Pre- and Postnatal Valproate Exposure Affects Brain Development.

Q3 Neuroscience
Michaela A Pettie, Linda C M Wilkin-Krug, Bart Ellenbroek
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引用次数: 0

Abstract

This review investigates the teratogenic impact of valproic acid (VPA) on brain development, focusing on dose-dependent and timing-related behavioural and neurological outcomes in rats and mice, with an emphasis on using it as a model for autism spectrum disorders (ASD). Single and multiple administration methods (e.g., oral gavage and intraperitoneal injections) across various rat and mouse strains consistently report behavioural alterations (i.e., altered social interaction and locomotor activity) and neuronal changes, particularly in the hippocampus and cerebellum. We underscore the importance of understanding dose-related changes and the critical role of VPA exposure in determining the long-term neurodevelopmental effects. While animal models provide valuable insights into the pre- and postnatal effects of drug exposure, this chapter also addresses the limitation of extrapolating such findings to humans given the face and construct validity of the model. Overall, this review emphasises VPA's utility in modelling ASD-like behaviours and the need for ongoing research to refine these models for better applicability to humans.

产前和产后丙戊酸暴露影响大脑发育。
本综述研究了丙戊酸(VPA)对大脑发育的致畸作用,重点关注大鼠和小鼠的剂量依赖性和时间相关的行为和神经学结果,并强调将其作为自闭症谱系障碍(ASD)的模型。在不同大鼠和小鼠品系中,单次和多次给药方法(如口服灌胃和腹腔注射)一致报告了行为改变(即社会互动和运动活动改变)和神经元变化,特别是在海马和小脑中。我们强调了解剂量相关变化的重要性,以及VPA暴露在确定长期神经发育影响中的关键作用。虽然动物模型为药物暴露的产前和产后影响提供了有价值的见解,但本章也解决了将这些发现外推到人类身上的局限性,因为该模型的外观和结构有效性。总的来说,这篇综述强调了VPA在模拟类自闭症行为方面的效用,以及对这些模型进行改进以更好地适用于人类的持续研究的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current topics in behavioral neurosciences
Current topics in behavioral neurosciences Neuroscience-Behavioral Neuroscience
CiteScore
4.80
自引率
0.00%
发文量
103
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