Current topics in behavioral neurosciences最新文献

Sensing the Self: The Role of the Insula and Interoception in Body Image. 感知自我：脑岛和内感受在身体意象中的作用。

Current topics in behavioral neurosciences Pub Date : 2025-04-04 DOI: 10.1007/7854_2025_581

Emily M Choquette, Sahib S Khalsa

引用次数: 0

Disturbances in Auditory and Visual Perceptual Function in Schizophrenia: Patterns, Causes, and Consequences. 精神分裂症的听觉和视觉知觉功能障碍：模式、原因和后果。

Current topics in behavioral neurosciences Pub Date : 2025-04-02 DOI: 10.1007/7854_2025_582

Daniel C Javitt

{"title":"Disturbances in Auditory and Visual Perceptual Function in Schizophrenia: Patterns, Causes, and Consequences.","authors":"Daniel C Javitt","doi":"10.1007/7854_2025_582","DOIUrl":"https://doi.org/10.1007/7854_2025_582","url":null,"abstract":"Schizophrenia is a severe mental disorder and a leading cause of global disability. Increasing evidence ties impairments in both auditory and visual perceptual processing to impaired functional outcomes. In the auditory system, deficits are observed in the ability to process changes in tonality, leading to deficits in the detection of nonverbal aspects of auditory communication, including emotion and sarcasm. In the auditory sytem, these deficits are indexed by impaired generation of mismatch negativity (MMN), which has become a widely utilized index of auditory perceptual dysfunction. In the visual system, deficits are especially observed in functions related to the magnocellular visual pathway, which projects preferentially to the dorsal visual stream. Dorsal stream dysfunction, in turn, contributes to impairments in processes such as fragmented object recognition, face emotion recognition, and social cognition. Indices of visual perceptual dysfunction include visual P1 responses to magnocellular-biased stimuli, as well as fMRI activation levels within the dorsal and ventral streams. Perceptual level deficits are tied most directly to impaired function of N-methyl-D-aspartate glutamate receptors (NMDAR) and thus may serve both as pathophysiologically based nosological biomarkers and as targets for neuromodulatory and pharmacological treatment development.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intergenerational Effects of Stress - A Focus on Learning and Memory. 压力的代际效应——学习和记忆的焦点。

Current topics in behavioral neurosciences Pub Date : 2025-03-22 DOI: 10.1007/7854_2025_578

L S Vasquez, S Stack, W W Taylor, B G Dias

{"title":"Intergenerational Effects of Stress - A Focus on Learning and Memory.","authors":"L S Vasquez, S Stack, W W Taylor, B G Dias","doi":"10.1007/7854_2025_578","DOIUrl":"https://doi.org/10.1007/7854_2025_578","url":null,"abstract":"Stress is a ubiquitous facet of life. Ranging in form (e.g., psychosocial, physical, nutritional, economic) and longevity (e.g., acute, chronic), stressors affect the biology of those directly in their line of attack. As is becoming increasingly appreciated, the pernicious effects of stress echo across generations (Dias et al. 2015; Yehuda and Lehrner 2018; Jawaid et al. 2021; Dion et al. 2022; Zhou and Ryan 2023; Dias 2024). With a focus on learning and memory, this chapter addresses how stressors derail learning and memory in the generation directly exposed to them andin future generations. To do so, with a specific emphasis on associative fear conditioning in humans and rodents, we touch upon the relevance of extinction training in the aftermath of such conditioning and the recall of such extinction training as windows into normative and disrupted learning. Next, we briefly discuss underlying neuroanatomical substrates mediating these processes. We then draw attention to influences of postnatal, in utero, and pre-conceptional stress on learning and memory across generations. Finally, we briefly outline biological factors that underlie how learning and memory is derailed by these stressors.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Life and Legacy of Arthur D. Craig, Jr.: A Pioneer in Interoception. 小阿瑟·d·克雷格的一生和遗产：心灵感应的先驱。

Current topics in behavioral neurosciences Pub Date : 2025-03-19 DOI: 10.1007/7854_2024_574

Anders Blomqvist, Jonathan O Dostrovsky

{"title":"The Life and Legacy of Arthur D. Craig, Jr.: A Pioneer in Interoception.","authors":"Anders Blomqvist, Jonathan O Dostrovsky","doi":"10.1007/7854_2024_574","DOIUrl":"https://doi.org/10.1007/7854_2024_574","url":null,"abstract":"A.D. (Bud) Craig (1951-2023) redefined the concept of interoception and provided a novel, revolutionary understanding of the neural basis for human awareness. In unsurpassed anatomical-physiological studies in monkeys, Craig showed that the insular cortex is the primary sensory cortex for interoception, or the image of the \"material me\" that provides a homeostatic representation of the physiological condition of the body. He showed that the insula contains a postero-anteriorly organized somatotopic map of the interoceptive sensations, and that it encodes both the localization and the intensity discrimination of interoceptive sensations. In seminal work in humans, he demonstrated that the interoceptive feelings are re-represented, and multimodally integrated, in anterior portions of the insula in sequence of increasingly homeostatically efficient representations that integrate all salient neural activity. He further showed that subjective awareness is associated with activation of the anterior insular cortex and suggested that this brain region also is critical for fluid intelligence and the perception of time. His work has led to a paradigm shift in our understanding of interoception and how interoceptive sensations underlie consciousness, a topic that long has been considered elusive, or even beyond our comprehension.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Body, Self, and Time: Bud Craig's Global Emotional Moments Theory. 身体、自我和时间：巴德·克雷格的全球情绪时刻理论。

Current topics in behavioral neurosciences Pub Date : 2025-03-12 DOI: 10.1007/7854_2024_575

Julian Kiverstein

{"title":"Body, Self, and Time: Bud Craig's Global Emotional Moments Theory.","authors":"Julian Kiverstein","doi":"10.1007/7854_2024_575","DOIUrl":"https://doi.org/10.1007/7854_2024_575","url":null,"abstract":"The topic of my chapter will be Bud Craig's theory of \"global emotional moments\" (henceforth the GEMs theory) and the relationship of GEMs to the experience of time. I connect three ideas prominent in Craig's writings: interoception, emotion, and time. Craig held that each GEM has as its neural substrate a large-scale network with the anterior insula cortex (AIC) serving as its central processing hub. This network integrates interoceptive signals that keep track of changes arising in the autonomic nervous system with hedonic and motivational signals based on the organism's sensory perception of its environment. Craig argued that GEMs function as moving windows of time within which \"a phenomenal self\" is experienced. By the \"phenomenal self,\" I mean a material, embodied self that forms an organism's subjective point of view on the world. Craig proposed what he called a \"cinemascopic\" theory of GEMs. GEMs are combined over time to form a stream of consciousness, which Craig compared to a movie, with each GEM corresponding to a single snapshot of this movie. I will argue that Craig's cinemascopic theory has implications for our understanding of what I will call the \"phenomenal now.\" There are three main theories of the phenomenal now in the philosophical literature. One point of contention between these theories is whether the phenomenal now has duration or temporal depth. I will argue that GEMs have duration and therefore count against so-called \"cinematic\" theories of the phenomenal now that take the contents of experience to be of discrete points or instances in time. However, there are different views within philosophy of how the phenomenal now can have duration. I end my chapter by considering how Craig's GEMs theory might bear on this debate.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Touched Body and the Experience of Self. 被触摸的身体与自我的体验。

Current topics in behavioral neurosciences Pub Date : 2025-03-12 DOI: 10.1007/7854_2025_577

Rebecca Böhme

{"title":"The Touched Body and the Experience of Self.","authors":"Rebecca Böhme","doi":"10.1007/7854_2025_577","DOIUrl":"https://doi.org/10.1007/7854_2025_577","url":null,"abstract":"Slow caressing of the skin activates C-tactile fibers in the periphery and the posterior insula cortex. Because of this, Bud Craig considered affective touch to be an interoceptive modality. Through the tactile sense, we perceive the border of our own body and the largest of our organs, the skin. Whether or not C-targeted touch is considered interoceptive, it contributes fundamentally to the development and maintenance of the bodily self. This is supported by experimental data from cases, where somatosensory processing is altered, and the other way around, i.e., when the bodily sense of self is changed either pharmacologically or in psychiatric conditions. Self-touch can be seen as a special case contributing to the bodily self-model by providing high fidelity signals within a closed feedback loop. Social touch, especially between parents and children and between romantic partners, plays a crucial role in social allostasis and the co-regulation of physiology and emotions. Touch, both self-touch and social touch, should therefore be considered foundational for the bodily self and essential for mental and physiological well-being. Through touch, we perceive the self in its most basic form, as a social body.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gestational Opioid Exposure: From Morphine to MOUD - How Opioids Impact Offspring Development and Maternal Care. 妊娠期阿片类药物暴露：从吗啡到吗啡-阿片类药物如何影响后代发育和孕产妇护理。

Current topics in behavioral neurosciences Pub Date : 2025-03-12 DOI: 10.1007/7854_2024_570

Jecenia Duran, Sonia Khalid, Lauren Richardson, Kelly Bosse, Susanne Brummelte

{"title":"Gestational Opioid Exposure: From Morphine to MOUD - How Opioids Impact Offspring Development and Maternal Care.","authors":"Jecenia Duran, Sonia Khalid, Lauren Richardson, Kelly Bosse, Susanne Brummelte","doi":"10.1007/7854_2024_570","DOIUrl":"https://doi.org/10.1007/7854_2024_570","url":null,"abstract":"Opioid use disorder (OUD) continues to be a global problem, with particularly high opioid usage rates in the United States. One major contributor to this crisis has been the high rate of opioid prescriptions, which has increased access to opioids and contributed to many vulnerable individuals becoming dependent or addicted. Many of these affected people are women of reproductive age, which in turn results in many women using or abusing opioids during pregnancy and thus many infants being exposed to illicit opioids. OUD is typically treated with either methadone or buprenorphine (BUP), two effective opioid-based medications for OUD (MOUD). BUP has recently gained more attention and replaced methadone as the \"gold standard\" of treatment since its unique pharmacodynamic properties seem to result in better compliance, less withdrawal symptoms, and improved infant outcomes compared to methadone. However, the effects of BUP exposure on the long-term outcome of the offspring and mother-infant dyad are not fully understood. This chapter will review the current state of the literature regarding effects of gestational opioid exposure on offspring outcomes, focusing on morphine as a commonly used illicit substance and BUP as a widely used MOUD. Collectively, the literature reviewed here highlights the need for future research into the impact of gestational opioid use on mothers, their care behavior, and their subsequent mother-infant bonds.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurodevelopmental Pathways from Temperamental Fear to Anxiety. 从喜怒无常的恐惧到焦虑的神经发育途径。

Current topics in behavioral neurosciences Pub Date : 2025-03-12 DOI: 10.1007/7854_2024_571

Eunkyung Shin, Koraly Pérez-Edgar

引用次数: 0

Neuromodulation of Fear and Anxiety Circuits. 恐惧和焦虑回路的神经调节。

Current topics in behavioral neurosciences Pub Date : 2025-03-12 DOI: 10.1007/7854_2024_573

Joshua A Brown, Kevin J Clancy, Wen Li

{"title":"Neuromodulation of Fear and Anxiety Circuits.","authors":"Joshua A Brown, Kevin J Clancy, Wen Li","doi":"10.1007/7854_2024_573","DOIUrl":"https://doi.org/10.1007/7854_2024_573","url":null,"abstract":"Anxiety is a complex and heterogeneous condition consisting of multiple component processes and neural underpinnings. Recent neural accounts for anxiety have expanded beyond the canonical anxiety and fear circuitry centered on the amygdala to a distributed network. A burgeoning form of clinical intervention with remarkable potential to directly engage the neural substrates of anxiety is non-invasive brain stimulation (NIBS), which is especially notable for the ability to modulate macro- and meso-scopic circuits and networks. NIBS is poised as a powerful research tool with the ability to extend basic research in animal models to humans, as well as develop novel mechanistic insights and therapeutic targets for underexplored elements of anxiety. This chapter provides an updated review of the neural anatomy of fear and anxiety and discusses the application of NIBS methodologies (primarily, transcranial magnetic, direct-current, and alternating-current stimulation/transcranial magnetic stimulation, transcranial direct current stimulation, and transcranial alternating current stimulation) in testing, targeting, and normalizing the pathophysiology of fear and anxiety circuits. We conclude with a proposal of a unified approach for neuromodulation, promoting the synthesis of multiple neural circuits and systems involved in fear and anxiety.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Canonical Cannabinoid Receptors. 典型大麻素受体。

Current topics in behavioral neurosciences Pub Date : 2025-03-07 DOI: 10.1007/7854_2024_556

Beth Ehrlich, Monica Patel, Xiaoxi Zheng, Michelle Glass

{"title":"Canonical Cannabinoid Receptors.","authors":"Beth Ehrlich, Monica Patel, Xiaoxi Zheng, Michelle Glass","doi":"10.1007/7854_2024_556","DOIUrl":"https://doi.org/10.1007/7854_2024_556","url":null,"abstract":"This chapter will review the basic pharmacology of the canonical cannabinoid receptors. The endocannabinoid system is a complex signalling network involved in a wide range of physiological processes, including pain modulation, appetite regulation, and synaptic plasticity. The canonical cannabinoid receptors, CB1 and CB2, are central in orchestrating this system. CB1 is highly enriched in the central nervous system (CNS), where it plays a crucial role in modulating neurotransmitter release and synaptic plasticity. In contrast, CB2 is predominantly expressed in peripheral tissues and immune cells, participating in anti-inflammatory processes. Here, we focus on cannabinoid receptor distribution, intracellular signalling, and receptor regulation. We describe the intracellular signalling pathways activated by CB1, including the modulation of ion channels, second messengers, and protein kinases. Overall, this chapter provides an overview of the canonical cannabinoid receptors and their role in the regulation of neuronal signalling and plasticity, highlighting the molecular and cellular mechanisms underlying their effects in the CNS.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0