Current topics in behavioral neurosciences最新文献_第6页

Cognitive Decline in Alzheimer's Disease. 阿尔茨海默氏症患者的认知能力下降。

Current topics in behavioral neurosciences Pub Date : 2025-01-01 DOI: 10.1007/7854_2024_527

Abigail A Testo, Gwenyth Roundy, Julie A Dumas

{"title":"Cognitive Decline in Alzheimer's Disease.","authors":"Abigail A Testo, Gwenyth Roundy, Julie A Dumas","doi":"10.1007/7854_2024_527","DOIUrl":"10.1007/7854_2024_527","url":null,"abstract":"Deficits in memory, language, and other cognitive domains that impact an individual's ability to perform necessary tasks of daily living are symptoms of dementia, which is a major cause of death and disability in older adults. As the global population continues to age, deepening our understanding of dementia is crucial. Alzheimer's disease is the leading cause of dementia and accounts for between 60% and 80% of total dementia cases. Declines in episodic memory are considered a hallmark of Alzheimer's disease and occur early in disease progression. The cognitive effects of Alzheimer's disease differ from the cognitive changes expected in nonpathological or normal aging. While some cognitive changes are expected as a part of the aging processes, the declines in cognition associated with Alzheimer's disease are to a degree that the individual diagnosed with the disease is unable to function independently in activities of daily living. In this review, we will discuss how cognition is impacted by both normal and pathological aging, with a focus on Alzheimer's disease. We describe the progressive nature of Alzheimer's disease, as well as the effects of each stage of the disease on cognition.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"181-195"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex Differences in the Neurobiology of Fear and Anxiety. 恐惧和焦虑神经生物学中的性别差异。

Current topics in behavioral neurosciences Pub Date : 2025-01-01 DOI: 10.1007/7854_2024_536

Katelyn I Oliver, Dasani DelRosario, Jennifer S Stevens

引用次数: 0

The Neurophysiology of Interoceptive Disruptions in Trauma-Exposed Populations. 受创伤人群互感干扰的神经生理学》（The Neurophysiology of Interoceptive Disruptions in Trauma-Exposed Populations）。

Current topics in behavioral neurosciences Pub Date : 2025-01-01 DOI: 10.1007/7854_2024_469

Negar Fani, Travis Fulton, Boris Botzanowski

引用次数: 0

Dissociative Symptoms and Interoceptive Integration. 分离症状与感知间融合

Current topics in behavioral neurosciences Pub Date : 2025-01-01 DOI: 10.1007/7854_2024_480

Sascha P Woelk, Sarah N Garfinkel

{"title":"Dissociative Symptoms and Interoceptive Integration.","authors":"Sascha P Woelk, Sarah N Garfinkel","doi":"10.1007/7854_2024_480","DOIUrl":"10.1007/7854_2024_480","url":null,"abstract":"Dissociative symptoms and disorders of dissociation are characterised by disturbances in the experience of the self and the surrounding world, manifesting as a breakdown in the normal integration of consciousness, memory, identity, emotion, and perception. This paper aims to provide insights into dissociative symptoms from the perspective of interoception, the sense of the body's internal physiological state, adopting a transdiagnostic framework.Dissociative symptoms are associated with a blunting of autonomic reactivity and a reduction in interoceptive precision. In addition to the central function of interoception in homeostasis, afferent visceral signals and their neural and mental representation have been shown to shape emotional feeling states, support memory encoding, and contribute to self-representation. Changes in interoceptive processing and disrupted integration of interoceptive signals into wider cognition may contribute to detachment from the body and the world, blunted emotional experience, and altered subjective recall, as experienced by individuals who suffer from dissociation.A better understanding of the role of altered interoceptive integration across the symptom areas of dissociation could thus provide insights into the neurophysiological mechanisms underlying dissociative disorders. As new therapeutic approaches targeting interoceptive processing emerge, recognising the significance of interoceptive mechanisms in dissociation holds potential implications for future treatment targets.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"245-277"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensing the Self: The Role of the Insula and Interoception in Body Image. 感知自我：脑岛和内感受在身体意象中的作用。

Current topics in behavioral neurosciences Pub Date : 2025-01-01 DOI: 10.1007/7854_2025_581

Emily M Choquette, Sahib S Khalsa

引用次数: 0

Good Practice Guideline for Preclinical Alcohol Research: The STRINGENCY Framework. 临床前酒精研究良好实践指南》：STRINGENCY 框架。

Current topics in behavioral neurosciences Pub Date : 2025-01-01 DOI: 10.1007/7854_2024_484

Marcus W Meinhardt, Björn Gerlach, Rainer Spanagel

{"title":"Good Practice Guideline for Preclinical Alcohol Research: The STRINGENCY Framework.","authors":"Marcus W Meinhardt, Björn Gerlach, Rainer Spanagel","doi":"10.1007/7854_2024_484","DOIUrl":"10.1007/7854_2024_484","url":null,"abstract":"Research in the field of preclinical alcohol research, but also science in general, has a problem: Many published scientific results cannot be repeated. As a result, findings from preclinical research often do not translate well to humans, causing increasing disappointment and calls for restructuring of preclinical research, that is, better reproducibility of preclinical research. However, the replication crisis is an inherent problem in biomedical research. Replication failures are not only due to small experimental variations but are often the result of poor methodology. In response to the replication crisis, numerous guidelines and recommendations have been proposed to promote transparency, rigor, and reproducibility in scientific research. What is missing today is a framework that integrates all the confusing information that results from all these guidelines and recommendations. Here we present STRINGENCY, an integrative approach to good practice guidelines for preclinical alcohol research, which can also apply to behavioral research in general and which aims to improve preclinical research to better prepare it for translation and minimize the \"valley of death\" in translational research. STRINGENCY includes systematic review and, when possible, meta-analysis prior to study design, sample size calculation, preregistration, multisite experiments, scientific data management (FAIR), reporting of data using ARRIVE, generalization of research data, and transparent publications that allow reporting of null results. We invite the scientific community to adopt STRINGENCY to improve the reliability and impact of preclinical alcohol research.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"169-189"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural Circuitries and Alcohol Use Disorder: Cutting Corners in the Cycle. 神经回路与酒精使用障碍：循环中的切角

Current topics in behavioral neurosciences Pub Date : 2025-01-01 DOI: 10.1007/7854_2023_454

Marie A Doyle, Anne Taylor, Danny G Winder

{"title":"Neural Circuitries and Alcohol Use Disorder: Cutting Corners in the Cycle.","authors":"Marie A Doyle, Anne Taylor, Danny G Winder","doi":"10.1007/7854_2023_454","DOIUrl":"10.1007/7854_2023_454","url":null,"abstract":"An implicit tenet of the alcohol use disorder (AUD) research field is that knowledge of how alcohol interacts with the brain is critical to the development of an understanding of vulnerability to AUD and treatment approaches. Gaining this understanding requires the mapping of brain function critical to specific components of this heterogeneous disorder. Early approaches in humans and animal models focused on the determination of specific brain regions sensitive to alcohol action and their participation in AUD-relevant behaviors. Broadly speaking, this research has focused on three domains, Binge/Intoxication, Negative Affect/Withdrawal, and Preoccupation/Anticipation, with a number of regions identified as participating in each. With the generational advances in technologies that the field of neuroscience has undergone over the last two decades, this focus has shifted to a circuit-based analysis. A wealth of new data has sharpened the field's focus on the specific roles of the interconnectivity of multiple brain regions in AUD and AUD-relevant behaviors, as well as demonstrating that the three major domains described above have much fuzzier edges than originally thought.In this chapter, we very briefly review brain regions previously implicated in aspects of AUD-relevant behavior from animal model research. Next, we move to a more in-depth overview of circuit-based approaches, and the utilization of these approaches in current AUD research.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"379-399"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138800967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioral Neurobiology of Alcohol Addiction: A Decade of Great Challenges, New Hopes, and Hypes. 酒精成瘾的行为神经生物学：十年的巨大挑战，新的希望和炒作。

Current topics in behavioral neurosciences Pub Date : 2025-01-01 DOI: 10.1007/7854_2025_586

Wolfgang H Sommer, Rainer Spanagel

{"title":"Behavioral Neurobiology of Alcohol Addiction: A Decade of Great Challenges, New Hopes, and Hypes.","authors":"Wolfgang H Sommer, Rainer Spanagel","doi":"10.1007/7854_2025_586","DOIUrl":"10.1007/7854_2025_586","url":null,"abstract":"Over a decade after the first edition of \"Behavioral Neurobiology of Alcohol Addiction,\" this chapter revisits the field at a critical juncture, marked by both persistent challenges and emerging opportunities. We reflect on the translational gap that has stalled the development of new treatments for alcohol use disorder (AUD), despite decades of promising preclinical findings. Particular attention is given to the replicability crisis in animal research, publication biases, and the limited predictive validity of existing models. At the same time, we highlight advances that offer renewed hope, including molecular and circuit-level technologies, AI-driven data analysis, real-world assessments, and new pharmacological candidates, such as GLP-1 agonists and psychedelics. These breakthroughs are considered alongside the increasing recognition of inflammation, pain, and neuroimmune factors as integral to AUD. However, we caution against exaggerated claims and urge the field to avoid oversimplified models, especially those that conflate habits and compulsions. Finally, we argue that neurobiological progress must be complemented by public health strategies aimed at reducing stigma and improving access to care. By fostering empirical rigor, embracing complexity, and maintaining critical self-reflection, addiction science can better align its innovations with real-world clinical and societal needs.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"3-16"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal Antidepressant Exposure and the Developing Brain: A Review of Neuroimaging Findings. 产前抗抑郁药物暴露与大脑发育：神经影像学研究综述。

Current topics in behavioral neurosciences Pub Date : 2025-01-01 DOI: 10.1007/7854_2025_591

Kayleigh S J Campbell, Tim F Oberlander

{"title":"Prenatal Antidepressant Exposure and the Developing Brain: A Review of Neuroimaging Findings.","authors":"Kayleigh S J Campbell, Tim F Oberlander","doi":"10.1007/7854_2025_591","DOIUrl":"10.1007/7854_2025_591","url":null,"abstract":"Antenatal mood disturbances are experienced by as many as 20% of pregnant mothers and are commonly treated with serotonin reuptake inhibitor (SRI) antidepressants. Both maternal depression and SRIs during pregnancy are associated with low birth weight and infant neurobehavioral disturbances, as well as longer-term impacts on child neurodevelopment, behavior, and mental health. As maternal depression and its pharmacotherapy are inherently interrelated prenatal exposures, distinguishing how these early life factors uniquely impact child development remains methodologically challenging. Over the past several years, however, advanced neuroimaging has been successfully used to identify neural correlates of prenatal depression and SRI antidepressant exposure on the developing brain, extending from the early newborn period through adolescence. In this review, we examine the use of magnetic resonance imaging and electroencephalography to study child brain structure or function, with a specific focus on prenatal antidepressants as the primary exposure in relation to either typical development or exposure to maternal depressed mood alone. We include both cross-sectional and longitudinal neuroimaging studies, as well as those that link early brain findings with cognitive or behavioral outcome in childhood. We also discuss factors that may shape neurodevelopmental risk (e.g., maternal mental illness severity, sex differences, genetic variability) and present suggestions for future research that will advance our understanding of child brain development in the context of maternal mood disturbances during pregnancy.","PeriodicalId":11257,"journal":{"name":"Current topics in behavioral neurosciences","volume":" ","pages":"1-22"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Consequences Paternal Preconceptual Alcohol Consumption. 父亲孕前饮酒的功能后果。

Current topics in behavioral neurosciences Pub Date : 2025-01-01 DOI: 10.1007/7854_2025_601

Sahir Hussain, Darren Day, Bart Ellenbroek

引用次数: 0