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The enigma of picobirnaviruses: viruses of animals, fungi, or bacteria? 小核糖核酸病毒之谜:动物病毒、真菌病毒还是细菌病毒?
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2022-06-01 DOI: 10.1016/j.coviro.2022.101232
David Wang
{"title":"The enigma of picobirnaviruses: viruses of animals, fungi, or bacteria?","authors":"David Wang","doi":"10.1016/j.coviro.2022.101232","DOIUrl":"10.1016/j.coviro.2022.101232","url":null,"abstract":"<div><p>Picobirnaviruses are small double-stranded RNA viruses first discovered in 1988 in stool samples from patients with diarrhea. It has generally been assumed that picobirnaviruses infect animal hosts and that they are potential agents of diarrhea, but there is still no direct evidence demonstrating that picobirnaviruses infect animals. In the metagenomic era, virome studies have broadened our understanding of picobirnavirus genetic diversity and genome organization, expanded the types of animals in which they have been detected, and identified novel associations with human disease. Most importantly, from the wealth of new sequencing data and comparative genomic analyses, a provocative new hypothesis has emerged that picobirnaviruses may not infect animals, but rather that they may infect evolutionarily simpler denizens of the gastrointestinal tract: bacteria and/or fungi. Depending on whether the true hosts of picobirnaviruses are animals, fungi, or bacteria, the mechanisms by which they impact animal biology will vary dramatically.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1879625722000414/pdfft?md5=0345c0a13c88835a50839bb83c1cf145&pid=1-s2.0-S1879625722000414-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42959344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Asymmetry in icosahedral viruses 二十面体病毒的不对称性。
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2022-06-01 DOI: 10.1016/j.coviro.2022.101230
Joyce Jose , Susan L. Hafenstein
{"title":"Asymmetry in icosahedral viruses","authors":"Joyce Jose ,&nbsp;Susan L. Hafenstein","doi":"10.1016/j.coviro.2022.101230","DOIUrl":"10.1016/j.coviro.2022.101230","url":null,"abstract":"<div><p><span><span>Asymmetric structural elements are typically not readily visualized in icosahedral viruses that have other obvious symmetrical features and most asymmetry has gone unresolved for decades. Asymmetric features may be incorporated during assembly or maturation or develop during key steps in the infectious cycle of the virus. However, resolving asymmetric features requires abandoning capsid-wide symmetry averaging and relying on special applications during single-particle cryogenic </span>electron microscopy (cryo-EM) analysis. Thanks to the advances in the cryo-EM field, we are learning more about asymmetry of viruses. Here we summarize some of what is currently known about asymmetric structural features using as examples members of the </span><span><span><em>Togaviridae</em><em>, </em></span><em>Flaviviridae</em><span><em>, </em><em>Herpesviridae</em><span><em>, </em><em>Parvoviridae</em></span></span></span>, <span><em>and </em><em>Papillomaviridae</em></span>.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46270565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Editorial overview: 2022 “Virus–Host Interaction” section of Current Opinion in Virology 编辑概述:2022年《病毒学时事评论》“病毒-宿主相互作用”部分
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2022-06-01 DOI: 10.1016/j.coviro.2022.101229
Michaela U Gack , Susan C Baker
{"title":"Editorial overview: 2022 “Virus–Host Interaction” section of Current Opinion in Virology","authors":"Michaela U Gack ,&nbsp;Susan C Baker","doi":"10.1016/j.coviro.2022.101229","DOIUrl":"10.1016/j.coviro.2022.101229","url":null,"abstract":"","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1879625722000384/pdfft?md5=3399a765bf2acc865556f6125d2df4bb&pid=1-s2.0-S1879625722000384-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41803183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The road to effective and accessible antibody therapies against Ebola virus 通往有效和可获得的埃博拉病毒抗体疗法之路
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2022-06-01 DOI: 10.1016/j.coviro.2022.101210
Hugues Fausther-Bovendo , Gary Kobinger
{"title":"The road to effective and accessible antibody therapies against Ebola virus","authors":"Hugues Fausther-Bovendo ,&nbsp;Gary Kobinger","doi":"10.1016/j.coviro.2022.101210","DOIUrl":"10.1016/j.coviro.2022.101210","url":null,"abstract":"<div><p>Ebola virus (EBOV) outbreaks can claim thousands of lives, cripple healthcare systems and local economies. Effective vaccines and treatments against EBOV are therefore needed to limit the impact of this deadly disease. In 2019, a hallmark clinical trial demonstrated the efficacy of monoclonal antibody (mAb) against EBOV. Despite, this recent success, survival of individuals with high viremia remains low. Effective immunotherapies against other Ebolavirus species are still under pre-clinical development. More importantly, the cost of immunotherapies is prohibitive to most individual and affected countries. Novel manufacturing and administration strategies of mAb protein or genetic information could substantially reduce the cost of immunotherapies; hence making them valuable tools against EBOV and other infectious agents.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1879625722000190/pdfft?md5=c0ae1bfacd20a3feddc57027002349ce&pid=1-s2.0-S1879625722000190-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46664778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Fruit bats as natural reservoir of highly pathogenic henipaviruses: balance between antiviral defense and viral tolerance 果蝠作为高致病性亨尼帕病毒的天然宿主:抗病毒防御和病毒耐受性之间的平衡
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2022-06-01 DOI: 10.1016/j.coviro.2022.101228
Said Mougari, Claudia Gonzalez, Olivier Reynard, Branka Horvat
{"title":"Fruit bats as natural reservoir of highly pathogenic henipaviruses: balance between antiviral defense and viral tolerance","authors":"Said Mougari,&nbsp;Claudia Gonzalez,&nbsp;Olivier Reynard,&nbsp;Branka Horvat","doi":"10.1016/j.coviro.2022.101228","DOIUrl":"https://doi.org/10.1016/j.coviro.2022.101228","url":null,"abstract":"<div><p>Bats are the natural reservoir host for a number of zoonotic viruses, including Hendra and Nipah viruses of <em>Henipavirus</em> genus, which are highly pathogenic in humans and numerous other mammalian species. Despite being infected, bats present limited signs of disease but still retain the ability to transmit the infection to other susceptible hosts, presenting thus a permanent source of new viral outbreaks. Different mechanisms have evolved in fruit bats permitting them to efficiently control the <em>Henipavirus</em> infection. These mechanisms likely allow bats to establish an adequate equilibrium between viral tolerance and antiviral defense, enabling them thus to avoid both uncontrollable virus expansion as well as immunopathology linked to excessive antiviral responses.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1879625722000372/pdfft?md5=11dd534604a830e51f63c39e0726f6d3&pid=1-s2.0-S1879625722000372-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92016020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Fruit bats as natural reservoir of highly pathogenic henipaviruses: balance between antiviral defense and viral toleranceInteractions between Henipaviruses and their natural host, fruit bats. 果蝠作为高致病性亨尼帕病毒的天然宿主:抗病毒防御和病毒耐受的平衡亨尼帕病毒与其天然宿主——果蝠之间的相互作用
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2022-05-06 DOI: 10.1016/j.coviro.2022.101228
S. Mougari, C. González, O. Reynard, B. Horvat
{"title":"Fruit bats as natural reservoir of highly pathogenic henipaviruses: balance between antiviral defense and viral toleranceInteractions between Henipaviruses and their natural host, fruit bats.","authors":"S. Mougari, C. González, O. Reynard, B. Horvat","doi":"10.1016/j.coviro.2022.101228","DOIUrl":"https://doi.org/10.1016/j.coviro.2022.101228","url":null,"abstract":"","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47913470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Mitigation of evolved bacterial resistance to phage therapy 减轻进化的细菌对噬菌体治疗的耐药性
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2022-04-01 DOI: 10.1016/j.coviro.2022.101201
Clara Torres-Barceló , Paul E Turner , Angus Buckling
{"title":"Mitigation of evolved bacterial resistance to phage therapy","authors":"Clara Torres-Barceló ,&nbsp;Paul E Turner ,&nbsp;Angus Buckling","doi":"10.1016/j.coviro.2022.101201","DOIUrl":"10.1016/j.coviro.2022.101201","url":null,"abstract":"<div><p><span>The ease with which bacteria can evolve resistance to phages is a key consideration for development of phage therapy<span>. Here, we review recent work on the different evolutionary and ecological approaches to mitigate the problem. The approaches are broadly categorised into two areas: </span></span><em>Minimising</em> evolved phage resistance; and <em>Directing</em> phage-resistance evolution towards therapeutically beneficial outcomes.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39935115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Virus genomics: what is being overlooked? 病毒基因组学:什么被忽视了?
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2022-04-01 DOI: 10.1016/j.coviro.2022.101200
Kristopher Kieft , Karthik Anantharaman
{"title":"Virus genomics: what is being overlooked?","authors":"Kristopher Kieft ,&nbsp;Karthik Anantharaman","doi":"10.1016/j.coviro.2022.101200","DOIUrl":"10.1016/j.coviro.2022.101200","url":null,"abstract":"<div><p>Viruses are diverse biological entities that influence all life. Even with limited genome sizes, viruses can manipulate, drive, steal from, and kill their hosts. The field of virus genomics, using sequencing data to understand viral capabilities, has seen significant innovations in recent years. However, with advancements in metagenomic sequencing and related technologies, the bottleneck to discovering and employing the virosphere has become the analysis of genomes rather than generation. With metagenomics rapidly expanding available data, vital components of virus genomes and features are being overlooked, with the issue compounded by lagging databases and bioinformatics methods. Despite the field moving in a positive direction, there are noteworthy points to keep in mind, from how software-based virus genome predictions are interpreted to what information is overlooked by current standards. In this review, we discuss conventions and ideologies that likely need to be revised while continuing forward in the study of virus genomics.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201916/pdf/nihms-1770501.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9498636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Broad neutralizing antibody-based strategies to tackle influenza 以广泛中和抗体为基础的应对流感策略
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2022-04-01 DOI: 10.1016/j.coviro.2022.101207
Xiaoyu Sun , Zhiyang Ling , Zhuo Yang, Bing Sun
{"title":"Broad neutralizing antibody-based strategies to tackle influenza","authors":"Xiaoyu Sun ,&nbsp;Zhiyang Ling ,&nbsp;Zhuo Yang,&nbsp;Bing Sun","doi":"10.1016/j.coviro.2022.101207","DOIUrl":"10.1016/j.coviro.2022.101207","url":null,"abstract":"<div><p><span><span>Influenza viruses cause occasional pandemics and annual epidemics, thus persist as a threat to human society. The high variability of viral envelope proteins resulting from </span>antigenic shift and </span>antigenic drift<span><span><span> allows influenza viruses to escape human herd immunity<span><span>. During the past decade, along with the breakthroughs of human monoclonal antibody<span><span> technologies, many broad reactive monoclonal antibodies (mAbs) that neutralize diverse influenza subtypes have been isolated and characterized. The achievements in this field have provided potential candidates of anti-influenza therapeutics and shed light on the design of universal </span>influenza vaccines. Here, we review the broad </span></span>neutralizing antibodies (bnAbs) targeting the </span></span>virus </span>surface proteins, summarize their epitopes, broad spectrum and immunological mechanisms of action and discuss the design of universal influenza vaccines inspired by bnAbs.</span></p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39897908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Teaching old dogmas new tricks: recent insights into the nuclear import of HIV-1 教旧教条新把戏:最近对HIV-1核输入的见解
IF 5.9 2区 医学
Current opinion in virology Pub Date : 2022-04-01 DOI: 10.1016/j.coviro.2022.101203
Adarsh Dharan, Edward M Campbell
{"title":"Teaching old dogmas new tricks: recent insights into the nuclear import of HIV-1","authors":"Adarsh Dharan,&nbsp;Edward M Campbell","doi":"10.1016/j.coviro.2022.101203","DOIUrl":"10.1016/j.coviro.2022.101203","url":null,"abstract":"<div><p><span>A hallmark feature of lentiviruses<span>, which separates them from other members of the retrovirus<span><span> family, is their ability to infect non-dividing cells by traversing the nuclear pore complex. The viral determinant that mediates HIV-1 nuclear import is the </span>viral capsid (CA) protein, which forms the conical core protecting the HIV-1 genome in a mature virion. Recently, a series of novel approaches developed to monitor post-fusion events in infection have challenged previous textbook models of the </span></span></span>viral life cycle<span>, which envisage reverse transcription and disassembly of the capsid core as events that complete in the cytoplasm. In this review, we summarize these recent findings and describe their implications on our understanding of the spatiotemporal staging of HIV-1 infection with a focus on the nuclear import and its implications in other aspects of the viral lifecycle.</span></p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9595530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
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