Glycaemic variability and risk of adverse cardiovascular events in acute coronary syndrome.

IF 2.8 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes & Vascular Disease Research Pub Date : 2022-11-01 DOI:10.1177/14791641221137736

Lei Zhang, Feng Li, Huan-Huan Liu, Zhi-Yuan Zhang, Fan Yang, Ling-Ling Qian, Ru-Xing Wang

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引用次数: 5

Abstract

Objective: The relationship between different glycaemic variability (GV) indexes and adverse cardiovascular outcomes is not well understood. This study aims to determine whether GV is related to the occurrence of adverse cardiovascular events in patients with acute coronary syndrome (ACS).

Methods: PubMed, EMBASE, and Web of Science were comprehensively searched from the establishment of databases to 29 June 2022. The relationship between two important GV indexes, including the mean amplitude of glycemic excursion (MAGE) and standard deviation (SD), and the adverse cardiovascular events in ACS patients were evaluated, respectively.

Results: A total of 11 studies with 3709 ACS patients were included. Pooled results showed that patients with higher GV had significantly increased risk of adverse cardiovascular events, including MAGE (relative risk [RR] = 1.76, 95% CI: 1.40 to 2.22, p < 0.001, I² = 25%) and SD (RR = 2.14, 95% CI: 1.73 to 2.66, p < 0.001, I² = 0%).

Conclusions: Increased GV is related to the poor prognosis in patients with ACS. Additionally, more well-designed studies comparing different indicators of GV with adverse cardiovascular events in ACS patients are still warranted.

Abstract Image

查看原文本刊更多论文

急性冠状动脉综合征的血糖变异性和不良心血管事件的风险。

目的:不同血糖变异性(GV)指数与心血管不良结局之间的关系尚不清楚。本研究旨在确定GV是否与急性冠脉综合征(ACS)患者不良心血管事件的发生有关。方法:综合检索PubMed、EMBASE、Web of Science自建库至2022年6月29日。分别评价血糖漂移平均幅度(MAGE)和标准差(SD)两项重要GV指标与ACS患者心血管不良事件的关系。结果:共纳入11项研究，3709例ACS患者。综合结果显示，GV较高的患者不良心血管事件的风险显著增加，包括MAGE(相对危险度[RR] = 1.76, 95% CI: 1.40 ~ 2.22, p < 0.001, I2 = 25%)和SD (RR = 2.14, 95% CI: 1.73 ~ 2.66, p < 0.001, I2 = 0%)。结论:GV升高与ACS患者预后不良有关。此外，还需要更多精心设计的研究来比较ACS患者GV与不良心血管事件的不同指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes & Vascular Disease Research ENDOCRINOLOGY & METABOLISM-PERIPHERAL VASCULAR DISEASE

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Diabetes & Vascular Disease Research is the first international peer-reviewed journal to unite diabetes and vascular disease in a single title. The journal publishes original papers, research letters and reviews. This journal is a member of the Committee on Publication Ethics (COPE)