Diabetes & Vascular Disease Research最新文献

{"title":"Management of diabetic neuropathy with memantine: A randomized clinical trial.","authors":"Elnaz Jafarzadeh,&nbsp;Samineh Beheshtirouy,&nbsp;Nasser Aghamohammadzadeh,&nbsp;Saba Ghaffary,&nbsp;Parvin Sarbakhsh,&nbsp;Elnaz Shaseb","doi":"10.1177/14791641231191093","DOIUrl":"10.1177/14791641231191093","url":null,"abstract":"<p><strong>Background: </strong>Diabetes patients frequently experience diabetic neuropathy (DN), a microvascular complication that significantly reduces patients' quality of life. Memantine has demonstrated potential benefits for neuropathic pains in preclinical studies. This study aimed to assess the efficacy of memantine in the management of peripheral neuropathy in patients with type 2 diabetes mellitus (T2DM).</p><p><strong>Method: </strong>This randomized clinical trial includes 143 diabetic patients (aged between 18 and 75 years) with a confirmed diagnosis of diabetic neuropathy. Patients were randomly assigned to receive memantine 5 mg twice daily for 1 week, followed by 10 mg twice daily plus gabapentin 300 mg daily (<i>n</i> = 72) or just gabapentin 300 mg daily (<i>n</i> = 71) for 8 weeks. The DN4 questionnaire, monofilament, tuning fork, and Tip-therm tests were used to measure neuropathy at baseline and after the 8-week intervention.</p><p><strong>Results: </strong>The mean score of the DN4 questionnaire in the memantine group was significantly lower than the control group (<i>p</i>. value: .001). The number of patients with diabetic neuropathy remarkably decreased in the memantine group at the end of the study based on the performed tests (<i>p</i>. value: .001).</p><p><strong>Conclusion: </strong>Memantine functions as a beneficial agent in the management of diabetic neuropathy, which would significantly improve the quality of life in diabetic patients.</p>","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"20 4","pages":"14791641231191093"},"PeriodicalIF":2.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7d/90/10.1177_14791641231191093.PMC10387673.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10276096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in cardiovascular burden and mortality among adults with prediabetes in the US, 1999-2018.","authors":"Yi Zhang,&nbsp;Ruodi Lu,&nbsp;Jian Wang,&nbsp;Xingjian Zhang,&nbsp;Xiao Ma","doi":"10.1177/14791641231188704","DOIUrl":"10.1177/14791641231188704","url":null,"abstract":"<p><strong>Background: </strong>Trends in cardiovascular disease (CVD) risk factors and mortality have been reported among US adults with diabetes, but not among those with prediabetes. This study aimed to examine and compare the trends in CVD risk factors and mortality in US adults with diabetes and prediabetes.</p><p><strong>Methods: </strong>In this serial, cross-sectional study, medical records of prediabetic patients from the National Health and Nutrition Examination Survey (NHANES) among adults aged 18 years or older were retrospectively reviewed.</p><p><strong>Results: </strong>Data on 17,193 individuals including 7803 with diabetes and 9390 with prediabetes were analyzed from 1999-2000 to 2017-2018. A similar non-linear trend in the mean blood pressure (<i>p</i> = .991) and plasma fasting glucose (<i>p</i> = .068) was observed among the population with diabetes and prediabetes. The mean hemoglobin A1c decreased from 7.5% to 7.1% in diabetes and the trend was different from that in prediabetes (<i>p</i> = .004). Among both groups, a significant decline in the mean total cholesterol was identified while there was a difference in the trend (<i>p</i> = .003). The prevalence of hypertension remained largely the same for diabetes and it declined from 59.8% to 48.8% for prediabetes (<i>p</i> = .044). The prevalence of dyslipidemia increased from 40.4% to 53.5% in diabetes and it remained stable for prediabetes. The all-cause mortality decreased from 148.2 to 93.6 per 10,000 person-years between 1999-2006 and 2007-2014 in prediabetes and heart diseases mortality remained unchanged.</p><p><strong>Conclusion: </strong>In the US from 1999 to 2018, the adults with prediabetes had different secular trends in the mean hemoglobin A1c and the prevalence of hypertension and dyslipidemia compared to those with diabetes. There was a significant reduction in all-cause mortality from 1999 to 2014 for the population with prediabetes. However, heart diseases mortality remained stable among them.</p>","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"20 4","pages":"14791641231188704"},"PeriodicalIF":2.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fb/55/10.1177_14791641231188704.PMC10408320.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9964647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dapagliflozin attenuates cardiac remodeling and dysfunction in rats with β-adrenergic receptor overactivation through restoring calcium handling and suppressing cardiomyocyte apoptosis.","authors":"Tao Liu, Jinchun Wu, Shaobo Shi, Bo Cui, Feng Xiong, Shuang Yang, Min Yan","doi":"10.1177/14791641231197106","DOIUrl":"10.1177/14791641231197106","url":null,"abstract":"<p><p><b>Background:</b> Long-term β-adrenergic receptor (β-AR) activation can impair myocardial structure and function. Dapagliflozin (DAPA) has been reported to improve clinical prognosis in heart failure patients, whereas the exact mechanism remains unclear. Here, we investigated the effects of DAPA against β-AR overactivation toxicity and explored the underlying mechanism.<b>Methods and Results:</b> Rats were randomized to receive saline + placebo, isoproterenol (ISO, 5 mg/kg/day, intraperitoneally) + placebo, or ISO + DAPA (1 mg/kg/day, intragastrically) for 2-week. DAPA treatment improved cardiac function, alleviated myocardial fibrosis, prevented cardiomyocytes (CMs) apoptosis, and decreased the expression of ER stress-mediated apoptosis markers in ISO-treated hearts. In isolated CMs, 2-week ISO stimulation resulted in deteriorated kinetics of cellular contraction and relaxation, increased diastolic intracellular Ca²⁺ level and decay time constant of Ca²⁺ transient (CaT) but decreased CaT amplitude and sarcoplasmic reticulum (SR) Ca²⁺ level. However, DAPA treatment prevented abnormal Ca²⁺ handling and contractile dysfunction in CMs from ISO-treated hearts. Consistently, DAPA treatment upregulated the expression of SR Ca²⁺-ATPase protein and ryanodine receptor 2 (RyR2) but reduced the expression of phosphorylated-RyR2, Ca²⁺/calmodulin-dependent protein kinase II (CaMKII), and phosphorylated-CaMKII in ventricles from ISO-treated rats.<b>Conclusion:</b> DAPA prevented myocardial remodeling and cardiac dysfunction in rats with β-AR overactivation via restoring calcium handling and suppressing ER stress-related CMs apoptosis.</p>","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"20 4","pages":"14791641231197106"},"PeriodicalIF":2.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1b/d0/10.1177_14791641231197106.PMC10437211.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10048842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Arterial stiffness is not associated with changes in the circadian pattern of blood pressure in patients with type 1 diabetes mellitus and cardiovascular autonomic dysfunction\".","authors":"Lía Nattero-Chávez,&nbsp;Ane Bayona Cebada,&nbsp;Elena Fernández-Durán,&nbsp;Alejandra Quintero Tobar,&nbsp;Beatriz Dorado Avendaño,&nbsp;Héctor Escobar-Morreale,&nbsp;Manuel Luque-Ramírez","doi":"10.1177/14791641231173621","DOIUrl":"https://doi.org/10.1177/14791641231173621","url":null,"abstract":"<p><strong>Introduction: </strong>Cardiovascular autonomic neuropathy (CAN) associates an abnormal circadian pattern in blood pressure (BP) regulation that might be aggravated by the coexistence of arterial stiffness. We aimed to evaluate the effect of arterial stiffness in the circadian rhythm of BP in patients with type 1 diabetes and CAN.</p><p><strong>Methods: </strong>Cross-sectional study including 56 consecutive patients with type 1 diabetes and CAN, with (<i>n</i> = 28) or without (<i>n</i> = 24) arterial stiffness as defined by an ankle-brachial index above 1.2. CAN was diagnosed by BP and heart rate responses to active standing and cardiovascular autonomic reflex tests. Absence of nocturnal decrease in BP-\"<i>non-dipping</i>\" pattern- was defined by a daytime to nighttime decrease in mean BP smaller than 10%.</p><p><strong>Results: </strong>The study's subjects mean age was 40 ± 11 years-old, their mean duration of diabetes was 22 ± 10 years, and their mean A_1c was 7.9 ± 1.5%. A \"<i>non-dipping</i>\" pattern was observed in 28 patients (54%) regardless of the presence or absence of arterial stiffness. Age, waist circumference, body mass index, and A_1c, were introduced as independent variables into a multiple regression analysis. The stepwise model (<i>R</i>²: 0.113, <i>p</i> = 0.016) retained only A_1c levels (β: ‒ 0.333, 95% confidence interval [CI]: -3.10 to -0.33) as significant predictor of the percentage of nighttime decrease in mean BP.</p><p><strong>Conclusions: </strong>A <i>non-dipping</i> pattern in BP is very common in patients with type 1 diabetes presenting with subclinical CAN and is associated with a poorer metabolic control. On the contrary, coexistence of arterial stiffness is not associated with abnormalities in circadian BP regulation.</p>","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"20 3","pages":"14791641231173621"},"PeriodicalIF":2.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/04/cd/10.1177_14791641231173621.PMC10192811.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9729388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TyG-BMI and hypertension in Normoglycemia subjects in Japan: A cross-sectional study.","authors":"Xinming Huang,&nbsp;Jiacheng He,&nbsp;Guoxin Wu,&nbsp;Zishu Peng,&nbsp;Bin Yang,&nbsp;Langxi Ye","doi":"10.1177/14791641231173617","DOIUrl":"https://doi.org/10.1177/14791641231173617","url":null,"abstract":"<p><strong>Background: </strong>Insulin Resistance (IR) are associated with Hypertension (HTN). Triglyceride glucose-body mass index (TyG-BMI) is a readily available and clinically significant indicator of IR. This study aimed to investigate whether TyG-BMI is independently associated with HTN.</p><p><strong>Methods: </strong>A total of 15,464 patients with normal blood glucose from 2004 to 2016 participated in this study. Participants were divided into four groups using the quartile method: TyG-BMI below 153.1, between 153.1 and 174.2, between 174.2 and 199.3, and over 199.3. The covariates included age, sex, BMI, WC, HDL-C, TC, TG, HbA1c, FPG, ALT, AST, GGT, SBP, DBP, smoking status, alcohol consumption, and exercise habits.</p><p><strong>Results: </strong>The average age was 43.7 ± 8.9 years, and 45.4% were men. The prevalence of HTN was 6.2% (964/15464) of the population. TyG-BMI remained significantly associated with HTN after multivariate adjustment for TyG-BMI as a continuous variable (adjusted OR = 2.87, 95% CI: 1.90-4.34). Each 10-unit rise in TyG-BMI (continuous variable) was linked to a 31% increase in the prevalence of HTN (adjusted OR = 1.31, 95% CI: 1.25-1.37). In the subgroup analysis stratified by age, sex, waist circumference, and smoking status, the association between TyG-BMI and HTN were stable.</p><p><strong>Conclusion: </strong>In this study, TyG-BMI was highly correlated with HTN, but more experiments and different populations are needed to verify this.</p>","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"20 3","pages":"14791641231173617"},"PeriodicalIF":2.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5a/c3/10.1177_14791641231173617.PMC10201169.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9673456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of microvascular structural changes in the gestational diabetic placenta.","authors":"Xinyan Liang,&nbsp;Jiaqi Zhang,&nbsp;Yu Wang,&nbsp;You Wu,&nbsp;Hui Liu,&nbsp;Wei Feng,&nbsp;Ziyi Si,&nbsp;Ruige Sun,&nbsp;Zizhou Hao,&nbsp;Hongzhi Guo,&nbsp;Xue Li,&nbsp;Tao Xu,&nbsp;Mofeng Wang,&nbsp;Zhen Nan,&nbsp;Yang Lv,&nbsp;Xinan Shang","doi":"10.1177/14791641231173627","DOIUrl":"https://doi.org/10.1177/14791641231173627","url":null,"abstract":"<p><strong>Aims: </strong>Microvascular morphology and pathological changes in gestational diabetes mellitus (GDM) placentas and normal placentas were observed via vascular casting technology, electron microscopy, and pathological detection technology. Vascular structure and histological morphology changes in GDM placentas were examined to generate basic experimental data for the diagnosis and prognostic determination of GDM.</p><p><strong>Methods: </strong>This case-control study involving 60 placentas, 30 from healthy controls and 30 from patients with GDM. Differences in size, weight, volume, umbilical cord diameter, and gestational age were assessed. Histological changes in the placentas in the two groups were analyzed and compared. A placental vessel casting model was constructed using a self-setting dental powder technique, to compare the two groups. The placental cast microvessels of the two groups were compared using scanning electron microscopy.</p><p><strong>Results: </strong>There were no significant differences in maternal age or gestational age between the GDM group and the control group (<i>p</i> > .05). The size, weight, volume, and thickness of the placentas in the GDM group were significantly greater than those in the control group, as was umbilical cord diameter (<i>p</i> < .05). Immature villus, fibrinoid necrosis, calcification, and vascular thrombosis were significantly greater in the placental mass in the GDM group (<i>p</i> < .05). The terminal branches of the microvessels in diabetic placenta casts were sparse, with significantly fewer ends and lower villous volume (<i>p</i> < .05).</p><p><strong>Conclusion: </strong>Gestational diabetes can cause gross and histological changes in the placenta, particularly placental microvascular changes.</p>","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"20 3","pages":"14791641231173627"},"PeriodicalIF":2.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5d/23/10.1177_14791641231173627.PMC10192807.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9673444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycemic control and outcome after carotid intervention in patients with T2D: A Swedish nationwide cohort study.","authors":"Alexander Zabala,&nbsp;Anders Gottsäter,&nbsp;Marcus Lind,&nbsp;Björn Eliasson,&nbsp;Rebecka Bertilsson,&nbsp;Jan Ekelund,&nbsp;Magnus Jonsson,&nbsp;Thomas Nyström","doi":"10.1177/14791641231176767","DOIUrl":"https://doi.org/10.1177/14791641231176767","url":null,"abstract":"<p><strong>Aims: </strong>To investigate the association between glycemic control and outcome in people with type 2 diabetes (T2D) after carotid intervention due to carotid stenosis.</p><p><strong>Methods: </strong>Observational nationwide population-based cohort study using inverse probability treatment weighting (IPTW) and Cox regressions with covariates, that is, 4 stepwise models, investigating the relationship between terciles of glycated hemoglobin (HbA1c) levels and stroke or death.</p><p><strong>Results: </strong>1115 subjects with T2D undergoing carotid intervention were included during Jan 1st 2009 to Dec 31st 2015. Divided into terciles, with a mean HbA1c level of 44 (tercile 1), 53 (tercile 2), and 72 (tercile 3) mmol/mol. By using IPTW and Cox regression, each model was stepwise introduced for the investigating of relative risks, that is, hazard ratios (HRs) with associated 95% confidence intervals (CI). There was a significant increased risk for stroke or death, in every model observed for tercile 3, compared to tercile 1: HR for model 4: 1.35 (95% CI 1.02-1.78). No difference for stroke or death within 30 days was observed between the groups.</p><p><strong>Conclusion: </strong>Poor glycemic control in people with T2D after carotid intervention is associated with an increased long-term risk for stroke or death.</p>","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"20 3","pages":"14791641231176767"},"PeriodicalIF":2.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9700980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health care registers can be instrumental for endpoint capture in clinical diabetes trials: example of microvascular complications in Swedish patients with type 2 diabetes.","authors":"Martin H Lundqvist,&nbsp;Vagia Patsoukaki,&nbsp;Stefan Jansson,&nbsp;Henrietta Norman,&nbsp;Elisabet Granstam,&nbsp;Maria K Svensson,&nbsp;Johan Sundström,&nbsp;Björn Eliasson,&nbsp;Jan W Eriksson","doi":"10.1177/14791641231179878","DOIUrl":"https://doi.org/10.1177/14791641231179878","url":null,"abstract":"<p><strong>Aims: </strong>SMARTEST is a register-based randomized clinical trial (RRCT) that compares dapagliflozin to metformin in early-stage type 2 diabetes. The primary outcome includes progression of microvascular complications based on data from the Swedish National Diabetes Register (NDR). In this sub-study, the aim was to validate microvascular complication variables in the NDR against electronic health records (EHRs).</p><p><strong>Methods: </strong>Data were extracted from EHRs of 276 SMARTEST participants with a median observation period of 3 years in the Uppsala, Örebro and Sörmland counties and compared with NDR data. Agreement was determined for all corresponding data entries as well as for progression of microvascular complications after randomization.</p><p><strong>Results: </strong>The agreement for all corresponding data entries was 98.9% (Intraclass Correlation Coefficient 0.999) for creatinine and eGFR, 95.1% for albuminuria, 91.6% for foot-at-risk and 98.2% for retinopathy status (Kappa 0.67-0.91). The agreement for progression of microvascular complications was 98.0% for CKD stage, 98.9% for albuminuria grade, 96.3% for foot-at-risk grade and 99.6% for retinopathy grade progression (Gwet's AC₁ 0.96-1.00).</p><p><strong>Conclusion: </strong>Microvascular complication variables in the NDR show good agreement with EHR data. The use of a well-established national health care registry, exemplified by the NDR, for endpoint collection in RRCTs such as SMARTEST is supported by this study.</p>","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"20 3","pages":"14791641231179878"},"PeriodicalIF":2.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9707554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can prediabetes diagnosed using HemoglobinA1c or oral glucose tolerance test predict presence and severity of coronary artery disease in symptomatic patients?","authors":"Katrine S Overgaard, Thomas R Andersen, Roda A Mohamed, Laurits J Heinsen, Helle G Binderup, Sören Möller, Søren Auscher, Jess Lambrechtsen, Kenneth Egstrup","doi":"10.1177/14791641231179870","DOIUrl":"10.1177/14791641231179870","url":null,"abstract":"<p><p>We investigated whether prediabetes diagnosed by hemoglobinA1c (HbA1c) or oral glucose tolerance test (OGTT) could predict presence and severity of coronary artery disease (CAD) in symptomatic patients. The presence of plaque, stenosis, plaque characteristics, and coronary artery calcium (CAC) were evaluated by coronary CT angiography in 702 patients with suspicion of CAD. Patients were classified by glycemic status using the American Diabetes Association criteria for HbA1c and OGTT, and compared to their respective normal ranges. Prediabetes was observed in 24% by HbA1c and 72% by OGTT. Both prediabetes classifications were associated with increased presence of plaque, stenosis, calcified plaques, CAC >400, and a lower frequency of zero CAC compared to their respective normal range (all, <i>p</i> < 0.05). After adjusting for potential confounders, patients with HbA1c-prediabetes had an odds ratio of 2.1 (95% CI: 1.3-3.5) for CAC >400 and 1.5 (95% CI: 1.0-2.4) for plaque presence, while none of the associations for OGTT-prediabetes were significant. The receiver operating characteristic-curve for HbA1c-prediabetes showed an area under the curve of 0.81 for CAC >400 and 0.77 for plaque presence. Prediabetes defined by HbA1c predicts presence and severity of CAD. Although OGTT identified more patients with prediabetes, their risk of CAD were not explained by prediabetes using these diagnostic-criteria.</p>","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"20 3","pages":"14791641231179870"},"PeriodicalIF":2.8,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7d/dd/10.1177_14791641231179870.PMC10288424.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10068410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in metabolic indicators and microvascular complications in Chinese adults with newly diagnosed type 2 diabetes: A retrospective, single-centre study of twenty-years.","authors":"Lintao Shi,&nbsp;Jing Xue,&nbsp;Weibo Zhao,&nbsp;Yuxia Cheng,&nbsp;Jianjun Wang,&nbsp;Zhangrong Xu,&nbsp;Aihong Wang","doi":"10.1177/14791641231179867","DOIUrl":"https://doi.org/10.1177/14791641231179867","url":null,"abstract":"<p><strong>Background: </strong>The purpose of this study is to assess metabolic indicators and trends in microvascular complications among Chinese adults with newly diagnosed type 2 diabetes during 2000-2020.</p><p><strong>Methods: </strong>3,907 patients were included and divided into three groups according to a time period of 7 years. This study analyzed trends in proportions of patients reached therapeutic targets of blood glucose, pressure and lipids, and trends in albuminuria, retinopathy, and peripheral neuropathy.</p><p><strong>Results: </strong>In the past 20 years, the age of adults with newly diagnosed type 2 diabetes tended to be younger, and the proportion of female patients increased. There seemed no improvements in blood glucose and pressure. The rate of awareness and treatment on target of hypertension was less than 50%. There was a significant decrease in the prevalence of retinopathy, but no changes in nephropathy or peripheral neuropathy. Complications were more common for patients who were smoker, male, or with hypertension and obesity.</p><p><strong>Conclusions: </strong>Over the past two decades, there have been encouraging reductions in retinopathy in Chinese adults with newly diagnosed diabetes, but no significant change in albuminuria and peripheral neuropathy. It may be related to the low awareness of diabetes and insufficient controlled blood glucose, pressure and lipids on target.</p>","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"20 3","pages":"14791641231179867"},"PeriodicalIF":2.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/02/10.1177_14791641231179867.PMC10272657.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9645345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}