract":"<p><strong>Objective: </strong>This review aims to explore innovative therapeutic strategies, with a particular focus on recent advancements in drug delivery systems using bioinspired nanomaterials such as solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) for the idiopathic pulmonary fibrosis (IPF).</p><p><strong>Significance of the review: </strong>Current treatments for IPF, including the FDA-approved anti-fibrotic agents pirfenidone and nintedanib, primarily aim to slow disease progression rather than reverse fibrosis. Bioinspired nanomaterials like SLNs and NLCs have shown promise in enhancing the efficacy of anti-fibrotic agents by improving drug solubility, stability, and targeted delivery. These systems not only minimize systemic side effects but also maximize therapeutic impact in lung tissues, offering a new hope for improved patient management and outcomes in this debilitating disease.</p><p><strong>Key findings: </strong>SLNs facilitate sustained drug release and have demonstrated potential in delivering phosphodiesterase type 5 inhibitors effectively to lung cells. NLCs, on the other hand, exhibit superior biocompatibility and controlled release properties, making them suitable for pulmonary applications. Studies indicate that both SLNs and NLCs can enhance the bioavailability of drugs like ciprofloxacin and montelukast, thereby improving treatment outcomes in pulmonary conditions.</p><p><strong>Conclusion: </strong>The integration of nanotechnology into anti-fibrotic therapy represents a significant advancement in addressing the challenges posed by IPF. By leveraging the unique properties of SLNs and NLCs, there is potential to overcome the limitations of current treatments and provide new therapeutic options that offer better management and improved outcomes for patients suffering from this debilitating disease.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1-10"},"PeriodicalIF":2.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Docetaxel and niclosamide-loaded nanofiber systems for improved chemo-therapeutic activity and resistance reversal in prostate cancer.","authors":"Saurabh Shah, Paras Famta, Ganesh Vambhurkar, Rahul Kumar, Giriraj Pandey, Gurpreet Singh, Suraj Wagh, Shubham Kanaujiya, Dilip Kumar Arya, Abhishek Sharma, Akshay Shinde, Sajja Bhanu Prasad, Sachin Chandankar, Swapnil Shinde, Anamika Sharma, P S Rajinikanth, Dharmendra Kumar Khatri, Amit Asthana, Saurabh Srivastava","doi":"10.1080/03639045.2025.2453533","DOIUrl":"10.1080/03639045.2025.2453533","url":null,"abstract":"<p><strong>Objective: </strong>The objective of the study was to tackle the recurrence of prostate cancer (PCa) post-surgery and to re-sensitize the docetaxel (DTX)-resistant PC-3 cells to chemo-therapy using NIC.</p><p><strong>Significance: </strong>Prolonged DTX therapy leads to the emergence of chemo-resistance by overexpression of PI3K-AKT pathway in PCa along with tumor recurrence post-surgery. Suppression of this pathway could be essential in improving the anticancer activity of DTX and re-sensitizing the resistant cells.</p><p><strong>Method: </strong>Niclosamide (NIC), an anthelmintic drug has shown tremendous anticancer potential and has re-sensitized the resistant cells to various drugs. To mitigate the post-surgical tumor recurrence, an implant-based system facilitating the sustained release of DTX and NIC could be beneficial. DTX and NIC were incorporated within a nanofiber (NF) system to prevent on-site recurrence by local release and re-sensitize the DTX-resistant cells.</p><p><strong>Key findings: </strong>The fabricated DTX-NIC NF <i>via</i> electrospinning were 334 ± 96.14 nm in diameter and demonstrated sustained release profile till 6 d. Elevated mitochondrial damage, reactive oxygen species levels and apoptotic index revealed improvement in the cytotoxicity of DTX-NIC post incorporation into the NF owing to their sustained release profile. Re-sensitization of PC-3/DTX cells was observed by introduction of NIC which could be due to the suppression of p-Akt1, which was overexpressed in resistant cells.</p><p><strong>Conclusion: </strong>From superior activity of DTX-NIC NF and re-sensitization of resistant cells, we conclude that DTX-NIC NF could be a beneficial therapeutic regimen in preventing tumor recurrence in PCa.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"132-143"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}