Maternal SSRI Use During Pregnancy: Links Between Gut Microbiome, Offspring Behaviour, and Brain Transcriptomics.

Q3 Neuroscience
Mayerli A Prado Rivera, Joëlle D Jagersma, Jocelien D A Olivier
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引用次数: 0

Abstract

Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed to treat maternal depression during pregnancy, yet their potential impact on foetal brain development remains a concern. Although maternal illness is a known confounder, growing evidence from both clinical and preclinical studies suggests that perinatal SSRI exposure may independently influence neurodevelopmental outcomes. This review draws on rodent studies to explore how developmental SSRI exposure affects the gut microbiome, maternal behaviour, myelination, and offspring social behaviour. Elevated serotonin levels caused by SSRIs can alter both brain development and the maternal gut microbiota, with possible long-term effects on offspring. Behaviourally, SSRI-exposed offspring often show reduced social play, altered social interactions, and sex-specific effects on aggression and sexual behaviour, in which males appear more sensitive to these effects than females. Maternal care is only modestly affected. Overall, developmental SSRI exposure in the absence of maternal illness can disrupt brain development and social behaviour in offspring, potentially through gut-brain axis mechanisms and altered myelination.

怀孕期间母亲使用SSRI:肠道微生物组,后代行为和脑转录组之间的联系。
选择性血清素再摄取抑制剂(SSRIs)通常用于治疗怀孕期间的母亲抑郁症,但它们对胎儿大脑发育的潜在影响仍然令人担忧。虽然母体疾病是一个已知的混杂因素,但越来越多的临床和临床前研究证据表明,围产期SSRI暴露可能独立影响神经发育结果。这篇综述利用啮齿类动物研究来探讨发育性SSRI暴露如何影响肠道微生物群、母体行为、髓鞘形成和后代社会行为。SSRIs引起的血清素水平升高可以改变大脑发育和母体肠道微生物群,可能对后代产生长期影响。从行为上看,ssri暴露的后代往往表现出社交活动减少、社会互动改变以及对攻击性和性行为的性别特异性影响,其中雄性对这些影响似乎比雌性更敏感。产妇保健只受到轻微影响。总的来说,在没有母亲疾病的情况下,发育性SSRI暴露会破坏后代的大脑发育和社会行为,可能通过肠-脑轴机制和髓鞘形成的改变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current topics in behavioral neurosciences
Current topics in behavioral neurosciences Neuroscience-Behavioral Neuroscience
CiteScore
4.80
自引率
0.00%
发文量
103
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