Current opinion in virology最新文献_第9页

The enigmatic roles of Anelloviridae and Redondoviridae in humans 无绒病毒科和红多病毒科在人类中的神秘作用

IF 5.9 2区医学

Current opinion in virology Pub Date : 2022-08-01 DOI: 10.1016/j.coviro.2022.101248

Louis J Taylor , Emma L Keeler , Frederic D Bushman , Ronald G Collman

引用次数: 10

Editorial overview: Viral pathogenesis 编辑概述:病毒的发病机制

IF 5.9 2区医学

Current opinion in virology Pub Date : 2022-08-01 DOI: 10.1016/j.coviro.2022.101253

Antonio Bertoletti , Matteo Iannacone

引用次数: 0

Editorial overview: Anti-viral strategies: Human antibody immune response and antibody-based therapy against viruses 编辑概述:抗病毒策略:人类抗体免疫反应和基于抗体的病毒治疗

IF 5.9 2区医学

Current opinion in virology Pub Date : 2022-08-01 DOI: 10.1016/j.coviro.2022.101247

Qiao Wang, Zhong Huang

引用次数: 0

Lying low-chromatin insulation in persistent DNA virus infection 持续性DNA病毒感染中的低染色质绝缘

IF 5.9 2区医学

Current opinion in virology Pub Date : 2022-08-01 DOI: 10.1016/j.coviro.2022.101257

Christy S Varghese, Joanna L Parish, Jack Ferguson

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引用次数: 2

Immunotherapy for KSHV-associated diseases kshv相关疾病的免疫治疗

IF 5.9 2区医学

Current opinion in virology Pub Date : 2022-08-01 DOI: 10.1016/j.coviro.2022.101249

Kathryn Lurain, Robert Yarchoan, Ramya Ramaswami

引用次数: 4

Broadly neutralizing antibodies against HIV-1 and concepts for application 抗HIV-1的广泛中和抗体及其应用概念

IF 5.9 2区医学

Current opinion in virology Pub Date : 2022-06-01 DOI: 10.1016/j.coviro.2022.101211

Henning Gruell , Philipp Schommers

引用次数: 13

Emerging technologies in the study of the virome 病毒研究中的新兴技术。

IF 5.9 2区医学

Current opinion in virology Pub Date : 2022-06-01 DOI: 10.1016/j.coviro.2022.101231

Sophie E Smith , Wanqi Huang , Kawtar Tiamani , Magdalena Unterer , Mohammadali Khan Mirzaei , Li Deng

{"title":"Emerging technologies in the study of the virome","authors":"Sophie E Smith , Wanqi Huang , Kawtar Tiamani , Magdalena Unterer , Mohammadali Khan Mirzaei , Li Deng","doi":"10.1016/j.coviro.2022.101231","DOIUrl":"10.1016/j.coviro.2022.101231","url":null,"abstract":"<div><p>Despite the growing interest in the microbiome in recent years, the study of the virome, the major part of which is made up of bacteriophages, is relatively underdeveloped compared with their bacterial counterparts. This is due in part to the lack of a universally conserved marker such as the 16S rRNA gene. For this reason, the development of metagenomic approaches was a major milestone in the study of the viruses in the microbiome or virome. However, it has become increasingly clear that these wet-lab methods have not yet been able to detect the full range of viruses present, and our understanding of the composition of the virome remains incomplete. In recent years, a range of new technologies has been developed to further our understanding. Direct RNA-Seq technologies bypass the need for cDNA synthesis, thus avoiding biases subjected to this step, which further expands our understanding of RNA viruses. The new generation of amplification methods could solve the low biomass issue relevant to most virome samples while reducing the error rate and biases caused by whole genome amplification. The application of long-read sequencing to virome samples can resolve the shortcomings of short-read sequencing in generating complete viral genomes and avoid the biases introduced by the assembly. Novel experimental methods developed to measure viruses' host range can help overcome the challenges of assigning hosts to many phages, specifically unculturable ones.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":"54 ","pages":"Article 101231"},"PeriodicalIF":5.9,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1879625722000402/pdfft?md5=942c14c91b8ff050f65841d391a117ad&pid=1-s2.0-S1879625722000402-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43593351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

The enigma of picobirnaviruses: viruses of animals, fungi, or bacteria? 小核糖核酸病毒之谜:动物病毒、真菌病毒还是细菌病毒?

IF 5.9 2区医学

Current opinion in virology Pub Date : 2022-06-01 DOI: 10.1016/j.coviro.2022.101232

David Wang

{"title":"The enigma of picobirnaviruses: viruses of animals, fungi, or bacteria?","authors":"David Wang","doi":"10.1016/j.coviro.2022.101232","DOIUrl":"10.1016/j.coviro.2022.101232","url":null,"abstract":"<div><p>Picobirnaviruses are small double-stranded RNA viruses first discovered in 1988 in stool samples from patients with diarrhea. It has generally been assumed that picobirnaviruses infect animal hosts and that they are potential agents of diarrhea, but there is still no direct evidence demonstrating that picobirnaviruses infect animals. In the metagenomic era, virome studies have broadened our understanding of picobirnavirus genetic diversity and genome organization, expanded the types of animals in which they have been detected, and identified novel associations with human disease. Most importantly, from the wealth of new sequencing data and comparative genomic analyses, a provocative new hypothesis has emerged that picobirnaviruses may not infect animals, but rather that they may infect evolutionarily simpler denizens of the gastrointestinal tract: bacteria and/or fungi. Depending on whether the true hosts of picobirnaviruses are animals, fungi, or bacteria, the mechanisms by which they impact animal biology will vary dramatically.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":"54 ","pages":"Article 101232"},"PeriodicalIF":5.9,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1879625722000414/pdfft?md5=0345c0a13c88835a50839bb83c1cf145&pid=1-s2.0-S1879625722000414-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42959344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Asymmetry in icosahedral viruses 二十面体病毒的不对称性。

IF 5.9 2区医学

Current opinion in virology Pub Date : 2022-06-01 DOI: 10.1016/j.coviro.2022.101230

Joyce Jose , Susan L. Hafenstein

引用次数: 3

Editorial overview: 2022 “Virus–Host Interaction” section of Current Opinion in Virology 编辑概述:2022年《病毒学时事评论》“病毒-宿主相互作用”部分

IF 5.9 2区医学

Current opinion in virology Pub Date : 2022-06-01 DOI: 10.1016/j.coviro.2022.101229

Michaela U Gack , Susan C Baker

引用次数: 0