Toronto clinical scoring system: A promising diagnostic tool in leprosy neuropathy

IF 2.3 4区 医学 Q2 DERMATOLOGY
D. Dalimunthe, D. Sinambela, S. Lubis
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引用次数: 0

Abstract

Mycobacterium leprae causes leprosy and can impair peripheral nerves. If nerve function is damaged and is not treated immediately and effectively, it can cause disability. Hence, early detection of peripheral neuropathy is critical. Toronto Clinical Scoring System (TCSS) is a simple neuropathy assessment instrument for diabetic neuropathy, chemotherapy-induced peripheral neuropathy, and human immunodeficiency virus neuropathy. Therefore, TCSS is expected to be an alternative tool for diagnosing leprosy neuropathy. This study aims to determine the diagnostic value of TCSS in leprosy neuropathy. This is a cross-sectional observational study with 40 participants. The TCSS and Semmes–Weinstein Monofilament tests were used to assess neuropathy. The diagnostic analysis showed that the sensitivity was 85.7%, specificity was 84.2%, positive predictive value was 85.7%, negative predictive value was 84.2%, positive likelihood ratio (LR+) was 5.42, negative (LR-) was 0.17, accuracy was by 85%, and area under curve value of 93.2%. The optimal cut-off point score of TCSS is ≥6. It can be concluded that TCSS is an alternative diagnostic tool with a high accuracy value and can be used as a routine examination for the early detection of leprosy neuropathy.
多伦多临床评分系统:一个有前途的麻风病神经病变诊断工具
麻风分枝杆菌可引起麻风病,并可损害周围神经。如果神经功能受损,不立即有效治疗,可能会导致残疾。因此,早期发现周围神经病变是至关重要的。多伦多临床评分系统(Toronto Clinical Scoring System, TCSS)是一种简单的神经病变评估工具,可用于糖尿病性神经病变、化疗引起的周围神经病变和人类免疫缺陷病毒神经病变。因此,TCSS有望成为诊断麻风病神经病变的替代工具。本研究旨在探讨TCSS对麻风神经病变的诊断价值。这是一项有40名参与者的横断面观察研究。TCSS和Semmes-Weinstein单丝试验用于评估神经病变。诊断分析结果显示,敏感性85.7%,特异性84.2%,阳性预测值85.7%,阴性预测值84.2%,阳性似然比(LR+) 5.42,阴性似然比(LR-) 0.17,准确率85%,曲线下面积93.2%。TCSS的最佳分界点评分≥6分。TCSS是一种可替代的诊断工具,具有较高的准确性,可作为早期发现麻风神经病变的常规检查。
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来源期刊
Dermatologica Sinica
Dermatologica Sinica DERMATOLOGY-
CiteScore
2.80
自引率
20.00%
发文量
28
审稿时长
>12 weeks
期刊介绍: Dermatologica Sinica aims to publish high quality scientific research in the field of dermatology, with the goal of promoting and disseminating dermatological-related medical science knowledge to improve global health. Articles on clinical, laboratory, educational, and social research in dermatology and other related fields that are of interest to the medical profession are eligible for consideration. Review articles, original articles, brief reports, case reports and correspondence are accepted.
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