Diagnostics最新文献

筛选
英文 中文
Serum Galectin-3 and Presepsin Levels in Pediatric Familial Mediterranean Fever Patients During Remission: A Prospective Study. 儿童家族性地中海热缓解期患者血清半乳糖凝集素-3和胃泌素水平:一项前瞻性研究。
IF 3.3 3区 医学
Diagnostics Pub Date : 2025-09-21 DOI: 10.3390/diagnostics15182403
Seyda Dogantan, Peren Perk, Arzu Sekerci Yuksel, Rahime Koc, Adem Keskin
{"title":"Serum Galectin-3 and Presepsin Levels in Pediatric Familial Mediterranean Fever Patients During Remission: A Prospective Study.","authors":"Seyda Dogantan, Peren Perk, Arzu Sekerci Yuksel, Rahime Koc, Adem Keskin","doi":"10.3390/diagnostics15182403","DOIUrl":"10.3390/diagnostics15182403","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Familial Mediterranean fever (FMF) is the most common hereditary autoinflammatory syndrome, characterized by recurrent fever attacks and serositis. Galectin-3, a β-galactoside-binding lectin involved in inflammation and fibrosis, and presepsin, an established biomarker for bacterial infection and sepsis, have emerged as potential biomarkers for improving diagnostic and prognostic accuracy in autoinflammatory diseases. However, their use in FMF patients is not sufficiently evaluated. This study aims to compare serum galectin-3 and presepsin levels in children with FMF and healthy controls and assess their correlations with conventional acute-phase reactants. <b>Methods:</b> This prospective cross-sectional study included 74 children with confirmed FMF during attack-free periods and 67 age- and gender-matched healthy controls. Clinical and genetic characteristics, complete blood count, C-reactive protein (CRP), serum amyloid-A (SAA), and erythrocyte sedimentation rate (ESR) were recorded. Serum galectin-3 and presepsin levels were measured. Group comparisons and correlation analyses were performed using appropriate statistical tests. <b>Results:</b> Median serum galectin-3 and presepsin was significantly higher in FMF patients than controls (<i>p</i> < 0.001). ESR was significantly higher in FMF patients (<i>p</i> < 0.001), while CRP and SAA showed no significant differences. Correlation analysis revealed a strong positive correlation between galectin-3 and presepsin (r = 0.860, <i>p</i> < 0.001) in FMF patients, with neither correlating with other acute-phase reactants. <b>Conclusions:</b> Galectin-3 and presepsin were found to serve as novel biomarkers reflecting alternative inflammatory pathways in FMF, even during remission. These results, obtained during the attack-free period, indicate the need for further studies to determine the relationship between galectin-3 and presepsin levels and disease activity in FMF.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 18","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comparative Evaluation of Meta-Learning Models for Few-Shot Chest X-Ray Disease Classification. 几次胸片疾病分类元学习模型的比较评价。
IF 3.3 3区 医学
Diagnostics Pub Date : 2025-09-21 DOI: 10.3390/diagnostics15182404
Luis-Carlos Quiñonez-Baca, Graciela Ramirez-Alonso, Fernando Gaxiola, Alain Manzo-Martinez, Raymundo Cornejo, David R Lopez-Flores
{"title":"A Comparative Evaluation of Meta-Learning Models for Few-Shot Chest X-Ray Disease Classification.","authors":"Luis-Carlos Quiñonez-Baca, Graciela Ramirez-Alonso, Fernando Gaxiola, Alain Manzo-Martinez, Raymundo Cornejo, David R Lopez-Flores","doi":"10.3390/diagnostics15182404","DOIUrl":"10.3390/diagnostics15182404","url":null,"abstract":"<p><p><b>Background/Objectives</b>: The limited availability of labeled data, particularly in the medical domain, poses a significant challenge for training accurate diagnostic models. While deep learning techniques have demonstrated notable efficacy in image-based tasks, they require large annotated datasets. In data-scarce scenarios-especially involving rare diseases-their performance deteriorates significantly. Meta-learning offers a promising alternative by enabling models to adapt quickly to new tasks using prior knowledge and only a few labeled examples. This study aims to evaluate the effectiveness of representative meta-learning models for thoracic disease classification in chest X-rays. <b>Methods</b>: We conduct a comparative evaluation of four meta-learning models: Prototypical Networks, Relation Networks, MAML, and FoMAML. First, we assess five backbone architectures (ConvNeXt, DenseNet-121, ResNet-50, MobileNetV2, and ViT) using a Prototypical Network. The best-performing backbone is then used across all meta-learning models for fair comparison. Experiments are performed on the ChestX-ray14 dataset under a 2-way setting with multiple <i>k</i>-shot configurations. <b>Results</b>: Prototypical Networks combined with DenseNet-121 achieved the best performance, with a recall of 68.1%, an F1-score of 67.4%, and a precision of 0.693 in the 2-way, 10-shot configuration. In a disease-specific analysis, Hernia obtains the best classification results. Furthermore, Prototypical and Relation Networks demonstrate significantly higher computational efficiency, requiring fewer FLOPs and shorter execution times than MAML and FoMAML. <b>Conclusions</b>: Prototype-based meta-learning, particularly with DenseNet-121, proves to be a robust and computationally efficient approach for few-shot chest X-ray disease classification. These findings highlight its potential for real-world clinical applications, especially in scenarios with limited annotated medical data.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 18","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does the Position of the Mandibular Third Molar Have an Effect on the Lingual Bone Morphology? A Cone Beam Computed Tomography Evaluation. 下颌第三磨牙的位置对舌骨形态有影响吗?锥束计算机断层成像评价。
IF 3.3 3区 医学
Diagnostics Pub Date : 2025-09-20 DOI: 10.3390/diagnostics15182401
Ezgi Yüceer-Çetiner, Özgür Sakarya, Attila Vural, Dilara Kazan
{"title":"Does the Position of the Mandibular Third Molar Have an Effect on the Lingual Bone Morphology? A Cone Beam Computed Tomography Evaluation.","authors":"Ezgi Yüceer-Çetiner, Özgür Sakarya, Attila Vural, Dilara Kazan","doi":"10.3390/diagnostics15182401","DOIUrl":"10.3390/diagnostics15182401","url":null,"abstract":"<p><p><b>Background/Objectives:</b> This study aimed to investigate the association between the position of impacted mandibular third molars and the morphology of the lingual cortical bone using cone beam computed tomography (CBCT), and to determine how impaction depth and angulation influence the risk of lingual cortical perforation. <b>Methods</b>: CBCT scans of 120 impacted mandibular third molars from 71 adult patients were retrospectively evaluated. Teeth were classified based on Pell & Gregory's and Winter's classifications. Lingual cortical morphology was categorized as undercut, parallel, slanted, or round. The relationship between the root apex and the lingual plate was classified as non-contact, contact, or perforating. Linear measurements included cortical lingual bone thickness and the distance from the apex to the outer surface of the lingual cortex. <b>Results</b>: Lingual bone morphology showed significant associations with both impaction depth and angulation, with parallel morphology more common in deeper and more angulated impactions. Lingual cortical perforation was observed in approximately 30% of the teeth, predominantly at the apex, with horizontal and deeply impacted molars (Class II, Level C) representing the highest-risk configurations. Although cortical thickness and apex-to-cortex distance were significantly smaller in apically perforated cases, no definitive threshold could be established, and these parameters were insufficient as standalone predictors at the cementoenamel junction or mid-root levels. <b>Conclusions</b>: Tooth angulation and impaction depth are significant predictors of lingual bone morphology and perforation risk. CBCT imaging is therefore recommended beyond low-risk cases (Level A, Class I, vertical) to improve preoperative planning, strengthen informed consent, and guide surgical strategies aimed at minimizing complications and enhancing patient safety.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 18","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elevated Serum Trimethylamine N-Oxide Predicts Impaired Vascular Reactivity in Patients with Hypertension. 血清三甲胺n -氧化物升高预测高血压患者血管反应性受损
IF 3.3 3区 医学
Diagnostics Pub Date : 2025-09-20 DOI: 10.3390/diagnostics15182400
I-Min Su, Ji-Hung Wang, Chin-Hung Liu, Bang-Gee Hsu
{"title":"Elevated Serum Trimethylamine N-Oxide Predicts Impaired Vascular Reactivity in Patients with Hypertension.","authors":"I-Min Su, Ji-Hung Wang, Chin-Hung Liu, Bang-Gee Hsu","doi":"10.3390/diagnostics15182400","DOIUrl":"10.3390/diagnostics15182400","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Trimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite influenced by diet, has been linked to cardiovascular disease. Endothelial dysfunction, an early sign of vascular damage, is common in hypertension. This study examined the relationship between serum TMAO levels and endothelial function, assessed by the vascular reactivity index (VRI), in patients with hypertension. <b>Methods</b>: In total, 110 patients with hypertension were enrolled. Fasting serum TMAO was measured using high-performance liquid chromatography-mass spectrometry. Endothelial function was evaluated via digital thermal monitoring, with VRI categorized as good (>2.0), intermediate (1.0-1.9), or poor (<1.0). <b>Results</b>: Of the participants, 10 (9.1%) exhibited poor vascular reactivity, 57 (51.8%) had intermediate reactivity, and 43 (39.1%) exhibited good vascular reactivity. Poor reactivity correlated with older age (<i>p</i> = 0.010), higher total cholesterol (<i>p</i> = 0.007), low-density lipoprotein cholesterol (<i>p</i> = 0.009), and higher TMAO levels (<i>p</i> < 0.001). In multivariate forward stepwise linear regression, the log-transformed TMAO level (log-TMAO) remained independently and inversely associated with VRI (<i>p</i> < 0.001). Logistic regression analyses demonstrated that elevated TMAO concentrations were significantly associated with an increased likelihood of vascular reactivity dysfunction (intermediate and poor groups combined; odds ratio [OR] = 1.10, 95% confidence interval [CI]: 1.047-1.155; <i>p</i> < 0.001) and, in particular, with poor vascular reactivity (OR = 1.58, 95% CI: 1.002-2.492; <i>p</i> = 0.049). <b>Conclusions</b>: Elevated serum TMAO is independently associated with endothelial dysfunction in hypertension.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 18","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Warm Phase of CRPS Type-1: Is It Time to Review the Budapest Criteria? CRPS 1型的暖期:是时候重新审视布达佩斯标准了吗?
IF 3.3 3区 医学
Diagnostics Pub Date : 2025-09-20 DOI: 10.3390/diagnostics15182397
Gianantonio Saviola, Sergio Rosini, Luigi Molfetta, Luca Dalle Carbonare, Nazzarena Malavolta, Nunzia Di Meglio, Maria Antonietta Mazzei, Maurizio Muratore, Bruno Frediani
{"title":"The Warm Phase of CRPS Type-1: Is It Time to Review the Budapest Criteria?","authors":"Gianantonio Saviola, Sergio Rosini, Luigi Molfetta, Luca Dalle Carbonare, Nazzarena Malavolta, Nunzia Di Meglio, Maria Antonietta Mazzei, Maurizio Muratore, Bruno Frediani","doi":"10.3390/diagnostics15182397","DOIUrl":"10.3390/diagnostics15182397","url":null,"abstract":"<p><p>Complex Regional Pain Syndrome (CRPS) type 1 is a painful and disabling localized syndrome with a pathogenesis that is still unclear. The last revised diagnostic criteria for CRPS-1 syndrome were developed in 2012 (the so-called Budapest criteria), based only on clinical features, while the presence of bone marrow edema (BME) and the response to treatments were completely absent. As BME is usually present on magnetic resonance imaging (MRI) in the early (\"warm\") phase of CRPS-1, this criterion should be added as a necessary criterion to Budapest criteria. In addition, hyperalgesia and/or allodynia are also commonly present in the warm phase. Therefore, both of these symptoms should be included as essential criteria. Furthermore, the response to bisphosphonates may be another important parameter to add to the list of treatment options, as well as hyperbaric oxygen therapy. Finally, it must be clear that BME is not an exclusive finding of CRPS-1. Therefore, a correct clinical history and, if needed, further radiological studies and laboratory tests should be performed to avoid a false diagnosis. In this paper, the \"Bone Marrow Edema Diagnosis and Therapeutic Treatment\" Italian Group (GEODEIT) proposes a revision of Budapest's criteria to make them more meaningful and effective in reaching a correct and quick diagnosis of the disease.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 18","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic and Therapeutic Challenges in Pseudoangiomatous Stromal Hyperplasia (PASH) of the Breast in a 14-Year-Old Girl: A Case-Based Review. 14岁女孩乳腺假性血管瘤间质增生(PASH)的诊断和治疗挑战:基于病例的回顾。
IF 3.3 3区 医学
Diagnostics Pub Date : 2025-09-20 DOI: 10.3390/diagnostics15182395
Patrycja Sosnowska-Sienkiewicz, Przemysław Mańkowski, Danuta Januszkiewicz-Lewandowska
{"title":"Diagnostic and Therapeutic Challenges in Pseudoangiomatous Stromal Hyperplasia (PASH) of the Breast in a 14-Year-Old Girl: A Case-Based Review.","authors":"Patrycja Sosnowska-Sienkiewicz, Przemysław Mańkowski, Danuta Januszkiewicz-Lewandowska","doi":"10.3390/diagnostics15182395","DOIUrl":"10.3390/diagnostics15182395","url":null,"abstract":"<p><p><b>Introduction:</b> Pseudoangiomatous stromal hyperplasia (PASH) is a benign breast lesion characterized by stromal myofibroblast proliferation forming slit-like pseudoangiomatous spaces. Although most frequently diagnosed in premenopausal women, it has also been reported in adolescent girls, where it may present as a rapidly enlarging mass that mimics fibroadenoma or phyllodes tumor. The pathogenesis is thought to be hormonally influenced, particularly by progesterone, with a possible role for estrogen. <b>Case Report:</b> We report the case of a 14-year-old girl who presented with a painless, rapidly growing mass in the left breast, first noticed approximately six months earlier. Clinical examination revealed a mobile lesion about 10 cm in diameter without skin changes, lymphadenopathy, or nipple discharge. Ultrasound and MRI demonstrated a large, well-circumscribed solid tumor (10.4 × 11.2 × 4.2 cm<sup>3</sup>) displacing normal breast tissue but without infiltration; both were classified as BI-RADS 4. Given the tumor size, diagnostic uncertainty, and potential risk of a non-representative core needle biopsy, a decision was made to proceed with primary radical excision. The mass was completely removed with preservation of the glandular tissue. Histopathology confirmed PASH, described macroscopically as a solid, gray-yellow, encapsulated tumor and microscopically as slit-like spaces lined by spindle cells (CD34+, CD31-). Postoperatively, the breast gradually regained symmetry with the contralateral side, and at 14 months of follow-up, no recurrence was observed. <b>Conclusions:</b> PASH, although benign, may present as a large breast tumor in adolescents and clinically mimic both benign and malignant lesions. Histological evaluation based on an adequately performed biopsy is crucial for accurate diagnosis. Complete excision with capsule preservation is recommended to minimize the risk of recurrence. In adolescents, a watchful waiting approach after surgery may be beneficial, as breast tissue often remodels and regains symmetry spontaneously, reducing the need for reconstructive procedures. This case underscores the importance of individualized diagnostic and therapeutic strategies in managing rare benign breast lesions in pediatric patients.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 18","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12469236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Virtual Reality-Based System for Measuring Deviation Angle in Strabismus: A Prospective Study. 一种新型的基于虚拟现实的斜视偏斜角测量系统:前瞻性研究。
IF 3.3 3区 医学
Diagnostics Pub Date : 2025-09-20 DOI: 10.3390/diagnostics15182402
Jhih-Yi Lu, Yin-Cheng Liu, Jui-Bang Lu, Ming-Han Tsai, Wen-Ling Liao, I-Ming Wang, Hui-Ju Lin, Yu-Te Huang
{"title":"A Novel Virtual Reality-Based System for Measuring Deviation Angle in Strabismus: A Prospective Study.","authors":"Jhih-Yi Lu, Yin-Cheng Liu, Jui-Bang Lu, Ming-Han Tsai, Wen-Ling Liao, I-Ming Wang, Hui-Ju Lin, Yu-Te Huang","doi":"10.3390/diagnostics15182402","DOIUrl":"10.3390/diagnostics15182402","url":null,"abstract":"<p><p><b>Background/Objectives</b>: To develop a new Virtual Reality (VR) system software for measuring ocular deviation in strabismus patients. <b>Methods</b>: This prospective study included subjects with basic-type exotropia (XT) and non-refractive accommodative esotropia (ET). Ocular deviation was measured using the alternate prism cover test (APCT) and two VR-based methods: target offset (TO) and a newly developed camera rotation (CR) method. <b>Results</b>: A total of 28 subjects were recruited (5 cases were excluded for preliminary testing and 5 for not meeting inclusion criteria). Among the 18 included patients, 10 (66.7%) had XT and 5 (33.3%) had ET. The median age was 21.5 years (IQR 17 to 25). The mean age was 22.3 years (range: 9-46), with 5 (27.8%) having manifest strabismus and 12 (61.1%) measured while wearing glasses. VR-based methods (TO and CR) showed comparable results to APCT for deviation angle measurements (<i>p</i> = 0.604). Subgroup analysis showed no significant differences in ET patients (all <i>p</i> > 0.05). In XT patients, both TO and CR underestimated deviation angles compared to APCT (<i>p</i> = 0.008 and <i>p</i> = 0.001, respectively), but no significant difference was observed between the two methods (<i>p</i> = 0.811). Linear regression showed CR had a stronger correlation with APCT than TO (R<sup>2</sup> = 0.934 vs. 0.874). <b>Conclusions</b>: This newly developed VR system software, incorporating the CR method, provides a reliable approach for measuring ocular deviation. By shifting the entire visual scene rather than just the target, it lays a strong foundation for immersive diagnostic and therapeutic VR applications.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 18","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MRI Radiomics for Predicting the Diffuse Type of Tenosynovial Giant Cell Tumor: An Exploratory Study. MRI放射组学预测弥漫性腱鞘巨细胞瘤的探索性研究。
IF 3.3 3区 医学
Diagnostics Pub Date : 2025-09-20 DOI: 10.3390/diagnostics15182399
Seul Ki Lee, Min Wook Joo, Jee-Young Kim, Mingeon Kim
{"title":"MRI Radiomics for Predicting the Diffuse Type of Tenosynovial Giant Cell Tumor: An Exploratory Study.","authors":"Seul Ki Lee, Min Wook Joo, Jee-Young Kim, Mingeon Kim","doi":"10.3390/diagnostics15182399","DOIUrl":"10.3390/diagnostics15182399","url":null,"abstract":"<p><p><b>Objective:</b> To develop and validate a radiomics-based MRI model for prediction of diffuse-type tenosynovial giant cell tumor (D-TGCT), which has higher postoperative recurrence and more aggressive behavior than localized-type (L-TGCT). The study was conducted under the hypothesis that MRI-based radiomics models can predict D-TGCT with diagnostic performance significantly greater than chance level, as measured by the area under the receiver operating characteristic (ROC) curve (AUC) (null hypothesis: AUC ≤ 0.5; alternative hypothesis: AUC > 0.5). <b>Materials and Methods:</b> This retrospective study included 84 patients with histologically confirmed TGCT (54 L-TGCT, 30 D-TGCT) who underwent preoperative MRI between January 2005 and December 2024. Tumor segmentation was manually performed on T2-weighted (T2WI) and contrast-enhanced T1-weighted images. After standardized preprocessing, 1691 radiomic features were extracted, and feature selection was performed using minimum redundancy maximum relevance. Multivariate logistic regression (MLR) and random forest (RF) classifiers were developed using a training cohort (<i>n</i> = 52) and tested in an independent test cohort (<i>n</i> = 32). Model performance was assessed AUC, sensitivity, specificity, and accuracy. <b>Results:</b> In the training set, D-TGCT prevalence was 32.6%; in the test set, it was 40.6%. The MLR model used three T2WI features: wavelet-LHL_glszm_GrayLevelNonUniformity, wavelet-HLL_gldm_LowGrayLevelEmphasis, and square_firstorder_Median. Training performance was high (AUC 0.94; sensitivity 75.0%; specificity 90.9%; accuracy 85.7%) but dropped in testing (AUC 0.60; sensitivity 62.5%; specificity 60.6%; accuracy 61.2%). The RF classifier demonstrated more stable performance [(training) AUC 0.85; sensitivity 43.8%; specificity 87.9%; accuracy 73.5% and (test) AUC 0.73; sensitivity 56.2%; specificity 72.7%; accuracy 67.3%]. <b>Conclusions:</b> Radiomics-based MRI models may help predict D-TGCT. While the MLR model overfitted, the RF classifier demonstrated relatively greater robustness and generalizability, suggesting that it may support clinical decision-making for D-TGCT in the future.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 18","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidental Finding of Unilateral Tensor Fascia Lata Agenesis in a Marathon Runner: An Unreported Phenomenon. 偶然发现的单侧阔筋膜张肌发育不全在马拉松运动员:一个未报道的现象。
IF 3.3 3区 医学
Diagnostics Pub Date : 2025-09-20 DOI: 10.3390/diagnostics15182396
Tommaso Bellini, Claudio Bruno, Giacomo Brisca
{"title":"Incidental Finding of Unilateral Tensor Fascia Lata Agenesis in a Marathon Runner: An Unreported Phenomenon.","authors":"Tommaso Bellini, Claudio Bruno, Giacomo Brisca","doi":"10.3390/diagnostics15182396","DOIUrl":"10.3390/diagnostics15182396","url":null,"abstract":"<p><p>Congenital agenesis of the tensor fascia lata (TFL) muscle is an extremely rare anomaly, with very few reports in the literature and unclear clinical significance. We report the incidental finding of unilateral TFL agenesis in a 25-year-old male physician who had been enrolled as a healthy control in a muscle MRI study on genetic myopathies. Imaging demonstrated a complete absence of the right TFL with mild compensatory hypertrophy of the ipsilateral rectus femoris, while the contralateral side and all other muscles appeared normal. The subject had no history of neuromuscular disease, exhibited only a subtle waddling gait, and had previously completed the New York Marathon in 4 h and 16 min without symptoms. Laboratory tests, including creatine kinase, were within normal limits. Thirteen years later, he remains in good health, continues regular sports activities, and has not developed pain or functional impairment. This case emphasizes that TFL agenesis may remain clinically silent and compatible with high levels of physical activity. Nevertheless, awareness of such anomalies is important, as compensatory mechanisms might predispose to long-term biomechanical imbalance, and recognition on imaging can prevent misinterpretation or unnecessary investigations.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 18","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel Blood Collection Tubes Improve Sample Preservation in a Multicenter Study in Thailand. 在泰国的一项多中心研究中,新型采血管改善了样本保存。
IF 3.3 3区 医学
Diagnostics Pub Date : 2025-09-20 DOI: 10.3390/diagnostics15182398
Khundow Moonla, Renu Wiriyaprasit, Napaporn Apiratmateekul, Nam K Tran, Wanvisa Treebuphachatsakul
{"title":"Novel Blood Collection Tubes Improve Sample Preservation in a Multicenter Study in Thailand.","authors":"Khundow Moonla, Renu Wiriyaprasit, Napaporn Apiratmateekul, Nam K Tran, Wanvisa Treebuphachatsakul","doi":"10.3390/diagnostics15182398","DOIUrl":"10.3390/diagnostics15182398","url":null,"abstract":"<p><p><b>Background</b>: Blood collection tubes (BCTs) are critical in vitro diagnostic devices used in clinical laboratory testing. Innomed tubes are novel BCTs coated with heparin and anti-glycolytic agents (Innomed 1) and clot activators combined with anti-glycolytic agents (Innomed 2). This study, we focus on the verification and multicenter validation of Innomed tubes, aiming to assess their performance in glucose stability, hemolysis resistance, and biochemical interferences relevant to diabetes and non-communicable disease (NCD) monitoring. <b>Methods</b>: Two types of Innomed tubes were evaluated. The verification process, conducted in a reference laboratory, assessed biochemical interferences, glucose stability, and the potential for hemolysis due to centrifugation and blood collection techniques. The multicenter validation of biochemical interferences was carried out across five hospital laboratories. Subsequently, samples were centrifuged at 3500 rpm for 5-10 min and analyzed immediately after separation, not exceeding 2 h from collection. <b>Results</b>: Glucose levels in Innomed 1 and 2 remained stable within 8% of up to 8 h post-collection. No hemolysis was observed under varying centrifugation times (at 3500 rpm) and blood collection techniques, as confirmed through visual inspection and lactate dehydrogenase level determinations. Innomed tubes were suitable BCTs for glucose, HbA1c, thyroid stimulating hormone, free triiodothyronine, free thyroxin, triiodothyronine, carcinoembryonic antigen, and prostate-specific antigen, as well as for 19 routine biochemical assays. <b>Conclusions</b>: Innomed 1 and 2 BCTs maintain blood glucose stability for 8 h, ensuring accurate biochemical, HbA1c, thyroid, and tumor marker testing. Their hemolysis resistance supports diabetes screening and Non-Communicable Diseases (NCD) monitoring. thereby emphasizing their clinical relevance in chronic disease management.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 18","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信