Diabetes & Vascular Disease Research最新文献_第3页

miR-1187 induces podocyte injury and diabetic nephropathy through autophagy. miR-1187通过自噬诱导足细胞损伤和糖尿病肾病。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2023-05-01 DOI: 10.1177/14791641231172139

Bin Chen, Qiang He

引用次数: 1

Restoration of coronary microvascular function by OGA overexpression in a high-fat diet with low-dose streptozotocin-induced type 2 diabetic mice. 在高脂饮食和低剂量链脲佐菌素诱导的 2 型糖尿病小鼠体内过表达 OGA 可恢复冠状动脉微血管功能。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2023-05-01 DOI: 10.1177/14791641231173630

Jody Tori Cabrera, Rui Si, Atsumi Tsuji-Hosokawa, Hua Cai, Jason X-J Yuan, Wolfgang H Dillmann, Ayako Makino

{"title":"Restoration of coronary microvascular function by OGA overexpression in a high-fat diet with low-dose streptozotocin-induced type 2 diabetic mice.","authors":"Jody Tori Cabrera, Rui Si, Atsumi Tsuji-Hosokawa, Hua Cai, Jason X-J Yuan, Wolfgang H Dillmann, Ayako Makino","doi":"10.1177/14791641231173630","DOIUrl":"10.1177/14791641231173630","url":null,"abstract":"Sustained hyperglycemia results in excess protein O-GlcNAcylation, leading to vascular complications in diabetes. This study aims to investigate the role of O-GlcNAcylation in the progression of coronary microvascular disease (CMD) in inducible type 2 diabetic (T2D) mice generated by a high-fat diet with a single injection of low-dose streptozotocin. Inducible T2D mice exhibited an increase in protein O-GlcNAcylation in cardiac endothelial cells (CECs) and decreases in coronary flow velocity reserve (CFVR, an indicator of coronary microvascular function) and capillary density accompanied by increased endothelial apoptosis in the heart. Endothelial-specific O-GlcNAcase (OGA) overexpression significantly lowered protein O-GlcNAcylation in CECs, increased CFVR and capillary density, and decreased endothelial apoptosis in T2D mice. OGA overexpression also improved cardiac contractility in T2D mice. OGA gene transduction augmented angiogenic capacity in high-glucose treated CECs. PCR array analysis revealed that seven out of 92 genes show significant differences among control, T2D, and T2D + OGA mice, and Sp1 might be a great target for future study, the level of which was significantly increased by OGA in T2D mice. Our data suggest that reducing protein O-GlcNAcylation in CECs has a beneficial effect on coronary microvascular function, and OGA is a promising therapeutic target for CMD in diabetic patients.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"20 3","pages":"14791641231173630"},"PeriodicalIF":2.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ca/25/10.1177_14791641231173630.PMC10196148.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9750170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiometabolic risk factors, peripheral arterial tonometry and metformin in adults with type 1 diabetes participating in the REducing with MetfOrmin Vascular Adverse Lesions trial. 参与二甲双胍减少血管不良病变试验的成人1型糖尿病患者的心脏代谢危险因素、外周动脉血压计和二甲双胍

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2023-05-01 DOI: 10.1177/14791641231183634

David Chen, Alicia J Jenkins, Nicola Greenlaw, Katie Dudman, Tamsin Fernandes, David M Carty, Alun D Hughes, Andrzej S Januszewski, Coen DA Stehouwer, John R Petrie

{"title":"Cardiometabolic risk factors, peripheral arterial tonometry and metformin in adults with type 1 diabetes participating in the REducing with MetfOrmin Vascular Adverse Lesions trial.","authors":"David Chen, Alicia J Jenkins, Nicola Greenlaw, Katie Dudman, Tamsin Fernandes, David M Carty, Alun D Hughes, Andrzej S Januszewski, Coen DA Stehouwer, John R Petrie","doi":"10.1177/14791641231183634","DOIUrl":"https://doi.org/10.1177/14791641231183634","url":null,"abstract":"Background: Peripheral arterial tonometry (PAT) provides non-invasive measures of vascular health. Beneficial effects of metformin on vascular function have been reported in youth with type 1 diabetes (T1D). In the REducing with MetfOrmin Vascular Adverse Lesions (REMOVAL) trial in adults with T1D and high cardiovascular risk, we examined: (i) the extent to which routinely-measured cardiometabolic risk factors explain variance in baseline PAT; and (ii) the effects of metformin on PAT measures.Methods: Cross-sectional univariable and multivariable analyses of baseline reactive hyperaemia index (RHI) and augmentation index (AI) (EndoPAT® (Itamar, Israel); and analysis of 36-months metformin versus placebo on vascular tonometry.Results: In 364 adults ((mean ± SD) age 55.2 ± 8.5 years, T1D 34.0 ± 10.6 years, HbA1c 64.5 ± 9.0 mmol/mol (8.1 ± 0.8%)), RHI was 2.26 ± 0.74 and AI was 15.9 ± 19.2%. In an exhaustive search, independent associates of (i) RHI were smoking, waist circumference, systolic blood pressure and vitamin B12 (adjusted R2 = 0.11) and (ii) AI were male sex, pulse pressure, heart rate and waist circumference (adjusted R2 = 0.31). Metformin did not significantly affect RHI or AI.Conclusion: Cardiometabolic risk factors explained only a modest proportion of variance in PAT measures of vascular health in adults with T1D and high cardiovascular risk. PAT measures were not affected by metformin.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"20 3","pages":"14791641231183634"},"PeriodicalIF":2.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/eb/36/10.1177_14791641231183634.PMC10328035.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9754068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High serum Bhlhe40 levels are associated with subclinical atherosclerosis in patients with type 2 diabetes mellitus: A cross-sectional study. 高血清Bhlhe40水平与2型糖尿病患者亚临床动脉粥样硬化相关:一项横断面研究

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2023-03-01 DOI: 10.1177/14791641231169246

Hui Xu, Qun-Yan Xiang, Shuang Li, You-Shuo Liu

{"title":"High serum Bhlhe40 levels are associated with subclinical atherosclerosis in patients with type 2 diabetes mellitus: A cross-sectional study.","authors":"Hui Xu, Qun-Yan Xiang, Shuang Li, You-Shuo Liu","doi":"10.1177/14791641231169246","DOIUrl":"https://doi.org/10.1177/14791641231169246","url":null,"abstract":"Background: Our previous studies have shown that the basic helix-loop-helix family member e40 (Bhlhe40) plays a critical role in regulating calcification and senescence of vascular smooth muscle cells induced by high glucose. In this study, we determined the association between serum Bhlhe40 levels and subclinical atherosclerosis in patients with type 2 diabetes mellitus (T2DM).Methods: 247 patients with T2DM were included in this cross-sectional study between June 2021 and July 2022. The presence of subclinical atherosclerosis was evaluated by carotid ultrasonography. Serum Bhlhe40 concentrations were measured with an ELISA kit.Results: Serum Bhlhe40 levels were remarkably higher in the subclinical atherosclerosis group than in the subjects without subclinical atherosclerosis (p < 0.001). Correlation analysis showed a positive correlation between serum Bhlhe40 and carotid intima-media thickness (C-IMT) (r = 0.155, p = 0.015). The optimal threshold of serum Bhlhe40 > 5.67 ng/mL had an area under the ROC curve (AUC) was 0.709 (p < 0.001). In addition, serum Bhlhe40 levels were associated with the prevalence of subclinical atherosclerosis (OR: 1.790, 95% CI: 1.414-2.266, p < 0.001).Conclusion: Serum Bhlhe40 levels were significantly higher in T2DM subjects with subclinical atherosclerosis and positively associated with C-IMT.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"20 2","pages":"14791641231169246"},"PeriodicalIF":2.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ef/cf/10.1177_14791641231169246.PMC10064473.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9678775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improved extremity tissue oxygenation with short-term exposure to textiles embedded with far infrared light emitting thermoactive particles in patients with diabetes mellitus. 糖尿病患者短期接触嵌有远红外线热敏微粒的纺织品可改善肢体组织的氧合。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2023-03-01 DOI: 10.1177/14791641231170282

Diana Athonvarangkul, Kaicheng Wang, Yanhong Deng, Silvio E Inzucchi, Adam Mayerson

{"title":"Improved extremity tissue oxygenation with short-term exposure to textiles embedded with far infrared light emitting thermoactive particles in patients with diabetes mellitus.","authors":"Diana Athonvarangkul, Kaicheng Wang, Yanhong Deng, Silvio E Inzucchi, Adam Mayerson","doi":"10.1177/14791641231170282","DOIUrl":"10.1177/14791641231170282","url":null,"abstract":"Methods: A single-center, prospective, randomized, placebo-controlled, double-blinded, crossover study of 32 subjects with either type 1 or type 2 DM. An active FIR wrap followed by a placebo wrap (or vice versa) was applied to the arm, calf, ankle, and forefoot for 60 min each with continuous TcPO2 measurements. The treatment effect of the active versus placebo wrap was estimated using a linear mixed effect model adjusted for period, sequence, baseline value, and anatomic site.Results: The active FIR wrap increased mean TcPO2 at the arm (2.6 ± 0.8 mmHg, p = .002), calf (1.5 ± 0.7 mmHg, p = .03), and ankle (1.7 ± 0.8 mmHg, p = .04) and composite of all sites (1.4 ± 0.5 mmHg, p = .002) after 60 min. The estimated treatment effect was significant for the active FIR wrap at the calf (1.5 ± 0.7 mmHg, p = .045) and in composite of all sites (1.2 ± 0.5 mmHg, p = .013).Conclusion: Short-term exposure to FIR textiles improves peripheral tissue oxygenation in patients with diabetes.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"20 2","pages":"14791641231170282"},"PeriodicalIF":2.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9f/05/10.1177_14791641231170282.PMC10123901.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9678800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disruption of COMMD1 accelerates diabetic atherosclerosis by promoting glycolysis. COMMD1的破坏通过促进糖酵解加速糖尿病动脉粥样硬化。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2023-01-01 DOI: 10.1177/14791641231159009

Lili Zhang, Lihua Li, Yalan Li, Han Jiang, Zhen Sun, Guangyao Zang, Yongjiang Qian, Chen Shao, Zhongqun Wang

{"title":"Disruption of COMMD1 accelerates diabetic atherosclerosis by promoting glycolysis.","authors":"Lili Zhang, Lihua Li, Yalan Li, Han Jiang, Zhen Sun, Guangyao Zang, Yongjiang Qian, Chen Shao, Zhongqun Wang","doi":"10.1177/14791641231159009","DOIUrl":"https://doi.org/10.1177/14791641231159009","url":null,"abstract":"Aims: Diabetes will lead to serious complications, of which atherosclerosis is the most dangerous. This study aimed to explore the mechanisms of diabetic atherosclerosis.Methods: ApoE-/- mice were fed with an high-fat diet diet and injected with streptozotocin to establish an in vivo diabetic atherosclerotic model. RAW 264.7 cells were treated with oxidized low-density lipoprotein particles (ox-LDL) and high glucose to produce an in vitro diabetic atherosclerotic model.Results: In this study, we showed that diabetes promoted the progression of atherosclerosis in ApoE-/- mice and that high glucose potentiates macrophage proinflammatory activation and foam cell formation. Mechanistically, Copper metabolism MURR1 domain-containing 1(COMMD1) deficiency increased proinflammatory activation and foam cell formation, characterized by increased glycolysis, and then accelerated the process of atherosclerosis. Furthermore, 2-Deoxy-D-glucose (2-DG) reversed this effect.Conclusion: Taken together, we provided evidence that the lack of COMMD1 accelerates diabetic atherosclerosis via mediating the metabolic reprogramming of macrophages. Our study provides evidence of a protective role for COMMD1 and establishes COMMD1 as a potential therapeutic strategy in patients with diabetic atherosclerosis.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"20 1","pages":"14791641231159009"},"PeriodicalIF":2.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f4/7f/10.1177_14791641231159009.PMC9941604.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10030885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Responses of retinal and brain microvasculature to streptozotocin induced diabetes revealed by global expression profiling. 视网膜和脑微血管对链脲佐菌素诱导糖尿病的反应

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2023-01-01 DOI: 10.1177/14791641221147533

Youhai Li, Alen Faiz, Han Moshage, Lothar Schilling, Jan Aam Kamps

{"title":"Responses of retinal and brain microvasculature to streptozotocin induced diabetes revealed by global expression profiling.","authors":"Youhai Li, Alen Faiz, Han Moshage, Lothar Schilling, Jan Aam Kamps","doi":"10.1177/14791641221147533","DOIUrl":"https://doi.org/10.1177/14791641221147533","url":null,"abstract":"This study aims to determine the effects of diabetes in the retinal and brain microvasculature through gene expression profiling. Twelve male Wistar rats were randomly divided into two groups: streptozotocin-induced diabetic rats and time-matched nondiabetic rats. The retinal microvessels (RMVs) and brain microvessels (BMVs) were mechanically isolated from individual rats. Differentially expressed genes (DEGs) in diabetic and nondiabetic microvessels were identified by cDNA microarrays analysis. In RMVs, we identified 43 DEGs, of which 20 were upregulated while 23 were downregulated by diabetes. In BMVs, 35 genes DEGs were identified, of which 22 were upregulated and 13 were downregulated by diabetes. Altered expression of the Nars, Gars, Mars, Iars, Yars, Bcl2, Nqo1, NR4A3, Gpd1, Stc1, Tsc22d3, Tnfrsf21 mRNA as observed in the microarray analyses, was confirmed by quantitative RT-PCR. The aminoacyl-tRNA synthetases (aaRSs) pathway in RMVs was significantly overrepresented as compared to BMVs. Our study demonstrates for the first time that in the brain microvasculature multiple compensatory mechanisms exists, serving to protect brain tissue from diabetic insults, whereas these mechanisms are not activated in the retinal microvasculature. This provides new insights as to why brain microvasculature is less susceptible to diabetes.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"20 1","pages":"14791641221147533"},"PeriodicalIF":2.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10830506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Real-world study of flash glucose monitoring among adults with type 2 diabetes within the Swedish National Diabetes Register. 在瑞典国家糖尿病登记册中对成人2型糖尿病患者的瞬时血糖监测的真实世界研究。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2023-01-01 DOI: 10.1177/14791641211067418

Katarina Eeg-Olofsson, Ann-Marie Svensson, Stefan Franzén, Hodan Ahmed Ismail, Michael Törnblom, Fleur Levrat-Guillen

{"title":"Real-world study of flash glucose monitoring among adults with type 2 diabetes within the Swedish National Diabetes Register.","authors":"Katarina Eeg-Olofsson, Ann-Marie Svensson, Stefan Franzén, Hodan Ahmed Ismail, Michael Törnblom, Fleur Levrat-Guillen","doi":"10.1177/14791641211067418","DOIUrl":"https://doi.org/10.1177/14791641211067418","url":null,"abstract":"Background: The Swedish National Diabetes Register (NDR) initiated registration of the FreeStyle Libre® system and other continuous glucose monitoring (CGM) systems in June 2016. We investigated change in HbA1c for people with type 2 diabetes (T2DM) using FreeStyle Libre in Sweden.Methods: We included adults with T2DM, registered in the NDR after January 1, 2014, and an index date for first use of FreeStyle Libre of June 2016 or later. Methodology was a before/after comparison of HbA1c within 6 months before the index date versus HbA1c around 6 and 12 months after the index date.Results: 711 adults with T2DM using FreeStyle Libre had HbA1c measurements within the study period. Mean HbA1c was significantly reduced at 6 months (-0.50%-unit) and at 12 months (-0.52%-unit) in this group. Degree of change was negatively correlated to baseline HbA1c. Reductions in HbA1c were observed in incident users of FreeStyle Libre with T2DM who were truly naïve to CGM or had unknown prior experience of CGM, and aged 25-74 years.Conclusions: This real-world study on the Swedish NDR shows that people with T2DM using FreeStyle Libre system for 6 and 12 months significantly reduced their HbA1c.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"20 1","pages":"14791641211067418"},"PeriodicalIF":2.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/81/31/10.1177_14791641211067418.PMC9903025.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10750681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal trends in minor and major lower extremity amputation in people with type 2 diabetes: The Fremantle Diabetes Study. 2型糖尿病患者轻度和重度下肢截肢的时间趋势:Fremantle糖尿病研究

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2023-01-01 DOI: 10.1177/14791641231154162

Emma J Hamilton, Wendy A Davis, Mendel Baba, Timothy Me Davis

{"title":"Temporal trends in minor and major lower extremity amputation in people with type 2 diabetes: The Fremantle Diabetes Study.","authors":"Emma J Hamilton, Wendy A Davis, Mendel Baba, Timothy Me Davis","doi":"10.1177/14791641231154162","DOIUrl":"https://doi.org/10.1177/14791641231154162","url":null,"abstract":"Aims: To determine whether incident minor and major lower extremity amputations (LEAs) have declined in recent decades in type 2 diabetes.Methods: Participants with type 2 diabetes from the community-based Fremantle Diabetes Study Phases I (FDS1; n = 1,296, mean age 64.0 years, recruited 1993-1996) and II (FDS2; n = 1,509, mean age 65.4 years, recruited 2008-2011) were followed from entry to incident minor/major LEA, death or five years. Cox regression determined hazard ratios (HRs) for each outcome for FDS2 versus FDS1 and independent predictors of incident minor and major LEA in the combined cohort.Results: Age- and sex-adjusted HRs (95% CIs) in FDS2 versus FDS1 for incident minor and major LEA were, respectively, 0.60 (0.27, 1.35) and 0.59 (0.22, 1.59). Higher glycated haemoglobin, urine albumin: creatinine (uACR) ratio and peripheral sensory neuropathy (PSN) were independent predictors of incident minor LEA. Higher fasting serum glucose, peripheral arterial disease (PAD), end-stage kidney disease and prior diabetes-related minor LEA were associated with incident major LEA.Conclusions: There were non-significant reductions of approximately 40% in incident minor and major LEA in community-based people with type 2 diabetes during the 15 years between FDS Phases. Predictors of minor/major LEA confirm distinct high-risk patient groups with implications for clinical management.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"20 1","pages":"14791641231154162"},"PeriodicalIF":2.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/45/26/10.1177_14791641231154162.PMC9903017.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10807166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2022-11-01 DOI: 10.1177/14791641221137355

Mingfang Ye, Qi-Hong Wu, Ke Yang, Yukun Luo

{"title":"C1q/TNF-related protein-2 improved angiogenesis to protect myocardial function during ischaemia‒reperfusion.","authors":"Mingfang Ye, Qi-Hong Wu, Ke Yang, Yukun Luo","doi":"10.1177/14791641221137355","DOIUrl":"https://doi.org/10.1177/14791641221137355","url":null,"abstract":"Background: Collateral growth plays an important role in the recovery of acute myocardial infarction. C1q/TNF-related protein-2 (CTRP2), a CTRP family member, showed some protective effects on cell survival. In this study, the relationship between CTRP2 and collateral growth was examined.Methods: C57BL/6 mice were subjected to myocardial ischaemia/reperfusion (I/R), and the expression of CTRP2 and the effect of CTRP2 on infarction size, cardiac function and angiogenesis were examined. The ischaemic hindlimb model was also used to examine the effect of CTRP2. In vitro, CTRP2-mediated regulation of angiogenesis, AKT activation and VEGFR2 expression in endothelial cells was examined. The CTRP2 level associated with good collateral growth was observed in a cohort.Results: I/R reduced CTRP2 expression, and intraperitoneal injection of recombinant CTRP2 protein improved infarction size, cardiac function and angiogenesis. Overexpression of CTRP2 promoted blood refusion and collateral growth in ischaemic hindlimb mice. In vitro, CTRP2 enhanced tube formation and migration in a dose-dependent manner, while CTRP2 increased AKT phosphorylation and VEGFR2 expression. In an observational clinical cohort, CTRP2 levels were significantly increased in patients with good collateral growth, and CTRP2 was negatively associated with poor collateral growth in patients.Conclusion: CTRP2 improved cardiac function by promoting collateral growth by promoting AKT-VEGFR2.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"19 6","pages":"14791641221137355"},"PeriodicalIF":2.4,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/65/51/10.1177_14791641221137355.PMC9706074.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10368427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1