Drug Development and Industrial Pharmacy最新文献

{"title":"Simple but novel taxifolin@pro-glycymicelles as effective treatment for acetaminophen overdose-induced hepatotoxicity: preparation, in vitro characterizations, and in vivo experimental evaluations.","authors":"Yao Dong, Ling Zhang, Xixi Song, Xiaoli Chen, Yuyan He, Xianggen Wu, Mengshuang Li","doi":"10.1080/03639045.2025.2525968","DOIUrl":"10.1080/03639045.2025.2525968","url":null,"abstract":"<p><strong>Objective: </strong>To develop a simple but novel formulation named TAX@pro-glycymicelles with glycyrrhizin as the nanomaterial encapsulating taxifolin (TAX).</p><p><strong>Significance: </strong>TAX@pro-glycymicelles, simply prepared with two generally recognized as safe phytochemicals, demonstrated excellent characteristics, improved oral bioavailability of TAX, and strong effects against hepatotoxicity.</p><p><strong>Methods: </strong>TAX@pro-glycymicelles were prepared, and its physicochemical properties were determined. Safety assays, oral bioavailability in rats, treatment effects and mechanisms on liver injury in mice were also inflicted on TAX@pro-glycymicelle.</p><p><strong>Results: </strong>TAX@pro-glycymicelles were simply prepared, and the obtained powder demonstrated good storage stability and could be rapidly solubilized into water solutions to be clear nano-glycymicelle solutions. The apparent aqueous solubility of TAX from TAX@pro-glycymicelles was exceptionally improved to higher than 40 mg/ml. The <i>in vitro</i> release of TAX@pro-glycymicelles was also accelerated, and their <i>in vitro</i> antioxidative activity increased. Hemolysis and hen's egg test-chorioallantoic membrane assays showed that TAX@pro-glycymicelles exhibited good safety profiles. Oral bioavailability of TAX@pro-glycymicelles was approximately 32.1% higher than that of bare TAX in rats. TAX@pro-glycymicelles was also found to have a stronger dose-dependent treatment effect on acetaminophen overdose-induced hepatotoxicity in mice than bare TAX, including decreasing liver-to-body and spleen-to-body weight ratios, significantly decreasing alanine aminotransferase and aspartate aminotransferase levels in serum, decreasing inflammation and oxidative stress cytokine levels in livers, and reversing severe histological damage to liver tissues. The mechanisms of inhibiting oxidative stress and blocking high-mobility group box 1 signaling-related proinflammatory cytokines were involved in these strong treatment effects.</p><p><strong>Conclusions: </strong>TAX@pro-glycymicelles were found to be promising nano-formulations for treating acetaminophen overdose-induced hepatotoxicity.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1269-1284"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and <i>in-vitro</i> optimization of telmisartan-curcumin solid dispersion nanoparticles for the management of diabetic nephropathy using DoE approach.","authors":"Aruna Rawat, Samrat Chauhan, Rahul Pratap Singh, Monika, Sumeet Gupta, Vikas Jhawat","doi":"10.1080/03639045.2025.2525952","DOIUrl":"10.1080/03639045.2025.2525952","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to develop and optimize telmisartan (TLS)-curcumin (Cur) solid dispersion nanoparticles (SDNs) to improve the management of diabetic nephropathy (DN) by enhancing TLS's solubility and release rate.</p><p><strong>Methods: </strong>A Box-Behnken design (BBD) was used to optimize the formulation with critical excipients PVP VA S630 and Poloxamer 407. Pre-formulation studies assessed TLS's solubility and lipophilic nature. The optimized formulation (TLS-15) was evaluated for solubility, drug release, particle size, zeta potential, and <i>in vitro</i> release. A comparison was made with a formulation without Cur (TLS-15 WC). TEM imaging and release kinetics analysis were conducted.</p><p><strong>Results: </strong>The optimized formulation (TLS-15) demonstrated significantly improved solubility (4.801 μg/mL) and drug release (99.68%) with an appropriate particle size (303.5 nm) and zeta potential (-12.17 mV). TLS-15 WC exhibited lower values for solubility (4.74 μg/mL), drug release (98.3%), particle size (291.2 nm), and zeta potential (-25.4 mV). TEM revealed uniformly distributed spherical nanoparticles (NPs). TLS-15 showed a 99.54% release after 6 h, compared to 98.3% for TLS-15 WC, following first-order release kinetics (<i>R</i>² = 0.9934).</p><p><strong>Conclusions: </strong>The study successfully developed and optimized TLS-Cur SDNs, enhancing TLS's solubility and release. Cur played a critical role in boosting the therapeutic potential of the formulation. While challenges remain with stability and manufacturing, the formulation shows promise for improving bioavailability and efficacy in DN treatment. However, additional studies are needed to validate its effectiveness.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1244-1256"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel data-driven approach to assess the chewability and grittiness of the chewable tablets using a texture analysis.","authors":"Yu Zhang, Hongyue Liu, Jitong Wang, Fan Zhao, Jinru Hu, Zhidan Liu, Ruixiang Li, Minchen Liu, Jia Zeng, Li Qin, Ruofei Du","doi":"10.1080/03639045.2025.2523547","DOIUrl":"10.1080/03639045.2025.2523547","url":null,"abstract":"<p><strong>Context: </strong>Chewable tablet palatability significantly impacts patient compliance, but current pharmacopeias have no standardized evaluation methods. This requires developing an objective system for assessing the palatability of chewable dosage forms, which will aid in setting quality control standards.</p><p><strong>Objective: </strong>Using a texture analyzer, this study aimed to develop an objective, data-driven approach to evaluate chewability and grittiness in chewable tablets.</p><p><strong>Methods: </strong>10 commercially available chewable tablet formulations were assessed, with subjective sensory evaluations supplemented by texture analysis-based measurements to quantify attributes of chewability and grittiness. To evaluate chewability, measurements of axial compression force, work, and adhesion were conducted, establishing optimal conditions of 400 N, 3 mm, and 50% strain to simulate oral chewing. For grittiness, a correlation between particle size and linear distance value was demonstrated, with Calcium carbonate used as a reference material to establish a standardized evaluation scale.</p><p><strong>Results: </strong>Results indicated a strong correlation between tablet formulations and their sensory and texture analysis scores, with stickiness largely influenced by formulation ingredients such as milk powder and cacao powder. And the particle size of the insoluble material in the tablets largely influences the grit sensation.</p><p><strong>Conclusion: </strong>We developed a novel data-driven approach that offers a standardized assessment system to evaluate palatability characteristics in chewable tablets, facilitating more consistent formulation comparisons and potential optimization for consumer acceptability. This approach highlights the utility of texture analysis in transitioning empirical palatability assessments to objective, quantifiable methods, which may extend to other oral dosage forms.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1203-1217"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation on the protective effect of Ganoderma Lucidum spore oil on pustular acne based on molecular dynamics simulation and experimental validation.","authors":"Chunyu Wang, Hanxiao You, Yuting Yan, Yue Zhou, Xinxin Liu","doi":"10.1080/03639045.2025.2531403","DOIUrl":"10.1080/03639045.2025.2531403","url":null,"abstract":"<p><p>Ganoderma lucidum spore oil (GLSO), a bioactive natural product, demonstrates notable antioxidant, anti-inflammatory, and immunomodulatory properties, suggesting therapeutic potential. Pustular acne, characterized by intrafollicular pus accumulation, is primarily mediated by oxidative stress. This study investigated the antioxidative and therapeutic effects of GLSO on pustular acne through integrated computational and experimental approaches. Network pharmacological analysis revealed eight core targets associated with pustular acne pathogenesis. Molecular docking and dynamics simulations demonstrated stable binding of lucidone A and Cerevisterol to key targets (PTPN6/KDR), suggesting their role in modulating oxidative signaling pathways. <i>In vitro</i> experiments demonstrated that GLSO (25-100 mg/L) significantly improved the viability of H₂O₂-treated human keratinocytes and attenuated intracellular ROS levels, achieving efficacy comparable to that of vitamin C (positive control). Western blot and RT-PCR analyses confirmed that GLSO upregulates mRNA and protein expression of PTPN6 and KDR. Additionally, GLSO exhibited potent total antioxidant capacity (ABTS: 2.88 mmol/g; FRAP: 0.126 mmol/g). These findings suggest that GLSO alleviates pustular acne by targeting oxidative stress <i>via</i> active components such as lucidone A and Cerevisterol, which modulate PTPN6 and KDR signaling. This study provides mechanistic insights and preclinical evidence to support further clinical development of Ganoderma-derived therapeutics.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1318-1330"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An optimized and efficient method for immobilization and stabilization of penicillin G acylase onto PEI-coated magnetic Fe₃O₄ nanoparticles.","authors":"Mohammad Karim Emadzadeh, Hamidreza Pourzamani, Azadeh Hekmat, Mohsen Chiani, Dariush Norouzian","doi":"10.1080/03639045.2025.2567548","DOIUrl":"https://doi.org/10.1080/03639045.2025.2567548","url":null,"abstract":"<p><strong>Objective: </strong>The penicillin G acylase (PGA) enzyme, found in bacteria, yeast, and fungi, is used to produce 6-aminopenicillanic acid (6-APA) and beta-lactam antibiotics. To improve the catalytic activity and reusability of PGA, an efficient immobilization protocol was recruited.</p><p><strong>Methods: </strong>In this research, Fe₃O₄ magnetic nanoparticles (Fe₃O₄ MNPs) were functionalized through polyethylene imine, and the PGA was immobilized on nanoparticles using a glutaraldehyde linker. The nanoparticles were monodispersed with spherical shape and size around 35nm and analyzed by SEM and DLS methods. The optimization process was performed by Design Expert 10.0 software based on the RSM method and CCD design. The immobilization of the enzyme was confirmed by FT-IR.</p><p><strong>Results: </strong>At optimal stabilization conditions, the maximum amount of 6-APA intermediate substance was obtained at a temperature of 10 °C and a time of 336 minutes. The V_max and K_m were obtained around 0.024 mM and 1.04 mM for free PGA, and 0.47 mM and 1.53 mM for immobilized PGA. The stabilization increased the maximum speed of penicillin hydrolysis by a 2-fold. The antibiotic ampicillin was synthesized using 6-APA and phenylglycine methyl ester (PGME), and the immobilized enzyme maintained 45.87% of the initial activity after 10 reuse cycles, indicating that the immobilized enzyme had good stability and reusability.</p><p><strong>Conclusions: </strong>Overall, our results showed that this nanoparticle could be considered a promising matrix for PGA immobilization, with the advantages of high catalytic efficiency and enhanced stability and reusability.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1-17"},"PeriodicalIF":2.2,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and estimation of lipid hybrid nanocarriers co-loaded oxaliplatin and melatonin for breast cancer.","authors":"Gizem Ruya Topal, Seyma Adatepe, Jülide Secerli, Merve Gudul Bacanli","doi":"10.1080/03639045.2025.2562182","DOIUrl":"10.1080/03639045.2025.2562182","url":null,"abstract":"<p><strong>Objectives: </strong>Breast cancer remains the most frequently diagnosed cancer worldwide and the second leading cause of cancer-related mortality among women. Drug resistance and significant adverse effects limit anticancer drugs efficacy despite their availability. Oxaliplatin (OXA), a platinum-based chemotherapeutic agent, has shown potential in metastatic breast cancer, however, its toxicity limit its use. Melatonin (MEL) demonstrates anticancer activity and improves chemotherapy efficacy, but its therapeutic use is limited by poor stability and short half-life. Nanocarriers, particularly lipid-polymer-hybrid nanoparticles (LPNs), offer an innovative approach to improve drug delivery, enhance bioavailability, and limited systemic toxicity.</p><p><strong>Methods: </strong>OXA and MEL co-encapsulated LPNs were prepared. Design of Experiments (DoE)-based optimization was employed using the Box-Behnken design (BBD) to systematically evaluate critical formulation parameters. Particle size, polydispersity index, zeta potential, encapsulation efficiency, release, FTIR, DSC, and stability studies were carried out. The effects of OXA-MEL-loaded-LPNs were assessed on human breast cancer cell line (MCF-7).</p><p><strong>Results: </strong>Optimized LPNs exhibited a particle size of ∼240 nm, PDI of 0.17, zeta potential of -30 mV, and encapsulation efficiencies of 99.1% for MEL and 96.1% for OXA. <i>In vitro</i> release studies showed sustained release, with ∼26% OXA and ∼18% MEL released over 8 h. FTIR and DSC analysis showed all substances were loaded into particles. Stability data indicate that particle size remains within the acceptable range for up to one week. Lyophilization resulted in a slight increase in particle size and PDI. Co-loaded LPNs exhibited significant cellular cytotoxicity.</p><p><strong>Conclusion: </strong>The findings suggest that LPNs offer a promising platform for combination therapy, potentially improving treatment outcomes in breast cancer.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1-13"},"PeriodicalIF":2.2,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted delivery of resveratrol using PEGylated PLGA nanoparticles decorated with folic acid for cancer therapy: characterization, and <i>in vitro</i> studies.","authors":"Snehaprabha Tomar, Kapil Joshi, Vigi Chaudhary, Ragini Singh, Naveen Chaudhary, Vikram Kumar, Sudarshan Singh Lakhawat, Ashwani Kumar Yadav","doi":"10.1080/03639045.2025.2562181","DOIUrl":"10.1080/03639045.2025.2562181","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to develop, characterize, and evaluate resveratrol-loaded pegylated PLGA [poly (lactic-co-glycolic acid)] nanoparticles with folate conjugation for improved drug delivery and cytotoxic efficacy against MCF7 breast cancer cells.</p><p><strong>Significance: </strong>The significance of this drug delivery system is to enhance the wetting characteristics of resveratrol and reduce nanoparticle agglomeration for maximizing therapeutic efficacy while minimizing systemic cytotoxicity using PLGA and polyethylene glycol (PEG) polymeric nanoparticles as carriers. The process of fabrication and characterization of polymeric conjugate by utilizing PLGA-PEG surface engineered with folic acid for target specificity has already been investigated.</p><p><strong>Methods: </strong>Nanoparticles were prepared by double-emulsion solvent evaporation using PPF (PLGA-PEG-FOLATE conjugate polymer) and PVA (Poly vinyl alcohol) as a stabilizer. Compatibility studies were performed using FTIR, DSC, and XRD. Formulations (NF1-NF8) were evaluated for particle size, zeta potential, drug loading, entrapment efficiency, and <i>in vitro</i> release. Surface morphology was assessed by SEM and TEM. MTT assay evaluated cytotoxicity while fluorescence microscopy analyzed cellular uptake.</p><p><strong>Results: </strong>Compatibility studies confirmed no drug-excipient interactions. NF3 exhibited optimal characteristics: particle size 332.1 nm, zeta potential -24.6 mV, entrapment efficiency 78.65 ± 0.165%, and drug loading 36.19 ± 0.154%. <i>In vitro</i> release was sustained up to 120 h (75.17 ± 0.22%), fitting zero-order kinetics with Fickian diffusion. NF3 displayed enhanced cytotoxicity (IC50 340.26 nM) compared to free resveratrol (993.29 nM). Fluorescence microscopy confirmed improved cellular uptake <i>via</i> folate conjugation.</p><p><strong>Conclusion: </strong>Resveratrol-loaded PPF nanoparticles, particularly NF3, demonstrated superior stability, sustained release, and enhanced anticancer activity, making them a promising candidate for targeted breast cancer therapy.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1-16"},"PeriodicalIF":2.2,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in oral <i>in situ</i> gel drug delivery system: a polymeric approach.","authors":"Shreya L, Suma U S, Zohmingliani R","doi":"10.1080/03639045.2025.2559033","DOIUrl":"10.1080/03639045.2025.2559033","url":null,"abstract":"<p><strong>Objectives: </strong>This review aims to explore <i>in situ</i> gelling drug delivery systems with emphasis on formulation strategies, gelation mechanisms, administration routes, and therapeutic benefits. It also seeks to understand the role of different polymers in achieving optimal gelation and drug release profiles. Additionally, the review aims to identify current research gaps and highlight potential areas for future development and clinical translation.</p><p><strong>Significance: </strong><i>In situ</i> gels are liquid formulations that convert into gels upon exposure to physiological triggers such as pH, temperature, or ionic strength. These systems offer advantages like sustained drug release, improved bioavailability, and enhanced patient compliance. Their adaptability supports various administration routes including ocular, nasal, oral, gastrointestinal, vaginal, and bladder delivery.</p><p><strong>Key findings: </strong>A wide range of natural, synthetic, and semi-synthetic polymers have been studied for their <i>in situ</i> gelation properties. Most formulations exhibit rapid gelation upon contact with biological fluids and demonstrate good physicochemical stability. Controlled and sustained drug release was observed <i>in vitro</i> across different polymeric systems. The inclusion of mucoadhesive agents significantly improved residence time at the site of administration and enhanced drug absorption. These systems were found to be compatible with multiple delivery routes and maintained stability under physiological conditions.</p><p><strong>Conclusion: </strong><i>In situ</i> gelling drug delivery systems represent a versatile and efficient approach for site-specific, controlled drug release. Their ability to respond to physiological stimuli and improve mucosal retention makes them a promising alternative to traditional formulations. Continued research into polymer optimization and clinical application may further expand their therapeutic potential.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1-11"},"PeriodicalIF":2.2,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring efficient therapy for cutaneous neoplasm using gel formulations.","authors":"Usha D H, Keerthy H S","doi":"10.1080/03639045.2025.2560025","DOIUrl":"10.1080/03639045.2025.2560025","url":null,"abstract":"<p><strong>Objective: </strong>This review examines the pathology and treatment of cutaneous neoplasms, highlighting the limitations of conventional therapies and the potential of gel-based drug delivery systems for the efficient treatment of localized skin cancer.</p><p><strong>Significance: </strong>Skin cancer, including melanoma and non-melanoma types, has a growing concern in global health with increasing incidence due to UV exposure and lifestyle changes. Conventional therapies such as chemotherapy and radiation are often limited by systemic toxicity, drug resistance and poor skin barrier penetration. Gel-based drug delivery systems, including hydrogels, nanogels, and liposome gels, offer innovative solutions by improving drug stability enabling controlled release, and reducing adverse effects. These systems enhance localized treatment by improving drug retention and targeted delivery.</p><p><strong>Key findings: </strong>Conventional treatments face challenges such as high toxicity and inefficient drug penetration. Gel-based drug delivery systems provide enhanced drug stability, controlled release, and better skin permeability. Stimuli-responsive gels, which react to environmental factors like pH and temperature, optimize drug absorption and therapeutic efficacy while minimizing side effects. These systems address key challenges in cutaneous neoplasm therapy by improving drug delivery and patient outcomes.</p><p><strong>Conclusion: </strong>Gel-based drug delivery systems offer a promising advancement in skin cancer treatment. Their ability to enhance drug stability, provide targeted delivery, and reduce toxicity suggests a shift toward more effective and patient-friendly therapeutic strategies, ultimately improving treatment outcomes.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1-12"},"PeriodicalIF":2.2,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutting-edge strategies for delivering drugs to the brain based on nanocarriers.","authors":"Tapan Kumar Shaw, Saikat Mollick Shuvo, Paramita Paul, Abhishek Jana, Kazi Asraf Ali","doi":"10.1080/03639045.2025.2555858","DOIUrl":"10.1080/03639045.2025.2555858","url":null,"abstract":"<p><strong>Objective: </strong>This review aims to explore advanced nanotechnology-integrated delivery systems designed to facilitate the transport of therapeutic agents across the blood-brain barrier (BBB) for the treatment of central nervous system (CNS) disorders, particularly neurodegenerative diseases.</p><p><strong>Significance: </strong>CNS disorders remain a primary global health concern due to their progressive nature and limited treatment options. Conventional therapies exhibit minimal efficacy, primarily due to the restrictive nature of the BBB, which impedes drug access to brain tissue. Overcoming this barrier is crucial to improving therapeutic outcomes and minimizing systemic side effects.</p><p><strong>Methods: </strong>A comprehensive analysis of nanotechnology-based approaches was conducted, focusing on the physicochemical properties of nanocarriers, their interactions with the BBB, and their roles in targeted drug delivery. Strategies involving nanoparticle engineering, ligand-functionalized systems, and gene delivery vectors were critically reviewed.</p><p><strong>Results: </strong>Nanotechnology has shown considerable promise in facilitating drug delivery across the BBB. Nano-engineered platforms are capable of targeting specific cells, modulating signaling pathways, enhancing neuronal survival, and even inducing regeneration. Various successful nanocarriers, including liposomes, dendrimers, polymeric nanoparticles, and exosomes, demonstrate enhanced drug penetration and specificity.</p><p><strong>Conclusions: </strong>Nanotechnology holds transformative potential in treating CNS disorders by addressing the limitations posed by the BBB. Continued research into the design and optimization of brain-targeted nano-systems holds the key to safer, more effective therapies. The manuscript also highlights current challenges and considerations in developing such delivery systems for clinical application.</p>","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1-14"},"PeriodicalIF":2.2,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}