发育不良、畸形和畸形的区别——探讨髋关节发育障碍的正确诊断和治疗。

IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Jacek Dygut, Monika Piwowar
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引用次数: 0

摘要

(1)背景:本出版物的重点是破坏髋关节正常发育的过程。文献中描述了人类发育缺陷的四种病理机制,即发育不良、畸形、断裂和畸形。就髋关节发育而言,最大的挑战是对发育不良和畸形的混淆,这常常导致误诊、不正确的命名和错误的治疗选择。(2)方法:查阅相关科学文献。(3)结果:本文介绍了髋关节发育障碍的病理机制。基于Delpech-Hueter-Volkmann生长和重塑定律,试图回答这些疾病是源于组织生长的原发性疾病,导致解剖结构不正确,还是组织结构的二次改变(退行性或适应性)导致的解剖变形的结果。此外,重点放在所谓的临床和诊断沉默的情况下的存在。我们建议增加诊断程序与基因测试,以提高筛选的敏感性。(4)结论:在此基础上,提出了发展性髋关节疾病的新分类。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Distinction Between Dysplasia, Malformation, and Deformity-Towards the Proper Diagnosis and Treatment of Hip Development Disorders.

(1) Background: This publication focuses on processes that disrupt the proper development of the hip. Four pathomechanisms underlying human developmental defects are described in the literature, i.e., dysplasia, malformation, disruption, and deformity. In the case of hip development, arguably the greatest challenge involves confusion between dysplasia and deformity, which often leads to misdiagnosis, incorrect nomenclature, and incorrectly chosen treatment. (2) Methods: A review of the scientific literature was performed. (3) Results: The paper presents a description of hip joint development disorders in the context of their pathomechanisms. An attempt was made to answer the question of whether these disorders are rooted in a primary disorder of tissue growth, resulting in incorrect anatomy, or are the result of anatomical deformations with secondary modifications in tissue structures-of a degenerative or adaptive nature-based on Delpech-Hueter-Volkmann growth and remodeling laws. In addition, the emphasis is placed on the presence of so-called clinically and diagnostically mute cases. We suggest augmenting diagnostic procedures with genetic tests to increase the sensitivity of screening. (4) Conclusions: Based on the arguments, a new division of developmental hip disorders is proposed.

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来源期刊
Diagnostics
Diagnostics Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
4.70
自引率
8.30%
发文量
2699
审稿时长
19.64 days
期刊介绍: Diagnostics (ISSN 2075-4418) is an international scholarly open access journal on medical diagnostics. It publishes original research articles, reviews, communications and short notes on the research and development of medical diagnostics. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodological details must be provided for research articles.
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