Current topics in behavioral neurosciences最新文献_第2页

The Organization of Anxiety Symptoms Along the Threat Imminence Continuum. 焦虑症状在威胁临界点上的组织结构。

Current topics in behavioral neurosciences Pub Date : 2024-11-24 DOI: 10.1007/7854_2024_548

Ya'ira Somerville, Rany Abend

{"title":"The Organization of Anxiety Symptoms Along the Threat Imminence Continuum.","authors":"Ya'ira Somerville, Rany Abend","doi":"10.1007/7854_2024_548","DOIUrl":"https://doi.org/10.1007/7854_2024_548","url":null,"abstract":"Pathological anxiety is highly prevalent, impairing, and often chronic. Yet, despite considerable research, mechanistic understanding of anxiety and its translation to clinical practice remain limited. Here, we first highlight two foundational complications that contribute to this gap: a reliance on a phenomenology-driven definition of pathological anxiety in neurobiological mechanistic research, and a limited understanding of the chronicity of anxiety symptom expression. We then posit that anxiety symptoms may reflect aberrant expression of otherwise normative defensive responses. Accordingly, we propose that threat imminence, an organizing dimension for normative defensive responses observed across species, may be applied to organize and understand anxiety symptoms along a temporal dimension of expression. Empirical evidence linking distinct anxiety symptoms and the aberrant expression of imminence-dependent defensive responses is reviewed, alongside the neural mechanisms which may underpin these cognitive, physiological, and behavioral responses. Drawing from extensive translational and clinical research, we suggest that understanding anxiety symptoms through this neurobiologically-informed framework may begin to overcome the conceptual complications hindering advancement in mechanistic research and clinical interventions for pathological anxiety.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deepening Psychedelic Integration: Exploring Complex Settings, Understanding User's Struggles, and Implementing Safe Interventions. 深化迷幻融合：探索复杂环境，了解使用者的挣扎，实施安全干预。

Current topics in behavioral neurosciences Pub Date : 2024-11-24 DOI: 10.1007/7854_2024_532

Marc Aixalà

{"title":"Deepening Psychedelic Integration: Exploring Complex Settings, Understanding User's Struggles, and Implementing Safe Interventions.","authors":"Marc Aixalà","doi":"10.1007/7854_2024_532","DOIUrl":"10.1007/7854_2024_532","url":null,"abstract":"This chapter adopts a transdisciplinary approach to explore the concept of psychedelic integration, considering its various contexts ranging from clinical trials to Neo-shamanic, traditional, and recreational settings. It aims to provide a comprehensive understanding and description of integration, distinguishing between the needs of maximising potential benefits and addressing adverse reactions. Psychedelic Integration is a widely used term that refers to a variety of practices commonly employed after psychedelic experiences to help ground the benefits or address the challenges that arise from them. Although the term is broadly accepted, it lacks a precise definition, and a wide range of practices and techniques, often quite different from one another, are included under this category. Drawing on the experiences at the ICEERS (International Center for Ethnobotanical Education Research and Services) Integration and Support Service since 2012, the chapter highlights the practical aspects of clinical intervention.The chapter delves into the profiles of individuals seeking integration support, focusing on the primary challenges they encounter. These profiles include lack of preparation, unresolved experiences, difficulties with facilitators, traumatic psychedelic episodes, the exacerbation of pre-existing mental disorders, the emergence of previously unknown traumatic events, repeated psychedelic use without proper integration, and perceptions of being attacked or possessed by entities.Moreover, an overview of a method of clinical intervention that underscores the fundamental values inherent in psychedelic work is presented. This approach aims to integrate these values into the intervention process, employing a brief and focused methodology. By tailoring the intervention to the individual's specific needs, this method facilitates effective integration and support.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disentangling the Neural Circuits of Arousal and Anxiety-Like Behavior. 解开唤醒和焦虑行为的神经回路

Current topics in behavioral neurosciences Pub Date : 2024-11-24 DOI: 10.1007/7854_2024_539

Antonio Florido, Vincent R Curtis, Nicolas C Pégard, Jose Rodriguez-Romaguera

引用次数: 0

Developmental Shifts in Amygdala Function. 杏仁核功能的发育转变

Current topics in behavioral neurosciences Pub Date : 2024-11-16 DOI: 10.1007/7854_2024_538

J Amiel Rosenkranz

引用次数: 0

Genetic Vulnerability to Social Anxiety Disorder. 社交焦虑症的遗传易感性。

Current topics in behavioral neurosciences Pub Date : 2024-11-14 DOI: 10.1007/7854_2024_544

Janna Marie Bas-Hoogendam

{"title":"Genetic Vulnerability to Social Anxiety Disorder.","authors":"Janna Marie Bas-Hoogendam","doi":"10.1007/7854_2024_544","DOIUrl":"10.1007/7854_2024_544","url":null,"abstract":"Most anxiety disorders 'run within families': people suffering from an anxiety disorder often have family members who are highly anxious as well. In this chapter, we explore recent work devoted to unraveling the complex interplay between genes and environment in the development of anxiety. We review studies focusing on the genetic vulnerability to develop social anxiety disorder (SAD), as SAD is one of the most prevalent anxiety disorders, with an early onset, a chronic course, and associated with significant life-long impairments. More insight into the development of SAD is thus of uttermost importance.First, we will discuss family studies, twin studies, and large-sized population-based registry studies and explain what these studies can reveal about the genetic vulnerability to develop anxiety. Next, we describe the endophenotype approach; in this context, we will summarize results from the Leiden Family Lab study on Social Anxiety Disorder. Subsequently, we review the relationship between the heritable trait 'behavioral inhibition' and the development of SAD, and highlight the relevance of this work for the development and improvement of preventative and therapeutic interventions for socially anxious youth.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Contribution of the Renin-Angiotensin System to Alzheimer's Disease. 肾素-血管紧张素系统对阿尔茨海默氏症的影响。

Current topics in behavioral neurosciences Pub Date : 2024-11-14 DOI: 10.1007/7854_2024_525

Özge Güzel, Patrick G Kehoe

引用次数: 0

The Impact of Early Life Experiences on Stress Neurobiology and the Development of Anxiety. 早期生活经历对压力神经生物学和焦虑症发展的影响。

Current topics in behavioral neurosciences Pub Date : 2024-11-13 DOI: 10.1007/7854_2024_542

Yanbin Niu, M Catalina Camacho, Shuang Wu, Kathryn L Humphreys

引用次数: 0

Interoception, Insula, and Autonomic Integration: Relevance to the Expression and Treatment of Psychiatric Symptoms. 互感、脑岛和自律神经整合：与精神症状的表现和治疗的相关性》。

Current topics in behavioral neurosciences Pub Date : 2024-11-13 DOI: 10.1007/7854_2024_518

Hugo D Critchley, Joel Patchitt

引用次数: 0

Sex Differences in the Neurobiology of Fear and Anxiety. 恐惧和焦虑神经生物学中的性别差异。

Current topics in behavioral neurosciences Pub Date : 2024-11-08 DOI: 10.1007/7854_2024_536

Katelyn I Oliver, Dasani DelRosario, Jennifer S Stevens

引用次数: 0

Structural Brain Correlates of Anxiety During Development. 发育过程中焦虑的大脑结构相关性

Current topics in behavioral neurosciences Pub Date : 2024-11-08 DOI: 10.1007/7854_2024_541

E Leighton Durham, Antonia N Kaczkurkin

{"title":"Structural Brain Correlates of Anxiety During Development.","authors":"E Leighton Durham, Antonia N Kaczkurkin","doi":"10.1007/7854_2024_541","DOIUrl":"https://doi.org/10.1007/7854_2024_541","url":null,"abstract":"Anxiety and related disorders are prevalent across the lifespan, often have their onset during youth, and are associated with notable levels of impairment and burden across multiple domains. Elucidating the associations between differential patterns of neurodevelopment and anxiety in youth is a promising approach for developing deeper insights regarding the neurobiological etiologies and maintenance factors associated with anxiety and related disorders. A growing body of literature has yielded evidence of associations between patterns of brain structure (i.e., volume, cortical thickness, and cortical surface area) and anxiety. Here, we present a review and synthesis of the existing body of literature surrounding neurostructural correlates of anxiety in youth spanning multiple anxiety presentations and three neurostructural modalities. We reveal substantially more research focusing on brain volume than cortical thickness or surface area and a greater number of studies examining anxiety broadly defined, obsessive-compulsive disorder, or posttraumatic stress disorder. There is also evidence of considerable variability in the brain regions implicated and the direction of associations across studies. Finally, we discuss the gaps and limitations in this body of work, which suggest avenues for future directions.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0