Diagnostics最新文献

{"title":"Quantitative Analysis of Diagnostic Reasoning Using Initial Electronic Medical Records.","authors":"Shinya Takeuchi, Yoshiyasu Okuhara, Yutaka Hatakeyama","doi":"10.3390/diagnostics15121561","DOIUrl":"10.3390/diagnostics15121561","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Diagnostic reasoning is essential in clinical practice and medical education, yet it often becomes an automated process, making its cognitive mechanisms less visible. Despite the widespread use of electronic medical records, few studies have quantitatively evaluated how clinicians' reasoning is documented in real-world electronic medical records. This study aimed to investigate whether initial electronic medical records contain valuable information for diagnostic reasoning and assess the feasibility of using text analysis and logistic regression to make this reasoning process visible. <b>Methods</b>: We conducted a retrospective analysis of initial electronic medical records at Kochi University Hospital between 2008 and 2022. Two patient cohorts presenting with dizziness and headaches were analysed. Text analysis was performed using GiNZA, a Japanese natural language processing library, and logistic regression analyses were conducted to identify associations with final diagnoses. <b>Results</b>: We identified 1277 dizziness cases, of which 248 were analysed, revealing 48 significant diagnostic terms. Moreover, we identified 1904 headache cases, of which 616 were analysed, revealing 46 significant diagnostic terms. The logistic regression analysis demonstrated that the presence of specific terms, as well as whether they were expressed affirmatively or negatively, was significantly associated with diagnostic outcomes. <b>Conclusions</b>: Initial EMRs contain quantifiable linguistic cues relevant to diagnostic reasoning. Even simple analytical methods can reveal reasoning patterns, offering valuable insights for medical education and supporting the development of explainable diagnostic support systems.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 12","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12191538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MCM4 as Potential Metastatic Biomarker in Lung Adenocarcinoma.","authors":"Hung-Chih Lai, Ju-Fang Liu, Tsung-Ming Chang, Thai-Yen Ling","doi":"10.3390/diagnostics15121555","DOIUrl":"10.3390/diagnostics15121555","url":null,"abstract":"<p><p><b>Background:</b> Lung adenocarcinoma (LUAD) is the most common subtype of non-small-cell lung cancer and is frequently diagnosed at advanced stages with metastasis, contributing to its poor prognosis. Identifying key metastasis-related biomarkers is critical for improving early diagnosis and therapeutic targeting. <b>Methods:</b> We analyzed four GEO microarray datasets (GSE32863, GSE27262, GSE40275, and GSE33356) and TCGA data to identify differentially expressed genes (DEGs) in LUAD. Functional enrichment of DEGs was analyzed using Gene Ontology, Kyoto Encyclopedia of Genes and Genomes analysis, and a Cancer Hallmark Enrichment Plot. Hub gene analysis was conducted using Cytoscape. Hub genes were evaluated for their expression, prognostic significance (via the Kaplan-Meier plotter), and clinical correlation using additional platforms (TCGA, Lung Cancer Explorer, TNMplot, and the Human Protein Atlas). <b>Results:</b> A total of 333 consistently dysregulated DEGs were identified, enriched in pathways related to metastasis, including angiogenesis, immune escape, and ECM interaction. Ten hub genes (<i>AURKA</i>, <i>TOP2A</i>, <i>CCNB2</i>, <i>CENPF</i>, <i>MCM4</i>, <i>TPX2</i>, <i>KIF20A</i>, <i>ASPM</i>, <i>MELK</i>, and <i>NEK2</i>) were identified through network analysis. Among these, <i>MCM4</i> showed strong upregulation in LUAD and was significantly associated with poor overall survival. Notably, <i>MCM4</i> expression also correlated with post-progression survival and markers of invasiveness. Immunohistochemistry and transcriptomic analyses confirmed <i>MCM4</i> overexpression at both mRNA and protein levels. Additionally, <i>MCM4</i> expression was positively correlated with various matrix metalloproteinases, supporting its role in promoting tumor invasiveness. <b>Conclusions:</b><i>MCM4</i> is a novel potential biomarker for LUAD metastasis and prognosis. Its consistent upregulation, association with metastatic markers, and clinical significance suggest it may serve as a candidate target for diagnostic use or therapeutic intervention in advanced LUAD.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 12","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12192313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"18F-FDG PET/CT Impact on Malignant Melanoma Patients Undergoing Staging and Restaging: A Single-University-Center Experience in a Real-World Setting.","authors":"Silvija Lucic, Milena Spirovski, Borislava Nikolin, Dragana Stojanovic, Andrea Peter, Branislava Gajic, Vanja Cimbaljevic, Milos A Lucic","doi":"10.3390/diagnostics15121560","DOIUrl":"10.3390/diagnostics15121560","url":null,"abstract":"<p><p><b>Background/Objectives:</b> The global increase in the incidence of malignant melanoma, without significant changes in the mortality rate, may be influenced by the changes in the diagnostic approach and criteria, and the impact of innovative therapies on the survival of patients. Advances in treatment options, influencing prolonged survival, are bringing up a strong need for close surveillance of melanoma patients. In this observational, retrospective, and single-center study, we determined the impact of 18F-FDG PET/CT diagnostics on the outcomes and survival of malignant melanoma patients at different stages from an extensive and unselected group in a real-life clinical management setting. <b>Methods:</b> A total number of 189 malignant melanoma patients who underwent 18F-FDG PET/CT examination in the course of the treatment at one university oncology institute during the period from January 2010 to December 2024 were included in the study, and the multifactorial impact on the outcome and survival of malignant melanoma patients was observed in regard to the differences resulting from the therapeutic approaches and the introduction of new therapeutic options and drugs. <b>Results & Conclusions:</b> Our results indicate that 18F-FDG PET/CT is a sensitive imaging tool for the detection of predominantly distant metastases in malignant melanoma patients belonging to an extensive and unselected population in a real-world clinical setting, not only at advanced melanoma stages but also at early stages of high-risk patients' surveillance. Follow-up appears to be of substantial importance for patients at advanced stages, but also for patients at early stages of disease, in particular in the presence of a strong clinical suspicion. Immunotherapy and combined therapy are improving overall survival in melanoma patients in real-world circumstances and equivalent clinical surroundings.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 12","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12192031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Serum Selenium with Clinical Features and Inflammatory and Oxidative Stress Markers in Iranian Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease-A Cross-Sectional Study.","authors":"Abbas Pishdadian, Reza Sharifi, Adele Shafaghi, Soudabeh Hamedi-Shahraki, Farshad Amirkhizi, Aleksandra Klisic","doi":"10.3390/diagnostics15121559","DOIUrl":"10.3390/diagnostics15121559","url":null,"abstract":"<p><p><b>Background</b>: There are conflicting epidemiological studies regarding the association between selenium (Se) and metabolic disorders. Furthermore, the pathophysiological links between Se and metabolic dysfunction-associated steatotic liver disease (MASLD) have not yet been fully elucidated. Therefore, we evaluated the association between serum Se levels and the clinical features of MASLD and the inflammatory and oxidative stress markers in these patients as potential risk factors for the progression of this disease. <b>Methods</b>: This cross-sectional study involved 150 patients aged 20 to 50 years who were newly diagnosed with MASLD. Oxidative stress was evaluated by measuring serum thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (TAC), and the activities of erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GPx). Tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and transforming growth factor beta (TGF-β) were measured as inflammatory markers. A one-way analysis of variance (ANOVA), Pearson chi-square test, Kruskal-Wallis test, and multiple linear regression were employed for data analysis. <b>Results</b>: We observed a significant inverse association between serum Se concentrations and liver steatosis severity in the participants. There was a significant decrease in serum concentrations of insulin and the homeostasis model assessment of insulin resistance (HOMA-IR), triglycerides, TNF-α, and TBARS with ascending quartiles of serum Se. Conversely, the mean serum levels of TAC and erythrocyte GPx activities exhibited a consistent increasing trend in relation to rising serum Se concentrations. However, no significant trends were identified for serum FSG, IL-6, TGF-β, or erythrocyte SOD activities across the varying levels of serum Se. <b>Conclusions</b>: Our results demonstrate that decreased serum selenium levels in Iranian patients with MASLD correlate with elevated inflammatory markers, increased oxidative stress, and more severe liver steatosis.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 12","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12191626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinction Between Dysplasia, Malformation, and Deformity-Towards the Proper Diagnosis and Treatment of Hip Development Disorders.","authors":"Jacek Dygut, Monika Piwowar","doi":"10.3390/diagnostics15121547","DOIUrl":"10.3390/diagnostics15121547","url":null,"abstract":"<p><p>(1) Background: This publication focuses on processes that disrupt the proper development of the hip. Four pathomechanisms underlying human developmental defects are described in the literature, i.e., dysplasia, malformation, disruption, and deformity. In the case of hip development, arguably the greatest challenge involves confusion between dysplasia and deformity, which often leads to misdiagnosis, incorrect nomenclature, and incorrectly chosen treatment. (2) Methods: A review of the scientific literature was performed. (3) Results: The paper presents a description of hip joint development disorders in the context of their pathomechanisms. An attempt was made to answer the question of whether these disorders are rooted in a primary disorder of tissue growth, resulting in incorrect anatomy, or are the result of anatomical deformations with secondary modifications in tissue structures-of a degenerative or adaptive nature-based on Delpech-Hueter-Volkmann growth and remodeling laws. In addition, the emphasis is placed on the presence of so-called clinically and diagnostically mute cases. We suggest augmenting diagnostic procedures with genetic tests to increase the sensitivity of screening. (4) Conclusions: Based on the arguments, a new division of developmental hip disorders is proposed.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 12","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12191916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolutionizing Medical Imaging: The Transformative Role of Artificial Intelligence in Diagnostics and Treatment.","authors":"Daniele Giansanti","doi":"10.3390/diagnostics15121557","DOIUrl":"10.3390/diagnostics15121557","url":null,"abstract":"<p><p>The field of medical imaging is undergoing a significant transformation, driven by the rapid integration of artificial intelligence (AI) into clinical workflows and research methodologies [...].</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 12","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12191749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Teacher-Assistant-Student Collaborative and Competitive Network for Brain Tumor Segmentation with Missing Modalities.","authors":"Junjie Wang, Huanlan Kang, Tao Liu","doi":"10.3390/diagnostics15121552","DOIUrl":"10.3390/diagnostics15121552","url":null,"abstract":"<p><p><b>Background</b>: Magnetic Resonance Imaging (MRI) provides rich tumor information through different imaging modalities (T1, T1ce, T2, and FLAIR). Each modality offers distinct contrast and tissue characteristics, which help in the more comprehensive identification and analysis of tumor lesions. However, in clinical practice, only a single modality of medical imaging is available due to various factors such as imaging equipment. The performance of existing methods is significantly hindered when handling incomplete modality data. <b>Methods</b>: A Teacher-Assistant-Student Collaborative and Competitive Net (TASCCNet) is proposed, which is based on traditional knowledge distillation techniques. First, a Multihead Mixture of Experts (MHMoE) module is developed with multiple experts and multiple gated networks to enhance information from fused modalities. Second, a competitive function is formulated to promote collaboration and competition between the student network and the teacher network. Additionally, we introduce an assistant module inspired by human visual mechanisms to provide supplementary structural knowledge, which enriches the information available to the student and facilitates a dynamic teacher-assistant collaboration. <b>Results</b>: The proposed model (TASCCNet) is evaluated on the BraTS 2018 and BraTS 2021 datasets and demonstrates robust performance even when only a single modality is available. <b>Conclusions</b>: TASCCNet successfully addresses the challenge of incomplete modality data in brain tumor segmentation by leveraging collaborative knowledge distillation and competitive learning mechanisms.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 12","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12192063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amelanotic Melanocytic Nevus of the Oral Cavity: A Case Report and Literature Review.","authors":"Rossana Izzetti, Filippo Minuti, Angela Pucci, Chiara Cinquini, Antonio Barone, Marco Nisi","doi":"10.3390/diagnostics15121554","DOIUrl":"10.3390/diagnostics15121554","url":null,"abstract":"<p><p>Amelanotic melanocytic nevi of the oral cavity are uncommon lesions that often present a diagnostic challenge for clinicians, primarily due to their nonspecific clinical appearance and the broad spectrum of possible differential diagnoses. These lesions can mimic a variety of benign and malignant conditions, requiring precise histopathological confirmation. The primary objective of this article is to present a comprehensive case report-tracing the course from initial presentation through diagnostic workup to final diagnosis-and to provide an overview of the current literature on oral amelanotic melanocytic nevi. We report the case of a 27-year-old female who presented with a small, exophytic mass located in the anterior mandibular gingival region. The lesion was asymptomatic and lacked pigmentation, adding to the diagnostic uncertainty. A range of differential diagnoses was considered, including pyogenic granuloma, peripheral ossifying fibroma, and squamous cell carcinoma. Due to the lesion's limited size and accessibility, an excisional biopsy was performed under local anesthesia. Histopathological examination revealed an amelanotic melanocytic nevus, a rare variant characterized by the absence of melanin pigment, further complicating the clinical impression. The diagnosis was confirmed through immunohistochemical staining, which demonstrated melanocytic markers consistent with a nevus. The patient was followed up with for six months postoperatively, with no evidence of recurrence or malignant transformation. This case highlights the critical role of biopsy in achieving a definitive diagnosis, especially in lesions with atypical clinical presentations. It also underscores the importance of considering amelanotic melanocytic nevi in the differential diagnosis of nonpigmented oral lesions, as well as maintaining vigilance regarding the rare possibility of amelanotic melanoma.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 12","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12192119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Menstrual Cycle on Exercise Treadmill Parameters and Cardiac Troponin Release in Premenstrual Women.","authors":"Aysu Oktay, Inanc Torustag, Ferruh Kemal Isman, Mehmet Agirbasli","doi":"10.3390/diagnostics15121548","DOIUrl":"10.3390/diagnostics15121548","url":null,"abstract":"<p><p><b>Background:</b> The diagnostic accuracy of the exercise treadmill test (ETT) remains suboptimal in premenopausal women. Menstrual cycle phases display hormonal variations and biological effects in premenopausal women. The early and late follicular phases of the menstrual cycle demonstrate nearly four-fold differences in estrogen levels. <b>Methods:</b> This study assessed the variability in ETT results between the early and late follicular phases in premenopausal women. This study included premenopausal females with regular menstrual cycles and chest pain. As per the study protocol, patients underwent two separate ETTs at the early and late follicular phases of the menstrual cycle. Hormones and high-sensitivity cardiac troponin T (hs-cTnT) were measured. The primary endpoint was the ST segment/heart rate (HR) index. The secondary endpoints were maximum ST/HR slope, ST segment depression, HR and blood pressure (BP) response, exercise capacity, and hs-cTnT change after ETT. <b>Results:</b> False-positive ETT results were common in premenopausal women. The early follicular phase displayed significantly higher hs-cTnT and BP responses to ETT compared to the late follicular phase. This study reports that ETT results are similar between the early and late follicular phases of the menstrual cycle in premenopausal women. Biological variability is observed in the BP and hs-cTnT response to ETT between the two phases. <b>Conclusions:</b> The menstrual cycle phase (early versus late follicular phase) did not affect the ETT results. The consideration of estrogen and hormonal status when evaluating the diagnostic test results can improve our understanding of cardiovascular disease in women.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 12","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12192016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can We Determine Osteoarthritis Severity Based on Systemic Immuno-Inflammatory Index?","authors":"Bilge Kagan Yilmaz, Recep Altin, Alper Sari","doi":"10.3390/diagnostics15121556","DOIUrl":"10.3390/diagnostics15121556","url":null,"abstract":"<p><p><b>Background:</b> Osteoarthritis (OA) is one of the common joint diseases. Hematologic markers have been investigated to determine its severity and predict the prognosis of joint diseases. In this study, we investigated whether the systemic immune-inflammatory index (SII) is a marker for assessing the severity of OA. <b>Methods</b>: The records of patients diagnosed with OA at various stages between 1 January 2020 and 1 January 2022 were retrospectively analyzed. Patients aged 18-75 years with complete blood count within the last 15 days and not taking anti-inflammatory drugs were included in the study. Patients were classified according to the Kellgren-Lawrance classification as stage 1-2-3 mild to moderate OA (Group I) and stage 4 severe OA (Group II). A total of 1580 patients were diagnosed with knee OA and 946 were included in the study. Of the patients, 246 (26%) were male and 700 (74%) were female. The mean age of the patients was 61.00 (53.00-68.00) years. <b>Results</b>: There were 449 (47.5%) patients in Group I and 497 (52.5%) patients in Group II. Statistically significant differences were found between the groups in age, gender, hemoglobin, lymphocytes, and SII (<i>p</i> < 0.05). An SII value of 627.9 was found to distinguish severe OA from mild-moderate OA with 42.5% sensitivity and 70.6% specificity. <b>Conclusions</b>: Although this study is the first in the literature, it shows that SII has limited predictive value in assessing the severity of knee OA. Future research should focus on longitudinal studies to establish causality and explore therapeutic implications.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 12","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12192534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144494989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}