Can We Determine Osteoarthritis Severity Based on Systemic Immuno-Inflammatory Index?

IF 3.3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Bilge Kagan Yilmaz, Recep Altin, Alper Sari
{"title":"Can We Determine Osteoarthritis Severity Based on Systemic Immuno-Inflammatory Index?","authors":"Bilge Kagan Yilmaz, Recep Altin, Alper Sari","doi":"10.3390/diagnostics15121556","DOIUrl":null,"url":null,"abstract":"<p><p><b>Background:</b> Osteoarthritis (OA) is one of the common joint diseases. Hematologic markers have been investigated to determine its severity and predict the prognosis of joint diseases. In this study, we investigated whether the systemic immune-inflammatory index (SII) is a marker for assessing the severity of OA. <b>Methods</b>: The records of patients diagnosed with OA at various stages between 1 January 2020 and 1 January 2022 were retrospectively analyzed. Patients aged 18-75 years with complete blood count within the last 15 days and not taking anti-inflammatory drugs were included in the study. Patients were classified according to the Kellgren-Lawrance classification as stage 1-2-3 mild to moderate OA (Group I) and stage 4 severe OA (Group II). A total of 1580 patients were diagnosed with knee OA and 946 were included in the study. Of the patients, 246 (26%) were male and 700 (74%) were female. The mean age of the patients was 61.00 (53.00-68.00) years. <b>Results</b>: There were 449 (47.5%) patients in Group I and 497 (52.5%) patients in Group II. Statistically significant differences were found between the groups in age, gender, hemoglobin, lymphocytes, and SII (<i>p</i> < 0.05). An SII value of 627.9 was found to distinguish severe OA from mild-moderate OA with 42.5% sensitivity and 70.6% specificity. <b>Conclusions</b>: Although this study is the first in the literature, it shows that SII has limited predictive value in assessing the severity of knee OA. Future research should focus on longitudinal studies to establish causality and explore therapeutic implications.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 12","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12192534/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diagnostics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/diagnostics15121556","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Osteoarthritis (OA) is one of the common joint diseases. Hematologic markers have been investigated to determine its severity and predict the prognosis of joint diseases. In this study, we investigated whether the systemic immune-inflammatory index (SII) is a marker for assessing the severity of OA. Methods: The records of patients diagnosed with OA at various stages between 1 January 2020 and 1 January 2022 were retrospectively analyzed. Patients aged 18-75 years with complete blood count within the last 15 days and not taking anti-inflammatory drugs were included in the study. Patients were classified according to the Kellgren-Lawrance classification as stage 1-2-3 mild to moderate OA (Group I) and stage 4 severe OA (Group II). A total of 1580 patients were diagnosed with knee OA and 946 were included in the study. Of the patients, 246 (26%) were male and 700 (74%) were female. The mean age of the patients was 61.00 (53.00-68.00) years. Results: There were 449 (47.5%) patients in Group I and 497 (52.5%) patients in Group II. Statistically significant differences were found between the groups in age, gender, hemoglobin, lymphocytes, and SII (p < 0.05). An SII value of 627.9 was found to distinguish severe OA from mild-moderate OA with 42.5% sensitivity and 70.6% specificity. Conclusions: Although this study is the first in the literature, it shows that SII has limited predictive value in assessing the severity of knee OA. Future research should focus on longitudinal studies to establish causality and explore therapeutic implications.

我们可以根据全身免疫炎症指数来确定骨关节炎的严重程度吗?
背景:骨关节炎(Osteoarthritis, OA)是常见的关节疾病之一。血液学指标已被研究以确定其严重程度和预测关节疾病的预后。在这项研究中,我们研究了系统性免疫炎症指数(SII)是否是评估OA严重程度的标志。方法:回顾性分析2020年1月1日至2022年1月1日期间诊断为OA的不同阶段患者的记录。年龄在18-75岁之间,最近15天内全血细胞计数且未服用消炎药的患者被纳入研究。根据kellgren - lawrence分类法将患者分为1-2-3期轻中度OA (I组)和4期重度OA (II组)。共有1580例患者被诊断为膝关节OA,其中946例被纳入研究。其中男性246例(26%),女性700例(74%)。患者平均年龄为61.00(53.00 ~ 68.00)岁。结果:ⅰ组449例(47.5%),ⅱ组497例(52.5%)。年龄、性别、血红蛋白、淋巴细胞、SII组间比较差异有统计学意义(p < 0.05)。SII值为627.9,以42.5%的敏感性和70.6%的特异性区分重度OA和轻中度OA。结论:虽然这项研究是文献中的第一次,但它表明SII在评估膝关节OA严重程度方面具有有限的预测价值。未来的研究应侧重于纵向研究,以建立因果关系并探索治疗意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Diagnostics
Diagnostics Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
4.70
自引率
8.30%
发文量
2699
审稿时长
19.64 days
期刊介绍: Diagnostics (ISSN 2075-4418) is an international scholarly open access journal on medical diagnostics. It publishes original research articles, reviews, communications and short notes on the research and development of medical diagnostics. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodological details must be provided for research articles.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信