Current topics in behavioral neurosciences最新文献_第4页

Involvement of Complement in Alzheimer's Disease: From Genetics Through Pathology to Therapeutic Strategies. 补体在阿尔茨海默病中的参与：从遗传学到病理学再到治疗策略。

Current topics in behavioral neurosciences Pub Date : 2024-10-26 DOI: 10.1007/7854_2024_524

Nikoleta Daskoulidou, Sarah M Carpanini, Wioleta M Zelek, B Paul Morgan

{"title":"Involvement of Complement in Alzheimer's Disease: From Genetics Through Pathology to Therapeutic Strategies.","authors":"Nikoleta Daskoulidou, Sarah M Carpanini, Wioleta M Zelek, B Paul Morgan","doi":"10.1007/7854_2024_524","DOIUrl":"https://doi.org/10.1007/7854_2024_524","url":null,"abstract":"Complement is a critical component of innate immunity, evolved to defend against pathogens and clear toxic debris ranging from dead and dying cells to immune complexes. These roles make complement a key player in homeostasis; however, complement has a dark side. When the rigid control mechanisms fail, complement becomes dysregulated, acting as a driver of inflammation and resultant pathology in numerous diseases. Roles of complement in Alzheimer's disease (AD) and other dementias have emerged in recent years, supported by genetic, biomarker and pathological evidence and animal model studies. Numerous questions remain regarding the precise roles of complement in the brain in health and disease, including where and when complement is expressed, how it contributes to immune defence and garbage disposal in the healthy brain, and exactly how complement contributes to pathology in dementias. In this brief review, we will summarise current knowledge on complement roles in brain, present the evidence implicating complement in AD and explore whether complement represents an attractive therapeutic target for AD.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interoceptive and Bodily Processing in Prospective and Retrospective Timing. 前瞻性和回溯性计时中的互感和身体处理。

Current topics in behavioral neurosciences Pub Date : 2024-10-23 DOI: 10.1007/7854_2024_516

Alice Teghil

引用次数: 0

Hearing Loss and Alzheimer Disease. 听力损失与阿尔茨海默病

Current topics in behavioral neurosciences Pub Date : 2024-10-23 DOI: 10.1007/7854_2024_526

Arianna Di Stadio, Mickie J Hamiter, Dalila Roccamatisi, Anil K Lalwani

引用次数: 0

How Bud Craig's Insights Reshape the Research on Pain and Mind-Body Therapies. 巴德-克雷格的见解如何重塑疼痛和心身疗法研究。

Current topics in behavioral neurosciences Pub Date : 2024-10-23 DOI: 10.1007/7854_2024_521

Wolf E Mehling

引用次数: 0

Insights from Ecstatic Epilepsy: From Uncertainty to Metacognitive Feelings. 狂喜性癫痫的启示：从不确定性到元认知感受。

Current topics in behavioral neurosciences Pub Date : 2024-10-23 DOI: 10.1007/7854_2024_528

Nina M Sooter, Federico Seragnoli, Fabienne Picard

引用次数: 0

Music in the Air and in the Body: An Interoceptive System's Perspective on Musical Emotions, Awareness, and Time. 空气中和身体里的音乐：从互感系统的角度看音乐情感、意识和时间。

Current topics in behavioral neurosciences Pub Date : 2024-10-23 DOI: 10.1007/7854_2024_517

Clemens Wöllner

引用次数: 0

Anxiety and Affective Symptoms Related to the Use of Classic Psychedelics: A Systematic Review. 与使用经典迷幻药有关的焦虑和情感症状：系统综述》。

Current topics in behavioral neurosciences Pub Date : 2024-10-23 DOI: 10.1007/7854_2024_534

Grace Viljoen, Felix Betzler

{"title":"Anxiety and Affective Symptoms Related to the Use of Classic Psychedelics: A Systematic Review.","authors":"Grace Viljoen, Felix Betzler","doi":"10.1007/7854_2024_534","DOIUrl":"https://doi.org/10.1007/7854_2024_534","url":null,"abstract":"There is a large and rapidly growing body of literature investigating the therapeutic effects of classic psychedelics in affective and anxiety disorders, but very few studies have examined the inverse of this, that is, the potential for psychedelics to inflict anxiety and affective symptoms. A systematic literature search was performed and 39 papers were included in the final review to qualitatively synthesize the current literature on anxiety and affective disorders related to the use of classic psychedelics. Persisting disorders were less frequent but generally occurred in individuals who presented with several risk factors (overdose, polydrug use, unstructured recreational setting, psychosocial stress, personal/familial psychiatric histories). When psychedelics were administered in clinical studies under the framework of psychedelic-assisted therapy, the incidence of enduring anxiety and affective symptoms was low. In most cases, acute transient anxiety emerged and resolved during the dosing session without the need for additional treatment interventions. The nuance of such cases is discussed, shedding light on the role of emotional catharsis in the therapeutic process. Several suggestions are proposed to enhance patient safety including strengthening the therapeutic alliance, ensuring adequate mental preparation, acclimating to high doses and providing on-going therapeutic support.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Guiding Through Challenging Psychedelic Experiences and "Bad Trips". 指导人们度过具有挑战性的迷幻体验和 "糟糕之旅"。

Current topics in behavioral neurosciences Pub Date : 2024-08-28 DOI: 10.1007/7854_2024_515

Michael Koslowski, Peter Gasser

引用次数: 0

Good Practice Guideline for Preclinical Alcohol Research: The STRINGENCY Framework. 临床前酒精研究良好实践指南》：STRINGENCY 框架。

Current topics in behavioral neurosciences Pub Date : 2024-08-09 DOI: 10.1007/7854_2024_484

Marcus W Meinhardt, Björn Gerlach, Rainer Spanagel

{"title":"Good Practice Guideline for Preclinical Alcohol Research: The STRINGENCY Framework.","authors":"Marcus W Meinhardt, Björn Gerlach, Rainer Spanagel","doi":"10.1007/7854_2024_484","DOIUrl":"https://doi.org/10.1007/7854_2024_484","url":null,"abstract":"Research in the field of preclinical alcohol research, but also science in general, has a problem: Many published scientific results cannot be repeated. As a result, findings from preclinical research often do not translate well to humans, causing increasing disappointment and calls for restructuring of preclinical research, that is, better reproducibility of preclinical research. However, the replication crisis is an inherent problem in biomedical research. Replication failures are not only due to small experimental variations but are often the result of poor methodology. In response to the replication crisis, numerous guidelines and recommendations have been proposed to promote transparency, rigor, and reproducibility in scientific research. What is missing today is a framework that integrates all the confusing information that results from all these guidelines and recommendations. Here we present STRINGENCY, an integrative approach to good practice guidelines for preclinical alcohol research, which can also apply to behavioral research in general and which aims to improve preclinical research to better prepare it for translation and minimize the \"valley of death\" in translational research. STRINGENCY includes systematic review and, when possible, meta-analysis prior to study design, sample size calculation, preregistration, multisite experiments, scientific data management (FAIR), reporting of data using ARRIVE, generalization of research data, and transparent publications that allow reporting of null results. We invite the scientific community to adopt STRINGENCY to improve the reliability and impact of preclinical alcohol research.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Completing the Circle: A History of Psychedelics and Harm Reduction. 完成循环：迷幻药和减低伤害的历史。

Current topics in behavioral neurosciences Pub Date : 2024-08-08 DOI: 10.1007/7854_2024_511

Erika Dyck, James Dixon

{"title":"Completing the Circle: A History of Psychedelics and Harm Reduction.","authors":"Erika Dyck, James Dixon","doi":"10.1007/7854_2024_511","DOIUrl":"https://doi.org/10.1007/7854_2024_511","url":null,"abstract":"Harm reduction officially entered the public health lexicon in the 1980s as a response to the HIV/AIDS crisis and its spread amongst intravenous drug users, but risk prevention has been an important part of psychedelic consumption in ways that predate this formal conceptualization.We look at psychedelic drug trials in the 1950s and 1960s to consider how people-first perspectives informed those early clinical studies, and how pioneering psychedelic researchers themselves approached risk management at a time that predates the formal recognition of harm reduction. Next, we follow psychedelic drugs out of the clinic and into music scenes and festivals that proliferated during the war on the drugs, where community-based organizations stepped up to support music fans who chose to combine psychoactive substances with dancing and drugs at all-day festivals. Finally, we reflect on the longer history and traditions of the Native American Church as one specific example of how Indigenous ceremonies involving psychedelic substances combined spirituality and healing in a community setting curated to promote wellness. Ultimately, we argue that psychedelic risk management has deep historical roots in psychedelic communities representing biomedical, cultural, and Indigenous perspectives - we might heed these historical lessons as we consider how to promote sustainable risk management strategies with psychedelics going forward.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0