Current topics in behavioral neurosciences最新文献_第2页

Alcohol-Induced Changes in Brain Microstructure: Uncovering Novel Pathophysiological Mechanisms of AUD Using Translational DTI in Humans and Rodents. 酒精诱导的大脑微观结构变化：利用人类和啮齿动物的平移DTI揭示AUD的新病理生理机制。

Current topics in behavioral neurosciences Pub Date : 2025-05-14 DOI: 10.1007/7854_2025_585

Wolfgang H Sommer, Santiago Canals

{"title":"Alcohol-Induced Changes in Brain Microstructure: Uncovering Novel Pathophysiological Mechanisms of AUD Using Translational DTI in Humans and Rodents.","authors":"Wolfgang H Sommer, Santiago Canals","doi":"10.1007/7854_2025_585","DOIUrl":"https://doi.org/10.1007/7854_2025_585","url":null,"abstract":"Alcohol use disorder (AUD) induces significant structural alterations in both gray and white matter, contributing to cognitive and functional impairments. This chapter presents a translational neuroimaging approach using diffusion-weighted MRI in humans and rodents to uncover novel pathophysiological mechanisms underlying AUD. Our studies demonstrate that increased mean diffusivity (MD) in gray matter reflects microglial reactivity and reduced extracellular space tortuosity, leading to enhanced volume neurotransmission. In white matter, fractional anisotropy (FA) reductions indicate progressive deterioration of key tracts, particularly the fimbria/fornix, linked to impaired cognitive flexibility. Importantly, longitudinal analyses reveal that white matter degeneration continues during early abstinence, suggesting that neuroinflammation and demyelination persist beyond alcohol cessation. Finally, we discuss how neuromodulatory interventions, such as transcranial magnetic stimulation (TMS), may promote recovery by enhancing myelin plasticity. These findings provide crucial insights into AUD's neurobiological underpinnings and highlight potential therapeutic targets for improving treatment outcomes.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensory and Multisensory Processing Changes and Their Contributions to Autism and Schizophrenia. 感觉和多感觉加工的变化及其对自闭症和精神分裂症的影响。

Current topics in behavioral neurosciences Pub Date : 2025-05-11 DOI: 10.1007/7854_2025_589

Sarah G Vassall, Mark T Wallace

引用次数: 0

A Personal and Scientific Introduction to the Work of A.D. (Bud) Craig on Interoception and the Insular Cortex. ad . (Bud) Craig关于内感受和岛叶皮层工作的个人科学介绍。

Current topics in behavioral neurosciences Pub Date : 2025-05-09 DOI: 10.1007/7854_2025_583

Irina A Strigo, Alan N Simmons, Marc Wittmann

{"title":"A Personal and Scientific Introduction to the Work of A.D. (Bud) Craig on Interoception and the Insular Cortex.","authors":"Irina A Strigo, Alan N Simmons, Marc Wittmann","doi":"10.1007/7854_2025_583","DOIUrl":"https://doi.org/10.1007/7854_2025_583","url":null,"abstract":"A.D. (Bud) Craig was best known to us colloquially as Bud Craig; his groundbreaking work has advanced our understanding of the neuroanatomical basis of the bodily self, emotion, and subjective time. His research elucidated the intricate pathways of interoception - the brain's processing of internal body signals - and highlighted the insula's pivotal role in integrating these signals. Craig's pioneering insights demonstrated that bodily sensations, such as pain and temperature, are deeply intertwined with emotional experiences and homeostatic needs. By mapping the thalamocortical pathways and emphasizing the insula's function in predicting future bodily states, he provided a comprehensive framework that connects physiological states to emotional and temporal experiences. This fundamental work has profoundly influenced a new generation of scientists and inspired the current volume. In this book, we have invited researchers influenced by Craig's theories to explore the neural correlates of emotion, pain, interoception, and time. In this chapter, we present how the editors of this book were directly influenced by Craig's findings and lay the groundwork for the large collective contribution of the authors of the subsequent chapters that continue to explore this ever-evolving scientific landscape.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traumatic Psychedelic Experiences. 创伤性迷幻体验。

Current topics in behavioral neurosciences Pub Date : 2025-04-29 DOI: 10.1007/7854_2025_579

Abigail E Calder, Vincent J Diehl, Gregor Hasler

引用次数: 0

Interoception in Adolescence: Impacts on Mental Health and Adaptive Functioning. 青少年间感受：对心理健康和适应功能的影响。

Current topics in behavioral neurosciences Pub Date : 2025-04-18 DOI: 10.1007/7854_2025_580

April C May, Susan Tapert

引用次数: 0

Sensing the Self: The Role of the Insula and Interoception in Body Image. 感知自我：脑岛和内感受在身体意象中的作用。

Current topics in behavioral neurosciences Pub Date : 2025-04-04 DOI: 10.1007/7854_2025_581

Emily M Choquette, Sahib S Khalsa

引用次数: 0

Disturbances in Auditory and Visual Perceptual Function in Schizophrenia: Patterns, Causes, and Consequences. 精神分裂症的听觉和视觉知觉功能障碍：模式、原因和后果。

Current topics in behavioral neurosciences Pub Date : 2025-04-02 DOI: 10.1007/7854_2025_582

Daniel C Javitt

{"title":"Disturbances in Auditory and Visual Perceptual Function in Schizophrenia: Patterns, Causes, and Consequences.","authors":"Daniel C Javitt","doi":"10.1007/7854_2025_582","DOIUrl":"https://doi.org/10.1007/7854_2025_582","url":null,"abstract":"Schizophrenia is a severe mental disorder and a leading cause of global disability. Increasing evidence ties impairments in both auditory and visual perceptual processing to impaired functional outcomes. In the auditory system, deficits are observed in the ability to process changes in tonality, leading to deficits in the detection of nonverbal aspects of auditory communication, including emotion and sarcasm. In the auditory sytem, these deficits are indexed by impaired generation of mismatch negativity (MMN), which has become a widely utilized index of auditory perceptual dysfunction. In the visual system, deficits are especially observed in functions related to the magnocellular visual pathway, which projects preferentially to the dorsal visual stream. Dorsal stream dysfunction, in turn, contributes to impairments in processes such as fragmented object recognition, face emotion recognition, and social cognition. Indices of visual perceptual dysfunction include visual P1 responses to magnocellular-biased stimuli, as well as fMRI activation levels within the dorsal and ventral streams. Perceptual level deficits are tied most directly to impaired function of N-methyl-D-aspartate glutamate receptors (NMDAR) and thus may serve both as pathophysiologically based nosological biomarkers and as targets for neuromodulatory and pharmacological treatment development.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intergenerational Effects of Stress - A Focus on Learning and Memory. 压力的代际效应——学习和记忆的焦点。

Current topics in behavioral neurosciences Pub Date : 2025-03-22 DOI: 10.1007/7854_2025_578

L S Vasquez, S Stack, W W Taylor, B G Dias

{"title":"Intergenerational Effects of Stress - A Focus on Learning and Memory.","authors":"L S Vasquez, S Stack, W W Taylor, B G Dias","doi":"10.1007/7854_2025_578","DOIUrl":"10.1007/7854_2025_578","url":null,"abstract":"Stress is a ubiquitous facet of life. Ranging in form (e.g., psychosocial, physical, nutritional, economic) and longevity (e.g., acute, chronic), stressors affect the biology of those directly in their line of attack. As is becoming increasingly appreciated, the pernicious effects of stress echo across generations (Dias et al. 2015; Yehuda and Lehrner 2018; Jawaid et al. 2021; Dion et al. 2022; Zhou and Ryan 2023; Dias 2024). With a focus on learning and memory, this chapter addresses how stressors derail learning and memory in the generation directly exposed to them andin future generations. To do so, with a specific emphasis on associative fear conditioning in humans and rodents, we touch upon the relevance of extinction training in the aftermath of such conditioning and the recall of such extinction training as windows into normative and disrupted learning. Next, we briefly discuss underlying neuroanatomical substrates mediating these processes. We then draw attention to influences of postnatal, in utero, and pre-conceptional stress on learning and memory across generations. Finally, we briefly outline biological factors that underlie how learning and memory is derailed by these stressors.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Life and Legacy of Arthur D. Craig, Jr.: A Pioneer in Interoception. 小阿瑟·d·克雷格的一生和遗产：心灵感应的先驱。

Current topics in behavioral neurosciences Pub Date : 2025-03-19 DOI: 10.1007/7854_2024_574

Anders Blomqvist, Jonathan O Dostrovsky

{"title":"The Life and Legacy of Arthur D. Craig, Jr.: A Pioneer in Interoception.","authors":"Anders Blomqvist, Jonathan O Dostrovsky","doi":"10.1007/7854_2024_574","DOIUrl":"https://doi.org/10.1007/7854_2024_574","url":null,"abstract":"A.D. (Bud) Craig (1951-2023) redefined the concept of interoception and provided a novel, revolutionary understanding of the neural basis for human awareness. In unsurpassed anatomical-physiological studies in monkeys, Craig showed that the insular cortex is the primary sensory cortex for interoception, or the image of the \"material me\" that provides a homeostatic representation of the physiological condition of the body. He showed that the insula contains a postero-anteriorly organized somatotopic map of the interoceptive sensations, and that it encodes both the localization and the intensity discrimination of interoceptive sensations. In seminal work in humans, he demonstrated that the interoceptive feelings are re-represented, and multimodally integrated, in anterior portions of the insula in sequence of increasingly homeostatically efficient representations that integrate all salient neural activity. He further showed that subjective awareness is associated with activation of the anterior insular cortex and suggested that this brain region also is critical for fluid intelligence and the perception of time. His work has led to a paradigm shift in our understanding of interoception and how interoceptive sensations underlie consciousness, a topic that long has been considered elusive, or even beyond our comprehension.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Body, Self, and Time: Bud Craig's Global Emotional Moments Theory. 身体、自我和时间：巴德·克雷格的全球情绪时刻理论。

Current topics in behavioral neurosciences Pub Date : 2025-03-12 DOI: 10.1007/7854_2024_575

Julian Kiverstein

{"title":"Body, Self, and Time: Bud Craig's Global Emotional Moments Theory.","authors":"Julian Kiverstein","doi":"10.1007/7854_2024_575","DOIUrl":"https://doi.org/10.1007/7854_2024_575","url":null,"abstract":"The topic of my chapter will be Bud Craig's theory of \"global emotional moments\" (henceforth the GEMs theory) and the relationship of GEMs to the experience of time. I connect three ideas prominent in Craig's writings: interoception, emotion, and time. Craig held that each GEM has as its neural substrate a large-scale network with the anterior insula cortex (AIC) serving as its central processing hub. This network integrates interoceptive signals that keep track of changes arising in the autonomic nervous system with hedonic and motivational signals based on the organism's sensory perception of its environment. Craig argued that GEMs function as moving windows of time within which \"a phenomenal self\" is experienced. By the \"phenomenal self,\" I mean a material, embodied self that forms an organism's subjective point of view on the world. Craig proposed what he called a \"cinemascopic\" theory of GEMs. GEMs are combined over time to form a stream of consciousness, which Craig compared to a movie, with each GEM corresponding to a single snapshot of this movie. I will argue that Craig's cinemascopic theory has implications for our understanding of what I will call the \"phenomenal now.\" There are three main theories of the phenomenal now in the philosophical literature. One point of contention between these theories is whether the phenomenal now has duration or temporal depth. I will argue that GEMs have duration and therefore count against so-called \"cinematic\" theories of the phenomenal now that take the contents of experience to be of discrete points or instances in time. However, there are different views within philosophy of how the phenomenal now can have duration. I end my chapter by considering how Craig's GEMs theory might bear on this debate.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0