Diabetes & Vascular Disease Research最新文献_第4页

Intermittently scanned continuous glucose monitoring is associated with lower spontaneous abortion rate compared with conventional blood glucose monitoring in pregnant women with type 1 diabetes: An observational study. 1型糖尿病孕妇间歇扫描连续血糖监测与常规血糖监测相比可降低自然流产率:一项观察性研究

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2022-11-01 DOI: 10.1177/14791641221136837

Madleen Lemaitre, Kenza Faiz, Florence Baudoux, Damien Subtil, Anne Vambergue

{"title":"Intermittently scanned continuous glucose monitoring is associated with lower spontaneous abortion rate compared with conventional blood glucose monitoring in pregnant women with type 1 diabetes: An observational study.","authors":"Madleen Lemaitre, Kenza Faiz, Florence Baudoux, Damien Subtil, Anne Vambergue","doi":"10.1177/14791641221136837","DOIUrl":"https://doi.org/10.1177/14791641221136837","url":null,"abstract":"Aim The objective of the present real-life study in France was to assess and compare characteristics and outcomes in a cohort of pregnant women with type 1 diabetes (T1D) using intermittently scanned continuous glucose monitoring (isCGM) or conventional blood glucose monitoring (BGM). Material and Methods We performed an observational study of a cohort of 153 women with T1D: 77 women were using isCGM, and 76 were using BGM. We compared the groups’ maternal characteristics and maternal-fetal complications. The level of HbA1c was measured before pregnancy and then four times (after 8–12, 24–28, 30–33, and 35–37 weeks of gestation). Results The two groups were similar in terms of age, prepregnancy BMI, diabetes duration, and diabetic vascular complications. There were no significant intergroup differences in the obstetric history. The spontaneous abortion rate was lower in the isCGM group than in the blood glucose monitoring group (5.3% vs. 20%, respectively; p = .0129), while the prepregnancy and first-trimester HbA1c levels were similar. There were no significant intergroup differences in the incidence of other maternal-fetal complications. Conclusions This observational study demonstrates that isCGM use is associated with lower spontaneous abortion compared with conventional BGM. Large prospective studies are needed to corroborate our findings and fully understand the relationship between glucose data at the time of conception/early pregnancy and foetal outcome.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"19 6","pages":"14791641221136837"},"PeriodicalIF":2.4,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ee/8d/10.1177_14791641221136837.PMC9756364.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10385963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Ten-year incidence of post-transplant Diabetes Mellitus in renal transplant patients. 肾移植术后糖尿病10年发病率分析。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2022-11-01 DOI: 10.1177/14791641221137352

Fatemeh Habibnia, Farshid Oliaei, Hoda Shirafkan, Mobarakeh Abbasi Firoozjah, Mobina Rezaei Roshan, Roghayeh Akbari

{"title":"Ten-year incidence of post-transplant Diabetes Mellitus in renal transplant patients.","authors":"Fatemeh Habibnia, Farshid Oliaei, Hoda Shirafkan, Mobarakeh Abbasi Firoozjah, Mobina Rezaei Roshan, Roghayeh Akbari","doi":"10.1177/14791641221137352","DOIUrl":"https://doi.org/10.1177/14791641221137352","url":null,"abstract":"Background: Kidney transplantation is the treatment of choice for renal failure. Development of New-Onset Diabetes After Transplantation (NODAT) significantly increases kidney graft loss and mortality. This study aimed to evaluate the 10-years prevalence of NODAT in renal transplant patients.Methods: In this cross-sectional study, medical records of non-diabetic patients undergoing kidney transplant in Shahid-Beheshti Hospital of Babol, between March 2009-2019 were retrospectively reviewed.Results: Totally 284 patients with the mean age of 40.83 ± 12.94 years were included. New-Onset Diabetes After Transplantation was identified in 57 (20.1%) patients and 92.98% developed NODAT during the first month after transplantation. New-Onset Diabetes After Transplantation and non-NODAT patients were 43.8% and 34.38% female. Graft rejection occurred in 18 (31%) of NODAT and 78 (34%) of non-NODAT patients (p = .69). Patients with NODAT were about 10 years older (47.88 ± 11.06 vs 38.96 ± 13.12 years; p = .002). The pre-transplant Fasting Blood Sugar (FBS) was higher in the NODAT group (93.78 ± 13.78 vs 87.07 ± 11.56, p = .001) and post-transplantation cytomegalovirus (CMV) infection was higher in NODAT group (56% vs 40%, p = .021). New-Onset Diabetes After Transplantation patients had significantly higher BMI (27.16 ± 5.39 vs 23.94 ± 4.71, p < .001).Conclusion: New-Onset Diabetes After Transplantation is more prevalent in subjects with older age, higher BMI, post-transplant CMV infection, and higher pre-transplant FBS but gender, pre-transplant CMV infection, type of dialysis and smoking were not associated with it. So, these patients should be followed-up more diligently.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"19 6","pages":"14791641221137352"},"PeriodicalIF":2.4,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7f/ba/10.1177_14791641221137352.PMC9729995.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10389682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Glycaemic variability and risk of adverse cardiovascular events in acute coronary syndrome. 急性冠状动脉综合征的血糖变异性和不良心血管事件的风险。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2022-11-01 DOI: 10.1177/14791641221137736

Lei Zhang, Feng Li, Huan-Huan Liu, Zhi-Yuan Zhang, Fan Yang, Ling-Ling Qian, Ru-Xing Wang

{"title":"Glycaemic variability and risk of adverse cardiovascular events in acute coronary syndrome.","authors":"Lei Zhang, Feng Li, Huan-Huan Liu, Zhi-Yuan Zhang, Fan Yang, Ling-Ling Qian, Ru-Xing Wang","doi":"10.1177/14791641221137736","DOIUrl":"https://doi.org/10.1177/14791641221137736","url":null,"abstract":"Objective: The relationship between different glycaemic variability (GV) indexes and adverse cardiovascular outcomes is not well understood. This study aims to determine whether GV is related to the occurrence of adverse cardiovascular events in patients with acute coronary syndrome (ACS).Methods: PubMed, EMBASE, and Web of Science were comprehensively searched from the establishment of databases to 29 June 2022. The relationship between two important GV indexes, including the mean amplitude of glycemic excursion (MAGE) and standard deviation (SD), and the adverse cardiovascular events in ACS patients were evaluated, respectively.Results: A total of 11 studies with 3709 ACS patients were included. Pooled results showed that patients with higher GV had significantly increased risk of adverse cardiovascular events, including MAGE (relative risk [RR] = 1.76, 95% CI: 1.40 to 2.22, p < 0.001, I2 = 25%) and SD (RR = 2.14, 95% CI: 1.73 to 2.66, p < 0.001, I2 = 0%).Conclusions: Increased GV is related to the poor prognosis in patients with ACS. Additionally, more well-designed studies comparing different indicators of GV with adverse cardiovascular events in ACS patients are still warranted.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"19 6","pages":"14791641221137736"},"PeriodicalIF":2.4,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/81/59/10.1177_14791641221137736.PMC9643761.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10411730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Triglyceride glucose index is independently associated with aortic intima-media thickness in patients without known atherosclerotic cardiovascular disease or diabetes. 在没有已知动脉粥样硬化性心血管疾病或糖尿病的患者中，甘油三酯葡萄糖指数与主动脉内膜-中膜厚度独立相关。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2022-09-01 DOI: 10.1177/14791641221136203

Süleyman Özbiçer, Gülhan Yüksel, Örsan Deniz Urgun

{"title":"Triglyceride glucose index is independently associated with aortic intima-media thickness in patients without known atherosclerotic cardiovascular disease or diabetes.","authors":"Süleyman Özbiçer, Gülhan Yüksel, Örsan Deniz Urgun","doi":"10.1177/14791641221136203","DOIUrl":"https://doi.org/10.1177/14791641221136203","url":null,"abstract":"Background: The triglyceride-glucose (TyG) index is a reliable marker of insulin resistance. We aimed to investigate the relationship between the TyG index and aortic intima-media thickness (IMT) in individuals without diabetes mellitus and atherosclerotic cardiovascular disease undergoing transoesophageal echocardiography due to suspected structural heart disease.Methods: One hundred twenty-two patients enrolled in the study between January 2021 and June 2021. Patients were divided into two groups according to their median IMT; patients with an IMT equal to or less than 1.42 mm were low IMT group, and higher than 1.42 mm were high IMT group. Triglyceride-glucose index were higher in the high IMT group (8.69 ± 0.59 vs. 8.37 ± 0.53, p = .003).Results: Triglyceride-glucose index was correlated with IMT (r = 0.259, p = .005) and in binary logistic regression analysis age and TyG was independently associated with having high IMT (β = 0.076, exp(B)=1.079 95%CI = 1.041-1.118, p < .001 and β = 0.847, exp(B)= 2.334 95%CI= 1.048-5.199, p = .038, respectively).Conclusion: We found an independent relationship between TyG and IMT of the thoracic aorta, an early marker of subclinical atherosclerosis in patients without known atherosclerotic cardiovascular disease or diabetes. Therefore, the TyG index can identify high-risk subjects in the general population.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"19 5","pages":"14791641221136203"},"PeriodicalIF":2.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/48/9d/10.1177_14791641221136203.PMC9597021.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10403734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Coronary artery calcium score and coronary computed tomography angiography predict one-year mortality in patients with type 2 diabetes and peripheral artery disease undergoing partial foot amputation. 冠状动脉钙化评分和冠状动脉计算机断层扫描血管造影可预测接受部分截肢的 2 型糖尿病和外周动脉疾病患者的一年死亡率。

IF 2.8 4区医学

Diabetes & Vascular Disease Research Pub Date : 2022-09-01 DOI: 10.1177/14791641221125190

Evgeniya Shalaeva, Arjola Bano, Ulugbek Kasimov, Bakhtiyor Janabaev, Iris Baumgartner, Markus Laimer, Hugo Saner

{"title":"Coronary artery calcium score and coronary computed tomography angiography predict one-year mortality in patients with type 2 diabetes and peripheral artery disease undergoing partial foot amputation.","authors":"Evgeniya Shalaeva, Arjola Bano, Ulugbek Kasimov, Bakhtiyor Janabaev, Iris Baumgartner, Markus Laimer, Hugo Saner","doi":"10.1177/14791641221125190","DOIUrl":"10.1177/14791641221125190","url":null,"abstract":"Methods: This is a single-center prospective cohort study including 199 consecutive patients with T2D, PAD (mean age 62.3 ± 7.2 years; 62.8% males), and preoperative CACS and CCTA undergoing PFA and followed-up over 1 year.Results: Over a period of 1 year follow-up, a total of 35 (17.6%) participants died. The area under ROC curve to predict mortality for the CACS was 0.835 (95% CI:0.769-0.900), for CCTA 0.858 (95% CI:0.788-0.927). After adjustment for confounders, compared to no-stenosis on CCTA (reference), the risk of all-cause mortality in non-obstructive coronary atery disease (CAD) increased (HR = 1.38, 95% CI [0.75-12.86], p = .284), 1-vessel obstructive CAD (HR = 8.13, 95% CI [0.87-75.88], p = .066), 2-vessels (HR = 10.94, 95% CI [1.03-115.8], p = .047), and 3-vessels (HR = 45.73, 95% CI [4.6-454.7], p = .001) respectively. Increasing levels of CACS tended to be associated with increased risk of all-cause mortality (HR = 1.002, 95% CI [1.0-1.003], p = .061). 61/95 patients with obstructive CAD underwent coronary revascularization.Conclusions: Coronary artery calcium score and CCTA have a high predictive value for 1-year all-cause mortality in T2D patients undergoing minor amputations and may be considered for preoperative risk assessment allowing timely preventive interventions.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"19 5","pages":"14791641221125190"},"PeriodicalIF":2.8,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10760620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of diabetes on outcomes of cardiogenic shock: A systematic review and meta-analysis. 糖尿病对心源性休克结局的影响:一项系统回顾和荟萃分析。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2022-09-01 DOI: 10.1177/14791641221132242

Chao Luo, Feng Chen, Lingpei Liu, Zuanmin Ge, Chengzhen Feng, Yuehua Chen

{"title":"Impact of diabetes on outcomes of cardiogenic shock: A systematic review and meta-analysis.","authors":"Chao Luo, Feng Chen, Lingpei Liu, Zuanmin Ge, Chengzhen Feng, Yuehua Chen","doi":"10.1177/14791641221132242","DOIUrl":"https://doi.org/10.1177/14791641221132242","url":null,"abstract":"To provide synthesized evidence on the association of diabetes with clinical outcomes of patients with acute myocardial infarction (AMI) and associated cardiogenic shock (CS). We analyzed observational studies on patients with AMI and CS, identified through a systematic search using PubMed and Scopus databases. The main outcome was mortality and other outcomes of interest were risk of major bleeding, re-infarction, cerebrovascular adverse events, and need for revascularization. We conducted the meta-analysis with data from 15 studies. Compared to patients without diabetes, those with diabetes had an increased risk of in-hospital mortality (OR, 1.34; 95% CI, 1.17-1.54) and cerebrovascular complications (OR, 1.28; 95% CI, 1.11-1.48). We found similar risk of major bleeding (OR, 0.68; 95% CI, 0.43-1.09), re-infarction (OR, 0.98; 95% CI, 0.48-1.98) and need for re-vascularization (OR, 0.96; 95% CI, 0.75-1.22) as well as hospital stay lengths (in days) (WMD 0.00; 95% CI, -0.27-0.28; n = 4; I2 = 99.7%) in the two groups of patients. Patients with diabetes, acute MI and associated cardiogenic shock have increased risks of mortality and adverse cerebrovascular events than those without diabetes.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"19 5","pages":"14791641221132242"},"PeriodicalIF":2.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cd/f5/10.1177_14791641221132242.PMC9580099.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10471750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Shared and specific biological signalling pathways for diabetic retinopathy, peripheral neuropathy and nephropathy by high-throughput sequencing analysis. 通过高通量测序分析糖尿病视网膜病变、周围神经病变和肾病的共享和特异性生物信号通路。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2022-07-01 DOI: 10.1177/14791641221122918

Zhu Hui, Yan-Ming Chen, Wei-Kun Gong, Jing-Bo Lai, Bin-Bin Yao, Zhi-Jia Zhao, Qin-Kang Lu, Ke Ye, Lin-Dan Ji, Jin Xu

{"title":"Shared and specific biological signalling pathways for diabetic retinopathy, peripheral neuropathy and nephropathy by high-throughput sequencing analysis.","authors":"Zhu Hui, Yan-Ming Chen, Wei-Kun Gong, Jing-Bo Lai, Bin-Bin Yao, Zhi-Jia Zhao, Qin-Kang Lu, Ke Ye, Lin-Dan Ji, Jin Xu","doi":"10.1177/14791641221122918","DOIUrl":"https://doi.org/10.1177/14791641221122918","url":null,"abstract":"Objectives: We aimed to explore the shared and specific signalling pathways involved in diabetic retinopathy (DR), diabetic peripheral neuropathy (DPN) and diabetic nephropathy (DN).Methods: Differentially expressed mRNAs and lncRNAs were identified by high-throughput sequencing. Subsequently, functional enrichment analysis, protein-protein interaction (PPI) analysis and lncRNAs-mRNAs networks were conducted to determine the pathogenic mechanisms underlying DR, DPN and DN.Results: Twenty-six biological pathways were shared among DR, DPN and DN groups compared to the type 2 diabetes mellitus (T2DM) group without complications, and most of the shared pathways and core proteins were involved in immune and inflammatory responses of microvascular damage. Cytokine‒cytokine receptor interactions and chemokine signalling pathway were the most significant and specific pathways for DR, and the lncRNA‒mRNA regulatory networks affected DR by targeting these pathways. Sphingolipid metabolism and neuroactive ligand-receptor pathways were found to be specific for the pathogenesis of DPN. Moreover, multiple amino acid metabolic pathways were involved in the occurrence and progression of DN.Conclusions: Diabetic retinopathy, DPN and DN exhibited commonality and heterogeneity simultaneously. The shared pathologic mechanisms underlying these diabetic complications are involved in diabetic microvascular damage via immune and inflammatory pathways. Our findings predict several biomarkers and therapeutic targets for these diabetic complications.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"19 4","pages":"14791641221122918"},"PeriodicalIF":2.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e1/33/10.1177_14791641221122918.PMC9397373.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10424418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Diabetic nephropathy ameliorated in patients with normal home blood pressure compared to those with isolated high home systolic blood pressure: A 5-year prospective cohort study among patients with type 2 diabetes mellitus 与孤立的家庭收缩压高患者相比，家庭血压正常患者的糖尿病肾病得到改善：一项针对2型糖尿病患者的5年前瞻性队列研究

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2022-05-01 DOI: 10.1177/14791641221098193

Nobuko Kitagawa, E. Ushigome, Noriyuki Kitagawa, H. Ushigome, Isao Yokota, Naoko Nakanishi, M. Hamaguchi, M. Asano, M. Yamazaki, M. Fukui

{"title":"Diabetic nephropathy ameliorated in patients with normal home blood pressure compared to those with isolated high home systolic blood pressure: A 5-year prospective cohort study among patients with type 2 diabetes mellitus","authors":"Nobuko Kitagawa, E. Ushigome, Noriyuki Kitagawa, H. Ushigome, Isao Yokota, Naoko Nakanishi, M. Hamaguchi, M. Asano, M. Yamazaki, M. Fukui","doi":"10.1177/14791641221098193","DOIUrl":"https://doi.org/10.1177/14791641221098193","url":null,"abstract":"Background: Using normal home blood pressure (home BP) as a reference, isolated high home systolic blood pressure (IH-home SBP) increases the risk of diabetic nephropathy. However, whether diabetic nephropathy would improve among diabetic patients without IH-home SBP has not been previously assessed. Methods: This prospective 5-year cohort study of 264 patients with moderate or severe albuminuria investigated the effect of IH-home SBP or normal home BP on the risk of diabetic nephropathy in patients with type 2 diabetes mellitus. Improvement of diabetic nephropathy was defined as remission or regression from moderate or severe albuminuria to normal or mildly increased albuminuria. Results: Improvement of diabetic nephropathy was shown in 59 out of 264 patients during 5 years. The adjusted odds ratio (95% confidence interval) of normal home BP for improving diabetic nephropathy was 2.52 (1.01–5.99, p = 0.05). Conclusion: Normal home BP had relation to an improvement in diabetic nephropathy among type 2 diabetic patients with moderate and severe increased albuminuria in the observation period of 5 years. Good home BP control might be valuable to ameliorate diabetic nephropathy.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42861948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Glucolipotoxicity induces endothelial cell dysfunction by activating autophagy and inhibiting autophagic flow 糖脂毒性通过激活自噬和抑制自噬流诱导内皮细胞功能障碍

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2022-05-01 DOI: 10.1177/14791641221102513

Yulan Liu, Hong Xiang, Wenfang Xiong, J. Ouyang, Hengdao Liu, Shao-li Zhao, Jie Xiao, Jialing Li, Zhihao Shu, Xuewen Wang, Huiqin Liu, Jing Zhang, Jianing Fan, Ying Li, Shuhua Chen, Hongwei Lu

{"title":"Glucolipotoxicity induces endothelial cell dysfunction by activating autophagy and inhibiting autophagic flow","authors":"Yulan Liu, Hong Xiang, Wenfang Xiong, J. Ouyang, Hengdao Liu, Shao-li Zhao, Jie Xiao, Jialing Li, Zhihao Shu, Xuewen Wang, Huiqin Liu, Jing Zhang, Jianing Fan, Ying Li, Shuhua Chen, Hongwei Lu","doi":"10.1177/14791641221102513","DOIUrl":"https://doi.org/10.1177/14791641221102513","url":null,"abstract":"Objectives This study aims to determine the role and mechanism of autophagy in endothelial cell dysfunction by glucolipotoxicity. Methods Human umbilical vein endothelial cells (HUVECs) were treated with high glucose and high palmitic acid. The number of autophagosomes was evaluated by monodansylcadaverine (MDC) staining and transmission electron microscopy (TEM). The expression of autophagy-related proteins (LC3 and P62) was assessed by Western blotting. Capillary tube-like formation was evaluated on Matrigel. Reactive oxygen species (ROS) production was detected by DCFH-DA. Cell apoptosis was measured by Hoechst 33258 staining and flow cytometry. Phosphorylation of AMPK, mTOR, and ULK1 was also analyzed by Western blotting. Results We found that glucolipotoxicity induced autophagy initiation and hindered autophagosomes degradation. Moreover, glucolipotoxicity increased the production of intracellular ROS, decreased the ability of tubular formation, and increased cell apoptosis. However, endothelial cell dysfunction was alleviated by 3-methyladenine, an early-stage autophagy inhibitor. Additionally, glucolipotoxicity promoted the phosphorylation of AMPK and ULK1 and inhibited the phosphorylation of mTOR. Conclusions Glucolipotoxicity initiates autophagy through the AMPK/mTOR/ULK1 signaling pathway and inhibits autophagic flow, leading to the accumulation of autophagosomes, thereby inducing apoptosis and impairing endothelial cell function.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42995155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Impact of insulin therapy on outcomes of diabetic patients with heart failure: A systematic review and meta-analysis 胰岛素治疗对糖尿病心衰患者预后的影响:一项系统综述和荟萃分析

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2022-05-01 DOI: 10.1177/14791641221093175

Jingxing Liu, Xinhua Hu

{"title":"Impact of insulin therapy on outcomes of diabetic patients with heart failure: A systematic review and meta-analysis","authors":"Jingxing Liu, Xinhua Hu","doi":"10.1177/14791641221093175","DOIUrl":"https://doi.org/10.1177/14791641221093175","url":null,"abstract":"Objective: To compare clinical outcomes in diabetic patients with heart failure managed by insulin with those managed by non-insulin (oral hypoglycemic agents and/or lifestyle modification) based therapy. Methods: PubMed and Scopus databases were searched for studies conducted on diabetic patients with heart failure. Studies were to compare outcomes of patients managed by insulin versus non-insulin therapies. Results: 15 studies were included. Compared to those who were managed using non-insulin therapy, insulin-treated patients had increased risk of all-cause mortality (RR 1.46, 95% CI: 1.14, 1.88) and cardiovascular specific mortality (RR 1.62, 95% CI: 1.33, 1.96). Those managed using insulin also had increased risk of hospitalization (RR 1.45, 95% CI: 1.09, 1.93) and readmission (RR 1.49, 95% CI: 1.32, 1.67). There was no additional risk for stroke (RR 1.07, 95% CI: 0.91, 1.27) or myocardial infarction (MI) (RR 1.10, 95% CI: 0.96, 1.27) between the two groups of patients. Conclusions: Receipt of insulin among diabetic patients with heart failure was associated with an increased risk of mortality, hospitalization and readmission compared to management using oral hypoglycemic agents and/or lifestyle modification. Such patients should be closely monitored for any adverse events.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42953913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6