Dermatologica Sinica最新文献_第7页

The emerging role of Artificial Intelligence in diagnosis and clinical analysis of dermatology 人工智能在皮肤科诊断和临床分析中的新兴作用

4区医学

Dermatologica Sinica Pub Date : 2023-01-01 DOI: 10.4103/ds.ds-d-23-00025

Mingling Chen, Shengzhen Ye

{"title":"The emerging role of Artificial Intelligence in diagnosis and clinical analysis of dermatology","authors":"Mingling Chen, Shengzhen Ye","doi":"10.4103/ds.ds-d-23-00025","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00025","url":null,"abstract":"Dermatology, as a highly intuitive clinical discipline, requires dermatologists to apply their own knowledge and clinical experience to make a reasonable diagnosis for various skin diseases. However, the diagnosis results are largely affected by the subjective consciousness of dermatologists, and there is a certain misdiagnosis rate, especially in areas with low medical levels. Therefore, there is an urgent need for more accurate, objective, and efficient auxiliary diagnostic tools to improve the diagnostic level of skin diseases. Facing an increasing number of patients and higher requirements for accurate diagnosis of diseases, Artificial Intelligence (AI) technology has attracted considerable attention in the field of dermatology. As a nonorganism, the computer is not affected by subjective consciousness, emotion, fatigue, and other factors in the recognition process. It helps to improve the efficiency of diagnosis and assists human doctors to provide objective and accurate diagnosis results. This paper systematically summarizes the research progress of AI in the diagnosis and application of skin cancers, acne, rosacea, onychomycosis, psoriasis, vitiligo, atopic dermatitis, and eczema diseases at home and abroad in recent years, hoping to help dermatologists have a deeper understanding of AI.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135913333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

HOX transcript antisense intergenic RNA is differentially expressed in hypertrophic scar tissues and regulates the biological function of scar fibroblasts through sponging miR-30a-5p HOX转录反义基因间RNA在增生性瘢痕组织中差异表达，并通过海绵化miR-30a-5p调控瘢痕成纤维细胞的生物学功能

4区医学

Dermatologica Sinica Pub Date : 2023-01-01 DOI: 10.4103/ds.ds-d-22-00120

Yi Wang, Yong Song, Minjian Chen, Zhenni Wei

{"title":"HOX transcript antisense intergenic RNA is differentially expressed in hypertrophic scar tissues and regulates the biological function of scar fibroblasts through sponging miR-30a-5p","authors":"Yi Wang, Yong Song, Minjian Chen, Zhenni Wei","doi":"10.4103/ds.ds-d-22-00120","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00120","url":null,"abstract":"Background: The pathogenesis of hypertrophic scars (HS) is complex and unclear. It is of great importance to investigate the formation mechanism of HS at the gene level, find new targets for gene therapy, and establish effective prevention strategies for the formation of HS. Objectives: The study explored the expression pattern of HOX transcript antisense intergenic RNA (HOTAIR) and miR-30a-5p in scar tissues of HS patients and investigated their regulatory role in fibroblast function. Methods: Forty HS patients were recruited, and their scar tissues and adjacent normal skin tissues were collected. Fibroblasts were extracted from these tissues. The quantitative reverse transcription–polymerase chain reaction was used for the mRNA measurement. The CCK-8 and transwell assay were applied for cell proliferation and migration assessment. Luciferase reporter assay was done to verify the target gene of HOTAIR. Results: Elevated HOTAIR and decreased miR-30a-5p were measured in both scar tissues and scar fibroblasts, and their levels were negatively correlated. HOTAIR acted as the sponge of miR-30a-5p. HOTAIR knockdown inhibited fibroblast proliferation, migration, and the expression of collagen synthesis-related proteins (procollagen, alpha-smooth muscle actin, and collagen I), but these functions were abolished by miR-30a-5p downregulation. Conclusion: HS patients owned elevated HOTAIR and decreased miR-30a-5p. HOTAIR knockdown can inhibit the proliferation, migration, and collagen synthesis of scar fibroblasts by negatively regulating the expression of miR-30a-5p.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135913351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Breakthrough monkeypox infection in a Taiwanese male with human immunodeficiency virus 6 days after vaccination 接种猴痘疫苗6天后，台湾男性猴痘突破感染人类免疫缺陷病毒

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-01-01 DOI: 10.4103/ds.ds-d-22-00136

Yuan-Chen Chao, Bor-shen Hu, Connie S Liu, Meng-Sui Lee

引用次数: 1

Multiple hyperkeratotic white papules in a 6-year-old girl: A rare presentation of granuloma annulare 6岁女童多发角化性白色丘疹:罕见的环形肉芽肿

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-01-01 DOI: 10.4103/ds.ds-d-22-00159

Yavuz Semiz, Ezgi Aktaş, Sila Aktas, O. Yalçın

引用次数: 0

Subcutaneous panniculitis-like T-cell lymphoma presenting as an ulcerated plaque: A case report 皮下膜炎样t细胞淋巴瘤表现为溃疡斑块:1例报告