Binyamin Sikander, Kristoffer Andresen, Hagar Al Fartoussi, Niklas Nygaard Baastrup, Camilla Kjelkvist-Born, Jacob Rosenberg, Siv Fonnes
{"title":"A survey of preoperative diagnosis and management of complicated appendicitis.","authors":"Binyamin Sikander, Kristoffer Andresen, Hagar Al Fartoussi, Niklas Nygaard Baastrup, Camilla Kjelkvist-Born, Jacob Rosenberg, Siv Fonnes","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Complicated appendicitis is a severe condition, requiring early diagnosis and intervention to prevent complications. We aimed to investigate how resident surgeons distinguish and manage complicated appendicitis and their perspectives on preoperative diagnostic markers.</p><p><strong>Methods: </strong>The electronic survey was face validated. It contained questions about demographics, resident surgeons' considerations on the preoperative diagnosis of complicated appendicitis, and views on the need for and relevance of preoperative diagnostic markers. It was sent to all resident surgeons in the Eastern part of Denmark.</p><p><strong>Results: </strong>Seven hospitals and their 92 resident surgeons received the survey, and 90% responded. Most resident surgeons used symptoms and signs of pain to diagnose suspected complicated appendicitis. Half of the surgeons used computed tomographies, and 95% used routine blood tests. Most surgeons (83%) would change the management of patients with preoperatively diagnosed complicated appendicitis in comparison to uncomplicated appendicitis. However, only 17% felt the need for a preoperative diagnostic marker.</p><p><strong>Conclusions: </strong>Resident surgeons in Eastern Denmark use non-specific diagnostic techniques to distinguish complicated from uncomplicated appendicitis and would change treatment if appendicitis was diagnosed preoperatively. However, despite limited interest, our results suggest a need for new diagnostic markers to differentiate between the severity of appendicitis, thus enhancing education and training in managing such cases.</p><p><strong>Funding: </strong>None.</p><p><strong>Trial registration: </strong>None.</p>","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"70 12","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138451172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Can Deniz Deveci, Jason Joe Baker, Binyamin Sikander, Jacob Rosenberg
{"title":"A comparison of cover letters written by ChatGPT-4 or humans.","authors":"Can Deniz Deveci, Jason Joe Baker, Binyamin Sikander, Jacob Rosenberg","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Artificial intelligence has started to become a part of scientific studies and may help researchers with a wide range of tasks. However, no scientific studies have been published on its ussefulness in writing cover letters for scientific articles. This study aimed to determine whether Generative Pre-Trained Transformer (GPT)-4 is as good as humans in writing cover letters for scientific papers.</p><p><strong>Methods: </strong>In this randomised non-inferiority study, we included two parallel arms consisting of cover letters written by humans and by GPT-4. Each arm had 18 cover letters, which were assessed by three different blinded assessors. The assessors completed a questionnaire in which they had to assess the cover letters with respect to impression, readability, criteria satisfaction, and degree of detail. Subsequently, we performed readability tests with Lix score and Flesch Kincaid grade level.</p><p><strong>Results: </strong>No significant or relevant difference was found on any parameter. A total of 61% of the blinded assessors guessed correctly as to whether the cover letter was written by GPT-4 or a human. GPT-4 had a higher score according to our objective readability tests. Nevertheless, it performed better than human writing on readability in the subjective assessments.</p><p><strong>Conclusion: </strong>We found that GPT-4 was non-inferior at writing cover letters compared to humans. This may be used to streamline cover letters for researchers, providing an equal chance to all researchers for advancement to peer-review.</p><p><strong>Funding: </strong>This study received no financial support from external sources.</p><p><strong>Trial registration: </strong>This study was not registered before the study commenced.</p>","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"70 12","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138451171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anne Cathrine Baun Thuesen, Mette K Andersen, Torben Hansen
{"title":"Genetics of metabolic traits in Greenlanders.","authors":"Anne Cathrine Baun Thuesen, Mette K Andersen, Torben Hansen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The history of the Greenlandic population has contributed to a unique genetic composition in which high-impact and often novel genetic variants segregate at a high frequency. As a result, research in smaller populations like the Greenlandic has the potential to reveal genetic variation and associations that are not present or discoverable in other populations. In this review, we provide a summary of our research in Greenlanders and our findings of genetic variants with high impact on metabolic health, and outline the implications that this research has for the equitable distribution of genomic precision medicine.</p>","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"70 12","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138451174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kamran Abbasi, Parveen Ali, Virginia Barbour, Thomas Benfield, Kirsten Bibbins-Domingo, Stephen Hancocks, Richard Horton, Laurie Laybourn-Langton, Robert Mash, Peush Sahni, Wadeia Mohammad Sharief, Paul Yonga, Chris Zielinski
{"title":"Time to treat the climate and nature crisis as one indivisible global health emergency.","authors":"Kamran Abbasi, Parveen Ali, Virginia Barbour, Thomas Benfield, Kirsten Bibbins-Domingo, Stephen Hancocks, Richard Horton, Laurie Laybourn-Langton, Robert Mash, Peush Sahni, Wadeia Mohammad Sharief, Paul Yonga, Chris Zielinski","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"70 12","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138451176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Victor Schwartz Hvingelby, Miriam Höjholt Terkelsen, Rikke Nan Valdemarsen, Anne Sofie Møller Andersen, Erik H Danielsen, Mette Møller, Nicola Pavse, Erik Johnsen
{"title":"Prevalence and severity of freezing of gait in a Danish cohort of people with Parkinson's disease.","authors":"Victor Schwartz Hvingelby, Miriam Höjholt Terkelsen, Rikke Nan Valdemarsen, Anne Sofie Møller Andersen, Erik H Danielsen, Mette Møller, Nicola Pavse, Erik Johnsen","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Parkinson's disease (PD) is a widespread neurodegenerative disorder characterised by wide range of symptoms. Freezing of gait (FoG), a transient feeling that the patient's feet are nailed to the floor, resulting in an inability to move, is a particularly distressful symptom. The assessment of FoG can be challenging. Often, clinicians are reliant on patients' subjective experiences and patient questionnaires such as the Freezing of Gait Questionnaire (FOGQ) and its updated version, the New FOGQ (NFOGQ).Until now, the NFOGQ has not been validated and piloted for use in Danish. Therefore, few attempts have been made to assess the prevalence and severity of FoG in Danish patients with PD.</p><p><strong>Methods: </strong>This report describes a two-step process of adapting the NFOGQ into Danish and piloting its use among a cohort of patients with PD. A satisfactory translation (Danish NFOGQ) was produced and successfully piloted.</p><p><strong>Results: </strong>The translation showed robust test-retest reliability after two weeks. Patients fully understood the questionnaire. Using the Danish NFOGQ in an online prevalence survey, we found that 35.7% of respondents had experienced FoG and that the prevalence correlated with disease duration.</p><p><strong>Conclusion: </strong>The Danish NFOGQ appears to be appropriate for assessing FoG in Danish patients with PD in both clinical and research settings.</p><p><strong>Funding: </strong>None.</p><p><strong>Trial registration: </strong>Not relevant.</p>","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"70 12","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138451175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Caroline Rebbe Kjellerup, Marco Juul Thomsen, Nanna Marie Uldall Torp, Jesper Karmisholt, Stine Linding Andersen
{"title":"Characteristics of patients with subacute thyroiditis.","authors":"Caroline Rebbe Kjellerup, Marco Juul Thomsen, Nanna Marie Uldall Torp, Jesper Karmisholt, Stine Linding Andersen","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The diagnosis and management of subacute thyroiditis (SAT) may be challenging, and more evidence on patient and disease characteristics is warranted.</p><p><strong>Methods: </strong>This was a retrospective cohort study of all patients in the North Denmark Region with a SAT diagnosis in the Danish National Patient Registry, 2016-2018. The medical records and biochemical results prior to the diagnosis and during a two-year follow-up period were reviewed.</p><p><strong>Results: </strong>A total of 71 patients with a SAT diagnosis were identified, and the diagnosis was verified in 44 (62.0%) cases with an incidence rate of 2.4/100,000/year. Patients with verified SAT were predominantly females (72.7%) with a median age of 50.7 years. Biochemical results showed thyrotoxicosis at the initial examination in 69.8% and elevated C-reactive protein in 86.5% of patients. Longitudinal biochemical assessment showed a biphasic response (median thyroid-stimulating hormone, initially: 0.02 mIU/l, at three months: 4.7 mIU/l and 2.4 mIU/l after two years). Treatment with non-steroidal anti-inflammatory drugs, beta-blockers and/or prednisolone was initiated in 23 of the 38 patients (60.5%) evaluated, and ten of 33 patients (30.3%) with follow-up data received thyroid hormone replacement therapy.</p><p><strong>Conclusion: </strong>In the North Denmark Region, a hospital diagnosis of SAT was verified in less than two thirds of cases. Further large studies are warranted to extend the findings concerning the treatment and outcome of SAT.</p><p><strong>Funding: </strong>None.</p><p><strong>Trial registration: </strong>Not relevant.</p>","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"70 11","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66783708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julie Dam Jessen, Gritt Overbeck, Rasmus Køster-Rasmussen
{"title":"Psychosocial consequences of weight screening of school-age children - a systematic review.","authors":"Julie Dam Jessen, Gritt Overbeck, Rasmus Køster-Rasmussen","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Weight-screening children in schools is an ingrained part of preventive health programmes worldwide. Even though there is no evidence that weight monitoring in the context of preventive health work prevents weight gain, evidence indicates that a focus on weight among children may negatively impact mental health. We aimed to review the existing literature on potential psychosocial consequences of routine weighing and weight feedback in school-aged children.</p><p><strong>Methods: </strong>A comprehensive search was performed in four databases (PubMed, PsycINFO, Sociological Abstracts and CINAHL) and included all original studies investigating psychological or social consequences of routine weighing or weight feedback in school-aged children. Data extracted from all included studies were coded thematically and summarised considering the nature of the effect on psychosocial outcomes.</p><p><strong>Results: </strong>Six studies were included in this review. They were heterogeneous regarding aim and study design. Negative consequences included decreased weight satisfaction, increased weight focus and frequency of peer weight talk, over sensitisation about weight and emotional distress and discomfort.</p><p><strong>Conclusions: </strong>The literature in the field was sparse and heterogeneous. Even so, the literature indicated that routine weighing and weight feedback resulted in harmful psychosocial consequences for some children. Unfavourable effects primarily seemed to affect children with a high BMI, whereas children categorised as normal weight seemed to have mainly positive or neutral experiences.</p>","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"70 11","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66783710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karen Mikkelsen, Adam Witten, Per Hölmich Møller, Kristoffer W Barfod, Birgitte Hougs Kjær
{"title":"Interrater reliability of subacromial ultrasound measures in the hands of novice sonographers.","authors":"Karen Mikkelsen, Adam Witten, Per Hölmich Møller, Kristoffer W Barfod, Birgitte Hougs Kjær","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Ultrasound measures of subacromial structures are reliable in the hands of experienced sonographers, but it remains unknown if inexperienced clinicians can achieve a satisfactory level of interrater reliability. The aim was to investigate if standardised subacromial ultrasound measures are reliable in the hands of novice sonographers.</p><p><strong>Methods: </strong>Two novice sonographers performed standardised ultrasound measures on patients diagnosed with subacromial pain syndrome and asymptomatic shoulders. The measures were: supraspinatus tendon thickness (SUPRA), subacromial bursa thickness (SASD), acromio-humeral distance (AHD) and dynamic impingement (DI). Reliability and agreement were evaluated by intraclass correlation coefficient (ICC (2.1)), standard error of measurement, minimal detectable change, 95% limits of agreement, Bland-Altman plots and Cohen's unweighted κ.</p><p><strong>Results: </strong>Twenty-eight patients were recruited (28 symptomatic and 20 asymptomatic shoulders). The ICC of SUPRA ranged from 0.73 to 0.77. The ICC of SASD ranged from 0.41 to 0.88 and AHD from 0.68 to 0.72. Cohen's κ of DI in symptomatic shoulders was 0.29.</p><p><strong>Conclusion: </strong>The interrater reliability of novice sonographers was found to be moderate to good when assessing SUPRA and AHD. For SASD and DI, the reliability ranged from poor to good. No significant differences in SUPRA and SASD thickness were found between symptomatic and asymptomatic shoulders.</p><p><strong>Funding: </strong>None.</p><p><strong>Trial registration: </strong>Not relevant.</p>","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"70 11","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66783709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christian Elleby Marcussen, Karoline Bendix Bräuner, Henrik Alstrøm, Ann Merete Møller
{"title":"Accuracy of triage systems for mass casualty incidents in live simulations - a systematic review.","authors":"Christian Elleby Marcussen, Karoline Bendix Bräuner, Henrik Alstrøm, Ann Merete Møller","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>In mass casualty incidents, insufficient triage may lead to increased morbidity and mortality due to delayed evacuation and treatment of the most critically injured patients. We report current litterature findings on accuracy of primary prehospital triage systems for mass casualty incidents in full-scale live simulations and map the challenges that lie ahead for finding the most accurate triage system.</p><p><strong>Methods: </strong>This study was registered with PROSPERO ID: CRD42018091889. We searched the databases EMBASE, MEDLINE, Central, Web of Science, Reference lists, Scopus, ClinicalTrials.gov and Google Scholar. We included primary triage systems, studies reporting accuracy or outcomes convertible to accuracy and studies performed in full-scale live simulations. We excluded studies using paediatric, chemical, biological, radiological or nuclear populations or triage systems. Bias rating was based on a modified version of the QUADAS-2.</p><p><strong>Results: </strong>A total of 15 studies were included. Six of 41 existing triage methods were tested. The studies showed substantial heterogeneity in both study characteristics and findings. Different reference standards were applied and most were based on author-defined triage categories. All studies carried an unclear-to-high risk of bias. Therefore, no quantitative comparisons were made.</p><p><strong>Conclusion: </strong>In general, the studies suffered from substantial heterogeneity and risk of bias. A standardised protocol for future live simulations is needed to encourage consistent and comparable data collection. We identified some of the most important topics to address in such a protocol.</p>","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"70 11","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66783707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An explorative study of nurses' perception of turnover and retention.","authors":"Helle Folden, Annette Berit Larsen, Thea Palsgaard Møller, Doris Østergaard","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>High nurse turnover at hospitals is a major societal problem. Knowledge of how to decrease the turnover rate is important. The aim of this study was to explore nurses' perception of nurse turnover and retention.</p><p><strong>Methods: </strong>An explorative study was designed with table-top simulations involving newly graduated nurses, experienced nurses and nurse supervisors in internal medicine departments. The simulations were audio-recorded and transcribed. The participants took notes, which were transcribed. The citations were sorted into subthemes and themes by use of inductive content analysis.</p><p><strong>Results: </strong>Fifteen workshops involving a total of 43 nurses were conducted. Four overarching themes were identified: core clinical competence, professionalism, organisation and culture. The new nurses focused on development and evaluation of core clinical competences to be able to provide safe patient care. The experienced nurses favoured influence on own work and a plan for continuous professional development. The importance of a good learning culture and of collegial and social factors was mentioned by both groups of nurses.</p><p><strong>Conclusions: </strong>The table-top simulations with newly graduated nurses, senior nurses and nurses responsible for education provided valuable insights into the nurses´ perspectives of determinants of nurse turnover and retention in internal medicine wards.</p><p><strong>Funding: </strong>None.</p><p><strong>Trial registration: </strong>Not relevant.</p>","PeriodicalId":11119,"journal":{"name":"Danish medical journal","volume":"70 10","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66783653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}