Dermatologica Sinica最新文献_第8页

Protein O-fucosyltransferase-1 mutation in familial Dowling-Degos Disease concomitant with atopic dermatitis 家族性Dowling-Degos病伴特应性皮炎的蛋白O-聚焦转移酶-1突变

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2022-10-01 DOI: 10.4103/1027-8117.359341

Ro-Wei Wu, Hui-Ying Weng, Wei-ping Huang, Yung-feng Lin, Yen-Ming Liu, S. Tsai, Chung-Hsing Chang

引用次数: 0

Autoinflammatory keratinization diseases: The concept, diseases involved, and pathogeneses 自体炎症性角化疾病:概念、涉及的疾病和发病机制

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2022-10-01 DOI: 10.4103/1027-8117.365590

M. Akiyama

{"title":"Autoinflammatory keratinization diseases: The concept, diseases involved, and pathogeneses","authors":"M. Akiyama","doi":"10.4103/1027-8117.365590","DOIUrl":"https://doi.org/10.4103/1027-8117.365590","url":null,"abstract":"As predisposing factors and pathogenic mechanisms of inflammatory keratinization disorders of the skin have become increasingly elucidated in recent years, a number of inflammatory keratinization disorders are now known to have the excessive activation of innate immunity as their pathogenesis. Autoinflammation-associated pathogeneses have been clarified in patients with generalized pustular psoriasis (GPP), pityriasis rubra pilaris (PRP) type V, and familial keratosis lichenoides chronica (KLC). Thus, based on these findings, in 2017, we proposed the clinical entity “autoinflammatory keratinization disease (AiKD),” which comprehensively includes inflammatory keratinization disorders with pathogenic mechanisms related to autoinflammation (the excessive activation of innate immunity). In 2017, GPP and associated diseases, PRP type V, and familial KLC came to be considered as AiKDs. In addition to these diseases, hidradenitis suppurative, porokeratosis, keratosis linearis with ichthyosis congenita and sclerosing keratoderma syndrome, and AiKDs with hepatitis and autism have been newly recognized as AiKDs. The concept of AiKD may contribute to the selection of novel treatment methods. For example, recognizing hidradenitis suppurativa precisely as an AiKD has resulted in the application of adalimumab, an anti-tumor necrosis factor alpha antibody, as a treatment. The concept of AiKD is thought to be useful toward our accurate understanding of the pathogeneses of inflammatory keratinization disorders and our choice of appropriate treatment methods. As the pathogenic mechanisms of inflammatory keratinization disorders are further elucidated, it is presumed that the number of keratinization diseases whose pathogeneses are associated with autoinflammation will increase and that the number of diseases recognized as AiKDs will grow more and more.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"23 1","pages":"197 - 203"},"PeriodicalIF":2.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81713418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Radiation recall dermatitis triggered by the AstraZeneca COVID-19 vaccine: A case report and literature review 阿斯利康COVID-19疫苗引发的辐射召回性皮炎1例报告及文献复习

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2022-10-01 DOI: 10.4103/1027-8117.363059

Y. Tsai, Chun-Bing Chen, Tzong-Yun Ger

引用次数: 0

Zinc-responsive seronegative necrolytic acral erythema: A case report and literature review 锌反应性血清阴性坏死性肢端红斑1例并文献复习

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2022-10-01 DOI: 10.4103/1027-8117.359342

Yu-Hsun Wei, Sheng-Hsiang Ma, Yung-Ting Chang, Cheng-Yuan Li

引用次数: 0

A report of stable segmental vitiligo with exacerbations following Oxford–AstraZeneca and MVC-COV1901 COVID-19 vaccinations 牛津-阿斯利康和MVC-COV1901 COVID-19疫苗接种后病情加重的稳定节段性白癜风报告

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2022-10-01 DOI: 10.4103/1027-8117.362563

Tsung-Fu Tsai, C. Ng

引用次数: 1

New-onset bullous pemphigoid triggered by AstraZeneca COVID-19 vaccine 阿斯利康COVID-19疫苗引发新发大疱性类天疱疮

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2022-10-01 DOI: 10.4103/1027-8117.358000

Yin-Cheng Chao, Kwei-Lan Liu

引用次数: 4

Recent developments in our understanding of autoinflammatory keratinization diseases 我们对自身炎症性角化疾病的认识的最新进展

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2022-10-01 DOI: 10.4103/1027-8117.365589

S. Hu

引用次数: 0

Diosmetin ameliorates imiquimod-induced psoriasis by regulating apoptosis and inflammation via toll-like receptor 4/nuclear factor kappa B pathway 薯蓣皂苷通过toll样受体4/核因子κ B通路调节细胞凋亡和炎症，改善吡喹莫德诱导的银屑病

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2022-10-01 DOI: 10.4103/ds.ds_31_22

Jinyan Yang, Mingfeng Zhan, Zhaohui Chen, Lihua Li, Juan Lu, Min Yang, Xuewen Gao

{"title":"Diosmetin ameliorates imiquimod-induced psoriasis by regulating apoptosis and inflammation via toll-like receptor 4/nuclear factor kappa B pathway","authors":"Jinyan Yang, Mingfeng Zhan, Zhaohui Chen, Lihua Li, Juan Lu, Min Yang, Xuewen Gao","doi":"10.4103/ds.ds_31_22","DOIUrl":"https://doi.org/10.4103/ds.ds_31_22","url":null,"abstract":"Background: Psoriasis is a common skin inflammatory disease. Dysregulated growth and differentiation of keratinocytes are the main characteristics of psoriasis. Diosmetin is a naturally occurring flavonoid with antioxidant, anti-inflammatory, and antibacterial properties. However, the anti-psoriatic role and mechanism of diosmetin remain unclear. Objectives: To investigate anti-psoriatic role and mechanism of diosmetin. Methods: Human immortalized epidermal cells (HaCaT) were treated with tumor necrosis factor-alpha (TNF-α) to establish the cell model of psoriasis. Mice were treated with imiquimod (IMQ) to establish the animal model of psoriasis. Cell viability and apoptosis were detected by methyl thiazolyl tetrazolium and flow cytometry, respectively. Reverse transcription-quantitative polymerase chain reaction and ELISA assays were performed to detect the expression of interleukin (IL)-6 and IL-8. Hematoxylin and eosin staining was used to detect the skin lesion. Results: Diosmetin reduced cell viability and promoted the apoptosis of TNF-α-induced HaCaT. Protein expression of Bax in TNF-α-induced HaCaT was up-regulated, while Bcl-2 was down-regulated by diosmetin. Diosmetin attenuated TNF-α-induced increase in IL-6 and IL-8 in HaCaT. The enhanced protein expression of toll-like receptor 4 (TLR 4) (toll-like receptor 4), p65 and IκBα phosphorylation, as well as reduced IκBα in TNF-α-induced HaCaT were restored by diosmetin. Diosmetin improved IMQ-induced skin lesion and attenuated inflammatory response in psoriasis-like mouse model. Conclusion: Diosmetin exerted anti-inflammatory and pro-apoptotic effects on TNF-α-induced HaCaT and IMQ-induced mice through inactivation of TLR4/nuclear factor kappa B pathway.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"68 1","pages":"207 - 213"},"PeriodicalIF":2.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82066879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Periungual xanthomas in a case of hepatocellular carcinoma and dyslipidemia 肝细胞癌合并血脂异常的甲周黄斑1例

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2022-10-01 DOI: 10.4103/1027-8117.359340

Chia-Lun Li, Ding-Dar Lee

引用次数: 0

Refractory bullous pemphigoid with prurigo nodularis successfully treated with dupilumab monotherapy 杜匹单抗单药治疗难治性大疱性类天疱疮结节性痒疹成功

IF 2.5 4区医学

Dermatologica Sinica Pub Date : 2022-10-01 DOI: 10.4103/1027-8117.357999

Po-Ta Lai, H. Tseng

引用次数: 4