Current topics in behavioral neurosciences最新文献

{"title":"Emotion Regulation Under Stress: A Social Processing and Memory Perspective.","authors":"Nicholas J Dennis, Tasha Bulgin, Casey M Nicastri, Cassandra Bell, Mauricio R Delgado","doi":"10.1007/7854_2024_560","DOIUrl":"10.1007/7854_2024_560","url":null,"abstract":"<p><p>Research on emotion regulation often focuses on cognitively effortful self-regulation strategies, but exposure to stress has been shown to interfere with the underlying mechanisms supporting such processes. Understanding alternative strategies that potentially bolster emotion regulation under stress is an important topic of investigation. Two potential alternatives involve everyday occurrences of social processing and memory recall. Social support and past emotional experiences may help in guiding us toward appropriate neurophysiological responses through overlapping circuitry with stress and reward systems, while also buttressing cognitive regulation strategies by expanding one's perspective and allowing multiple opportunities to regulate retrospectively. In recognition that ongoing social and emotional events are often at the beginning of a cascade of both emotion regulation and memory processes, this chapter focuses on the emerging role of social relationships and autobiographical memory recall in regulating emotions under stress, highlighting opportunities and challenges associated with this process.</p>","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"179-204"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Isle of Craig: Neuroanatomical and Functional Evidence for a Role of the Insular Cortex in Subjective Feelings.","authors":"Henry C Evrard","doi":"10.1007/7854_2025_590","DOIUrl":"10.1007/7854_2025_590","url":null,"abstract":"<p><p>At the start of the twenty-first century, Arthur D. (Bud) Craig brought back to the fore the Island of Reil (insular cortex or insula). He did so by following, step by step, with rigor and tenacity, the afferent sensory pathway that informs the forebrain about the ongoing physiological status of the organs and tissues of the body. Along with his demonstration of the existence of a primate-specific ascending interoceptive pathway and his subsequent re-interpretation of Sherrington's concept of interoception, Bud Craig's seminal experiments and profound interpretations led him to make the groundbreaking proposals that the dorsal posterior insular cortex provides an ideal substrate for James's concept of emotional embodiment, that the insular cortex contextualizes interoception across a posterior-to-mid-to-anterior integration with multimodal activities, and that the anterior insular cortex has a crucial role in the evolutionary emergence of the awareness of subjective feelings in humans, for the purpose of optimizing metabolic energy usage. Bud Craig's unique work paves the path for further elucidation of the role of the insula and other brain regions in subjective feelings. His discoveries and proposals rest on implacable attention to neuroanatomical and neurophysiological details and a serendipitous quest for the fundamental evolutionary Logic of Life. This chapter provides a detailed description of the ascending interoceptive pathway and the functional and comparative neuroanatomy of the insular cortex in primates. Building on Bud Craig's work, our recent findings suggest that the primary interoceptive cortex serves as a representation of the spino-solitary-parabrachial neuraxis, merging with posterior-to-mid-anterior and dorsal-to-ventral processing streams that form a latticework integration pattern. At the ventral anterior tip of this integration, the von Economo neuron area closes the corticofugal interoceptive-autonomic loop of the sensory-motor homeostatic system through projections to all brainstem nuclei integrating interoceptive afferences.</p>","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"33-61"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensory and Multisensory Processing Changes and Their Contributions to Autism and Schizophrenia.","authors":"Sarah G Vassall, Mark T Wallace","doi":"10.1007/7854_2025_589","DOIUrl":"10.1007/7854_2025_589","url":null,"abstract":"<p><p>Natural environments are typically multisensory, comprising information from multiple sensory modalities. It is in the integration of these incoming sensory signals that we form our perceptual gestalt that allows us to navigate through the world with relative ease. However, differences in multisensory integration (MSI) ability are found in a number of clinical conditions. Throughout this chapter, we discuss how MSI differences contribute to phenotypic characterization of autism and schizophrenia. Although these clinical populations are often described as opposite each other on a number of spectra, we describe similarities in behavioral performance and neural functions between the two conditions. Understanding the shared features of autism and schizophrenia through the lens of MSI research allows us to better understand the neural and behavioral underpinnings of both disorders. We provide potential avenues for remediation of MSI function in these populations.</p>","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"73-103"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Layer-Specific fMRI Can Contribute to Understanding Perceptual Disturbances Across Psychiatric Disorders.","authors":"Joost Haarsma, Peter Kok","doi":"10.1007/7854_2025_595","DOIUrl":"10.1007/7854_2025_595","url":null,"abstract":"<p><p>Perceptual disturbances occur across various sensory domains and contribute to significant suffering in numerous psychiatric and neurological conditions. Despite decades of research into the neural mechanisms underlying these distressing experiences, progress has been relatively limited. Here we explore the potential of layer-specific fMRI to enhance our understanding of these phenomena. We posit that perceptual disturbances can stem from alterations in the neural integration of internally generated signals-such as memory, imagination, prediction, and expectations-with sensory evidence being used to optimize inferences about the world. Emerging evidence suggests that these key computations are distributed across different cortical layers, highlighting the utility of layer-specific imaging in identifying the mechanisms driving such disruptions. We review recent findings that underscore the promise of layer-specific fMRI in elucidating these neural processes and discuss how pharmacological layer-specific fMRI could further advance this understanding. Finally, we address the current limitations of layer-specific fMRI and the progress made toward overcoming these challenges.</p>","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"41-72"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA Methylation in Alzheimer's Disease.","authors":"Luke Weymouth, Adam R Smith, Katie Lunnon","doi":"10.1007/7854_2024_530","DOIUrl":"10.1007/7854_2024_530","url":null,"abstract":"<p><p>To date, DNA methylation is the best characterized epigenetic modification in Alzheimer's disease. Involving the addition of a methyl group to the fifth carbon of the cytosine pyrimidine base, DNA methylation is generally thought to be associated with the silencing of gene expression. It has been hypothesized that epigenetics may mediate the interaction between genes and the environment in the manifestation of Alzheimer's disease, and therefore studies investigating DNA methylation could elucidate novel disease mechanisms. This chapter comprehensively reviews epigenomic studies, undertaken in human brain tissue and purified brain cell types, focusing on global methylation levels, candidate genes, epigenome wide approaches, and recent meta-analyses. We discuss key differentially methylated genes and pathways that have been highlighted to date, with a discussion on how new technologies and the integration of multiomic data may further advance the field.</p>","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"149-178"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Can We Learn About Alzheimer's Disease from People with Down Syndrome?","authors":"Lucia Maure-Blesa, Iñigo Rodríguez-Baz, Maria Carmona-Iragui, Juan Fortea","doi":"10.1007/7854_2024_546","DOIUrl":"10.1007/7854_2024_546","url":null,"abstract":"<p><p>Down syndrome (DS) is the most frequent cause of intellectual disability of genetic origin, estimated to affect about 1 in 700 babies born worldwide (CDC 2023). In Europe and the United States, current estimates indicate a population prevalence of 5.6 and 6.7 per 10,000 individuals, respectively, which translates to more than 200,000 people in the United States, more than 400,000 people in Europe, and approximately six million worldwide. Advances in healthcare and the treatment of accompanying conditions have significantly prolonged the lifespan of those with DS over the past 50 years. Consequently, there is a pressing need to address the challenges associated with ageing among this population, with Alzheimer's disease (AD) being the primary concern. In this chapter, we will review the significance of studying this population to understand AD biology, the insights gained on AD in DS (DSAD), and how this knowledge can help us understand the AD not only in DS but also in the general population. We will conclude by exploring the objectives that remain to be accomplished.</p>","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"197-226"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational Mechanisms of Information-Seeking in Anxiety.","authors":"Ko-Ping Chou, Ryan Smith","doi":"10.1007/7854_2024_552","DOIUrl":"10.1007/7854_2024_552","url":null,"abstract":"<p><p>The drive to seek information through exploratory behavior is widespread in both humans and other animals. This can be adaptive in reducing uncertainty about the best course of action within novel or changing environments. However, exploratory behaviors can also become maladaptive if subjective uncertainty levels remain too high or too low, as may happen in states of elevated anxiety. In this article, we review recent studies investigating the influence of anxiety on information-seeking behavior. We focus primarily on studies using cognitive computational models and associated behavioral tasks designed to test specific exploratory strategies, which could each be affected by anxiety in distinct ways. Results of current studies remain mixed and highlight the importance of distinguishing potential effects of task, state vs. trait anxiety, somatic vs. cognitive anxiety, and clinical vs. sub-clinical anxiety. There are also a range of different information-seeking strategies that are necessary to consider. At present, many findings could be taken to support a picture in which cognitive anxiety, and/or trait anxiety more broadly, may increase information-seeking, while somatic and/or state anxiety could have opposing effects. However, a number of previous results also appear inconsistent or task-dependent. Future studies are needed to resolve these apparent inconsistencies and more directly disentangle effects of different dimensions of anxiety on the adaptive and maladaptive use of information-seeking.</p>","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"155-177"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synopsis of Current Trends in Behavioral Neuroscience Volume __.","authors":"Murray B Stein","doi":"10.1007/7854_2025_594","DOIUrl":"10.1007/7854_2025_594","url":null,"abstract":"<p><p>Following is a synopsis of the reviews contained within this volume. Each of these reviews is written by experts in their field, and each provides an authoritative treatise on its subject matter. The topics cover the gamut of anxiety-relevant research, from basic mechanistic and animal models through to clinical studies. The authors do a splendid job of introducing key concepts and terms relevant to their fields of study, thereby opening vistas of information for interested readers. The authors-and clearly some credit must also go to the editors-have made great efforts not only to review what has been done, but to imagine where the field(s) will go and how those may, eventually if not immediately, impact the prevention and treatment of anxiety disorders. I hope you enjoy reading and learning from this cadre of experts as much as I did.</p>","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"639-653"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Organization of Anxiety Symptoms Along the Threat Imminence Continuum.","authors":"Ya'ira Somerville, Rany Abend","doi":"10.1007/7854_2024_548","DOIUrl":"10.1007/7854_2024_548","url":null,"abstract":"<p><p>Pathological anxiety is highly prevalent, impairing, and often chronic. Yet, despite considerable research, mechanistic understanding of anxiety and its translation to clinical practice remain limited. Here, we first highlight two foundational complications that contribute to this gap: a reliance on a phenomenology-driven definition of pathological anxiety in neurobiological mechanistic research, and a limited understanding of the chronicity of anxiety symptom expression. We then posit that anxiety symptoms may reflect aberrant expression of otherwise normative defensive responses. Accordingly, we propose that threat imminence, an organizing dimension for normative defensive responses observed across species, may be applied to organize and understand anxiety symptoms along a temporal dimension of expression. Empirical evidence linking distinct anxiety symptoms and the aberrant expression of imminence-dependent defensive responses is reviewed, alongside the neural mechanisms which may underpin these cognitive, physiological, and behavioral responses. Drawing from extensive translational and clinical research, we suggest that understanding anxiety symptoms through this neurobiologically-informed framework may begin to overcome the conceptual complications hindering advancement in mechanistic research and clinical interventions for pathological anxiety.</p>","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"93-121"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction.","authors":"Rebecca Böhme","doi":"10.1007/7854_2025_577","DOIUrl":"10.1007/7854_2025_577","url":null,"abstract":"","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"87-106"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}