Glycemic control and outcome after carotid intervention in patients with T2D: A Swedish nationwide cohort study.

IF 2.8 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes & Vascular Disease Research Pub Date : 2023-05-01 DOI:10.1177/14791641231176767

Alexander Zabala, Anders Gottsäter, Marcus Lind, Björn Eliasson, Rebecka Bertilsson, Jan Ekelund, Magnus Jonsson, Thomas Nyström

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引用次数: 0

Abstract

Aims: To investigate the association between glycemic control and outcome in people with type 2 diabetes (T2D) after carotid intervention due to carotid stenosis.

Methods: Observational nationwide population-based cohort study using inverse probability treatment weighting (IPTW) and Cox regressions with covariates, that is, 4 stepwise models, investigating the relationship between terciles of glycated hemoglobin (HbA1c) levels and stroke or death.

Results: 1115 subjects with T2D undergoing carotid intervention were included during Jan 1st 2009 to Dec 31st 2015. Divided into terciles, with a mean HbA1c level of 44 (tercile 1), 53 (tercile 2), and 72 (tercile 3) mmol/mol. By using IPTW and Cox regression, each model was stepwise introduced for the investigating of relative risks, that is, hazard ratios (HRs) with associated 95% confidence intervals (CI). There was a significant increased risk for stroke or death, in every model observed for tercile 3, compared to tercile 1: HR for model 4: 1.35 (95% CI 1.02-1.78). No difference for stroke or death within 30 days was observed between the groups.

Conclusion: Poor glycemic control in people with T2D after carotid intervention is associated with an increased long-term risk for stroke or death.

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t2dm患者颈动脉干预后的血糖控制和预后:瑞典全国队列研究

目的:探讨2型糖尿病(T2D)患者颈动脉狭窄介入治疗后血糖控制与预后的关系。方法:采用逆概率治疗加权法(IPTW)和带协变量的Cox回归，即4个逐步模型，观察全国人群队列研究，探讨糖化血红蛋白(HbA1c)水平与卒中或死亡的关系。结果:2009年1月1日至2015年12月31日共纳入1115例接受颈动脉介入治疗的T2D患者。HbA1c平均水平为44 (tercile 1)、53 (tercile 2)、72 (tercile 3) mmol/mol。通过IPTW和Cox回归，逐步引入每个模型来调查相对风险，即风险比(hr)和相关的95%置信区间(CI)。在观察到的每个模型中，与模型1相比，模型3的卒中或死亡风险显著增加:模型4的HR为1.35 (95% CI 1.02-1.78)。30天内中风或死亡在两组之间没有差异。结论:T2D患者颈动脉介入治疗后血糖控制不良与卒中或死亡的长期风险增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes & Vascular Disease Research ENDOCRINOLOGY & METABOLISM-PERIPHERAL VASCULAR DISEASE

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Diabetes & Vascular Disease Research is the first international peer-reviewed journal to unite diabetes and vascular disease in a single title. The journal publishes original papers, research letters and reviews. This journal is a member of the Committee on Publication Ethics (COPE)