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Simplifying Knee OA Prognosis: A Deep Learning Approach Using Radiographs and Minimal Clinical Inputs. 简化膝关节OA预后:利用x线片和最小临床输入的深度学习方法。
IF 3.3 3区 医学
Diagnostics Pub Date : 2025-10-09 DOI: 10.3390/diagnostics15192543
Cheng-Tzu Wang, Kai-Ting Chang, Feipei Lai, Jwo-Luen Pao, Shang-Ming Lin, Chih-Hung Chang
{"title":"Simplifying Knee OA Prognosis: A Deep Learning Approach Using Radiographs and Minimal Clinical Inputs.","authors":"Cheng-Tzu Wang, Kai-Ting Chang, Feipei Lai, Jwo-Luen Pao, Shang-Ming Lin, Chih-Hung Chang","doi":"10.3390/diagnostics15192543","DOIUrl":"10.3390/diagnostics15192543","url":null,"abstract":"<p><p><b>Objectives:</b> To predict the progression of knee osteoarthritis (OA), a deep convolutional neural network model was developed and applied to basic images and clinical data. <b>Design:</b> A vision transformer-based model was trained using 5565 knee radiographs as baseline images from the osteoarthritis initiative (OAI), including 578 testing images. Each knee had a corresponding Kellgren and Lawrence (KL) stage after 48 months of follow-up. Another 274 cases from the Far Eastern Memorial Hospital were used for external validation. The data included a combination of single/pairing images and full/essential clinical factors. Area under the receiver operating characteristics (AUROC), accuracy, sensitivity, specificity, odds ratio, and ability to discriminate surgical candidates were applied to evaluate model performance. <b>Results:</b> In cases with OA progression, the AUROC for identifying surgical candidates was 0.844, 0.804, 0.766, and 0.718 in the combination of a single image with essential factors, single image with full factors, pairing images with essential factors, and pairing images with full factors, respectively. In OAI testing using the simplest input, AUROC of identifying OA progression was 0.808, with 74.1% accuracy, 91.8% sensitivity, and 71% specificity. In external validation, AUROC of identifying OA progression was 0.709, with 71.2% accuracy, 72.2% sensitivity, and 70.3% specificity. Positive model prediction had an odds ratio of 23.87 (CI: 11.24~50.67) in OAI and 5.92 (CI: 3.50~10.03) in external validation. <b>Conclusions:</b> Our model provides reliable prediction results for knee OA cases with the advantages of simplicity and flexibility. The model performance was excellent in progression cases, potentially making early intervention in OA patients more efficient.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 19","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12523892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145298866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond Radiomics Alone: Enhancing Prostate Cancer Classification with ADC Ratio in a Multicenter Benchmarking Study. 放疗组学之外:多中心基准研究中ADC比值增强前列腺癌分类。
IF 3.3 3区 医学
Diagnostics Pub Date : 2025-10-09 DOI: 10.3390/diagnostics15192546
Dimitrios Samaras, Georgios Agrotis, Alexandros Vamvakas, Maria Vakalopoulou, Marianna Vlychou, Katerina Vassiou, Vasileios Tzortzis, Ioannis Tsougos
{"title":"Beyond Radiomics Alone: Enhancing Prostate Cancer Classification with ADC Ratio in a Multicenter Benchmarking Study.","authors":"Dimitrios Samaras, Georgios Agrotis, Alexandros Vamvakas, Maria Vakalopoulou, Marianna Vlychou, Katerina Vassiou, Vasileios Tzortzis, Ioannis Tsougos","doi":"10.3390/diagnostics15192546","DOIUrl":"10.3390/diagnostics15192546","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Radiomics enables extraction of quantitative imaging features to support non-invasive classification of prostate cancer (PCa). Accurate detection of clinically significant PCa (csPCa; Gleason score ≥ 3 + 4) is crucial for guiding treatment decisions. However, many studies explore limited feature selection, classifier, and harmonization combinations, and lack external validation. We aimed to systematically benchmark modeling pipelines and evaluate whether combining radiomics with the lesion-to-normal ADC ratio improves classification robustness and generalizability in multicenter datasets. <b>Methods</b>: Radiomic features were extracted from ADC maps using IBSI-compliant pipelines. Over 100 model configurations were tested, combining eight feature selection methods, fifteen classifiers, and two harmonization strategies across two scenarios: (1) repeated cross-validation on a multicenter dataset and (2) nested cross-validation with external testing on the PROSTATEx dataset. The ADC ratio was defined as the mean lesion ADC divided by contralateral normal tissue ADC, by placing two identical ROIs in each side, enabling patient-specific normalization. <b>Results</b>: In Scenario 1, the best model combined radiomics, ADC ratio, LASSO, and Naïve Bayes (AUC-PR = 0.844 ± 0.040). In Scenario 2, the top-performing configuration used Recursive Feature Elimination (RFE) and Boosted GLM (a generalized linear model trained with boosting), generalizing well to the external set (AUC-PR = 0.722; F1 = 0.741). ComBat harmonization improved calibration but not external discrimination. Frequently selected features were texture-based (GLCM, GLSZM) from wavelet- and LoG-filtered ADC maps. <b>Conclusions</b>: Integrating radiomics with the ADC ratio improves csPCa classification and enhances generalizability, supporting its potential role as a robust, clinically interpretable imaging biomarker in multicenter MRI studies.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 19","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12523272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synchronous Pulmonary and Cecal High-Grade Neuroendocrine Carcinomas Presenting as Hepatic Metastases: A Diagnostic Challenges and Literature Review. 同步肺和盲肠高级别神经内分泌癌表现为肝转移:诊断挑战和文献综述。
IF 3.3 3区 医学
Diagnostics Pub Date : 2025-10-08 DOI: 10.3390/diagnostics15192535
Georgiana Elena Sârbu, Alina Ecaterina Jucan, Claudiu Vasile Mihai, Carmen Atodiresei, Madalina Ene, Carmen Ungureanu, Ioana Ruxandra Mihai, Otilia Nedelciuc, Mihaela Dranga, Cristina Cijevschi Prelipcean, Catalina Mihai
{"title":"Synchronous Pulmonary and Cecal High-Grade Neuroendocrine Carcinomas Presenting as Hepatic Metastases: A Diagnostic Challenges and Literature Review.","authors":"Georgiana Elena Sârbu, Alina Ecaterina Jucan, Claudiu Vasile Mihai, Carmen Atodiresei, Madalina Ene, Carmen Ungureanu, Ioana Ruxandra Mihai, Otilia Nedelciuc, Mihaela Dranga, Cristina Cijevschi Prelipcean, Catalina Mihai","doi":"10.3390/diagnostics15192535","DOIUrl":"10.3390/diagnostics15192535","url":null,"abstract":"<p><p>Background and Clinical Significance: Neuroendocrine neoplasms (NENs) are a group of malignancies that may remain clinically silent for many years. The presence of hepatic metastases can be the first clue leading to diagnosis. Case Presentation: We report the case of a 67-year-old man with intermittent tiredness and suspicious hepatic nodules detected on routine abdominal ultrasound. Contrast-enhanced ultrasonography showed arterial hyperenhancement with early washout, suggestive of metastases. Synchronous high-grade neuroendocrine carcinomas (NECs) of the lung and cecum were identified. Although the liver lesions were initially presumed to arise from the cecal tumor, liver biopsy immunohistochemistry was TTF-1 positive/CDX2 negative, whereas the cecal lesion was TTF-1 negative/CDX2 positive. This mutually exclusive immunophenotype confirmed two separate primary carcinomas. Given the high-grade histology, the patient received platinum-based chemotherapy and achieved a partial response. Conclusions: This case illustrates the diagnostic complexity of synchronous lesions and highlights the \"mirage of the first lesion\" phenomenon, in which the initially detected tumor may not represent the true primary site. A comprehensive, multidisciplinary strategy is crucial for establishing the correct diagnosis and guiding optimal management.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 19","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12523674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145298887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes of Endoscopic Resection of Circumferential Colorectal Laterally Spreading Lesions: A Western Experience. 内镜下切除环结直肠外展病变的结果:西方经验。
IF 3.3 3区 医学
Diagnostics Pub Date : 2025-10-08 DOI: 10.3390/diagnostics15192534
Gianluca Andrisani, Mattia Brigida, Giulio Antonelli, Cesare Hassan, Chiara Taffon, Andrea D'Amico, Virginia Gregorio, Giovanni Parente, Michele Cicala, Antonio Facciorusso, Francesco Maria Di Matteo
{"title":"Outcomes of Endoscopic Resection of Circumferential Colorectal Laterally Spreading Lesions: A Western Experience.","authors":"Gianluca Andrisani, Mattia Brigida, Giulio Antonelli, Cesare Hassan, Chiara Taffon, Andrea D'Amico, Virginia Gregorio, Giovanni Parente, Michele Cicala, Antonio Facciorusso, Francesco Maria Di Matteo","doi":"10.3390/diagnostics15192534","DOIUrl":"10.3390/diagnostics15192534","url":null,"abstract":"<p><p><b>Background</b>: Circumferential or near-circumferential colorectal lesions are challenging to remove endoscopically; therefore, they are often surgically managed. There are limited data on the outcomes of endoscopic submucosal dissection (ESD) for these lesions, usually from Eastern settings, where ESD is more well established. <b>Objective</b>: The objective of the study was to retrospectively analyze the outcomes of circumferential colorectal ESD in a Western center. <b>Methods</b>: Consecutive patients referred for endoscopic resection of colorectal lesions between January 2015 and April 2025 were included if they had undergone ESD for colorectal laterally spreading tumors with ≥90% involvement of the luminal circumference. <b>Results</b>: Overall, 53 patients were enrolled (26 females, 49.1%; 70.6 ± 9.3 years). Mean lesion size was 91.8 ± 25.3 mm. The most frequent lesion location was the rectum (<i>n</i> = 36, 67.9%). Thirty-three lesions (62.3%) were circumferential, and twenty (37.7%) were near-circumferential. Median procedural time was 160.0 min (IQR 112.0-200.0 min). Histological analysis revealed high-grade dysplasia in 25/53 cases (47.2%) and adenocarcinoma in 28 patients (52.8%). Resection was en bloc in 51 cases (96.2%) and R0 in all cases (100%). Curative resection was achieved in 21 out of 28 adenocarcinoma patients (75%). Adverse events were intra-procedural major bleeding (<i>n</i> = 19, 18.9%), post-procedural bleeding (<i>n</i> = 2, 3.8%), delayed bleeding (<i>n</i> = 1, 1.9%), and intra-procedural perforation (<i>n</i> = 3, 5.7%). Post-ESD stricture was observed in 18.9% of cases (10/53); three of these (30%) were asymptomatic. All were successfully managed endoscopically. Patients who developed strictures had a longer median procedural time (206 min vs. 145 min, <i>p</i> = 0.0061) and a larger mean lesion size (110 mm vs. 90 mm, <i>p</i> = 0.035). <b>Conclusions</b>: ESD for colorectal circumferential and near-circumferential lesions was safe and effective in a Western expert center, supporting the use of this technique in this subset of lesions. Strictures are a common consequence that can be effectively managed endoscopically.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 19","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12524117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Mutational Landscape in Acute Myeloid Leukemia: Overview and Prognostic Impacts. 急性髓系白血病的突变景观:概述和预后影响。
IF 3.3 3区 医学
Diagnostics Pub Date : 2025-10-08 DOI: 10.3390/diagnostics15192537
Jeff Chen, Fares Hassan, Carlos A Tirado
{"title":"A Mutational Landscape in Acute Myeloid Leukemia: Overview and Prognostic Impacts.","authors":"Jeff Chen, Fares Hassan, Carlos A Tirado","doi":"10.3390/diagnostics15192537","DOIUrl":"10.3390/diagnostics15192537","url":null,"abstract":"<p><p>Acute myeloid leukemia (AML) comprises 15-20% of pediatric leukemia and 35% of adult leukemia cases, requiring insights into prognostic factors of this disease to be an important aspect of diagnosis and treatment. A mutational profile of patients with AML is a crucial predictor of their outcome. Discernment of present mutations, co-mutation combinations, and variations in the mutations in a single gene requires proper research and analysis to determine their impact on a patient's prognosis. Common and infrequent mutations are continuously investigated and analyzed in different patient cohorts, bringing new insights that lead to changes in classifications, treatments, and diagnoses. For instance, mutations in <i>NPM1</i>, <i>FLT3,</i> and <i>DNMT3A</i>, three frequent driver mutations, have high incident rates with differing prognoses and treatments in pediatric and adult patients. AML patients with <i>MECOM</i> face particularly dire outcomes, as well as those with <i>ASXL1</i> and <i>TP53</i>, making their mutational analysis crucial for review in developing a prognosis.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 19","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12524057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145298899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Performance of ChatGPT-4o in Determining Radiology-Pathology Concordance and Management Recommendations Following Image-Guided Breast Biopsies. chatgpt - 40在影像引导乳腺活检后影像学病理一致性和处理建议中的表现。
IF 3.3 3区 医学
Diagnostics Pub Date : 2025-10-08 DOI: 10.3390/diagnostics15192536
Albert Lee, Belinda Curpen, Afsaneh Alikhassi
{"title":"Performance of ChatGPT-4o in Determining Radiology-Pathology Concordance and Management Recommendations Following Image-Guided Breast Biopsies.","authors":"Albert Lee, Belinda Curpen, Afsaneh Alikhassi","doi":"10.3390/diagnostics15192536","DOIUrl":"10.3390/diagnostics15192536","url":null,"abstract":"<p><p><b>Background:</b> Determining radiology-pathology concordance after breast biopsies is critical to ensuring appropriate patient management. However, expertise and multidisciplinary input are not universally accessible. <b>Purpose:</b> To evaluate the performance of a large language model, ChatGPT-4o, in determining the radiology-pathology concordance of breast biopsies and suggesting subsequent management steps. <b>Methods:</b> A retrospective single-center study analyzed 244 cases of image-guided breast biopsies of women. ChatGPT-4o assessed de-identified radiology and pathology reports for concordance and recommended management. Radiologist assessments served as the reference standard with final surgical pathology and 2-year imaging follow-up serving as gold standards when applicable. Concordance rates, management recommendations, and diagnostic agreement with the gold standard were compared using statistical tests, including McNemar's, chi-square, Fisher-Freeman-Halton, and Cohen's kappa. <b>Results:</b> ChatGPT-4o achieved a concordance rate of 98.8% vs. 98.0% for radiologists (<i>p</i> = 0.625) and demonstrated high diagnostic agreement with the gold standard (kappa = 0.947, <i>p</i> < 0.001). ChatGPT-4o favored imaging follow-up more than radiologists (49.2% vs. 41.8%, <i>p</i> < 0.001) and surgical management less frequently (41.8% vs. 46.7%). <b>Conclusions:</b> ChatGPT-4o demonstrated diagnostic performance comparable to radiologists with breast imaging subspecialities in evaluating breast biopsy concordance. Its slightly more conservative management approach may enhance shared decision-making in resource-limited settings.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 19","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12523907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selective Angiographic Roadmap Analysis (SARA) of Hepatocellular Carcinoma Feeding Arteries for Transarterial Chemoembolization. 肝癌供血动脉经动脉化疗栓塞的选择性血管造影路线图分析。
IF 3.3 3区 医学
Diagnostics Pub Date : 2025-10-08 DOI: 10.3390/diagnostics15192533
Sultan R Alharbi
{"title":"Selective Angiographic Roadmap Analysis (SARA) of Hepatocellular Carcinoma Feeding Arteries for Transarterial Chemoembolization.","authors":"Sultan R Alharbi","doi":"10.3390/diagnostics15192533","DOIUrl":"10.3390/diagnostics15192533","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) is a hypervascular malignancy commonly treated with transarterial chemoembolization (TACE), in which success relies on the accurate identification and embolization of tumor feeding arteries while sparing the nontumorous liver parenchyma. This review introduces the concept of selective angiographic roadmap analysis (SARA), a systematic and stepwise approach to evaluating hepatic arterial supply in HCC, with the aim of standardizing angiographic planning and improving TACE outcomes. SARA emphasizes recognition of typical and variant hepatic arterial anatomy, systematic identification of accessory and extrahepatic feeders, and integration with intraprocedural cone-beam computed tomography (CBCT) to enhance feeder detection and reduce nontarget embolization. Although primarily applied in TACE, the principles of SARA are equally relevant to transarterial radioembolization (TARE) where precise arterial mapping is critical. Embolization strategies are discussed across different levels of selectivity, from lobar to superselective techniques. The complementary role of advanced imaging modalities, such as CT angiography (CTA), MR angiography (MRA), and artificial intelligence-assisted vessel tracking, is also explored. Adopting the SARA framework in conjunction with these technologies may improve technical success and tumor control and preserve liver function in patients undergoing intra-arterial therapies.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 19","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12523393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond Nerve Entrapment: A Narrative Review of Muscle-Tendon Pathologies in Deep Gluteal Syndrome. 超越神经压迫:深臀症候群肌肉-肌腱病理的叙述回顾。
IF 3.3 3区 医学
Diagnostics Pub Date : 2025-10-07 DOI: 10.3390/diagnostics15192531
Yong Hyun Yoon, Ji Hyo Hwang, Ho Won Lee, MinJae Lee, Chanwool Park, Jonghyeok Lee, Seungbeom Kim, JaeYoung Lee, Jeimylo C de Castro, King Hei Stanley Lam, Teinny Suryadi, Kwan Hyun Youn
{"title":"Beyond Nerve Entrapment: A Narrative Review of Muscle-Tendon Pathologies in Deep Gluteal Syndrome.","authors":"Yong Hyun Yoon, Ji Hyo Hwang, Ho Won Lee, MinJae Lee, Chanwool Park, Jonghyeok Lee, Seungbeom Kim, JaeYoung Lee, Jeimylo C de Castro, King Hei Stanley Lam, Teinny Suryadi, Kwan Hyun Youn","doi":"10.3390/diagnostics15192531","DOIUrl":"10.3390/diagnostics15192531","url":null,"abstract":"<p><p>Deep Gluteal Syndrome (DGS) has traditionally been defined as a clinical entity caused by sciatic nerve (SN) entrapment. However, recent anatomical and imaging studies suggest that muscle- and tendon-origin pathologies-including enthesopathy-may also serve as primary pain generators. This narrative review aims to broaden the current understanding of DGS by integrating muscle and tendon pathologies into its diagnostic and therapeutic framework. The literature was selectively reviewed from PubMed, Cochrane Library, Google Scholar, PEDro, and Web of Science to identify clinically relevant studies illustrating evolving concepts in DGS pathophysiology, diagnosis, and management. We review clinical features and diagnostic tools including physical examination, MRI, and dynamic ultrasonography, with special attention to deep external rotator enthesopathy. Treatment strategies are summarized, including conservative therapy, ultrasound-guided injections, hydrodissection, and prolotherapy. This narrative synthesis underscores the importance of recognizing muscle-origin enthesopathy and soft-tissue pathologies as significant contributors to DGS. A pathophysiology-based, multimodal approach is essential for accurate diagnosis and effective treatment.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 19","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12523305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145298997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional Independence Assessment in Children and Adolescents with Achondroplasia: A Multicenter Cross-Sectional Study Using the WeeFIM Scale. 软骨发育不全儿童和青少年的功能独立性评估:一项使用WeeFIM量表的多中心横断面研究。
IF 3.3 3区 医学
Diagnostics Pub Date : 2025-10-07 DOI: 10.3390/diagnostics15192532
Chung-Lin Lee, Hung-Hsiang Fang, Chih-Kuang Chuang, Dau-Ming Niu, Ju-Li Lin, Mei-Chyn Chao, Yen-Yin Chou, Pao Chin Chiu, Chia-Chi Hsu, Tzu-Hung Chu, Yin-Hsiu Chien, Huei-Ching Chiu, Ya-Hui Chang, Yuan-Rong Tu, Yun-Ting Lo, Hsiang-Yu Lin, Shuan-Pei Lin
{"title":"Functional Independence Assessment in Children and Adolescents with Achondroplasia: A Multicenter Cross-Sectional Study Using the WeeFIM Scale.","authors":"Chung-Lin Lee, Hung-Hsiang Fang, Chih-Kuang Chuang, Dau-Ming Niu, Ju-Li Lin, Mei-Chyn Chao, Yen-Yin Chou, Pao Chin Chiu, Chia-Chi Hsu, Tzu-Hung Chu, Yin-Hsiu Chien, Huei-Ching Chiu, Ya-Hui Chang, Yuan-Rong Tu, Yun-Ting Lo, Hsiang-Yu Lin, Shuan-Pei Lin","doi":"10.3390/diagnostics15192532","DOIUrl":"10.3390/diagnostics15192532","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Achondroplasia is the most common skeletal dysplasia, affecting 1 in 25,000 births. Limited research exists on the assessment of functional independence using standardized tools in children and adolescents with achondroplasia. The WeeFIM scale provides a comprehensive evaluation of daily living skills across multiple functional domains. This study aimed to assess the functional independence levels in children and adolescents with achondroplasia using WeeFIM and analyze functional capabilities. <b>Methods:</b> This multicenter cross-sectional study included 46 participants aged 6-18 years with confirmed achondroplasia. Data were collected through standardized WeeFIM assessments from medical centers and online surveys (2021-2024). WeeFIM evaluates 18 functional items across 3 domains: self-care (8 items), mobility (5 items), and cognition (5 items), scored 1-7 (complete dependence to independence). <b>Results:</b> Participants included 26 males (56.5%) and 20 females (43.5%). Most (78.3%) were diagnosed during infancy. The mean functional scores were highest for cognition (34.0/35, 97.1%), followed by self-care (51.2/56, 91.4%) and mobility (31.5/35, 90.0%). Most participants achieved near-complete independence in cognitive functions. Mobility tasks, particularly stair climbing and bathtub transfers, showed the greatest challenges. Functional independence increased with age, with significant improvements during early childhood to adolescence transition. <b>Conclusions:</b> Children and adolescents with achondroplasia demonstrate high functional independence across daily activities, with cognitive abilities largely unaffected. Although specific mobility challenges exist, most participants achieve independence with appropriate accommodations. These findings provide valuable baseline data for clinical care planning and support optimistic functional outcomes for pediatric patients with achondroplasia.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 19","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12523440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinician Perspectives on Digital and Computational Pathology: Clinical Benefits, Concerns, and Willingness to Adopt. 临床医生对数字和计算病理学的看法:临床益处、关注点和采用意愿。
IF 3.3 3区 医学
Diagnostics Pub Date : 2025-10-07 DOI: 10.3390/diagnostics15192527
Charu Aggarwal, Aakash Desai, Nicholas McConnell, Nicholas Cadirov, Gary Gustavsen, Arushi Agarwal, Nabil Chehab, Srividya Kotapati, Nikunj Patel
{"title":"Clinician Perspectives on Digital and Computational Pathology: Clinical Benefits, Concerns, and Willingness to Adopt.","authors":"Charu Aggarwal, Aakash Desai, Nicholas McConnell, Nicholas Cadirov, Gary Gustavsen, Arushi Agarwal, Nabil Chehab, Srividya Kotapati, Nikunj Patel","doi":"10.3390/diagnostics15192527","DOIUrl":"10.3390/diagnostics15192527","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Precision medicine has transformed how we manage cancer patients. As treatments and drug targets become more complex, the associated diagnostic technologies must also evolve to actualize the benefit of these therapeutic innovations. Digital and computational pathology (DP/CP) play a pivotal role in this evolution, offering enhanced analytical techniques and addressing workflow constraints in pathology labs. This study aims to understand clinicians' awareness, utilization, and willingness to adopt DP/CP-based tools, as well as the role they perceive themselves playing in the adoption of CP-based tests. <b>Methods</b>: A double-blinded, online quantitative survey was conducted among 101 U.S.-based medical oncologists. <b>Results</b>: Awareness of DP/CP varied among clinicians, with only 17% identifying as very aware. Subsequently, the current utilization of CP-based tests is also low. Despite this, clinicians are optimistic about the potential benefits of DP/CP, including reduced turnaround times, improved therapy selection, and more consistent slide review. To achieve full adoption, clinicians recognize that barriers must be addressed, including cost, regulatory guidance and, to a lesser extent, concerns with the \"black box\" nature of CP algorithms. While the focus for the adoption of DP has centered on pathologists, clinicians anticipate playing a more significant role in the adoption of CP-based tests. Finally, clinicians demonstrated clear willingness to utilize a CP-based CDx, with 90% of respondents identifying as potential adopters. <b>Conclusions</b>: This study highlights a positive outlook for the adoption of DP/CP among clinicians, despite varied awareness and low current utilization. Clinicians recognize the potential benefits of DP/CP but also acknowledge barriers to adoption. Addressing these barriers through education, regulatory approval, and collaboration with pathologists and biopharma is essential for successfully integrating DP/CP technologies into clinical practice.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 19","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12523993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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