Diabetes & Vascular Disease Research最新文献_第4页

Intermittently scanned continuous glucose monitoring is associated with lower spontaneous abortion rate compared with conventional blood glucose monitoring in pregnant women with type 1 diabetes: An observational study. 1型糖尿病孕妇间歇扫描连续血糖监测与常规血糖监测相比可降低自然流产率:一项观察性研究

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2022-11-01 DOI: 10.1177/14791641221136837

Madleen Lemaitre, Kenza Faiz, Florence Baudoux, Damien Subtil, Anne Vambergue

{"title":"Intermittently scanned continuous glucose monitoring is associated with lower spontaneous abortion rate compared with conventional blood glucose monitoring in pregnant women with type 1 diabetes: An observational study.","authors":"Madleen Lemaitre, Kenza Faiz, Florence Baudoux, Damien Subtil, Anne Vambergue","doi":"10.1177/14791641221136837","DOIUrl":"https://doi.org/10.1177/14791641221136837","url":null,"abstract":"Aim The objective of the present real-life study in France was to assess and compare characteristics and outcomes in a cohort of pregnant women with type 1 diabetes (T1D) using intermittently scanned continuous glucose monitoring (isCGM) or conventional blood glucose monitoring (BGM). Material and Methods We performed an observational study of a cohort of 153 women with T1D: 77 women were using isCGM, and 76 were using BGM. We compared the groups’ maternal characteristics and maternal-fetal complications. The level of HbA1c was measured before pregnancy and then four times (after 8–12, 24–28, 30–33, and 35–37 weeks of gestation). Results The two groups were similar in terms of age, prepregnancy BMI, diabetes duration, and diabetic vascular complications. There were no significant intergroup differences in the obstetric history. The spontaneous abortion rate was lower in the isCGM group than in the blood glucose monitoring group (5.3% vs. 20%, respectively; p = .0129), while the prepregnancy and first-trimester HbA1c levels were similar. There were no significant intergroup differences in the incidence of other maternal-fetal complications. Conclusions This observational study demonstrates that isCGM use is associated with lower spontaneous abortion compared with conventional BGM. Large prospective studies are needed to corroborate our findings and fully understand the relationship between glucose data at the time of conception/early pregnancy and foetal outcome.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"19 6","pages":"14791641221136837"},"PeriodicalIF":2.4,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ee/8d/10.1177_14791641221136837.PMC9756364.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10385963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Ten-year incidence of post-transplant Diabetes Mellitus in renal transplant patients. 肾移植术后糖尿病10年发病率分析。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2022-11-01 DOI: 10.1177/14791641221137352

Fatemeh Habibnia, Farshid Oliaei, Hoda Shirafkan, Mobarakeh Abbasi Firoozjah, Mobina Rezaei Roshan, Roghayeh Akbari

{"title":"Ten-year incidence of post-transplant Diabetes Mellitus in renal transplant patients.","authors":"Fatemeh Habibnia, Farshid Oliaei, Hoda Shirafkan, Mobarakeh Abbasi Firoozjah, Mobina Rezaei Roshan, Roghayeh Akbari","doi":"10.1177/14791641221137352","DOIUrl":"https://doi.org/10.1177/14791641221137352","url":null,"abstract":"Background: Kidney transplantation is the treatment of choice for renal failure. Development of New-Onset Diabetes After Transplantation (NODAT) significantly increases kidney graft loss and mortality. This study aimed to evaluate the 10-years prevalence of NODAT in renal transplant patients.Methods: In this cross-sectional study, medical records of non-diabetic patients undergoing kidney transplant in Shahid-Beheshti Hospital of Babol, between March 2009-2019 were retrospectively reviewed.Results: Totally 284 patients with the mean age of 40.83 ± 12.94 years were included. New-Onset Diabetes After Transplantation was identified in 57 (20.1%) patients and 92.98% developed NODAT during the first month after transplantation. New-Onset Diabetes After Transplantation and non-NODAT patients were 43.8% and 34.38% female. Graft rejection occurred in 18 (31%) of NODAT and 78 (34%) of non-NODAT patients (p = .69). Patients with NODAT were about 10 years older (47.88 ± 11.06 vs 38.96 ± 13.12 years; p = .002). The pre-transplant Fasting Blood Sugar (FBS) was higher in the NODAT group (93.78 ± 13.78 vs 87.07 ± 11.56, p = .001) and post-transplantation cytomegalovirus (CMV) infection was higher in NODAT group (56% vs 40%, p = .021). New-Onset Diabetes After Transplantation patients had significantly higher BMI (27.16 ± 5.39 vs 23.94 ± 4.71, p < .001).Conclusion: New-Onset Diabetes After Transplantation is more prevalent in subjects with older age, higher BMI, post-transplant CMV infection, and higher pre-transplant FBS but gender, pre-transplant CMV infection, type of dialysis and smoking were not associated with it. So, these patients should be followed-up more diligently.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"19 6","pages":"14791641221137352"},"PeriodicalIF":2.4,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7f/ba/10.1177_14791641221137352.PMC9729995.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10389682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Glycaemic variability and risk of adverse cardiovascular events in acute coronary syndrome. 急性冠状动脉综合征的血糖变异性和不良心血管事件的风险。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2022-11-01 DOI: 10.1177/14791641221137736

Lei Zhang, Feng Li, Huan-Huan Liu, Zhi-Yuan Zhang, Fan Yang, Ling-Ling Qian, Ru-Xing Wang

{"title":"Glycaemic variability and risk of adverse cardiovascular events in acute coronary syndrome.","authors":"Lei Zhang, Feng Li, Huan-Huan Liu, Zhi-Yuan Zhang, Fan Yang, Ling-Ling Qian, Ru-Xing Wang","doi":"10.1177/14791641221137736","DOIUrl":"https://doi.org/10.1177/14791641221137736","url":null,"abstract":"Objective: The relationship between different glycaemic variability (GV) indexes and adverse cardiovascular outcomes is not well understood. This study aims to determine whether GV is related to the occurrence of adverse cardiovascular events in patients with acute coronary syndrome (ACS).Methods: PubMed, EMBASE, and Web of Science were comprehensively searched from the establishment of databases to 29 June 2022. The relationship between two important GV indexes, including the mean amplitude of glycemic excursion (MAGE) and standard deviation (SD), and the adverse cardiovascular events in ACS patients were evaluated, respectively.Results: A total of 11 studies with 3709 ACS patients were included. Pooled results showed that patients with higher GV had significantly increased risk of adverse cardiovascular events, including MAGE (relative risk [RR] = 1.76, 95% CI: 1.40 to 2.22, p < 0.001, I2 = 25%) and SD (RR = 2.14, 95% CI: 1.73 to 2.66, p < 0.001, I2 = 0%).Conclusions: Increased GV is related to the poor prognosis in patients with ACS. Additionally, more well-designed studies comparing different indicators of GV with adverse cardiovascular events in ACS patients are still warranted.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"19 6","pages":"14791641221137736"},"PeriodicalIF":2.4,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/81/59/10.1177_14791641221137736.PMC9643761.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10411730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Monitoring and recovery of hyperglycaemia-induced endothelial dysfunction with rheopheresis in diabetic lower extremity ulceration with hyperviscosity. 糖尿病下肢高粘稠度溃疡伴流变的高血糖诱导内皮功能障碍的监测和恢复。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2022-11-01 DOI: 10.1177/14791641221131788

Kristóf Gál, Georgina Asbóth, Melinda Vass, Attila Bíró, Arnold Markovich, Judit Homoki, Gábor Fidler, Melinda Paholcsek, Zoltán Cziáky, Norbert Németh, Judit Remenyik, Pál Soltész

{"title":"Monitoring and recovery of hyperglycaemia-induced endothelial dysfunction with rheopheresis in diabetic lower extremity ulceration with hyperviscosity.","authors":"Kristóf Gál, Georgina Asbóth, Melinda Vass, Attila Bíró, Arnold Markovich, Judit Homoki, Gábor Fidler, Melinda Paholcsek, Zoltán Cziáky, Norbert Németh, Judit Remenyik, Pál Soltész","doi":"10.1177/14791641221131788","DOIUrl":"https://doi.org/10.1177/14791641221131788","url":null,"abstract":"Aims: Rheopheresis is an extracorporeal haematotherapy that improves haemorheological status by filtering proteins that enhance blood viscosity. It also has anti-inflammatory effects by removing inflammatory cytokines. Our study aims to examine the effects of rheopheresis on the endothelial status in diabetic lower extremity ulceration.Methods: In vitro experiments were performed in a HUVEC model to mimic hyperglycaemic stress. We determined the changes in gene expression levels of IL-6, IL-8, TNF-alpha, endothelin convertase enzyme, ET-1, and NO synthase, as well as the ROS and intracellular GSH levels upon hyperglycaemia. In in vivo studies, two rheopheresis procedures were performed on seven patients with diabetic lower extremity ulceration with hyperviscosity, and we measured the changes in plasma concentrations of ET-1, TXB2, SOD enzyme activity, and extracellular components of the glutathione pool depending on treatments.Results: Our results showed that hyperglycaemia increases endothelial expression of inflammatory cytokines, ET-1, and endothelin convertase enzyme, while NO synthase was decreased. As a result of rheopheresis, we observed decreased ET-1 and TXB2 concentrations in the plasma and beneficial changes in the parameters of the glutathione pool.Conclusion: To summarize our results, hyperglycaemia-induced oxidative stress and endothelial inflammation can be moderated by rheopheresis in diabetic lower extremity ulceration with hyperviscosity.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":" ","pages":"14791641221131788"},"PeriodicalIF":2.4,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b9/55/10.1177_14791641221131788.PMC9661626.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40675962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real life evaluation of sodium-glucose cotransporter 2 inhibition in type 1 diabetes and the risk of diabetic ketoacidosis. 1型糖尿病钠-葡萄糖共转运蛋白2抑制与糖尿病酮症酸中毒风险的现实生活评估

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2022-09-01 DOI: 10.1177/14791641221130043

Elisabeth B Stougaard, Peter L Kristensen, Urd Kielgast, Henrik U Andersen, Yasmin Hamid, Peter H Gæde, Esben Søndergaard, Gry H Dørflinger, Karen K Fjeldborg, Klavs W Hansen, Henrik H Thomsen, Thuraya M J Al-Imar, Michael Røder, Vikas S Sridhar, David Cherney, Peter Rossing, Frederik Persson

{"title":"Real life evaluation of sodium-glucose cotransporter 2 inhibition in type 1 diabetes and the risk of diabetic ketoacidosis.","authors":"Elisabeth B Stougaard, Peter L Kristensen, Urd Kielgast, Henrik U Andersen, Yasmin Hamid, Peter H Gæde, Esben Søndergaard, Gry H Dørflinger, Karen K Fjeldborg, Klavs W Hansen, Henrik H Thomsen, Thuraya M J Al-Imar, Michael Røder, Vikas S Sridhar, David Cherney, Peter Rossing, Frederik Persson","doi":"10.1177/14791641221130043","DOIUrl":"https://doi.org/10.1177/14791641221130043","url":null,"abstract":"Background: The indication for treatment of type 1 diabetes(T1D) with the sodium-glucose cotransporter 2 inhibitor (SGLT2i) dapagliflozin has been withdrawn in Europe likely because of concern for diabetic ketoacidosis (DKA). We calculated the incidence of DKA in people with T1D treated with SGLT2i in Denmark.Methods: Clinical data from adults with T1D in Denmark were collected from nine outpatient clinics. Electronic health records made the search for DKA accurate.Results: From a population of 10.500 we observed 134 people treated with SGLT2i over a total period of 222 patient-years. Of those 72% were female, mean age (SD) was 51.4 (13.6) years and median duration of treatment (median, IQR) with an SGLT2i were 12.0 (6.0-29.0) months. The incidence of DKA was zero%.Conclusion: In 134 people with T1D treated with SGLT2i we found that none of the participants developed DKA during the treatment.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":" ","pages":"14791641221130043"},"PeriodicalIF":2.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e7/67/10.1177_14791641221130043.PMC9585567.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40556699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Mitochondrial mitophagy protection combining rivaroxaban and aspirin in high glucose-exposed human coronary artery endothelial cell. An in vitro study. 利伐沙班联合阿司匹林对高糖暴露人冠状动脉内皮细胞线粒体自噬的保护作用。一项体外研究。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2022-09-01 DOI: 10.1177/14791641221129877

Khaoula Zekri-Nechar, José Javier Zamorano-León, Mercedes Cortina-Gredilla, Ana López-de-Andrés, Rodrigo Jiménez-García, Carlos Navarro-Cuellar, Antonio López-Farré, Carlos Hugo Martínez-Martínez

{"title":"Mitochondrial mitophagy protection combining rivaroxaban and aspirin in high glucose-exposed human coronary artery endothelial cell. An in vitro study.","authors":"Khaoula Zekri-Nechar, José Javier Zamorano-León, Mercedes Cortina-Gredilla, Ana López-de-Andrés, Rodrigo Jiménez-García, Carlos Navarro-Cuellar, Antonio López-Farré, Carlos Hugo Martínez-Martínez","doi":"10.1177/14791641221129877","DOIUrl":"https://doi.org/10.1177/14791641221129877","url":null,"abstract":"Purpose: Combination of Rivaroxaban plus Aspirin improved cardiovascular outcome in patients with stable cardiovascular disease. The aim was to determine if Rivaroxaban and acetylsalicylic acid alone or in combination may protect mitochondrial mitophagy in human coronary artery endothelial cells (HCAEC) exposed to D-glucose.Methods: HCAEC were incubated under different conditions: 5 mmol/L glucose D-glucose (control), 30 mmol/L D-Glucose with and without 50 nmol/L Rivaroxaban (Rivaroxaban), 0.33 mmol/L ASA (ASA) or Rivaroxaban (12.5 nmol/L)+ASA (0.33 mmol/L; (Riva+ASA).Results: HCAEC incubated with D-glucose showed an increased Factor Xa expression. The mitochondrial content of Pink-1 and Parkin were significantly reduced in high glucose-incubated HCAEC compared to control. Rivaroxaban+ASA significantly increased the mitochondrial content of Pink-1 and Parkin, and the mitochondrial membrane potential compared to D-Glucose group. Both ASA alone and Riva+ASA reduced reactive oxygen species (ROS) and tissue factor production induced by high glucose exposure.Conclusion: Under high glucose condition combining Rivaroxaban+ASA increased the mitochondrial content of Pink-1 and Parkin, restored mitochondria membrane potential and reduced ROS and tissue factor expression in HCAEC. It suggests potential effects induced by dual use of Rivaroxaban and ASA on the coronary endothelium subjected to high glucose condition.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":" ","pages":"14791641221129877"},"PeriodicalIF":2.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f9/0a/10.1177_14791641221129877.PMC9578168.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33516887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Triglyceride glucose index is independently associated with aortic intima-media thickness in patients without known atherosclerotic cardiovascular disease or diabetes. 在没有已知动脉粥样硬化性心血管疾病或糖尿病的患者中，甘油三酯葡萄糖指数与主动脉内膜-中膜厚度独立相关。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2022-09-01 DOI: 10.1177/14791641221136203

Süleyman Özbiçer, Gülhan Yüksel, Örsan Deniz Urgun

{"title":"Triglyceride glucose index is independently associated with aortic intima-media thickness in patients without known atherosclerotic cardiovascular disease or diabetes.","authors":"Süleyman Özbiçer, Gülhan Yüksel, Örsan Deniz Urgun","doi":"10.1177/14791641221136203","DOIUrl":"https://doi.org/10.1177/14791641221136203","url":null,"abstract":"Background: The triglyceride-glucose (TyG) index is a reliable marker of insulin resistance. We aimed to investigate the relationship between the TyG index and aortic intima-media thickness (IMT) in individuals without diabetes mellitus and atherosclerotic cardiovascular disease undergoing transoesophageal echocardiography due to suspected structural heart disease.Methods: One hundred twenty-two patients enrolled in the study between January 2021 and June 2021. Patients were divided into two groups according to their median IMT; patients with an IMT equal to or less than 1.42 mm were low IMT group, and higher than 1.42 mm were high IMT group. Triglyceride-glucose index were higher in the high IMT group (8.69 ± 0.59 vs. 8.37 ± 0.53, p = .003).Results: Triglyceride-glucose index was correlated with IMT (r = 0.259, p = .005) and in binary logistic regression analysis age and TyG was independently associated with having high IMT (β = 0.076, exp(B)=1.079 95%CI = 1.041-1.118, p < .001 and β = 0.847, exp(B)= 2.334 95%CI= 1.048-5.199, p = .038, respectively).Conclusion: We found an independent relationship between TyG and IMT of the thoracic aorta, an early marker of subclinical atherosclerosis in patients without known atherosclerotic cardiovascular disease or diabetes. Therefore, the TyG index can identify high-risk subjects in the general population.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"19 5","pages":"14791641221136203"},"PeriodicalIF":2.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/48/9d/10.1177_14791641221136203.PMC9597021.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10403734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Coronary artery calcium score and coronary computed tomography angiography predict one-year mortality in patients with type 2 diabetes and peripheral artery disease undergoing partial foot amputation. 冠状动脉钙化评分和冠状动脉计算机断层扫描血管造影可预测接受部分截肢的 2 型糖尿病和外周动脉疾病患者的一年死亡率。

IF 2.8 4区医学

Diabetes & Vascular Disease Research Pub Date : 2022-09-01 DOI: 10.1177/14791641221125190

Evgeniya Shalaeva, Arjola Bano, Ulugbek Kasimov, Bakhtiyor Janabaev, Iris Baumgartner, Markus Laimer, Hugo Saner

{"title":"Coronary artery calcium score and coronary computed tomography angiography predict one-year mortality in patients with type 2 diabetes and peripheral artery disease undergoing partial foot amputation.","authors":"Evgeniya Shalaeva, Arjola Bano, Ulugbek Kasimov, Bakhtiyor Janabaev, Iris Baumgartner, Markus Laimer, Hugo Saner","doi":"10.1177/14791641221125190","DOIUrl":"10.1177/14791641221125190","url":null,"abstract":"Methods: This is a single-center prospective cohort study including 199 consecutive patients with T2D, PAD (mean age 62.3 ± 7.2 years; 62.8% males), and preoperative CACS and CCTA undergoing PFA and followed-up over 1 year.Results: Over a period of 1 year follow-up, a total of 35 (17.6%) participants died. The area under ROC curve to predict mortality for the CACS was 0.835 (95% CI:0.769-0.900), for CCTA 0.858 (95% CI:0.788-0.927). After adjustment for confounders, compared to no-stenosis on CCTA (reference), the risk of all-cause mortality in non-obstructive coronary atery disease (CAD) increased (HR = 1.38, 95% CI [0.75-12.86], p = .284), 1-vessel obstructive CAD (HR = 8.13, 95% CI [0.87-75.88], p = .066), 2-vessels (HR = 10.94, 95% CI [1.03-115.8], p = .047), and 3-vessels (HR = 45.73, 95% CI [4.6-454.7], p = .001) respectively. Increasing levels of CACS tended to be associated with increased risk of all-cause mortality (HR = 1.002, 95% CI [1.0-1.003], p = .061). 61/95 patients with obstructive CAD underwent coronary revascularization.Conclusions: Coronary artery calcium score and CCTA have a high predictive value for 1-year all-cause mortality in T2D patients undergoing minor amputations and may be considered for preoperative risk assessment allowing timely preventive interventions.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"19 5","pages":"14791641221125190"},"PeriodicalIF":2.8,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10760620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of diabetes on outcomes of cardiogenic shock: A systematic review and meta-analysis. 糖尿病对心源性休克结局的影响：一项系统回顾和荟萃分析。

IF 2.8 4区医学

Diabetes & Vascular Disease Research Pub Date : 2022-09-01 DOI: 10.1177/14791641221132242

Chao Luo, Feng Chen, Lingpei Liu, Zuanmin Ge, Chengzhen Feng, Yuehua Chen

{"title":"Impact of diabetes on outcomes of cardiogenic shock: A systematic review and meta-analysis.","authors":"Chao Luo, Feng Chen, Lingpei Liu, Zuanmin Ge, Chengzhen Feng, Yuehua Chen","doi":"10.1177/14791641221132242","DOIUrl":"10.1177/14791641221132242","url":null,"abstract":"To provide synthesized evidence on the association of diabetes with clinical outcomes of patients with acute myocardial infarction (AMI) and associated cardiogenic shock (CS). We analyzed observational studies on patients with AMI and CS, identified through a systematic search using PubMed and Scopus databases. The main outcome was mortality and other outcomes of interest were risk of major bleeding, re-infarction, cerebrovascular adverse events, and need for revascularization. We conducted the meta-analysis with data from 15 studies. Compared to patients without diabetes, those with diabetes had an increased risk of in-hospital mortality (OR, 1.34; 95% CI, 1.17-1.54) and cerebrovascular complications (OR, 1.28; 95% CI, 1.11-1.48). We found similar risk of major bleeding (OR, 0.68; 95% CI, 0.43-1.09), re-infarction (OR, 0.98; 95% CI, 0.48-1.98) and need for re-vascularization (OR, 0.96; 95% CI, 0.75-1.22) as well as hospital stay lengths (in days) (WMD 0.00; 95% CI, -0.27-0.28; n = 4; I2 = 99.7%) in the two groups of patients. Patients with diabetes, acute MI and associated cardiogenic shock have increased risks of mortality and adverse cerebrovascular events than those without diabetes.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"19 5","pages":"14791641221132242"},"PeriodicalIF":2.8,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cd/f5/10.1177_14791641221132242.PMC9580099.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10471750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shared and specific biological signalling pathways for diabetic retinopathy, peripheral neuropathy and nephropathy by high-throughput sequencing analysis. 通过高通量测序分析糖尿病视网膜病变、周围神经病变和肾病的共享和特异性生物信号通路。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2022-07-01 DOI: 10.1177/14791641221122918

Zhu Hui, Yan-Ming Chen, Wei-Kun Gong, Jing-Bo Lai, Bin-Bin Yao, Zhi-Jia Zhao, Qin-Kang Lu, Ke Ye, Lin-Dan Ji, Jin Xu

{"title":"Shared and specific biological signalling pathways for diabetic retinopathy, peripheral neuropathy and nephropathy by high-throughput sequencing analysis.","authors":"Zhu Hui, Yan-Ming Chen, Wei-Kun Gong, Jing-Bo Lai, Bin-Bin Yao, Zhi-Jia Zhao, Qin-Kang Lu, Ke Ye, Lin-Dan Ji, Jin Xu","doi":"10.1177/14791641221122918","DOIUrl":"https://doi.org/10.1177/14791641221122918","url":null,"abstract":"Objectives: We aimed to explore the shared and specific signalling pathways involved in diabetic retinopathy (DR), diabetic peripheral neuropathy (DPN) and diabetic nephropathy (DN).Methods: Differentially expressed mRNAs and lncRNAs were identified by high-throughput sequencing. Subsequently, functional enrichment analysis, protein-protein interaction (PPI) analysis and lncRNAs-mRNAs networks were conducted to determine the pathogenic mechanisms underlying DR, DPN and DN.Results: Twenty-six biological pathways were shared among DR, DPN and DN groups compared to the type 2 diabetes mellitus (T2DM) group without complications, and most of the shared pathways and core proteins were involved in immune and inflammatory responses of microvascular damage. Cytokine‒cytokine receptor interactions and chemokine signalling pathway were the most significant and specific pathways for DR, and the lncRNA‒mRNA regulatory networks affected DR by targeting these pathways. Sphingolipid metabolism and neuroactive ligand-receptor pathways were found to be specific for the pathogenesis of DPN. Moreover, multiple amino acid metabolic pathways were involved in the occurrence and progression of DN.Conclusions: Diabetic retinopathy, DPN and DN exhibited commonality and heterogeneity simultaneously. The shared pathologic mechanisms underlying these diabetic complications are involved in diabetic microvascular damage via immune and inflammatory pathways. Our findings predict several biomarkers and therapeutic targets for these diabetic complications.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"19 4","pages":"14791641221122918"},"PeriodicalIF":2.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e1/33/10.1177_14791641221122918.PMC9397373.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10424418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3