Drug Development and Industrial Pharmacy最新文献

{"title":"Tumor microenvironment improved by nanostructured lipid carriers co-delivering paclitaxel and ubenimex to treat breast cancer.","authors":"Shuai Xia, Tao Sheng, Jia-Min Li, Bing-Feng Zhang, Ruo-Bin Peng, Ping-Bo Yan","doi":"10.1080/03639045.2026.2710363","DOIUrl":"10.1080/03639045.2026.2710363","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this research was to design nanostructured lipid carriers (NLCs) co-delivering paclitaxel (PTX) and ubenimex (Uben) to improve the tumor microenvironment (TME) and enhance efficacy against breast cancer.</p><p><strong>Significance: </strong>Nanostructured lipid carriers offer unique advantages for co-delivery of anti-tumor drugs, including high drug-loading capacity, controlled-release performance, and facile functionalization. This study developed a NLC co-loaded with PTX and Uben to achieve synergistic therapeutic effects on breast cancer by improving the immunosuppressive TME.</p><p><strong>Methods: </strong>Ubenimex was conjugated to vitamin E polyethylene glycol succinate (TPGS) via ester bonds, after which the synthetic conjugate, PTX, and lipid materials were formulated into the nanostructured lipid carrier (PTX/Uben-NLC) by the emulsified solvent evaporation-low-temperature curing method and subsequently characterized and evaluated for improved anti-tumor efficacy.</p><p><strong>Results: </strong>The prepared PTX/Uben-NLC was approximately spherical with a negative potential and a particle size of about 161 nm. The formulation demonstrated sustained drug release. Uben exhibited pH-responsive release in the weakly acidic TME and induced immune cell activation and secretion of anti-tumor cytokines (interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin-12 (IL-12)), while secretion of immunosuppressive cytokines (TGF-β and IL-10) was concurrently inhibited. PTX exerted direct anti-tumor effects on tumor cells. Consequently, the PTX/Uben-NLC alleviated TME immunosuppression and enhanced anti-breast-cancer activity.</p><p><strong>Conclusion: </strong>Dual-drug-loaded NLCs alleviated TME immunosuppression to enhance synergistic anti-breast cancer therapy and provided a feasible solution for breast cancer treatment.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"2001-2014"},"PeriodicalIF":2.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148590953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing the potential of spider silk proteins as emerging biomaterials for drug delivery: classification, comparative evaluation, and future perspectives.","authors":"Jahanvi Kumari, Shruti Chopra, Sanjay Bharati, Amit Bhatia, Abhinav Kanwal, Navjot Kanwar","doi":"10.1080/03639045.2026.2707555","DOIUrl":"10.1080/03639045.2026.2707555","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this review is to consolidate the role of native and recombinant spider silk in drug delivery systems. It aims to classify and compare their performance with natural and synthetic polymers, and emphasizes their potential biomedical applications. It also evaluates the limitations and technical challenges, while offering perspectives on future directions to advance the clinical practices of spider silk-based drug delivery systems.</p><p><strong>Significance: </strong>Spider silk offers biocompatibility, biodegradability, high mechanical strength, low immunogenicity, and stability, making it an outstanding candidate for an advanced drug delivery system. Its unique ability to self-assemble into nanoparticles, hydrogels, and films allows for encapsulation of various drugs.</p><p><strong>Key findings: </strong>This review highlights that recombinant silk proteins possess unique properties that make them superior to many natural and synthetic polymers for drug delivery. Recombinant production technologies allow precise control over amino acid sequences, enabling modification for targeted and sustained delivery. In drug delivery, recombinant spider silk-based systems have exhibited promise in cancer therapy, regenerative medicine, including wound healing in tissue engineering, and serving as carriers.</p><p><strong>Conclusion: </strong>Recombinant spider silk protein represents a versatile and biocompatible platform for advanced drug delivery systems. Although challenges in scalability and clinical translation exist, advances in engineering emphasize spider silk as a next-generation drug delivery biomaterial.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1912-1928"},"PeriodicalIF":2.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148548132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging trends in the integration of nanotechnology and 3D printing for next-generation drug delivery systems.","authors":"Debadrita Ghosh, Parekh Nirmit Jigneshkumar, Soji Soman","doi":"10.1080/03639045.2026.2729390","DOIUrl":"10.1080/03639045.2026.2729390","url":null,"abstract":"<p><strong>Purpose: </strong>To provide a comprehensive overview of three-dimensional (3D) printing as an emerging manufacturing approach in pharmaceutical and biomedical sciences, with a focus on its role in developing advanced and personalized drug delivery systems.</p><p><strong>Materials and methods: </strong>3D printing offers significant advantages over conventional manufacturing techniques by facilitating precise control over dosage, geometry, drug release, and material composition. The integration of nanomaterials further improves mechanical strength, targeting capability, and therapeutic efficacy, making it highly relevant for patient-mediated healthcare solutions.</p><p><strong>Results: </strong>In this review, major pharmaceutical 3D printing technologies, including inkjet printing, fused deposition modeling, stereolithography, binder jetting, and extrusion-based systems, are discussed. The applications of 3D printing technology are related to drug delivery, transdermal systems, biomedical implants, tissue engineering, bone regeneration, mucosal delivery, and microelectronic medicine. Recent advancements demonstrate the potential of nanoparticle-loaded scaffolds, smart responsive materials, microneedles, polypills, and personalized drug delivery platforms. Emerging clinical applications also indicate utility in surgical planning and patient-specific medical devices. However, challenges such as limited availability of excipients, scale-up constraints, regulatory uncertainties, drug stability concerns, and low production throughput persist.</p><p><strong>Conclusion: </strong>3D printing is rapidly advancing as a transformative platform in pharmaceutical manufacturing. Continued advancements in material science, printing precision, artificial intelligence-driven design, and regulatory harmonization are expected to overcome existing limitations, enabling the development of safer, more effective, and highly customized therapeutic solutions.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1-28"},"PeriodicalIF":2.6,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of HPTLC method for simultaneous estimation of gatifloxacin and flurbiprofen sodium using 3² factorial design.","authors":"Naazneen Surti, Zubiya Surti, Mitalben Parmar, Shailesh Koradia, Ashok Mahajan, Swati Kurtkoti","doi":"10.1080/03639045.2026.2729385","DOIUrl":"10.1080/03639045.2026.2729385","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to develop and validate an Analytical Quality by Design (AQbD)-based HPTLC method for simultaneous estimation of gatifloxacin and flurbiprofen sodium in ophthalmic formulations.</p><p><strong>Methods: </strong>Separation was achieved on silica gel 60 F254 precoated HPTLC plates using n-propanol: ammonia (8:2, v/v) as the mobile phase, with densitometric detection at 254 nm. A 3² full factorial design was employed to evaluate the effects of mobile phase composition and chamber saturation time on the Rf values of both drugs. The optimized method was validated according to ICH Q2(R1) guidelines for specificity, linearity, accuracy, precision, robustness, LOD, and LOQ. Sustainability and practicality were assessed using AGREE, GAPI, Analytical Eco-Scale, ComplexGAPI, BAGI, RAPI, and RGB12 multi-color assessment.</p><p><strong>Results: </strong>The method produced sharp, well-resolved peaks with Rf values of 0.32 ± 0.02 and 0.65 ± 0.02 for gatifloxacin and flurbiprofen sodium, respectively. Excellent linearity was observed over 600-2100 ng/band for gatifloxacin and 60-210 ng/band for flurbiprofen sodium, with correlation coefficients >0.999. Recoveries ranged from 98.30% to 99.96%, with %RSD <2%, confirming accuracy and precision. The method was successfully applied to FLUBIGAT^® eye drops without interference from excipients. RGB12 multi-color assessment yielded a Whiteness score of 80.5%.</p><p><strong>Conclusion: </strong>A simple, accurate, robust, and AQbD-based HPTLC method was successfully developed and validated for simultaneous determination of gatifloxacin and flurbiprofen sodium in ophthalmic formulations.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1-16"},"PeriodicalIF":2.6,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced wound dressings embedded with green copper oxide nanoparticles from <i>Inula viscosa</i>: Formulation and <i>in vitro</i> functional performance.","authors":"Nada Al Moudani, Ibtissam Ouahidi, Lotfi Aarab","doi":"10.1080/03639045.2026.2730310","DOIUrl":"10.1080/03639045.2026.2730310","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to develop a novel biogenic nano-formulation of copper oxide nanoparticles (CuO-NPs) using the Moroccan medicinal plant <i>Inula viscosa</i> to address critical challenges in wound care, specifically infection risks and coagulation disorders.</p><p><strong>Significance: </strong>By utilizing bioactive plant compounds as natural capping agents, this research provides an eco-friendly, multitargeted processing technology that transforms simple nanostructures into high-performance, biocompatible topical delivery systems for advanced pharmaceutical wound dressings.</p><p><strong>Methods: </strong>CuO-NPs were biosynthesized and characterized using UV-Visible, scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX) and Fourier transform infrared spectroscopy (FTIR) techniques. Biological characterization involved <i>in vitro</i> testing of anticoagulant activity, tissue regeneration potential through fibroblast proliferation (MTT assay), and hemocompatibility (Hemolysis rates). Finally, the CuO-NPs were incorporated <i>in situ</i> into polymeric dressings to assess antimicrobial efficacy against <i>Staphylococcus aureus (MRSA)</i>, <i>Escherichia coli</i>, and <i>Pseudomonas aeruginosa</i>.</p><p><strong>Results: </strong>Analytical characterization confirmed the successful fabrication and distinct structural integrity of the biosynthesized CuO-NPs. <i>In vitro</i> assays demonstrated significant anticoagulant properties, specifically modulating the intrinsic coagulation pathway. The MTT assay showed that the nano-formulation significantly accelerated fibroblast proliferation. Furthermore, hemocompatibility trials validated the material's safety yielding low hemolysis rates at low concentrations. Crucially, the engineered <i>in situ</i> wound dressings displayed potent, controlled antibacterial action, particularly against Gram-negative pathogens, matching positive controls.</p><p><strong>Conclusions: </strong>The developed CuO-NPs from <i>Inula viscosa</i> represent a sustainable, multifunctional biomaterial. Combining innovative processing with robust <i>in vitro</i> biological validation, this advanced formulation offers a viable technological alternative to conventional wound healing therapeutics.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1-20"},"PeriodicalIF":2.6,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levofloxacin hemihydrate-adorned floating drug delivery system to ameliorate <i>H. pylori</i> infection: formulation development, optimization, and characterization.","authors":"Sheikh Muhammad Mishkat Ullah, Sheikh Abdur Rashid, Nauman Rahim Khan, Kashif Maqbool Khan, Muhammad Khurshid Alam Shah, Faiza Naseem, Amina Riaz, Pervaiz Akhtar Shah, Farooq Bashir Butt, Mobina Manzoor, Syed Zia Husnain, Nisar Ahmed Shahwani","doi":"10.1080/03639045.2026.2729383","DOIUrl":"10.1080/03639045.2026.2729383","url":null,"abstract":"<p><strong>Objective: </strong>This study focused on developing and characterizing Levofloxacin hemihydrate floating bioadhesive tablets for the treatment of <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection.</p><p><strong>Significance: </strong>This study demonstrates a promising gastroretentive and bioadhesive drug delivery system that enhances the effectiveness of levofloxacin in the stomach for targeted <i>H. pylori</i> infection treatment.</p><p><strong>Methods: </strong>Floating bio-adhesive tablets were prepared by direct compression using sodium bicarbonate (NaHCO₃) as a gas-generating agent and HPMC K4M/chitosan and carbopol 940 P/sodium alginate as release retardants and bio-adhesives. Pre-formulation flow properties were evaluated. Tablets were characterized by physicochemical parameters, bioadhesion on goat stomach mucosa, and FTIR, which confirmed drug-excipient compatibility.</p><p><strong>Results: </strong>The optimized formulation (FT7) showed a buoyancy lag time of 62.59 ± 6.83 s, a total floating time of more than 12 h, a swelling index of 81.89%, and a bioadhesion strength of 28.19 ± 5.12 g. The formulation remained physically stable after three months of storage at 40 °C and 75% RH. Drug release followed a non-Fickian diffusion mechanism (<i>n</i> = 0.514) and best fit the Korsmeyer-Peppas model (R² = 0.989). <i>In vitro</i> and <i>in vivo</i> mucoadhesion studies demonstrated good retention of the tablet in the rabbit stomach for over 12 h. In-vivo barium sulfate X-ray imaging further confirmed that the tablet remained floating in the stomach 12 h after oral administration.</p><p><strong>Conclusion: </strong>A matrix-floating bio-adhesive tablet containing levofloxacin hemihydrate was successfully developed to effectively eliminate <i>H. pylori</i> infection.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1-13"},"PeriodicalIF":2.6,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Darwinian nanomedicine: artificial intelligence-driven evolutionary drug delivery for adaptive and precision therapeutics.","authors":"Chetana Krushna Belkare, Omkar Vishnu Daware","doi":"10.1080/03639045.2026.2729377","DOIUrl":"10.1080/03639045.2026.2729377","url":null,"abstract":"<p><strong>Objective: </strong>This review presents Darwinian nanomedicine as an artificial intelligence (AI)-enabled drug delivery strategy that applies Darwinian evolutionary principles as a computational and engineering analogy. Rather than implying biological evolution of nanoparticles, the framework employs iterative cycles of variation, selection, adaptation, and computational inheritance to optimize nanoparticle design through experimental feedback and AI-driven optimization.</p><p><strong>Significance of review: </strong>Conventional nanocarrier-based drug delivery systems have improved bioavailability, targeting, and therapeutic efficacy but remain static in design and limited in their ability to accommodate disease heterogeneity and variability. Darwinian nanomedicine represents a framework that integrates artificial intelligence with evolutionary optimization principles to iteratively refine nanoparticle formulations based on experimental performance rather than biological evolution.</p><p><strong>Key findings: </strong>Recent studies demonstrate that diverse nanoparticle libraries can be iteratively screened and computationally optimized according to performance. Advances in artificial intelligence, machine learning, high-throughput screening, Bayesian optimization, and evolutionary algorithms have accelerated the identification of nanoparticle formulations with improved targeting efficiency, drug release, stability, and performance through closed-loop design-test-learn workflows.</p><p><strong>Conclusions: </strong>Darwinian nanomedicine represents a paradigm shift from static nanoparticle design toward AI-guided adaptive optimization of drug delivery systems. Importantly, the evolutionary processes described in the framework are computationally inspired rather than biological, relying on iterative engineering and experimental optimization instead of nanoparticle self-replication or genetic inheritance. Although significant challenges remain regarding scalability, reproducibility, data standardization, manufacturing, and regulatory approval, continued advances in nanotechnology and artificial intelligence may facilitate the future translation of this framework into precision medicine applications.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1-20"},"PeriodicalIF":2.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astragalus polysaccharide liposomes for an enhanced therapeutic efficacy in treating chemotherapy-induced anemia: preparation and evaluation.","authors":"Zongzhi Luo, Xin Che, Enshun Yang, Kaiqi Zhang, Ziying Zhang, Lihong Wang","doi":"10.1080/03639045.2026.2729386","DOIUrl":"10.1080/03639045.2026.2729386","url":null,"abstract":"<p><p><b>Objective:</b> This study aimed to prepare an astragalus polysaccharide liposome formulation to enhance the therapeutic efficacy of astragalus polysaccharide in treating chemotherapy-induced anemia. <b>Significance:</b> The significance of this study lies in its ability to increase the drug exposure of astragalus polysaccharides in bone marrow tissue, thereby improving their efficacy in treating chemotherapy-induced anemia. <b>Methods:</b> Liposomes were prepared using the thin-film dispersion method, and their characteristics were verified. Subsequently, pharmacokinetic studies were conducted using animal experiments to calculate relevant pharmacokinetic parameters and to compare the pharmacodynamics of astragalus polysaccharide liposomes with free polysaccharides. <b>Results:</b> Data showed that the prepared astragalus polysaccharide liposome had a particle size of 291.23 ± 19.63 nm, a zeta potential of -37.75 ± 0.35 mV, and a polydispersity index of 0.24 ± 0.03, indicating good stability and biocompatibility. By comparing the pharmacokinetic parameters of astragalus polysaccharides and their liposomes, and analyzing the concentration changes in plasma and bone marrow, it was found that liposomes could increase the drug concentration in bone marrow. Animal experiments indicated that astragalus polysaccharide liposomes could enhance the anti-chemotherapy anemia effects of astragalus polysaccharides from multiple dimensions, including blood routine, organ index, oxidative stress factors, cell cycle, and apoptosis. <b>Conclusion</b>: Liposome-based formulations can prolong drug circulation time and thereby enhance the passive distribution and exposure of astragalus polysaccharides in the bone marrow, strengthening their anti-chemotherapy anemia effect.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1-18"},"PeriodicalIF":2.6,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and characterization of a topical spray containing <i>channa striata</i> and <i>anredera cordifolia</i> extracts for wound healing: <i>in vivo</i> evaluation in mice.","authors":"Heru Sasongko, Mikael H N Putro","doi":"10.1080/03639045.2026.2725654","DOIUrl":"10.1080/03639045.2026.2725654","url":null,"abstract":"<p><strong>Objective: </strong>This study developed and evaluated the physicochemical properties, antibacterial activity, and wound-healing efficacy of a topical spray combining <i>A. cordifolia</i> and <i>C. striata</i> extracts to optimize their combined natural therapeutic potential.</p><p><strong>Significance: </strong>Although <i>A. cordifolia</i> and <i>C. striata</i> promote healing, their combined application in a topical spray is underutilized. Therefore, this study aims to develop a functional topical delivery system to enhance their joint therapeutic potential.</p><p><strong>Methods: </strong>Topical spray formulations were prepared with a fixed 10% (w/v) concentration of <i>C. striata</i> extract and varying concentrations of <i>A. cordifolia</i> extract (F1: 2.5%, F2: 5%, F3: 10%, and F4: 20%). Formulations were evaluated for physicochemical properties and <i>in vitro</i> antibacterial activity against <i>Staphylococcus aureus, Pseudomonas aeruginosa</i>, and <i>Salmonella</i> sp. <i>In vivo</i> wound healing was assessed using a 1.5 cm full-thickness excisional wound model in 36 male BALB/c mice, evaluated <i>via</i> macroscopic observation and histological analysis.</p><p><strong>Results: </strong>F2 (5% <i>A. cordifolia</i> and 10% <i>C. striata</i>) was identified as the optimal formulation, exhibiting compliant physical properties (pH 4.90; viscosity 13.23 mPa·s) and consistent broad-spectrum antibacterial activity. <i>In vivo</i>, F2 demonstrated significant wound contraction and length reduction compared to the negative control (<i>p</i> < 0.05). Histological scoring showed that F2 and F3 achieved the highest total healing scores (9.80 <b>±</b> 0.84).</p><p><strong>Conclusions: </strong>The F2 topical spray is the optimal formulation, offering physical stability, broad antibacterial activity, and accelerated wound-healing efficacy, showing strong potential as a user-friendly natural agent for acute wound management.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1-12"},"PeriodicalIF":2.6,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of extended-release oral dosage forms of salbutamol sulfate using the Hot-Melt extrusion manufacturing technique.","authors":"Banan Ramadan, Nizar Al-Zoubi, Eman Migdadi, Alia Kh AlSuwais, Faisal Al-Akayleh, Mayyas Al-Remawi, Eman Alawamleh, Obadah M Shullar, Ghaith A Alansary, Ahmad Aljaberi","doi":"10.1080/03639045.2026.2726947","DOIUrl":"10.1080/03639045.2026.2726947","url":null,"abstract":"<p><strong>Objective: </strong>To fabricate and characterize extrudable polymeric matrices using a combination of ethyl cellulose (EC) and two different grades of hydroxypropyl cellulose (HPC) that can provide sustained drug release of the model drug salbutamol sulfate.</p><p><strong>Significance: </strong>Implementation of the Hot-Melt Extrusion (HME) technique in the fabrication of polymeric combinations that will provide ready-to-use matrices for sustained release dosage forms.</p><p><strong>Methods: </strong>Two formulation groups were developed; each with six formulations. The first group contained EC: HPC 370,000 ratios ranging from 55.52:13.8% to 6.9:62.46%, respectively. The second group contained EC: HPC 80,000 ranging from 59.4:10% to 9.4:60%, respectively. The release profiles were determined <i>via in vitro</i> studies to assess the ability of matrices to prolong salbutamol release. Solid-state characterization was also performed on the raw material and representative extrudates formulations using differential scanning calorimetry (DSC) and X-ray powder diffraction (XRPD) and polarized light microscopy (PLM).</p><p><strong>Results: </strong>The first group formulations exhibited prolonged drug release profiles that accelerated progressively as the level of HPC 370,000 increased. In contrast, the second group formulations exhibited a noticeably faster release, demonstrating that HPC 80,000 can effectively accelerate drug release through enhanced matrix erosion and water penetration. DSC and XRPD revealed that the model drug remained in its stable crystalline state even after thermal processing <i>via</i> HME. PLM further confirmed drug crystallinity within the extrudates.</p><p><strong>Conclusion: </strong>EC-HPC matrices successfully demonstrated the feasibility of using HME to prepare sustained-release matrices for salbutamol sulfate with the ability to tune drug release by varying polymer grade and ratio.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1-10"},"PeriodicalIF":2.6,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}