Current topics in behavioral neurosciences最新文献_第10页

Subjective Time in Ordinary and Non-ordinary States of Consciousness: How Interoceptive Feelings Inform Us About the Passage of Time. 普通和非普通意识状态下的主观时间：感知间感觉如何告诉我们时间的流逝》。

Current topics in behavioral neurosciences Pub Date : 2025-01-01 DOI: 10.1007/7854_2024_520

Marc Wittmann, Sylvie Droit-Volet

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Interoception: Synthesizing Insights and Charting New Frontiers. 内感受：综合见解和绘制新领域。

Current topics in behavioral neurosciences Pub Date : 2025-01-01 DOI: 10.1007/7854_2025_587

Alan N Simmons, Marc Wittmann, Irina A Strigo

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Fetal Alcohol Spectrum Disorders. 胎儿酒精谱系障碍

Current topics in behavioral neurosciences Pub Date : 2025-01-01 DOI: 10.1007/7854_2024_569

Riley J Felicicchia, Christina R Veziris, Sarah N Mattson

{"title":"Fetal Alcohol Spectrum Disorders.","authors":"Riley J Felicicchia, Christina R Veziris, Sarah N Mattson","doi":"10.1007/7854_2024_569","DOIUrl":"10.1007/7854_2024_569","url":null,"abstract":"Prenatal alcohol exposure (PAE) can cause a wide range of physical, neurobehavioral, and neurocognitive impairments that impact developmental trajectories throughout the lifespan. Clinically, individuals who have been exposed to alcohol prenatally and who show physical or neurobehavioral difficulties may be classified as having a condition included in fetal alcohol spectrum disorders (FASDs). The aim of this chapter is to summarize the current knowledge of FASD including diagnostic criteria, neurobehavioral outcomes, lifespan considerations, and interventions. Individuals with PAE exhibit challenges in the cognitive domains of executive functioning, general intelligence, motor function, learning, and memory. Aggression, trouble with the law, and oppositional behavior are also commonly associated with individuals with FASD. The effects of PAE can be attributed to altered neural development such as smaller total brain volume and structural abnormalities. Prenatal exposure to alcohol increases risk for co-occurring neurodevelopmental conditions and psychiatric disorders. This chapter will also review the current literature on pre- and postnatal interventions to target the effects of PAE.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"99-116"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Epigenetic Dysregulation in Alcohol-Associated Behaviors: Preclinical and Clinical Evidence. 酒精相关行为中的表观遗传失调：临床前和临床证据。

Current topics in behavioral neurosciences Pub Date : 2025-01-01 DOI: 10.1007/7854_2022_410

Esi Domi, Riccardo Barchiesi, Estelle Barbier

{"title":"Epigenetic Dysregulation in Alcohol-Associated Behaviors: Preclinical and Clinical Evidence.","authors":"Esi Domi, Riccardo Barchiesi, Estelle Barbier","doi":"10.1007/7854_2022_410","DOIUrl":"10.1007/7854_2022_410","url":null,"abstract":"Alcohol use disorder (AUD) is characterized by loss of control over intake and drinking despite harmful consequences. At a molecular level, AUD is associated with long-term neuroadaptations in key brain regions that are involved in reward processing and decision-making. Over the last decades, a great effort has been made to understand the neurobiological basis underlying AUD. Epigenetic mechanisms have emerged as an important mechanism in the regulation of long-term alcohol-induced gene expression changes. Here, we review the literature supporting a role for epigenetic processes in AUD. We particularly focused on the three most studied epigenetic mechanisms: DNA methylation, Histone modification and non-coding RNAs. Clinical studies indicate an association between AUD and DNA methylation both at the gene and global levels. Using behavioral paradigms that mimic some of the characteristics of AUD, preclinical studies demonstrate that changes in epigenetic mechanisms can functionally impact alcohol-associated behaviors. While many studies support a therapeutic potential for targeting epigenetic enzymes, more research is needed to fully understand their role in AUD. Identification of brain circuits underlying alcohol-associated behaviors has made major advances in recent years. However, there are very few studies that investigate how epigenetic mechanisms can affect these circuits or impact the neuronal ensembles that promote alcohol-associated behaviors. Studies that focus on the role of circuit-specific and cell-specific epigenetic changes for clinically relevant alcohol behaviors may provide new insights on the functional role of epigenetic processes in AUD.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"309-346"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9152196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The Intersection of Interoception and Anticipation Related to Pain. 与疼痛相关的内感受和预期的交集。

Current topics in behavioral neurosciences Pub Date : 2025-01-01 DOI: 10.1007/7854_2025_588

Irina A Strigo, Alan N Simmons

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The Effects of THC and Nicotine on Attention: A Narrative Review. 四氢大麻酚和尼古丁对注意力的影响：述评。

Current topics in behavioral neurosciences Pub Date : 2025-01-01 DOI: 10.1007/7854_2024_568

Kennedy Oleszak, Lily Freeman Striegel, Nicole Roeder, Patrick Mohr, Samantha Penman, Lorraine Collins, Danielle M Smith, Panayotis K Thanos

{"title":"The Effects of THC and Nicotine on Attention: A Narrative Review.","authors":"Kennedy Oleszak, Lily Freeman Striegel, Nicole Roeder, Patrick Mohr, Samantha Penman, Lorraine Collins, Danielle M Smith, Panayotis K Thanos","doi":"10.1007/7854_2024_568","DOIUrl":"10.1007/7854_2024_568","url":null,"abstract":"Since cannabis and nicotine are two of most commonly used substances and are often used together, this paper will review the effects of cannabis (specifically THC, or tetrahydrocannabinol) and nicotine on selective attention, sustained attention, visuospatial attention, attentional bias, and attentional disorders. This review includes preclinical and clinical findings throughout all periods of development and adulthood. Selective attention is directly impacted by cannabis use, while reaction time is dependent on the timing of the last cannabis exposure. Among individuals who use cannabis, there is an attentional bias that reduces anxiety and increases focus on cannabis-related cues. Preclinical studies show that cannabis induces attention deficits that persist even after an abstinence period. Preclinical and clinical studies of prenatal cannabis exposure (PCE) provide evidence that offspring will have an increased risk for drug-seeking behavior, attention deficits, and impulsivity, which may lead to attentional disorders such as attention deficit hyperactivity disorder (ADHD) and schizophrenia. Nicotine has a dose-dependent effect on attention in adults, though preclinical studies have shown mixed results, possibly due to differences in experimental design. Prenatal nicotine exposure (PNE) impairs attentional networks by increasing one's risk for ADHD, oppositional defiant disorder, and conduct disorder. Additionally, maternal secondhand smoke exposure is linked to ADHD/conduct disorder risk in offspring. Preclinical studies on prenatal nicotine exposure suggest that there may be sex differences in which males are affected more so than females with PNE. Summary: Overall, cannabis/THC impairs attention, and nicotine enhances attention; however, both substances impair attention when individuals are exposed prenatally.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"183-238"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13255862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Correction to: Hearing Loss and Alzheimer Disease. 更正：听力损失和阿尔茨海默病。

Current topics in behavioral neurosciences Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-84920-6_577

Arianna Di Stadio, Mickie J Hamiter, Dalila Roccamatisi, Anil K Lalwani

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Behavioral and Brain Mechanisms of Active Avoidance and Their Relevance to Anxiety Disorders. 主动回避的行为和脑机制及其与焦虑障碍的相关性。

Current topics in behavioral neurosciences Pub Date : 2025-01-01 DOI: 10.1007/7854_2025_593

Hannah McManus, Mohammed R Milad

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Insights from Ecstatic Epilepsy: From Uncertainty to Metacognitive Feelings. 狂喜性癫痫的启示：从不确定性到元认知感受。

Current topics in behavioral neurosciences Pub Date : 2025-01-01 DOI: 10.1007/7854_2024_528

Nina M Sooter, Federico Seragnoli, Fabienne Picard

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New Approaches to Addiction Treatment Based on Learning and Memory. 基于学习和记忆的戒毒新方法。

Current topics in behavioral neurosciences Pub Date : 2025-01-01 DOI: 10.1007/7854_2023_457

Patrick Bach, Falk Kiefer

{"title":"New Approaches to Addiction Treatment Based on Learning and Memory.","authors":"Patrick Bach, Falk Kiefer","doi":"10.1007/7854_2023_457","DOIUrl":"10.1007/7854_2023_457","url":null,"abstract":"Preclinical studies suggest that physiological learning processes are similar to changes observed in addiction at the molecular, neuronal and structural levels. Based on the importance of classical and instrumental conditioning in the development and maintenance of addictive disorders, many have suggested cue-exposure-based extinction training of conditioned, drug-related responses as a potential treatment of addiction. Recently, the development of virtual reality-assisted cue-exposure treatment has put forward new approaches to extinction training. Recent data indicated that it may also be possible to facilitate this extinction training through pharmacological interventions that strengthen memory consolidation during cue exposure. Another potential therapeutic intervention is based on the so-called reconsolidation theory. According to this hypothesis, already-consolidated memories return to a labile state when reactivated, allowing them to undergo another phase of consolidation - reconsolidation - which can be interfered with by pharmacological and behavioural interventions. These approaches suggest that the extinction of drug-related memories may represent a viable treatment strategy in the future treatment of addiction.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"689-717"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138800969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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