Drug Development and Industrial Pharmacy最新文献_第10页

Enhanced dissolution rates of glibenclamide through solid dispersions on microcrystalline cellulose and mannitol, combined with phosphatidylcholine 微晶纤维素和甘露醇与磷脂酰胆碱的固体分散体提高了格列本脲的溶解率

IF 3.4 4区医学

Drug Development and Industrial Pharmacy Pub Date : 2024-02-22 DOI: 10.1080/03639045.2024.2321388

Wanlop Weecharangsan, Robert J. Lee

引用次数: 0

Potential Anticancer Effect of Free and Nanoformulated Deferasirox for Breast Cancer Treatment: In-vitro and In-vivo Evaluation 游离和纳米制剂地拉罗司治疗乳腺癌的潜在抗癌效果：体外和体内评估

IF 3.4 4区医学

Drug Development and Industrial Pharmacy Pub Date : 2024-02-02 DOI: 10.1080/03639045.2024.2314189

Nadeen Diaa Abdel-Wahab, Mohamed Fawzi Kabil, Ibrahim M. El-Sherbiny, Mohamed F. Salama, Gehad El-Sayed, El-Said El-Sherbini

引用次数: 0

Borneol-modified docetaxel plus tetrandrine micelles for treatment of drug-resistant brain glioma. 用于治疗耐药性脑胶质瘤的硼醇改性多西他赛加四氢化萘胶束。

IF 3.4 4区医学

Drug Development and Industrial Pharmacy Pub Date : 2024-02-01 Epub Date: 2024-01-23 DOI: 10.1080/03639045.2024.2302886

Yang Liu, Jia-Yu Cai, Yang Liu, Lu Zhang, Rui-Bo Guo, Xue-Tao Li, Ling-Yue Ma, Liang Kong

{"title":"Borneol-modified docetaxel plus tetrandrine micelles for treatment of drug-resistant brain glioma.","authors":"Yang Liu, Jia-Yu Cai, Yang Liu, Lu Zhang, Rui-Bo Guo, Xue-Tao Li, Ling-Yue Ma, Liang Kong","doi":"10.1080/03639045.2024.2302886","DOIUrl":"10.1080/03639045.2024.2302886","url":null,"abstract":"Objective: Glioma is the most common and deadly primary malignant tumor in adults. Treatment outcomes are ungratified due to the presence of blood-brain barrier (BBB), glioma stem cells (GSCs) and multidrug resistance (MDR). Docetaxel (DTX) is considered as a potential drug for the treatment of brain tumor, but its effectiveness is limited by its low bioavailability and drug resistance. Tetrandrine (TET) reverses the resistance of tumor cells to chemotherapy drugs. Borneol (BO) modified in micelles has been shown to promote DTX plus TET to cross the BBB, allowing the drug to better act on tumors. Therefore, we constructed BO-modified DTX plus TET micelles to inhibit chemotherapeutic drug resistance.Significance: Provide a new treatment method for drug-resistant brain gliomas.Methods: In this study, BO-modified DTX plus TET micelles were prepared by thin film dispersion method, their physicochemical properties were characterized. Its targeting ability was investigated. The therapeutic effect on GSCs was investigated by in vivo and in vitro experiments.Results: The BO-modified DTX plus TET micelles were successfully constructed by thin film dispersion method, and the micelles showed good stability. The results showed that targeting micelles increased bEnd.3 uptake and helped drugs cross the BBB in vitro. And we also found that targeting micelles could inhibit cell proliferation, promote cell apoptosis and inhibit the expression of drug-resistant protein, thus provide a new treatment method for GSCs in vitro and in vivo.Conclusions: BO-modified DTX plus TET micelles may provide a new treatment method for drug-resistant brain gliomas.","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"135-149"},"PeriodicalIF":3.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139485202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revisiting the significance of nano-vitamin D for food fortification and therapeutic application. 重新审视纳米维生素 D 在食品添加剂和治疗应用中的意义。

IF 3.4 4区医学

Drug Development and Industrial Pharmacy Pub Date : 2024-02-01 Epub Date: 2024-01-26 DOI: 10.1080/03639045.2023.2301478

Gaurav K Jain, Vidya Raina, Rakshita Grover, Jagriti Sharma, Musarrat Husain Warsi, Geeta Aggarwal, Prashant Kesharwani

{"title":"Revisiting the significance of nano-vitamin D for food fortification and therapeutic application.","authors":"Gaurav K Jain, Vidya Raina, Rakshita Grover, Jagriti Sharma, Musarrat Husain Warsi, Geeta Aggarwal, Prashant Kesharwani","doi":"10.1080/03639045.2023.2301478","DOIUrl":"10.1080/03639045.2023.2301478","url":null,"abstract":"Objective: Vitamin D (a prohormone) is an important micronutrient required by the body for skeletal homeostasis and a range of non-skeletal actions. Calcitriol, the active form of vitamin D, regulates a variety of cellular and metabolic processes through both genomic and nongenomic pathways. Often prescribed for treating rickets and osteoporosis, vitamin D deficiency can exacerbate various other medical conditions.Significance, methods, and results: Despite its multifunctional uses, the sensitivity of vitamin D makes formulating an efficient drug delivery system a challenging task, which is further complicated by its poor aqueous solubility. Enhancing the oral absorption of vitamin D is vital in utilizing its full efficacy. Recent developments in encapsulation and nanotechnology have shown promising results in overcoming these constraints.Conclusion: This review thus offers an insight to adequately comprehend the mechanistic pharmacology of vitamin D, its pathophysiological role, and justification of its medical indications, along with the benefits of utilizing nanotechnology for vitamin D delivery.","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"89-101"},"PeriodicalIF":3.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139086346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating chemical similarity and bioequivalence: an overall evaluation of the quality consistency of traditional decoction and dispensing granule decoction of Amomum villosum. 整合化学相似性和生物等效性：对传统煎剂和点滴颗粒煎剂的质量一致性进行整体评价。

IF 3.4 4区医学

Drug Development and Industrial Pharmacy Pub Date : 2024-02-01 Epub Date: 2024-01-16 DOI: 10.1080/03639045.2024.2303381

Yousong Yue, Haiyang Li, Manwen Xu, Lijie Ma, Xiaopeng Wang, Yan Miao, Lu Zhang, Xuelin Li, Ruixin Liu

{"title":"Integrating chemical similarity and bioequivalence: an overall evaluation of the quality consistency of traditional decoction and dispensing granule decoction of Amomum villosum.","authors":"Yousong Yue, Haiyang Li, Manwen Xu, Lijie Ma, Xiaopeng Wang, Yan Miao, Lu Zhang, Xuelin Li, Ruixin Liu","doi":"10.1080/03639045.2024.2303381","DOIUrl":"10.1080/03639045.2024.2303381","url":null,"abstract":"Objective: This study aims to investigate the quality consistency between traditional decoction (TD) of Amomum villosum and its dispensing granule decoction (DGD). Fifteen batches of TD and nine batches of dispensing granules (manufactured by A, B, and C) were prepared and evaluated for their consistency.Methods: Firstly, The chemical similarity of TD and DGD was examined using GC and HPLC, coupled with hierarchical cluster analysis (HCA), criteria importance though intercrieria correlation(CRITIC) weighting method, and principal component analysis (PCA). Secondly, the gastrointestinal motility experiments in mice, along with the CRITIC weighting method, were employed to assess the bioequivalence of TD and DGD of Amomum villosum. Finally, the entropy weight technique-gray relative analysis(GRA) method was used to compare the quality of Amomum villosum decoctions.Results: ①The CRITIC weighting method indicated significantly higher scores for TD than DGD (p < 0.01). HCA and PCA results demonstrated a clear distinction between TD and DGD. ②Gastrointestinal motility test results revealed no significant difference between TD and DGD in other indicators (p > 0.05).③Gray relative analysis results showed that the relative correlation of TD was more significant than that of DGD.Conclusion: The chemical composition of DGD and TD differed. The biological activity of DGD-A/B was consistent with that of TD, while the difference between DGD-C and TD was significant. A comprehensive evaluation showed that TD exhibited better quality than DGD. DGD manufacturers should optimize the preparation process to enhance product quality.","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"150-162"},"PeriodicalIF":3.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139402290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative pharmacokinetic evaluation of glimepiride orodispersable and conventional tablets in rabbits. 格列美脲分散片与传统片剂在兔子体内的药代动力学比较评估

IF 3.4 4区医学

Drug Development and Industrial Pharmacy Pub Date : 2024-02-01 DOI: 10.1080/03639045.2024.2307421

Altaf Ur Rahman, Fazli Nasir, Muzna Ali Khattak, Talaya Hidayatullah, Sadia Pervez, Syeda Rabqa Zainab, Arbab Tahir Ali, Shazma Gohar, Gul E Maryam, Waleed H Almalki

{"title":"Comparative pharmacokinetic evaluation of glimepiride orodispersable and conventional tablets in rabbits.","authors":"Altaf Ur Rahman, Fazli Nasir, Muzna Ali Khattak, Talaya Hidayatullah, Sadia Pervez, Syeda Rabqa Zainab, Arbab Tahir Ali, Shazma Gohar, Gul E Maryam, Waleed H Almalki","doi":"10.1080/03639045.2024.2307421","DOIUrl":"10.1080/03639045.2024.2307421","url":null,"abstract":"Objectives: Glimepiride Orodispersable Tablets (ODT) were prepared with the goal to have rapid onset of action and higher bioavailability with ease administration to individuals with swallowing difficulty to ameliorate patient compliance.Significance: Glimepiride is a contemporary hypoglycemic medication that belongs to the family of sulfonylurea derivatives. It is used in type 2 diabetes mellitus. Compliance adherence remains one of the limitations with the conventional drug delivery system especially in pediatric, geriatric, psychiatric, and traveling patients, for such population ODT provides a good alternate dosage form compared with Commercial Tablets.Method: The Comparative in vivo pharmacokinetic parameters of the prepared ODT and conventional tablets (CT) were evaluated using an animal model. The plasma concentration of Glimepiride after oral administration of a single dose was determined at predetermined time intervals with HPLC. The pharmacokinetic parameters were calculated using PK Solutions 2.0 from Summit PK® software.Results: The Cmax obtained with ODT (22.08 µg/ml) was significantly (p = 0.006) high, a lower tmax of 3.0 hr was achieved with the orodispersable formulation of the drug. The ODT showed 104.34% relative bioavailability as compared to CT and left shift of tmax as well.Conclusion: As per findings of the in vivo investigation, the Glimepiride ODT would be beneficial in terms of patient compliance, quick onset of action, and increased bioavailability.","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"173-180"},"PeriodicalIF":3.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139541396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solvent-free method for masking the bitter taste of azithromycin dihydrate using supercritical fluid technology. 利用超临界流体技术掩盖二水阿奇霉素苦味的无溶剂方法

IF 3.4 4区医学

Drug Development and Industrial Pharmacy Pub Date : 2024-02-01 Epub Date: 2024-01-08 DOI: 10.1080/03639045.2023.2298892

Hadeia Mashaqbeh, Rana M Obaidat, Mo'tasem M Alsmadi

{"title":"Solvent-free method for masking the bitter taste of azithromycin dihydrate using supercritical fluid technology.","authors":"Hadeia Mashaqbeh, Rana M Obaidat, Mo'tasem M Alsmadi","doi":"10.1080/03639045.2023.2298892","DOIUrl":"10.1080/03639045.2023.2298892","url":null,"abstract":"Introduction and purpose: The unpleasant extremely bitter taste of the orally administered broad-spectrum antibiotic azithromycin decreases patient compliance, especially in pediatrics. This issue can be overcome by decreasing drug interaction with the tasting buds using insoluble polymers at salivary pH (6.8 - 7.4), like the cationic polymer Eudragit EPO. Supercritical fluid technology is a green synthesis method for preparing pharmaceutical preparations that replace organic solvents with safe supercritical CO2. This study aimed to mask the bitter taste of azithromycin using the supercritical fluid method and a pH-sensitive Eudragit EPO polymer.Methods: A foaming process was investigated for preparing a formulation (TEST), which comprises treating the polymer with supercritical carbon dioxide (CO2) fluid to prepare a taste-masked dosage form without employing organic solvents or flavors.Results: The use of the supercritical technique at 40 °C and 10 MPa for 2 h allowed the manufacturing of solvent-free polymeric foam with azithromycin dispersions; the average calculated percentage of apparent volume change was 62.5 ± 5.9% with an average pore diameter of 34.879 Å. The formulated sample showed low drug release in simulated salivary fluid while keeping its crystalline nature. Moreover, clinical studies on healthy subjects showed that the formula successfully masked azithromycin's bitter taste.Conclusions: Overall, it has been shown herein that the supercritical fluid technology foaming method is promising in masking the bitter taste of bitter ingredients.","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"102-111"},"PeriodicalIF":3.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139097541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of stoichiometry upon the characteristics of quercetin-arginine cocrystals formulated through solution crystallization. 配量对通过溶液结晶配制的槲皮素-精氨酸共晶体特性的影响。

IF 3.4 4区医学

Drug Development and Industrial Pharmacy Pub Date : 2024-02-01 Epub Date: 2024-01-24 DOI: 10.1080/03639045.2024.2306281

Mahima Mishra, Shivanshu Agrawal, Pratap Bahadur, Sanjay Tiwari

{"title":"Effect of stoichiometry upon the characteristics of quercetin-arginine cocrystals formulated through solution crystallization.","authors":"Mahima Mishra, Shivanshu Agrawal, Pratap Bahadur, Sanjay Tiwari","doi":"10.1080/03639045.2024.2306281","DOIUrl":"10.1080/03639045.2024.2306281","url":null,"abstract":"Objective: The aim of this study is to demonstrate the effect of stoichiometry upon characteristics of quercetin-arginine (QCT-Arg) cocrystals.Significance: Quercetin (QCT) is a most abundant flavonoid in vegetables and fruits and has been widely used as an antioxidant. However, its oral bioavailability remains low due to poor aqueous solubility. We illustrate that QCT-Arg cocrystals formulated through an optimized stoichiometry can be a useful approach for its solubilization.Method: Cocrystals were prepared using solvent evaporation method. Characterizations were performed through microscopic, spectroscopic, and thermal techniques. The stoichiometry was confirmed from the binary phase diagram which was prepared using thermograms derived from differential scanning calorimetric experiments.Result: Cocrystal formation was accompanied by the conversion of isotropic phase into anisotropic one. Thread-like cocrystals were formed, regardless of QCT-Arg stoichiometry and solvent's polarity. Spectral analyses suggested that cocrystal structure was held together by hydrogen bonding between QCT and Arg. We ruled out the existence of eutectic mixture based on the observation of two eutectic points in the binary phase diagram.Conclusion: Morphology of cocrystals remained unaffected by the solvent type, stoichiometry and the presence of surfactant. We noticed that the cocrystals could improve the aqueous solubility of QCT.","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"163-172"},"PeriodicalIF":3.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139471442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Doxorubicin-sanguinarine nanoparticles: formulation and evaluation of breast cancer cell apoptosis and cell cycle. 多柔比星-鞘氨醇纳米颗粒：乳腺癌细胞凋亡和细胞周期的制备与评估

IF 3.4 4区医学

Drug Development and Industrial Pharmacy Pub Date : 2024-01-05 DOI: 10.1080/03639045.2024.2302557

Mahmoud Zaki El-Readi, Majed Abdurhman Abdulkarim, Ahmed A H Abdellatif, Mohamed E Elzubeir, Bassem Refaat, Mohammad Althubiti, Riyad Adnan Almaimani, Mohammed Hasan Mukhtar, Issa Saad Al-Moraya, Safaa Yehia Eid

{"title":"Doxorubicin-sanguinarine nanoparticles: formulation and evaluation of breast cancer cell apoptosis and cell cycle.","authors":"Mahmoud Zaki El-Readi, Majed Abdurhman Abdulkarim, Ahmed A H Abdellatif, Mohamed E Elzubeir, Bassem Refaat, Mohammad Althubiti, Riyad Adnan Almaimani, Mohammed Hasan Mukhtar, Issa Saad Al-Moraya, Safaa Yehia Eid","doi":"10.1080/03639045.2024.2302557","DOIUrl":"10.1080/03639045.2024.2302557","url":null,"abstract":"Background: Therapeutic resistance fails cancer treatment. Drug-nanoparticle combinations overcome resistance. Sanguinarine-conjugated nanoparticles may boost sanguinarine's anticancer effects.Methods: Sanguinarine, HPMC-NPs, and doxorubicin were tested on Adriamycin-resistant MCF-7/ADR breast cancer cells, parent-sensitive MCF-7, and MCR-5 normal cells (DX).Results: Regular distribution, 156 nm diameter, <1 μm average size, 100% intensity-SN is therapeutic. Furthermore, the obtained NPs showed PDI = 0.145, zeta-potential=-37.6, and EE%=90.5%. DX sensitized MCF-7 cells (IC50 = 1.4 μM) more than MCF-7/ADR cells (IC50 = 27 μM) with RR = 19.3. SA and SN were more toxic to MCF-7/ADR cells (overexpressed with P-gp) than their sensitive parent MCF-7 cells (IC50 = 4 μM, RR = 0.6 and 0.6 μM, RR = 0.7). MCR-5 normal lung cells were more resistant to SA (IC50 = 7.2 μM) and SN (IC50 = 1.6 μM) with a selection index > 2. Synergistic cytotoxic interactions reduced the IC50 from 27 μM to 1.6 (CI = 0.1) and 0.9 (CI = 0.4) after DX and nontoxic dosages (IC20) of SA and SN. DS and SN killed 27.1% and 39.4% more cells than DX (7.7%), SA (4.9%), SN (5.5%), or untreated control (0.3%). DS and DSN lowered CCND1 and survival in MCF-7/ADR cells while raising p21 and Casp3 gene and protein expression.Conclusions: Cellular and molecular studies suggested adjuvant chemosensitizers SA and SN to reverse MDR in breast cancer cells.","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":" ","pages":"1-15"},"PeriodicalIF":3.4,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139097520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assistive technology for adults on the autism spectrum: A systematic survey. 自闭症谱系成人辅助技术：系统调查。

IF 4.7 4区医学

Drug Development and Industrial Pharmacy Pub Date : 2024-01-01 Epub Date: 2023-01-08 DOI: 10.1080/10447318.2022.2163568

Manhua Wang, Myounghoon Jeon

{"title":"Assistive technology for adults on the autism spectrum: A systematic survey.","authors":"Manhua Wang, Myounghoon Jeon","doi":"10.1080/10447318.2022.2163568","DOIUrl":"10.1080/10447318.2022.2163568","url":null,"abstract":"While the needs and care for children on the autism spectrum have been widely investigated, the intervention and services available to autistic adults have been overlooked for a long time. This survey paper reviewed 32 articles that described and evaluated assistive technologies that have been developed and evaluated through a complete circle of interactive product design from ideation, prototype, and user evaluation. These assistive technologies aim to improve independence and living quality in autistic adults. We extracted information from the perspective of requirement gathering, technology designing, and effectiveness of evaluation in the design cycle. We found a general lack of requirements-driven design, and the evaluation process was not standardized either. The lack of requirement gathering results in designs purely based on existing literature without targeting actual user needs. Our synthesis of included paper contributes to developing iterative design considerations in assistive technologies for autistic adults. We also suggest that assistive technologies for autistic adults shift some attention from assisting only autistic adults who require at least substantial support to embracing also those who have been living independently but rather have difficulties in social interaction. Assistive technologies for them have the potentials to help them consolidate and enhance their experiences in independent living.","PeriodicalId":11263,"journal":{"name":"Drug Development and Industrial Pharmacy","volume":"9 1","pages":"2433-2452"},"PeriodicalIF":4.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11114460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91251135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0