TyG-BMI and hypertension in Normoglycemia subjects in Japan: A cross-sectional study.

IF 2.8 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes & Vascular Disease Research Pub Date : 2023-05-01 DOI:10.1177/14791641231173617

Xinming Huang, Jiacheng He, Guoxin Wu, Zishu Peng, Bin Yang, Langxi Ye

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引用次数: 0

Abstract

Background: Insulin Resistance (IR) are associated with Hypertension (HTN). Triglyceride glucose-body mass index (TyG-BMI) is a readily available and clinically significant indicator of IR. This study aimed to investigate whether TyG-BMI is independently associated with HTN.

Methods: A total of 15,464 patients with normal blood glucose from 2004 to 2016 participated in this study. Participants were divided into four groups using the quartile method: TyG-BMI below 153.1, between 153.1 and 174.2, between 174.2 and 199.3, and over 199.3. The covariates included age, sex, BMI, WC, HDL-C, TC, TG, HbA1c, FPG, ALT, AST, GGT, SBP, DBP, smoking status, alcohol consumption, and exercise habits.

Results: The average age was 43.7 ± 8.9 years, and 45.4% were men. The prevalence of HTN was 6.2% (964/15464) of the population. TyG-BMI remained significantly associated with HTN after multivariate adjustment for TyG-BMI as a continuous variable (adjusted OR = 2.87, 95% CI: 1.90-4.34). Each 10-unit rise in TyG-BMI (continuous variable) was linked to a 31% increase in the prevalence of HTN (adjusted OR = 1.31, 95% CI: 1.25-1.37). In the subgroup analysis stratified by age, sex, waist circumference, and smoking status, the association between TyG-BMI and HTN were stable.

Conclusion: In this study, TyG-BMI was highly correlated with HTN, but more experiments and different populations are needed to verify this.

Abstract Image

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日本正常血糖受试者的TyG-BMI和高血压:一项横断面研究。

背景:胰岛素抵抗(IR)与高血压(HTN)相关。甘油三酯葡萄糖-体重指数(TyG-BMI)是一种容易获得且具有临床意义的IR指标。本研究旨在探讨TyG-BMI是否与HTN独立相关。方法:2004 - 2016年共15464例血糖正常的患者参与本研究。使用四分位数法将参与者分为四组:TyG-BMI低于153.1，在153.1至174.2之间，在174.2至199.3之间，以及超过199.3。协变量包括年龄、性别、BMI、WC、HDL-C、TC、TG、HbA1c、FPG、ALT、AST、GGT、收缩压、舒张压、吸烟状况、饮酒和运动习惯。结果:平均年龄43.7±8.9岁，男性占45.4%。HTN患病率为6.2%(964/15464)。将TyG-BMI作为连续变量进行多因素调整后，TyG-BMI仍与HTN显著相关(调整后OR = 2.87, 95% CI: 1.90-4.34)。TyG-BMI(连续变量)每增加10个单位与HTN患病率增加31%相关(调整OR = 1.31, 95% CI: 1.25-1.37)。在按年龄、性别、腰围和吸烟状况分层的亚组分析中，TyG-BMI与HTN之间的关联是稳定的。结论:在本研究中，TyG-BMI与HTN高度相关，但需要更多的实验和不同的人群来验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes & Vascular Disease Research ENDOCRINOLOGY & METABOLISM-PERIPHERAL VASCULAR DISEASE

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Diabetes & Vascular Disease Research is the first international peer-reviewed journal to unite diabetes and vascular disease in a single title. The journal publishes original papers, research letters and reviews. This journal is a member of the Committee on Publication Ethics (COPE)