Current topics in behavioral neurosciences最新文献_第3页

Hippocampal Synaptic Plasticity: Integrating Memory and Anxiety Impairments in the Early Stages of Alzheimer's Disease. 海马体突触可塑性：阿尔茨海默病早期整合记忆和焦虑障碍。

Current topics in behavioral neurosciences Pub Date : 2025-01-03 DOI: 10.1007/7854_2024_565

Mark A Good, David M Bannerman

{"title":"Hippocampal Synaptic Plasticity: Integrating Memory and Anxiety Impairments in the Early Stages of Alzheimer's Disease.","authors":"Mark A Good, David M Bannerman","doi":"10.1007/7854_2024_565","DOIUrl":"https://doi.org/10.1007/7854_2024_565","url":null,"abstract":"A decline in hippocampal function has long been associated with the progression of cognitive impairments in patients with Alzheimer's disease (AD). The disruption of hippocampal synaptic plasticity [primarily the reduction of long-term potentiation LTP] by excess production of soluble beta-amyloid (Aβ) has long been accepted as the mechanism by which AD pathology impairs memory, at least during the early stages of AD pathogenesis. However, the premise that hippocampal LTP underpins the formation of associative, long-term memories has been challenged. Here, we consider evidence that this canonical view of LTP needs to be refined. Similarly, the view that the hippocampus simply supports memory ignores the wealth of data showing that the hippocampus is functionally heterogeneous along its septo-temporal axis. The ventral (but not the dorsal) hippocampus plays a major role in modulating emotional reactions to conflict. Here, we suggest that hippocampal LTP is not involved in forming long-term associative memories, but instead contributes to the disambiguation of overlapping memories in situations of conflict and associative interference. This conceptualisation of hippocampal synaptic plasticity may help explain how early-stage AD pathology may impact both memory and anxiety.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current State of the Neuroscience of Fear Extinction and Its Relevance to Anxiety Disorders. 恐惧消退的神经科学现状及其与焦虑症的相关性。

Current topics in behavioral neurosciences Pub Date : 2025-01-03 DOI: 10.1007/7854_2024_555

Elena Andres, Benjamin Meyer, Kenneth S L Yuen, Raffael Kalisch

{"title":"Current State of the Neuroscience of Fear Extinction and Its Relevance to Anxiety Disorders.","authors":"Elena Andres, Benjamin Meyer, Kenneth S L Yuen, Raffael Kalisch","doi":"10.1007/7854_2024_555","DOIUrl":"https://doi.org/10.1007/7854_2024_555","url":null,"abstract":"The elucidation of the functional neuroanatomy of human fear, or threat, extinction has started in the 2000s by a series of enthusiastically greeted functional magnetic resonance imaging (fMRI) studies that were able to translate findings from rodent research about an involvement of the ventromedial prefrontal cortex (vmPFC) and the hippocampus in fear extinction into human models. Enthusiasm has been painfully dampened by a meta-analysis of human fMRI studies by Fullana and colleagues in 2018 who showed that activation in these areas is inconsistent, sending shock waves through the extinction research community. The present review guides readers from the field (as well as non-specialist readers desiring safe knowledge about human extinction mechanisms) during a series of exposures with corrective information. New information about extinction-related brain activation not considered by Fullana et al. will also be presented. After completion of this exposure-based fear reduction program, readers will trust that the reward learning system, the cerebellum, the vmPFC, the hippocampus, and a wider brain network are involved in human fear extinction, along with the neurotransmitters dopamine and noradrenaline. Specific elements of our exposure program include exploitation of the temporal dynamics of extinction, of the spatial heterogeneity of extinction-related brain activation, of functional connectivity methods, and of large sample sizes. Implications of insights from studies in healthy humans for the understanding and treatment of anxiety-related disorders are discussed.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emotion Regulation Under Stress: A Social Processing and Memory Perspective. 压力下的情绪调节：一个社会加工和记忆的视角。

Current topics in behavioral neurosciences Pub Date : 2024-12-31 DOI: 10.1007/7854_2024_560

Nicholas J Dennis, Tasha Bulgin, Casey M Nicastri, Cassandra Bell, Mauricio R Delgado

{"title":"Emotion Regulation Under Stress: A Social Processing and Memory Perspective.","authors":"Nicholas J Dennis, Tasha Bulgin, Casey M Nicastri, Cassandra Bell, Mauricio R Delgado","doi":"10.1007/7854_2024_560","DOIUrl":"https://doi.org/10.1007/7854_2024_560","url":null,"abstract":"Research on emotion regulation often focuses on cognitively effortful self-regulation strategies, but exposure to stress has been shown to interfere with the underlying mechanisms supporting such processes. Understanding alternative strategies that potentially bolster emotion regulation under stress is an important topic of investigation. Two potential alternatives involve everyday occurrences of social processing and memory recall. Social support and past emotional experiences may help in guiding us toward appropriate neurophysiological responses through overlapping circuitry with stress and reward systems, while also buttressing cognitive regulation strategies by expanding one's perspective and allowing multiple opportunities to regulate retrospectively. In recognition that ongoing social and emotional events are often at the beginning of a cascade of both emotion regulation and memory processes, this chapter focuses on the emerging role of social relationships and autobiographical memory recall in regulating emotions under stress, highlighting opportunities and challenges associated with this process.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into the Neurobiology of Behavioral Inhibition from Nonhuman Primate Models. 非人类灵长类动物行为抑制的神经生物学研究。

Current topics in behavioral neurosciences Pub Date : 2024-12-31 DOI: 10.1007/7854_2024_561

Lillian J Campos, Carly M Drzewiecki, Andrew S Fox

引用次数: 0

Phenomenology of Psychedelic Experiences and Psychedelic-Associated Distressing Effects: Quantifying Subjective Experiences. 迷幻体验的现象学和迷幻相关的苦恼效应：量化主观体验。

Current topics in behavioral neurosciences Pub Date : 2024-12-31 DOI: 10.1007/7854_2024_562

Cyril Costines, Timo Torsten Schmidt

{"title":"Phenomenology of Psychedelic Experiences and Psychedelic-Associated Distressing Effects: Quantifying Subjective Experiences.","authors":"Cyril Costines, Timo Torsten Schmidt","doi":"10.1007/7854_2024_562","DOIUrl":"https://doi.org/10.1007/7854_2024_562","url":null,"abstract":"The range of phenomena that can be induced by psychedelic substances is broad and variable, including effects on perception, cognition, and emotion. The umbrella term \"psychedelic phenomenology\" is used to refer to a combination of altered experiential features, such as hallucinations or ego dissolution, which together constitute a psychedelic experience. However, there is no consensus on the set of alterations of consciousness that qualifies an altered state to be a \"psychedelic state.\" In this chapter we summarize the most commonly discussed changes in subjective experiences which could be seen as \"core features\" of psychedelic experiences. While acknowledging the rich history of pioneering phenomenological work of the last century, this chapter focuses on more recent developments in the quantitative work on the assessment of these phenomena. We also address the under-researched phenomenology of distressing effects, often referred to as \"challenging experiences\" or \"bad trips,\" and point to their importance in understanding the therapeutic potential and risks associated with psychedelic phenomenology. Historically, one can find many links between psychedelic phenomenology and the phenomenology of psychopathology. We stress the importance to refine the assessment and description also of distressing effects, to identify factors that promote acute experiences which are beneficial and limit those which can have potentially harmful long-term effects.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Cannabinoids and the Endocannabinoid System in the Treatment and Regulation of Nausea and Vomiting. 大麻素和内源性大麻素系统在恶心呕吐的治疗和调节中的作用。

Current topics in behavioral neurosciences Pub Date : 2024-12-31 DOI: 10.1007/7854_2024_554

Erin M Rock, Linda A Parker

引用次数: 0

The Use of Cannabis-Based Medicine in Selected Neurological Disorders. 以大麻为基础的药物在特定神经系统疾病中的应用。

Current topics in behavioral neurosciences Pub Date : 2024-12-31 DOI: 10.1007/7854_2024_564

Natalia Szejko, Kamila Saramak, Kirsten R Müller-Vahl

{"title":"The Use of Cannabis-Based Medicine in Selected Neurological Disorders.","authors":"Natalia Szejko, Kamila Saramak, Kirsten R Müller-Vahl","doi":"10.1007/7854_2024_564","DOIUrl":"https://doi.org/10.1007/7854_2024_564","url":null,"abstract":"Cannabis-based medicine (CBM) is used in a wide variety of different neurological disorders. While the use of CBM in the treatment of pain, AIDS wasting, loss of appetite, and spasticity is well established, CBM application in movement disorders and neurodegenerative disorders is still an emerging topic. The purpose of this chapter is to summarize current evidence behind the use of CBM in selected neurological diseases, mainly movement and neurodegenerative disorders. The best evidence for efficacy of CBM is for Tourette syndrome resulting in an improvement of tics and psychiatric comorbidities. In this indication, delta-9-tetrahydrocannabinol (THC)-containing CBMs are recommended. There is limited evidence that CBMs are also effective in Parkinson's disease in which they may improve tremor, but also non-motor symptoms such as pain and sleeping problems. With respect to other neurodegenerative diseases, there is limited evidence that CBMs may improve behavioral symptoms in Huntington's disease. In addition, it has been speculated that CBMs may have neuroprotective effects, but this has not yet been confirmed in the clinical setting.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Informed Consent in Psychedelic-Assisted Therapy. 迷幻药辅助治疗中的知情同意。

Current topics in behavioral neurosciences Pub Date : 2024-12-31 DOI: 10.1007/7854_2024_559

Mazdak M Bradberry, Paul S Appelbaum, Natalie Gukasyan

引用次数: 0

Computational Mechanisms of Information-Seeking in Anxiety. 焦虑中信息寻求的计算机制。

Current topics in behavioral neurosciences Pub Date : 2024-12-19 DOI: 10.1007/7854_2024_552

Ko-Ping Chou, Ryan Smith

{"title":"Computational Mechanisms of Information-Seeking in Anxiety.","authors":"Ko-Ping Chou, Ryan Smith","doi":"10.1007/7854_2024_552","DOIUrl":"https://doi.org/10.1007/7854_2024_552","url":null,"abstract":"The drive to seek information through exploratory behavior is widespread in both humans and other animals. This can be adaptive in reducing uncertainty about the best course of action within novel or changing environments. However, exploratory behaviors can also become maladaptive if subjective uncertainty levels remain too high or too low, as may happen in states of elevated anxiety. In this article, we review recent studies investigating the influence of anxiety on information-seeking behavior. We focus primarily on studies using cognitive computational models and associated behavioral tasks designed to test specific exploratory strategies, which could each be affected by anxiety in distinct ways. Results of current studies remain mixed and highlight the importance of distinguishing potential effects of task, state vs. trait anxiety, somatic vs. cognitive anxiety, and clinical vs. sub-clinical anxiety. There are also a range of different information-seeking strategies that are necessary to consider. At present, many findings could be taken to support a picture in which cognitive anxiety, and/or trait anxiety more broadly, may increase information-seeking, while somatic and/or state anxiety could have opposing effects. However, a number of previous results also appear inconsistent or task-dependent. Future studies are needed to resolve these apparent inconsistencies and more directly disentangle effects of different dimensions of anxiety on the adaptive and maladaptive use of information-seeking.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Tools in Rodents to Study Cannabinoid Functions. 遗传工具在啮齿动物研究大麻素功能。

Current topics in behavioral neurosciences Pub Date : 2024-12-17 DOI: 10.1007/7854_2024_550

Krisztina Monory, Inigo Ruiz de Azua, Beat Lutz

{"title":"Genetic Tools in Rodents to Study Cannabinoid Functions.","authors":"Krisztina Monory, Inigo Ruiz de Azua, Beat Lutz","doi":"10.1007/7854_2024_550","DOIUrl":"https://doi.org/10.1007/7854_2024_550","url":null,"abstract":"During the past 30 years, the endocannabinoid system (ECS) has emerged as a major signalling system in the mammalian brain regulating neurotransmission in numerous brain regions and in various cell populations. Endocannabinoids are able to regulate specific physiological functions and thus modify their behavioural manifestations and allostatic alterations of the ECS linked to different pathological conditions. As discussed in detail in other chapters of this book, endocannabinoids are involved in learning and memory, stress, and anxiety, feeding, energy balance, development, and ageing. Likewise, many CNS disorders (e.g. schizophrenia, epilepsy, substance use disorders, and multiple sclerosis) are associated with dysregulation of the ECS. Discerning the physiological functions of the synthetic and degrading enzymes of endocannabinoids and their receptors is a challenging task because of their distinct and complex expression patterns. Techniques of genetic engineering have been able to shed light on a number of complex ECS-related tasks during the past years. In this chapter, first, we take a critical look at the toolbox available to researchers who would like to investigate cannabinoid effects using genetic engineering techniques, then we comprehensively discuss genetically modified rodent models in various neuronal and non-neuronal cell populations, both within and outside the nervous system.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0