Current topics in behavioral neurosciences最新文献_第10页

SSRIs in the Treatment of Depression: A Pharmacological CUL-DE-SAC? SSRIs治疗抑郁症：药理学CUL-DE-SAC？

Current topics in behavioral neurosciences Pub Date : 2024-01-01 DOI: 10.1007/7854_2023_447

Philip J Cowen

{"title":"SSRIs in the Treatment of Depression: A Pharmacological CUL-DE-SAC?","authors":"Philip J Cowen","doi":"10.1007/7854_2023_447","DOIUrl":"10.1007/7854_2023_447","url":null,"abstract":"The widespread adoption of selective serotonin reuptake inhibitors (SSRIs) as first-line pharmacological treatments in the management of clinical depression transformed the landscape of drug therapy for this condition. SSRIs are safer and better tolerated than the tricyclic antidepressants (TCAs) that they replaced. However, they have limitations that may have placed a ceiling on the expectations of first-line pharmacological treatment. Notable problems with SSRIs include induction of anxiety on treatment initiation, delayed onset of significant therapeutic effect, sexual dysfunction, sleep disturbance and overall modest efficacy. The latter is linked with an inability of SSRIs to effectively treat syndromes of anhedonia and cognitive impairment. Combined serotonin and noradrenaline reuptake inhibitors (SNRIs), such as venlafaxine, have produced some limited improvements over SSRIs in efficacy, at the cost of a greater side-effect burden. Attempts to supplement serotonin reuptake activity with actions at serotonin receptor sub-types have not yet yielded substantial benefits; however, vortioxetine may provide more utility in the management of cognitive impairment. Future advances might come from the development of SNRIs, which more closely mimic the actions of effective TCAs. There may also be possible benefits to be derived from combining SSRIs with 5-HT4 receptor agonists and 5-HT7 receptor antagonists.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"1-19"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71433973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Maturation of the Human Brain, from Infancy to Adolescence. 人类大脑从婴儿期到青春期的发育和成熟。

Current topics in behavioral neurosciences Pub Date : 2024-01-01 DOI: 10.1007/7854_2024_514

Tomáš Paus

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Correction to: Area-level Measures of the Social Environment: Operationalization, Pitfalls, and Ways Forward. 更正：社会环境的地区级衡量标准：操作、陷阱和前进方向。

Current topics in behavioral neurosciences Pub Date : 2024-01-01 DOI: 10.1007/7854_2024_481

Marco Helbich, Yi Zeng, Abeed Sarker

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Psilocybin and Other Classic Psychedelics in Depression. 裸盖菇素和其他经典致幻剂治疗抑郁症。

Current topics in behavioral neurosciences Pub Date : 2024-01-01 DOI: 10.1007/7854_2023_451

D J Nutt, J M Peill, B Weiss, K Godfrey, R L Carhart-Harris, D Erritzoe

{"title":"Psilocybin and Other Classic Psychedelics in Depression.","authors":"D J Nutt, J M Peill, B Weiss, K Godfrey, R L Carhart-Harris, D Erritzoe","doi":"10.1007/7854_2023_451","DOIUrl":"10.1007/7854_2023_451","url":null,"abstract":"Psychedelic drugs such as psilocybin and ketamine are returning to clinical research and intervention across several disorders including the treatment of depression. This chapter focusses on psychedelics that specifically target the 5-HT2A receptor such as psilocybin and DMT. These produce plasma-concentration related psychological effects such as hallucinations and out of body experiences, insightful and emotional breakthroughs as well as mystical-type experiences. When coupled with psychological support, effects can produce a rapid improvement in mood among people with depression that can last for months. In this chapter, we summarise the scientific studies to date that explore the use of psychedelics in depressed individuals, highlighting key clinical, psychological and neuroimaging features of psychedelics that may account for their therapeutic effects. These include alterations in brain entropy that disrupt fixed negative ruminations, a period of post-treatment increased cognitive flexibility, and changes in self-referential psychological processes. Finally, we propose that the brain mechanisms underlying the therapeutic effect of serotonergic psychedelics might be distinct from those underlying classical serotonin reuptake-blocking antidepressants.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"149-174"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89717344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of SSRI Therapy and Discontinuation. SSRI治疗和停药的机制。

Current topics in behavioral neurosciences Pub Date : 2024-01-01 DOI: 10.1007/7854_2023_452

Trevor Sharp, Helen Collins

{"title":"Mechanisms of SSRI Therapy and Discontinuation.","authors":"Trevor Sharp, Helen Collins","doi":"10.1007/7854_2023_452","DOIUrl":"10.1007/7854_2023_452","url":null,"abstract":"SSRIs are one of the most widely used drug therapies in primary care and psychiatry, and central to the management of the most common mental health problems in today's society. Despite this, SSRIs suffer from a slow onset of therapeutic effect and relatively poor efficacy as well as adverse effects, with recent concerns being focused on a disabling SSRI discontinuation syndrome. The mechanism underpinning their therapeutic effect has long shifted away from thinking that SSRIs act simply by increasing 5-HT in the synapse. Rather, a current popular view is that increased 5-HT is just the beginning of a series of complex downstream signalling events, which trigger changes in neural plasticity at the functional and structural level. These changes in plasticity are then thought to interact with neuropsychological processes to enhance re-learning of emotional experiences that ultimately brings about changes in mood. This compelling view of SSRI action is underpinning attempts to understand fast-acting antidepressants, such as ketamine and psychedelic drugs, and aid the development of future therapies. An important gap in the theory is evidence that changes in plasticity are causally linked to relevant behavioural effects. Also, predictions that the SSRI-induced neural plasticity might have applicability in other areas of medicine have not yet been borne out. In contrast to the sophisticated view of the antidepressant action of SSRIs, the mechanism underpinning SSRI discontinuation is little explored. Nevertheless, evidence of rebound increases in 5-HT neuron excitability immediately on cessation of SSRI treatment provide a starting point for future investigation. Indeed, this evidence allows formulation of a mechanistic explanation of SSRI discontinuation which draws on parallels with the withdrawal states of other psychotropic drugs.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"21-47"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89717334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Invasive Neuromodulation Techniques for Treatment-Resistant Depression. 治疗难治性抑郁症的侵入性神经调控技术。

Current topics in behavioral neurosciences Pub Date : 2024-01-01 DOI: 10.1007/7854_2023_460

Peter Theiss, Francesco G Pucci, Konstantin V Slavin

引用次数: 0

Exercise and Fear and Safety Learning. 运动与恐惧和安全学习。

Current topics in behavioral neurosciences Pub Date : 2024-01-01 DOI: 10.1007/7854_2024_494

Ameera Azar, Troy Hubert, Thomas G Adams, Josh M Cisler, Kevin M Crombie

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Exercise for the Prevention and Treatment of Depression. 运动预防和治疗抑郁症。

Current topics in behavioral neurosciences Pub Date : 2024-01-01 DOI: 10.1007/7854_2024_496

Brandon L Alderman, Hannah M Perdue, Amber H Sarwani

引用次数: 0

Multiple Sex- and Circuit-Specific Mechanisms Underlie Exercise-Induced Stress Resistance. 多种性别和回路特异性机制是运动诱导应激抵抗的基础

Current topics in behavioral neurosciences Pub Date : 2024-01-01 DOI: 10.1007/7854_2024_490

Margaret K Tanner, Simone M Mellert, Isabella P Fallon, Michael V Baratta, Benjamin N Greenwood

{"title":"Multiple Sex- and Circuit-Specific Mechanisms Underlie Exercise-Induced Stress Resistance.","authors":"Margaret K Tanner, Simone M Mellert, Isabella P Fallon, Michael V Baratta, Benjamin N Greenwood","doi":"10.1007/7854_2024_490","DOIUrl":"10.1007/7854_2024_490","url":null,"abstract":"Prior physical activity reduces the risk of future stress-related mental health disorders including depression, anxiety, and post-traumatic stress disorder. Rodents allowed to engage in voluntary wheel running are similarly protected from behavioral consequences of stress. The present review summarizes current knowledge on mechanisms underlying exercise-induced stress resistance. A conceptual framework involving the development (during exercise) and expression (during stress) of stress resistance from exercise is proposed. During the development of stress resistance, adaptations involving multiple exercise signals and molecular mediators occur within neural circuits orchestrating various components of the stress response, which then respond differently to stress during the expression of stress resistance. Recent data indicate that the development and expression of stress resistance from exercise involve multiple independent mechanisms that depend on sex, stressor severity, and behavioral outcome. Recent insight into the role of the prefrontal cortex in exercise-induced stress resistance illustrates these multiple mechanisms. This knowledge has important implications for the design of future experiments aimed at identifying the mechanisms underlying exercise-induced stress resistance.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"37-60"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise and Acute Cognitive Enhancement. 运动与急性认知增强。

Current topics in behavioral neurosciences Pub Date : 2024-01-01 DOI: 10.1007/7854_2024_492

Jennifer L Etnier, Samuel W Kibildis, Samantha L DuBois

{"title":"Exercise and Acute Cognitive Enhancement.","authors":"Jennifer L Etnier, Samuel W Kibildis, Samantha L DuBois","doi":"10.1007/7854_2024_492","DOIUrl":"10.1007/7854_2024_492","url":null,"abstract":"Substantial research has explored the effects of a single session of exercise on cognitive performance. Meta-analytic reviews provide summary statistics relative to these effects when the cognitive task is performed while exercising and when performed after exercise. When performed concomitantly the effects of exercise are typically small or negative with the exception of moderate effects for speed of cognitive performance during moderate intensity exercise. When cognitive performance is assessed following the cessation of exercise, the effects are typically positive. When considering the effects following exercise, most studies have focused on executive function and episodic memory as the cognitive outcomes of interest with meta-analyses supporting small-to-moderate benefits. When potential moderators related to exercise parameters or participants characteristics are examined, results suggest that 20 minutes of moderate to vigorous intensity exercise consistently benefits performance with larger effects evident for executive function tasks with higher cognitive demands, for long-term memory tasks when exercise is performed prior to information encoding, and when considering individuals with lower initial cognitive performance levels. These observed benefits are likely due to the impacts acute exercise can have on physiological arousal, brain function, and brain neurotrophic factors. Advancements in our understanding of the potential of a single session of exercise to benefit cognitive performance are important for exercise prescription and to inform chronic exercise programs designed to benefit cognition.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"79-102"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0