Dermatologica Sinica最新文献_第6页

Biocomputational-mediated screening and molecular docking platforms for discovery of coumarin-derived antimelanogenesis agents 香豆素衍生抗黑色素生成药物的生物计算介导筛选和分子对接平台的发现

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-01-01 DOI: 10.4103/ds.ds-d-22-00087

Jing Lim, L. Gew, Yin-Quan Tang

{"title":"Biocomputational-mediated screening and molecular docking platforms for discovery of coumarin-derived antimelanogenesis agents","authors":"Jing Lim, L. Gew, Yin-Quan Tang","doi":"10.4103/ds.ds-d-22-00087","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00087","url":null,"abstract":"Background: Hyperpigmentation occurs when excess melanin accumulates in the skin and causes the skin to become darker in color. Pursuing attractive appearance and colorism have promoted the development of the skin whitening market globally. The proteins targeted in this research are tyrosinase-related protein 1, cyclic adenosine monophosphate response element-binding protein, receptor tyrosine kinase, and endothelin receptor type B. Objectives: This study aims to identify the potential of coumarin derivatives as novel effective, safe, and natural antimelanogenesis agents for whitening purposes or therapeutical intention to treat hyperpigmentation disorders. Methods: Four three-dimensional structures of the targeted proteins and 94 ligands were obtained from Protein Data Bank and PubChem, respectively. The ligands were docked against modified targeted proteins to examine the binding affinity and protein-ligand interactions using PyRx and BIOVIA Discovery Studio. The top 13 derivatives were selected for further analysis on the pharmacokinetic properties through SwissADME and pkCSM web servers. A total of eight compounds were further chosen to conduct multiple ligand simultaneous docking (MLSD). Results: Difenacoum is the most potential antimelanogenesis agent due to its strong inhibitory binding affinity in targeted protein models (5M8M, 4TQN, 5X93), but it does not exhibit favorable behavior pharmacokinetic properties. From the in silico pharmacokinetics screening, novobiocin sodium is the most potent derivative due to its relatively appropriate and safer properties. However, none of the ligand pairs investigated in MLSD possesses a synergistic effect on the binding affinity. Conclusion: Our findings identified colladin, farnesiferol C and novobiocin sodium may be promising natural resources for developing antimelanogenesis agents.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"1 1","pages":"8 - 17"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83765073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Mortality and cause of death in patients with dermatologic diseases: An 11-year record-based observational study 皮肤病患者的死亡率和死亡原因:一项基于记录的11年观察性研究

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-01-01 DOI: 10.4103/ds.ds-d-22-00134

M. Saber, G. Faghihi, Seyed-Amirmohammad Seyedghafouri, S. Hosseini

{"title":"Mortality and cause of death in patients with dermatologic diseases: An 11-year record-based observational study","authors":"M. Saber, G. Faghihi, Seyed-Amirmohammad Seyedghafouri, S. Hosseini","doi":"10.4103/ds.ds-d-22-00134","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00134","url":null,"abstract":"Background: Information on the cause of death is critical in guiding decisions on health infrastructure. However, there is a relative paucity of mortality data in patients with dermatologic diseases. Objectives: We aim to assess the overall mortality from dermatological disorders in a third-level university hospital which serves as a dermatology referral center. Methods: A retrospective medical note review of patients with dermatologic diseases who died during an 11-year period (from March 2008 to February 2020) was undertaken. Results: There were 63 death cases out of 2810 admissions for patients with dermatologic diseases (crude mortality 2.24%). The average age was 61.8 years and the male-to-female ratio was 2.3. Cutaneous malignancies (53.96%) were the primary causes of death, followed by drug reactions (23.8%). Among skin cancers, squamous cell carcinoma (SCC; 47.05%) and melanoma (35.29%) were the leading causes of death. Toxic epidermal necrolysis (53.33%) was the leading cause of death among drug reactions. Sepsis (30.74%) was the most common immediate cause of mortality in this series. A large fraction of patients (73%) had significant underlying comorbidities. Conclusion: The principal cause of mortality was cutaneous malignancies (mainly SCC and melanoma) followed by drug reactions. Sepsis was the most common immediate cause of death.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"15 1","pages":"18 - 24"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90828487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Anti-transcription intermediary factor 1-γ neuromyositis: A case report 抗转录中介因子1-γ神经肌炎1例报告

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-01-01 DOI: 10.4103/ds.ds-d-22-00078

Hui-En Chuo, Hsiao-Yu Li, Wen-Hsiu Wang, Yu-Hung Wu

引用次数: 0

Dyshidrotic bullous pemphigoid developing after Moderna mRNA-1273 vaccination 现代mRNA-1273疫苗接种后发生的多水性大疱性类天疱疮

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-01-01 DOI: 10.4103/ds.ds-d-22-00121

T. Hsieh, Jau‐Shiuh Chen, T. Tsai

引用次数: 1

The emerging role of Artificial Intelligence in diagnosis and clinical analysis of dermatology 人工智能在皮肤科诊断和临床分析中的新兴作用

4区医学

Dermatologica Sinica Pub Date : 2023-01-01 DOI: 10.4103/ds.ds-d-23-00025

Mingling Chen, Shengzhen Ye

{"title":"The emerging role of Artificial Intelligence in diagnosis and clinical analysis of dermatology","authors":"Mingling Chen, Shengzhen Ye","doi":"10.4103/ds.ds-d-23-00025","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00025","url":null,"abstract":"Dermatology, as a highly intuitive clinical discipline, requires dermatologists to apply their own knowledge and clinical experience to make a reasonable diagnosis for various skin diseases. However, the diagnosis results are largely affected by the subjective consciousness of dermatologists, and there is a certain misdiagnosis rate, especially in areas with low medical levels. Therefore, there is an urgent need for more accurate, objective, and efficient auxiliary diagnostic tools to improve the diagnostic level of skin diseases. Facing an increasing number of patients and higher requirements for accurate diagnosis of diseases, Artificial Intelligence (AI) technology has attracted considerable attention in the field of dermatology. As a nonorganism, the computer is not affected by subjective consciousness, emotion, fatigue, and other factors in the recognition process. It helps to improve the efficiency of diagnosis and assists human doctors to provide objective and accurate diagnosis results. This paper systematically summarizes the research progress of AI in the diagnosis and application of skin cancers, acne, rosacea, onychomycosis, psoriasis, vitiligo, atopic dermatitis, and eczema diseases at home and abroad in recent years, hoping to help dermatologists have a deeper understanding of AI.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135913333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

HOX transcript antisense intergenic RNA is differentially expressed in hypertrophic scar tissues and regulates the biological function of scar fibroblasts through sponging miR-30a-5p HOX转录反义基因间RNA在增生性瘢痕组织中差异表达，并通过海绵化miR-30a-5p调控瘢痕成纤维细胞的生物学功能

4区医学

Dermatologica Sinica Pub Date : 2023-01-01 DOI: 10.4103/ds.ds-d-22-00120

Yi Wang, Yong Song, Minjian Chen, Zhenni Wei

{"title":"HOX transcript antisense intergenic RNA is differentially expressed in hypertrophic scar tissues and regulates the biological function of scar fibroblasts through sponging miR-30a-5p","authors":"Yi Wang, Yong Song, Minjian Chen, Zhenni Wei","doi":"10.4103/ds.ds-d-22-00120","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00120","url":null,"abstract":"Background: The pathogenesis of hypertrophic scars (HS) is complex and unclear. It is of great importance to investigate the formation mechanism of HS at the gene level, find new targets for gene therapy, and establish effective prevention strategies for the formation of HS. Objectives: The study explored the expression pattern of HOX transcript antisense intergenic RNA (HOTAIR) and miR-30a-5p in scar tissues of HS patients and investigated their regulatory role in fibroblast function. Methods: Forty HS patients were recruited, and their scar tissues and adjacent normal skin tissues were collected. Fibroblasts were extracted from these tissues. The quantitative reverse transcription–polymerase chain reaction was used for the mRNA measurement. The CCK-8 and transwell assay were applied for cell proliferation and migration assessment. Luciferase reporter assay was done to verify the target gene of HOTAIR. Results: Elevated HOTAIR and decreased miR-30a-5p were measured in both scar tissues and scar fibroblasts, and their levels were negatively correlated. HOTAIR acted as the sponge of miR-30a-5p. HOTAIR knockdown inhibited fibroblast proliferation, migration, and the expression of collagen synthesis-related proteins (procollagen, alpha-smooth muscle actin, and collagen I), but these functions were abolished by miR-30a-5p downregulation. Conclusion: HS patients owned elevated HOTAIR and decreased miR-30a-5p. HOTAIR knockdown can inhibit the proliferation, migration, and collagen synthesis of scar fibroblasts by negatively regulating the expression of miR-30a-5p.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135913351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Breakthrough monkeypox infection in a Taiwanese male with human immunodeficiency virus 6 days after vaccination 接种猴痘疫苗6天后，台湾男性猴痘突破感染人类免疫缺陷病毒

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-01-01 DOI: 10.4103/ds.ds-d-22-00136

Yuan-Chen Chao, Bor-shen Hu, Connie S Liu, Meng-Sui Lee

引用次数: 1

Multiple hyperkeratotic white papules in a 6-year-old girl: A rare presentation of granuloma annulare 6岁女童多发角化性白色丘疹:罕见的环形肉芽肿

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2023-01-01 DOI: 10.4103/ds.ds-d-22-00159

Yavuz Semiz, Ezgi Aktaş, Sila Aktas, O. Yalçın

引用次数: 0

Subcutaneous panniculitis-like T-cell lymphoma presenting as an ulcerated plaque: A case report 皮下膜炎样t细胞淋巴瘤表现为溃疡斑块:1例报告