Current topics in behavioral neurosciences最新文献

Insights into Overlapping Brain Networks for Anxiety and Alcohol Use Disorders. 对焦虑和酒精使用障碍的重叠大脑网络的见解。

Current topics in behavioral neurosciences Pub Date : 2025-05-15 DOI: 10.1007/7854_2025_592

Nicole L Zabik, Jennifer Urbano Blackford

{"title":"Insights into Overlapping Brain Networks for Anxiety and Alcohol Use Disorders.","authors":"Nicole L Zabik, Jennifer Urbano Blackford","doi":"10.1007/7854_2025_592","DOIUrl":"https://doi.org/10.1007/7854_2025_592","url":null,"abstract":"Alcohol use disorder (AUD) is a debilitating condition affecting over 30 million Americans. AUD commonly co-occurs with other disorders, like other substance use disorders, trauma-related disorders, and anxiety disorders. Of the numerous co-occurring disorders, anxiety disorders are the most pervasive: anxiety disorders serve as a risk factor for developing AUD, emerge as co-occurring disorders that maintain alcohol drinking, and impede the effectiveness of treatments for AUD. Anxiety, therefore, shapes the development, course, and treatment of AUDs. AUDs can also increase anxiety, suggesting a complex, bidirectional relation between alcohol use and anxiety. The intersection of AUDs and anxiety is also supported by their overlapping neural circuits, specifically neural circuits involved in stress responding, reward processing, and cognitive control. The current review highlights findings from several decades of research on how anxiety impacts the brain and treatment outcomes in AUDs. We also provide important considerations for future research, with the goal of reducing the shame and burden of alcohol use for individuals with AUD and their families.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal Antidepressant Exposure and the Developing Brain: A Review of Neuroimaging Findings. 产前抗抑郁药物暴露与大脑发育：神经影像学研究综述。

Current topics in behavioral neurosciences Pub Date : 2025-05-14 DOI: 10.1007/7854_2025_591

Kayleigh S J Campbell, Tim F Oberlander

{"title":"Prenatal Antidepressant Exposure and the Developing Brain: A Review of Neuroimaging Findings.","authors":"Kayleigh S J Campbell, Tim F Oberlander","doi":"10.1007/7854_2025_591","DOIUrl":"https://doi.org/10.1007/7854_2025_591","url":null,"abstract":"Antenatal mood disturbances are experienced by as many as 20% of pregnant mothers and are commonly treated with serotonin reuptake inhibitor (SRI) antidepressants. Both maternal depression and SRIs during pregnancy are associated with low birth weight and infant neurobehavioral disturbances, as well as longer-term impacts on child neurodevelopment, behavior, and mental health. As maternal depression and its pharmacotherapy are inherently interrelated prenatal exposures, distinguishing how these early life factors uniquely impact child development remains methodologically challenging. Over the past several years, however, advanced neuroimaging has been successfully used to identify neural correlates of prenatal depression and SRI antidepressant exposure on the developing brain, extending from the early newborn period through adolescence. In this review, we examine the use of magnetic resonance imaging and electroencephalography to study child brain structure or function, with a specific focus on prenatal antidepressants as the primary exposure in relation to either typical development or exposure to maternal depressed mood alone. We include both cross-sectional and longitudinal neuroimaging studies, as well as those that link early brain findings with cognitive or behavioral outcome in childhood. We also discuss factors that may shape neurodevelopmental risk (e.g., maternal mental illness severity, sex differences, genetic variability) and present suggestions for future research that will advance our understanding of child brain development in the context of maternal mood disturbances during pregnancy.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Intersection of Interoception and Anticipation Related to Pain. 与疼痛相关的内感受和预期的交集。

Current topics in behavioral neurosciences Pub Date : 2025-05-14 DOI: 10.1007/7854_2025_588

Irina A Strigo, Alan N Simmons

引用次数: 0

Alcohol-Induced Changes in Brain Microstructure: Uncovering Novel Pathophysiological Mechanisms of AUD Using Translational DTI in Humans and Rodents. 酒精诱导的大脑微观结构变化：利用人类和啮齿动物的平移DTI揭示AUD的新病理生理机制。

Current topics in behavioral neurosciences Pub Date : 2025-05-14 DOI: 10.1007/7854_2025_585

Wolfgang H Sommer, Santiago Canals

{"title":"Alcohol-Induced Changes in Brain Microstructure: Uncovering Novel Pathophysiological Mechanisms of AUD Using Translational DTI in Humans and Rodents.","authors":"Wolfgang H Sommer, Santiago Canals","doi":"10.1007/7854_2025_585","DOIUrl":"https://doi.org/10.1007/7854_2025_585","url":null,"abstract":"Alcohol use disorder (AUD) induces significant structural alterations in both gray and white matter, contributing to cognitive and functional impairments. This chapter presents a translational neuroimaging approach using diffusion-weighted MRI in humans and rodents to uncover novel pathophysiological mechanisms underlying AUD. Our studies demonstrate that increased mean diffusivity (MD) in gray matter reflects microglial reactivity and reduced extracellular space tortuosity, leading to enhanced volume neurotransmission. In white matter, fractional anisotropy (FA) reductions indicate progressive deterioration of key tracts, particularly the fimbria/fornix, linked to impaired cognitive flexibility. Importantly, longitudinal analyses reveal that white matter degeneration continues during early abstinence, suggesting that neuroinflammation and demyelination persist beyond alcohol cessation. Finally, we discuss how neuromodulatory interventions, such as transcranial magnetic stimulation (TMS), may promote recovery by enhancing myelin plasticity. These findings provide crucial insights into AUD's neurobiological underpinnings and highlight potential therapeutic targets for improving treatment outcomes.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensory and Multisensory Processing Changes and Their Contributions to Autism and Schizophrenia. 感觉和多感觉加工的变化及其对自闭症和精神分裂症的影响。

Current topics in behavioral neurosciences Pub Date : 2025-05-11 DOI: 10.1007/7854_2025_589

Sarah G Vassall, Mark T Wallace

引用次数: 0

A Personal and Scientific Introduction to the Work of A.D. (Bud) Craig on Interoception and the Insular Cortex. ad . (Bud) Craig关于内感受和岛叶皮层工作的个人科学介绍。

Current topics in behavioral neurosciences Pub Date : 2025-05-09 DOI: 10.1007/7854_2025_583

Irina A Strigo, Alan N Simmons, Marc Wittmann

{"title":"A Personal and Scientific Introduction to the Work of A.D. (Bud) Craig on Interoception and the Insular Cortex.","authors":"Irina A Strigo, Alan N Simmons, Marc Wittmann","doi":"10.1007/7854_2025_583","DOIUrl":"https://doi.org/10.1007/7854_2025_583","url":null,"abstract":"A.D. (Bud) Craig was best known to us colloquially as Bud Craig; his groundbreaking work has advanced our understanding of the neuroanatomical basis of the bodily self, emotion, and subjective time. His research elucidated the intricate pathways of interoception - the brain's processing of internal body signals - and highlighted the insula's pivotal role in integrating these signals. Craig's pioneering insights demonstrated that bodily sensations, such as pain and temperature, are deeply intertwined with emotional experiences and homeostatic needs. By mapping the thalamocortical pathways and emphasizing the insula's function in predicting future bodily states, he provided a comprehensive framework that connects physiological states to emotional and temporal experiences. This fundamental work has profoundly influenced a new generation of scientists and inspired the current volume. In this book, we have invited researchers influenced by Craig's theories to explore the neural correlates of emotion, pain, interoception, and time. In this chapter, we present how the editors of this book were directly influenced by Craig's findings and lay the groundwork for the large collective contribution of the authors of the subsequent chapters that continue to explore this ever-evolving scientific landscape.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traumatic Psychedelic Experiences. 创伤性迷幻体验。

Current topics in behavioral neurosciences Pub Date : 2025-04-29 DOI: 10.1007/7854_2025_579

Abigail E Calder, Vincent J Diehl, Gregor Hasler

引用次数: 0

Interoception in Adolescence: Impacts on Mental Health and Adaptive Functioning. 青少年间感受：对心理健康和适应功能的影响。

Current topics in behavioral neurosciences Pub Date : 2025-04-18 DOI: 10.1007/7854_2025_580

April C May, Susan Tapert

引用次数: 0

Sensing the Self: The Role of the Insula and Interoception in Body Image. 感知自我：脑岛和内感受在身体意象中的作用。

Current topics in behavioral neurosciences Pub Date : 2025-04-04 DOI: 10.1007/7854_2025_581

Emily M Choquette, Sahib S Khalsa

引用次数: 0

Disturbances in Auditory and Visual Perceptual Function in Schizophrenia: Patterns, Causes, and Consequences. 精神分裂症的听觉和视觉知觉功能障碍：模式、原因和后果。

Current topics in behavioral neurosciences Pub Date : 2025-04-02 DOI: 10.1007/7854_2025_582

Daniel C Javitt

{"title":"Disturbances in Auditory and Visual Perceptual Function in Schizophrenia: Patterns, Causes, and Consequences.","authors":"Daniel C Javitt","doi":"10.1007/7854_2025_582","DOIUrl":"https://doi.org/10.1007/7854_2025_582","url":null,"abstract":"Schizophrenia is a severe mental disorder and a leading cause of global disability. Increasing evidence ties impairments in both auditory and visual perceptual processing to impaired functional outcomes. In the auditory system, deficits are observed in the ability to process changes in tonality, leading to deficits in the detection of nonverbal aspects of auditory communication, including emotion and sarcasm. In the auditory sytem, these deficits are indexed by impaired generation of mismatch negativity (MMN), which has become a widely utilized index of auditory perceptual dysfunction. In the visual system, deficits are especially observed in functions related to the magnocellular visual pathway, which projects preferentially to the dorsal visual stream. Dorsal stream dysfunction, in turn, contributes to impairments in processes such as fragmented object recognition, face emotion recognition, and social cognition. Indices of visual perceptual dysfunction include visual P1 responses to magnocellular-biased stimuli, as well as fMRI activation levels within the dorsal and ventral streams. Perceptual level deficits are tied most directly to impaired function of N-methyl-D-aspartate glutamate receptors (NMDAR) and thus may serve both as pathophysiologically based nosological biomarkers and as targets for neuromodulatory and pharmacological treatment development.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0