Current topics in behavioral neurosciences最新文献

The Pharmacological Profile of Plant-Derived Cannabinoids In Vitro. 植物源性大麻素的体外药理研究。

Current topics in behavioral neurosciences Pub Date : 2025-10-10 DOI: 10.1007/7854_2025_605

Stephen P H Alexander

引用次数: 0

Psychedelic-Associated Depersonalization-Derealization Disorder. 迷幻相关的人格解体-现实感丧失障碍。

Current topics in behavioral neurosciences Pub Date : 2025-09-14 DOI: 10.1007/7854_2025_599

Matthias Michal

{"title":"Psychedelic-Associated Depersonalization-Derealization Disorder.","authors":"Matthias Michal","doi":"10.1007/7854_2025_599","DOIUrl":"https://doi.org/10.1007/7854_2025_599","url":null,"abstract":"Depersonalization (DP) and Derealization (DR) refer to perceptual changes of \"as-if-character\" where the self (→DP) or the surroundings (→DR) are experienced as unreal. These symptoms are highly prevalent in individuals with mental disorders. If these symptoms persist most of the day for months, the diagnosis of depersonalization-derealization-disorder (DDD) is likely. DDD is a common disorder with a high comorbidity with depression, anxiety disorders, and personality disorders.The intake of classic psychedelic drugs often elicits DP/DR symptoms, which cease in most cases when the drug is eliminated. DDD is frequently precipitated by drug intoxication (cannabis and classic psychedelics). Patients and some researchers assume, therefore, that drug intoxication is the cause of DDD and frame it as a \"never-ending trip.\" Researchers base their assumption on the potential of psychedelics to elicit DP/DR symptoms and on case series of individuals reporting long-lasting uncomfortable symptoms after drug intake. Arguments are presented that demonstrate this is a reductionist conclusion and that this assertion may lead to false illness perceptions, hinder awareness of emotional conflicts, and erode patients' self-efficacy. The main arguments are that, first, DDD is a mental disorder resulting from the avoidance of aversive emotional states. DDD is related to functional alterations of brain networks rather than organic brain damage. Second, psychedelics act as a catalyst that accelerates the onset of DDD in vulnerable individuals by mobilizing complex anxiety-laden unconscious emotions from early attachment traumas.The treatment of DDD encompasses psychoeducation about the nature of the disorder, challenging false causal attributions to external causes (such as drug intake) and helping the patient experience and process their emotions adaptively. To achieve remission, patients usually need long-term psychotherapy of 50-100 sessions.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pre- and Postnatal Valproate Exposure Affects Brain Development. 产前和产后丙戊酸暴露影响大脑发育。

Current topics in behavioral neurosciences Pub Date : 2025-08-29 DOI: 10.1007/7854_2025_603

Michaela A Pettie, Linda C M Wilkin-Krug, Bart Ellenbroek

引用次数: 0

Maternal SSRI Use During Pregnancy: Links Between Gut Microbiome, Offspring Behaviour, and Brain Transcriptomics. 怀孕期间母亲使用SSRI：肠道微生物组，后代行为和脑转录组之间的联系。

Current topics in behavioral neurosciences Pub Date : 2025-08-29 DOI: 10.1007/7854_2025_602

Mayerli A Prado Rivera, Joëlle D Jagersma, Jocelien D A Olivier

{"title":"Maternal SSRI Use During Pregnancy: Links Between Gut Microbiome, Offspring Behaviour, and Brain Transcriptomics.","authors":"Mayerli A Prado Rivera, Joëlle D Jagersma, Jocelien D A Olivier","doi":"10.1007/7854_2025_602","DOIUrl":"https://doi.org/10.1007/7854_2025_602","url":null,"abstract":"Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed to treat maternal depression during pregnancy, yet their potential impact on foetal brain development remains a concern. Although maternal illness is a known confounder, growing evidence from both clinical and preclinical studies suggests that perinatal SSRI exposure may independently influence neurodevelopmental outcomes. This review draws on rodent studies to explore how developmental SSRI exposure affects the gut microbiome, maternal behaviour, myelination, and offspring social behaviour. Elevated serotonin levels caused by SSRIs can alter both brain development and the maternal gut microbiota, with possible long-term effects on offspring. Behaviourally, SSRI-exposed offspring often show reduced social play, altered social interactions, and sex-specific effects on aggression and sexual behaviour, in which males appear more sensitive to these effects than females. Maternal care is only modestly affected. Overall, developmental SSRI exposure in the absence of maternal illness can disrupt brain development and social behaviour in offspring, potentially through gut-brain axis mechanisms and altered myelination.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delta-9-tetrahydrocannabinol and Cannabidiol for Pain: Preclinical and Clinical Models. -9-四氢大麻酚和大麻二酚治疗疼痛：临床前和临床模型。

Current topics in behavioral neurosciences Pub Date : 2025-08-29 DOI: 10.1007/7854_2025_604

H M Harris, C F Moore, B W Jenkins, M F Bedillion, E M Weerts, C A Arout

{"title":"Delta-9-tetrahydrocannabinol and Cannabidiol for Pain: Preclinical and Clinical Models.","authors":"H M Harris, C F Moore, B W Jenkins, M F Bedillion, E M Weerts, C A Arout","doi":"10.1007/7854_2025_604","DOIUrl":"https://doi.org/10.1007/7854_2025_604","url":null,"abstract":"Cannabinoids are increasingly being used to manage pain resulting from a variety of conditions. Both preclinical animal models and human studies have played a crucial role in advancing our knowledge of cannabinoids, their involvement in pain mechanisms, and their potential utility as novel analgesics. This chapter first reviews basic pain neurobiology and the most common experimental pain paradigms, which provide a basis for our discussion of preclinical, human laboratory, and clinical research characterizing the effectiveness of cannabinoids for managing pain. While a substantial body of literature exists describing these effects, findings are complex and largely mixed, dependent on the cannabinoid administered, route of administration, and pain modality/syndrome tested. Herein, we highlight the need for more rigorous, placebo-controlled research defining the therapeutic efficacy of cannabinoids. The chapter concludes by emphasizing the need for further investigation of other cannabis constituents (e.g., minor cannabinoids and terpenes), potential interactions between cannabinoids and other analgesic medications, as well as other emerging issues in the intersection between cannabinoids and pain management.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Consequences Paternal Preconceptual Alcohol Consumption. 父亲孕前饮酒的功能后果。

Current topics in behavioral neurosciences Pub Date : 2025-08-23 DOI: 10.1007/7854_2025_601

Sahir Hussain, Darren Day, Bart Ellenbroek

引用次数: 0

Acute Effects and Long-Term Neuropsychological Consequences of Classic Psychedelics Use. 经典致幻剂使用的急性效应和长期神经心理后果。

Current topics in behavioral neurosciences Pub Date : 2025-08-23 DOI: 10.1007/7854_2025_600

Lukas Andreas Basedow, Thomas Günther Riemer

{"title":"Acute Effects and Long-Term Neuropsychological Consequences of Classic Psychedelics Use.","authors":"Lukas Andreas Basedow, Thomas Günther Riemer","doi":"10.1007/7854_2025_600","DOIUrl":"https://doi.org/10.1007/7854_2025_600","url":null,"abstract":"Psychedelics are gaining attention for their potential as therapeutic adjuncts for the treatment of psychological disorders. Additionally, the recreational use of these substances has been rising for the past years. In the context of a comprehensive analysis of potential harms induced by these substances, concerns regarding the cognitive and neuropsychological impact of their use remain. This chapter explores the acute, subacute, and long-term neuropsychological consequences of psychedelic use. Studies show that neuropsychological performance, especially attention and working memory, is reduced under the influence of a psychedelic. While not harmful in itself, this effect poses potential risks when combined with high-risk environments, such as road traffic. While these acute impairments seem to disappear on the day after psychedelic use, there is limited evidence that some impairments in executive functioning can persist for up to 24 h. Thus, caution is not only warranted during psychedelic use but also for the following day. In contrast, psychedelics do not seem to induce persistent changes in neuropsychological performance through repeated use, indicating no direct neuropsychological harms. However, further research is required to clarify the differential effects of various psychedelic substances and to assess the impact of chronic use across different contexts.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Future of Perceptual Dysregulation in Psychiatric Nosology. 知觉失调在精神病学中的未来。

Current topics in behavioral neurosciences Pub Date : 2025-08-13 DOI: 10.1007/7854_2025_596

Albert R Powers, Sahib S Khalsa

{"title":"The Future of Perceptual Dysregulation in Psychiatric Nosology.","authors":"Albert R Powers, Sahib S Khalsa","doi":"10.1007/7854_2025_596","DOIUrl":"https://doi.org/10.1007/7854_2025_596","url":null,"abstract":"Like other medical illnesses, psychiatric conditions are defined by the presence of characteristic signs and symptoms that cause distress and dysfunction. Unlike most medical illnesses, however, the pathophysiological mechanisms underlying psychiatric symptoms remain largely unknown. Recent work in theory-driven computational neuroscience has proposed a unified account of how organisms derive estimates of both external and internal states by integrating prior beliefs with sensory input. This framework offers a powerful means of explaining typical perception and action, while also identifying how these processes may go awry to produce a panoply of psychiatric symptoms. Disruptions in this inferential process, which we term perceptual dysregulation, span exteroceptive, proprioceptive, and interoceptive systems and manifest across conditions ranging from psychosis and autism to anxiety and trauma-related disorders, functional neurological disorder, and dementia. This volume reviews emerging evidence for maladaptive sensory inference across psychiatric and neurological illness and explores how computational models based on Bayesian statistics can illuminate shared mechanisms beneath diverse symptom presentations. We argue that targeting perceptual dysregulation may not only enable new interventions but also catalyze the development of a revised psychiatric nosology grounded in testable models of brain-body interaction.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Genetic Tools in Rodents to Study Cannabinoid Functions. 更正：在啮齿类动物中研究大麻素功能的遗传工具。

Current topics in behavioral neurosciences Pub Date : 2025-08-08 DOI: 10.1007/7854_2025_584

Krisztina Monory, Inigo Ruiz de Azua, Beat Lutz

引用次数: 0

Pharmacotherapy for Cannabis Use Disorder: Preclinical and Clinical Models. 大麻使用障碍的药物治疗：临床前和临床模型。

Current topics in behavioral neurosciences Pub Date : 2025-08-05 DOI: 10.1007/7854_2025_598

Margaret F Bedillion, Catherine F Moore, Elise M Weerts, Caroline A Arout, Hannah M Harris, Margaret Haney

引用次数: 0