Current topics in behavioral neurosciences最新文献

{"title":"Classifying Psychedelic-Related Complications.","authors":"Tomislav Majić, Euphrosyne Gouzoulis-Mayfrank, Ricarda Evens","doi":"10.1007/7854_2026_614","DOIUrl":"10.1007/7854_2026_614","url":null,"abstract":"<p><p>Classic psychedelics such as psilocybin, lysergic acid diethylamide (LSD), and 5-methoxy-dimethyltryptamine (5-MeO-DMT) have shown promising effects in the treatment of certain mental health conditions. Enthusiastic claims about their therapeutic potential have led to overly optimistic reactions in the media and the public, subsequently resulting in increased use outside of clinical contexts and a heightened rate of psychedelic-related complications. As psychedelics exhibit low toxicity and hardly any habit-forming potential, the typical risks and harms of these substances are often overlooked by mental health professionals and under-assessed in psychedelic research. Similar to the medical history of other psychoactive substances introduced as medicines such as opioids, cocaine, and benzodiazepines, awareness for psychedelic-related complications has emerged with delay. Psychedelics are characterized by a wide range of acute effects on the human psyche and by a particular temporal dynamic in which these effects unfold, including acute, subacute, and long-term effects. Knowledge of how psychedelic effects unfold is not only essential for their use in therapy but also for the understanding and management of risks and complications.Here we provide an overview of complications that may be associated with the use of classic psychedelics, drawing on historical and current classification approaches and using the typical temporal dynamics of drug effects as a guiding thread. We will also discuss to what extent psychedelic-related disorders can be causally and specifically attributed to psychedelic use. Finally, considerations regarding the placement of psychedelic-related disorders within nosological-diagnostic classification systems will be discussed. The increasing interest in using psychedelics within the framework of psychotherapy and the rise of non-medical use underscore the need for a more nuanced classification of psychedelic-related risks and harms. The suggested classification can be used as a comprehensive starting point for the assessment of psychedelic-related complications, contributing to maximizing benefits and minimizing risks of these substances in research, therapy, and beyond.</p>","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"127-151"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147303502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fears Worth Testing Out: A Systematic Review of the Neural Mechanisms of Treatment Outcome for Anxiety-Related Disorders.","authors":"Robin Aupperle, Hannah Berg, Jacob Armstrong","doi":"10.1007/7854_2024_549","DOIUrl":"10.1007/7854_2024_549","url":null,"abstract":"<p><p>With the advent of human neuroimaging, researchers were drawn to the idea that by better understanding the human brain, more effective mental health interventions could be developed. It has been more than 20 years since the first functional magnetic resonance imaging (fMRI) studies were conducted to examine changes in brain activation with anxiety-related treatments and more than 60 studies have since been published in this vein. For the current review, we conduct a systematic review of this literature, focusing on adult studies using task-based fMRI to measure brain activation changes with pharmacologic or psychotherapy interventions for phobia, social anxiety disorder, panic disorder, generalized anxiety disorder, posttraumatic stress disorder, and obsessive-compulsive disorder. Neuroscientific theories of anxiety-related disorders and their treatment have focused on prefrontal-insula-amygdala networks. Treatment-related decreases in amygdala and/or anterior insula activation were identified as the most consistent finding across disorders, with the most consistent results reported for specific phobia. Directionality of change and specific regions implicated in the prefrontal cortex were inconsistent across studies. The potential importance for probing other networks and processes as mechanisms of anxiety treatment was recognized, such as striatal regions underlying inhibitory learning or reward responsivity. Future treatment-fMRI research related to anxiety disorders would benefit from larger sample sizes, use of more nuanced computational approaches, and increased focus on replication. There is continued promise that fMRI research will enhance our understanding of how treatments work and inform the evolution of more effective or personalized mental health treatment.</p>","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"495-526"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body, Self, and Time: Bud Craig's Global Emotional Moments Theory.","authors":"Julian Kiverstein","doi":"10.1007/7854_2024_575","DOIUrl":"10.1007/7854_2024_575","url":null,"abstract":"<p><p>The topic of my chapter will be Bud Craig's theory of \"global emotional moments\" (henceforth the GEMs theory) and the relationship of GEMs to the experience of time. I connect three ideas prominent in Craig's writings: interoception, emotion, and time. Craig held that each GEM has as its neural substrate a large-scale network with the anterior insula cortex (AIC) serving as its central processing hub. This network integrates interoceptive signals that keep track of changes arising in the autonomic nervous system with hedonic and motivational signals based on the organism's sensory perception of its environment. Craig argued that GEMs function as moving windows of time within which \"a phenomenal self\" is experienced. By the \"phenomenal self,\" I mean a material, embodied self that forms an organism's subjective point of view on the world. Craig proposed what he called a \"cinemascopic\" theory of GEMs. GEMs are combined over time to form a stream of consciousness, which Craig compared to a movie, with each GEM corresponding to a single snapshot of this movie. I will argue that Craig's cinemascopic theory has implications for our understanding of what I will call the \"phenomenal now.\" There are three main theories of the phenomenal now in the philosophical literature. One point of contention between these theories is whether the phenomenal now has duration or temporal depth. I will argue that GEMs have duration and therefore count against so-called \"cinematic\" theories of the phenomenal now that take the contents of experience to be of discrete points or instances in time. However, there are different views within philosophy of how the phenomenal now can have duration. I end my chapter by considering how Craig's GEMs theory might bear on this debate.</p>","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"285-306"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interoceptive and Bodily Processing in Prospective and Retrospective Timing.","authors":"Alice Teghil","doi":"10.1007/7854_2024_516","DOIUrl":"10.1007/7854_2024_516","url":null,"abstract":"<p><p>This chapter reviews some directions along which Craig's proposal of subjective time as emergent from interoceptive and bodily dynamics allows to frame recent findings on prospective and retrospective time processing. Behavioral and neuroimaging evidence from prospective timing studies demonstrates that an interoceptive-insular system may support the development of a primary representation of time in the context of large-scale networks involved in duration processing. Studies showing a tight link between episodic memory and interoceptive, emotional, and sensorimotor states further provide insights on processes supporting retrospective timing. These lines of evidence show that acknowledging its dependence on bodily states is most likely a crucial step toward a mechanistic understanding of time perception.</p>","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"223-245"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interoception in Adolescence: Impacts on Mental Health and Adaptive Functioning.","authors":"April C May, Susan Tapert","doi":"10.1007/7854_2025_580","DOIUrl":"10.1007/7854_2025_580","url":null,"abstract":"<p><p>Interoception plays a critical role in emotion regulation and mental health during adolescence, a critical period marked by profound biological, cognitive, and emotional changes. Variability in interoceptive processing during adolescence is shaped by biological, hormonal, and psychosocial factors, with implications for both resilience and vulnerability to affective disorders such as anxiety, depression, disordered eating, and substance use. This chapter reviews the trajectory of interoceptive development in adolescence, emphasizing its role in shaping emotional and behavioral outcomes. Interventions aimed at improving interoceptive awareness, including mindfulness practices and body-awareness training, are also reviewed as promising strategies to support emotional resilience and mental well-being during this formative stage. Understanding the complexities of interoception in adolescence provides a foundation for advancing research and interventions that promote adaptive functioning and long-term mental health.</p>","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"179-197"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre- and Postnatal Valproate Exposure Affects Brain Development.","authors":"Michaela A Pettie, Linda C M Wilkin-Krug, Bart Ellenbroek","doi":"10.1007/7854_2025_603","DOIUrl":"10.1007/7854_2025_603","url":null,"abstract":"<p><p>This review investigates the teratogenic impact of valproic acid (VPA) on brain development, focusing on dose-dependent and timing-related behavioural and neurological outcomes in rats and mice, with an emphasis on using it as a model for autism spectrum disorders (ASD). Single and multiple administration methods (e.g., oral gavage and intraperitoneal injections) across various rat and mouse strains consistently report behavioural alterations (i.e., altered social interaction and locomotor activity) and neuronal changes, particularly in the hippocampus and cerebellum. We underscore the importance of understanding dose-related changes and the critical role of VPA exposure in determining the long-term neurodevelopmental effects. While animal models provide valuable insights into the pre- and postnatal effects of drug exposure, this chapter also addresses the limitation of extrapolating such findings to humans given the face and construct validity of the model. Overall, this review emphasises VPA's utility in modelling ASD-like behaviours and the need for ongoing research to refine these models for better applicability to humans.</p>","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"43-68"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal SSRI Use During Pregnancy: Links Between Gut Microbiome, Offspring Behaviour, and Brain Transcriptomics.","authors":"Mayerli A Prado Rivera, Joëlle D Jagersma, Jocelien D A Olivier","doi":"10.1007/7854_2025_602","DOIUrl":"10.1007/7854_2025_602","url":null,"abstract":"<p><p>Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed to treat maternal depression during pregnancy, yet their potential impact on foetal brain development remains a concern. Although maternal illness is a known confounder, growing evidence from both clinical and preclinical studies suggests that perinatal SSRI exposure may independently influence neurodevelopmental outcomes. This review draws on rodent studies to explore how developmental SSRI exposure affects the gut microbiome, maternal behaviour, myelination, and offspring social behaviour. Elevated serotonin levels caused by SSRIs can alter both brain development and the maternal gut microbiota, with possible long-term effects on offspring. Behaviourally, SSRI-exposed offspring often show reduced social play, altered social interactions, and sex-specific effects on aggression and sexual behaviour, in which males appear more sensitive to these effects than females. Maternal care is only modestly affected. Overall, developmental SSRI exposure in the absence of maternal illness can disrupt brain development and social behaviour in offspring, potentially through gut-brain axis mechanisms and altered myelination.</p>","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"23-41"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Continuing Challenges of Studying Parallel Behaviours in Humans and Animal Models.","authors":"Hans S Crombag, Theodora Duka, David N Stephens","doi":"10.1007/7854_2024_485","DOIUrl":"10.1007/7854_2024_485","url":null,"abstract":"<p><p>The use of animal models continues to be essential for carrying out research into clinical phenomena, including addiction. However, the complexity of the clinical condition inevitably means that even the best animal models are inadequate, and this may go some way to account for the apparent failures of discoveries from animal models, including the identification of potential novel therapies, to translate to the clinic. We argue here that it is overambitious and misguided in the first place to attempt to model complex, multifacetted human disorders such as addiction in animals, and especially in rodents, and that all too frequently \"validity\" of such models is limited to superficial similarities, referred to as \"face validity\", that reflect quite different underlying phenomena and biological processes from the clinical situation. Instead, a more profitable approach is to identify (a) well-defined intermediate human behavioural phenotypes that reflect defined, limited aspects of, or contributors to, the human clinical disorder, and (b) to develop animal models that are homologous with those discrete human behavioural phenotypes in terms of psychological processes, and underlying neurobiological mechanisms. Examples of past and continuing weaknesses and suggestions for more limited approaches that may allow better homology between the test animal and human condition are made.</p>","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"551-594"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intergenerational Effects of Stress - A Focus on Learning and Memory.","authors":"L S Vasquez, S Stack, W W Taylor, B G Dias","doi":"10.1007/7854_2025_578","DOIUrl":"10.1007/7854_2025_578","url":null,"abstract":"<p><p>Stress is a ubiquitous facet of life. Ranging in form (e.g., psychosocial, physical, nutritional, economic) and longevity (e.g., acute, chronic), stressors affect the biology of those directly in their line of attack. As is becoming increasingly appreciated, the pernicious effects of stress echo across generations (Dias et al. 2015; Yehuda and Lehrner 2018; Jawaid et al. 2021; Dion et al. 2022; Zhou and Ryan 2023; Dias 2024). With a focus on learning and memory, this chapter addresses how stressors derail learning and memory in the generation directly exposed to them andin future generations. To do so, with a specific emphasis on associative fear conditioning in humans and rodents, we touch upon the relevance of extinction training in the aftermath of such conditioning and the recall of such extinction training as windows into normative and disrupted learning. Next, we briefly discuss underlying neuroanatomical substrates mediating these processes. We then draw attention to influences of postnatal, in utero, and pre-conceptional stress on learning and memory across generations. Finally, we briefly outline biological factors that underlie how learning and memory is derailed by these stressors.</p>","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"231-251"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13101576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Animal Models of Excessive Alcohol Consumption in Rodents.","authors":"Howard C Becker, Marcelo F Lopez","doi":"10.1007/7854_2024_461","DOIUrl":"10.1007/7854_2024_461","url":null,"abstract":"<p><p>The development of animal models that demonstrate excessive levels of alcohol consumption has played an important role in advancing our knowledge about neurobiological underpinnings and environmental circumstances that engender such maladaptive behavior. The use of these preclinical models has also provided valuable opportunities for discovering new and novel therapeutic targets that may be useful in the treatment of alcohol use disorder (AUD). While no single model can fully capture the complexities of AUD, the goal is to develop animal models that closely approximate characteristics of heavy alcohol drinking in humans to enhance their translational value and utility. A variety of experimental approaches have been employed to produce the desired phenotype of interest-robust and reliable excessive levels of alcohol drinking. Here we provide an updated review of five animal models that are commonly used. The models entail procedural manipulations of scheduled access to alcohol (time of day, duration, frequency), periods of time when access to alcohol is withheld, and history of alcohol exposure. Specially, the models involve (a) scheduled access to alcohol, (b) scheduled periods of alcohol deprivation, (c) scheduled intermittent access to alcohol, (d) scheduled-induced polydipsia, and (e) chronic alcohol (dependence) and withdrawal experience. Each of the animal models possesses unique experimental features that engender excessive levels of alcohol consumption. Both advantages and disadvantages of each model are described along with discussion of future work to be considered in developing more optimal models. Ultimately, the validity and utility of these models will lie in their ability to aid in the discovery of new and novel potential therapeutic targets as well as serve as a platform to evaluate treatment strategies that effectively reduce excessive levels of alcohol consumption associated with AUD.</p>","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"79-110"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13116246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139715942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}