Current Research in Pharmaceutical Sciences最新文献

{"title":"EVALUATION OF IN VIVO ANTI-ACNE ACTIVITY OF FLOWER EXTRACT OF WITHANIA COAGULANS","authors":"Rani Jatav, Vishnu Raj, B. Sirohi, S. Lariya","doi":"10.24092/crps.2023.130403","DOIUrl":"https://doi.org/10.24092/crps.2023.130403","url":null,"abstract":"Acne vulgaris is the widespread chronic skin illness. Conventional therapy has drawbacks, such as increasing antibiotic resistance in the microorganisms that cause acne. Herbs are a natural medicine source that has negligible to no adverse effects when used to treat acne. Numerous researches are carried out to help teens and other individuals avoid acne. Thus, this study deals with discovering the anti-acne potential of medicinal plants W. coagulans. Initially gathering of plant flowers, its extraction and qualitative and quantitative analysis was performed. The in vivo anti-acne activity was performed by inducing the heat killed P. acne in rats’ ear and measuring its thickness on specific days. The results showed that plant contains the alkaloid, flavonoid, phenol, protein, carbohydrate, saponin, diterpene, tannin. Total flavonoids content and Total phenol content were found to be0.67 and 0.95 mg/ 100 mg of dried extract of Withania coagulans respectively. In animal mode, at the end of 10th day the ear thickness in Withania coagulans 200 mg/kg treated rats was observed to be 0.19±0.05 which is near to ear thickness of 0.10±0.03 observed in Clindamycin 200 mg/kg p.o treated rats. The results of the extracts were comparable with standard. The data resulted from anti-acne effect of hydroalcoholic extract of Withania coagulans was significantly decreased the inflammation in rat’s ear. Thus, it can be concluded that that Withania coagulans had appreciable anti-acne activity. Withania coagulans can thus be utilized to develop antiacne formulations and tested in preclinical and clinical studies due to its good potency against bacteria that cause acne. KEYWORDS: Acne, Withania coagulans flowers, Phytochemicals, P. acne, Clindamycin, Ear thickness.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"47 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140512284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FORMULATION AND EVALUATION OF PHYTOSOMES LOADED WITH PITHECELLOBIUM BIJENINUM LEAF EXTRACT","authors":"Arihant Jain, Richa Verma, Parulben D Mehta","doi":"10.24092/crps.2023.130306","DOIUrl":"https://doi.org/10.24092/crps.2023.130306","url":null,"abstract":"The objective of the present study was to prepare phytosomal formulation loaded with aqueous extract of Pithecellobium bijeninum leaves. The extraction of leaf powder was done by maceration technique using 90:10 ethanol-water mixture with an extraction yield of 6.12%. The extract was found to contain alkaloids, and flavonoids and the total phenolic content was found to be 23.2 ± 0.827 %w/w. Phytosomes of the extract were prepared by solvent evaporation method using lecithin as the lipid molecule. The particle size of the phytosomes was from 468 nm to 1827 nm in size with a polydispersity index varying between 0.178 - 0.464. The phytosomes were visible as rigid, almost spherical vesicles in SEM image. The surface of the phytosome vesicles was found to be regular and smooth. The point prediction suggested level 3 (0.3 g) of lipid concentration and level 2 (0.2 g) of extract concentration to present the lowest particle size. Sharp and distinct endothermic peaks in DSC revealed the formulation of stable phytosomes due to molecular interactions between the extract and lecithin. The phytosomes were found to possess good antioxidant action against DPPH radical in the in vitro scavenging assay. The IC50 value of the extract against DPPH was found to be 48.24 µg and that of the phytosomal formulation loaded with the extract (F4) was obtained to be 48.90 µg. KEYWORDS: Phytosome, extraction, lecithin, Pithecellobium, antioxidant","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139321776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FORMULATION AND EVALUATION OF SOLID DISPERSION OF CHRYSIN FOR IMPROVED BIOAVAILABILITY","authors":"Devraj Pandey, Kajal Sharma, Parulben D Mehta","doi":"10.24092/crps.2023.130305","DOIUrl":"https://doi.org/10.24092/crps.2023.130305","url":null,"abstract":"The objective of the present study was to prepared solid dispersion of chrysin for improving its aqueous solubility and in turn its oral bioavailability. I-opitmal design approach was used for preparing the solid dispersion of chrysin. A total of eight formulations were prepared using four different ratios of drug to carrier. Mannitol and PVP-K30 were used as the two different carriers to improve the solubility of chrysin by formulating SD using solvent evaporation method employing ethanol as the common solvent for the drug and the carrier. The solubility study of chrysin was performed in distilled water and was found to be 3.7 µg/mL. The particles were irregular to spherical in shape and the average particle size ranged from 34.90-38.09 µm for the particles. The yield of the SD was highest for F5 (93.2%) and least for F8 (91.14%). For all the formulations the yield was nevertheless higher than 90% suggesting a proper binary mixture formation. The drug content was found to be highest in the formulation SD4 (94.23 ± 0.351 %) and the lowest in formulation SD5 (91.18 ± 0.251 %). KEYWORDS: Solid dispersion, chrysin, mannitol, PVP K30, solvent evaporation","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139321905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ISOLATION AND IDENTIFICATION OF ACTINOMYCETES WITH ANTIBACTERIAL ACTIVITY FROM SOIL SAMPLES AROUND KANDY, SRI LANKA","authors":"Navoda Bandara, Tennakoon T.M.I.U.K","doi":"10.24092/crps.2023.130301","DOIUrl":"https://doi.org/10.24092/crps.2023.130301","url":null,"abstract":"Commercially exploited antibiotics are originally isolated from Actinomycetes. Even so, Actinomycetes are mostly underestimated for their antibacterial potential. This study aimed to isolate and identify Actinomycetes with antibacterial activity from soil samples around Kandy Sri Lanka. Soils were taken from five different habitats (waste disposal (WS), originally cultivated (OR), riverbanks (RB), pasture (PS), and rhizospheric (RH)). Serially diluted samples were grown on an Actinomycetes isolation agar medium and screened for antibacterial activity against Escherichia coli (ATCC25922), Staphylococcus aureus (ATCC25923), Pseudomonas aeruginosa (ATCC27853) and Klebsiella pneumoniae (ATCC13883) using perpendicular streak method. Isolates with inhibitory activity were subjected to secondary screening. 19 actinomycetes isolates were identified of which 10 isolates showed inhibitory activity during preliminary screening. During the secondary screening, two isolates from RB site and one isolate from OR site expressed broad-spectrum antibacterial activity while the other five isolates from RB, OR, WS, and PS sites inhibited either Escherichia coli or Staphylococcus aureus. The soil samples are a promising source of novel antibacterial compounds and thus these findings can be used for further investigations in developing broad-spectrum antibiotics for therapeutic targets in the future. KEYWORDS: Actinomycetes, soil, antibacterial activity, S. aureus, E. coli","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139321861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DEVELOPMENT AND CHARACTERIZATION OF GAMMA ORYZANOL LOADED NIOSOMES","authors":"Shubham Sharma, Budhram Saharan, Jinendra Sardiya, Vishvas Pathak","doi":"10.24092/crps.2023.130303","DOIUrl":"https://doi.org/10.24092/crps.2023.130303","url":null,"abstract":"Over the past several years, treatment of infectious diseases and immunization has undergone a revolutionary shift. Noisome are vesicles composed of non-ionic surfactants, which are biodegradable, relatively nontoxic, more stable and inexpensive, an alternative to liposomes. Noisome are of nonionic multilamellar vesicular structure of surface-active agents, which is similar to liposomes. This article highlights Ƴ-oryzanol (Oz) exert their antioxidant activity and often associated with lowering level of cholesterol, anti-inflammatory, anti-diabetic and anti-cancer effects. All reformulation studies were performed. The thin-film hydration technique was used for encapsulation of OZ in noisome. More than 85 % entrapment of Oz was achieved. Nearly 90 % drug was released within 24 hours. Formulation was found sterilized. Formulation was found stable after 5 weeks. KEYWORDS: Niosomes, Gamma Oryzanol, Liposomes, Antioxidant","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139321881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATION OF NANOPARTICLES BASED GELS FROM EXTRACTION OF DIFFERENT FRUIT PEELS","authors":"Kanwar Madhu, Choudhary Suresh","doi":"10.24092/crps.2023.130304","DOIUrl":"https://doi.org/10.24092/crps.2023.130304","url":null,"abstract":"Nanoparticles are particles ranging in size from 1 nm to 100 nm. Triangles, spheres, irregular shapes, etc. They come in different sizes such as. In recent years, the synthesis of nanoparticles has received widespread attention due to their unique properties and potential applications. The powder sample (100gm) was extracted with 800ml ethanol using Soxhlet extraction method for 6 hours. The resulting extract is used in the preparation of nanoparticles. The main objective of the present work was to prepare green apple and orange peel extract based nano particles by chemical complexation method. Ethanol extracts of green apple and orange peel were prepared using Soxhlet extractor and analyzed for their phytochemical composition. qualitative analysis of green apple peel showed positive results for alkaloids, anthraquinones, saponins and terpenoids, while orange peel showed positive. Good results for alkaloids, tannins and saponins. The moisture percentage of two fruits (green apple and orange) is 72% and 96.12% respectively. Green apples and oranges have a pH of 3.6 and 3.8 respectively. The zeta potential of green apple extract nanoparticles is -24.6 mV to -34.5 mV (P20 and P50), and the zeta potential of orange extract is -21.4 mV to 32.0 mV (O20 and O50). For nanoparticles these values are higher, indicating less potential for aggregation. The size of the apple extract varies from 118.6 nm to 231.7 nm (P20 and P30), while the size of the orange extract varies from 178.8 nm to 191.6 nm (O20 and O50). This line confirms that the obtained particles are in the nanometer range, i.e. <500 nm in size. SEM results show the formation of nanoparticles and their shape is spherical. Energy dispersive spectroscopy (EDS) analysis confirmed the presence of silver nanoparticles. Silver nanoparticles were prepared using green and orange juice peels. Computability studies FT-IR showed that there was no change in the functional group of the shell in the prepared nanoparticles. Zeta potential indicates higher efficiency and therefore less particle aggregation. The prepared nanoparticles are spherical in shape and have a particle size of approximately 200 ± 20nm. Further the study will be extended for anti- microbial and wound healing activities. KEYWORDS: Orange peel extract, Qualitative analysis, Nano particles, Zeta potential, Particle Size","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139321891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FORMULATION AND EVALUATION OF GASTRO-RETENTIVE MICROSPHERE OF SAXAGLIPTIN ANTIDIABETIC AGENT","authors":"Purshottam Kumar Thakur, C. K. Tyagi, Neelesh Choubey","doi":"10.24092/crps.2023.130302","DOIUrl":"https://doi.org/10.24092/crps.2023.130302","url":null,"abstract":"The objective of this study was to develop a gastro-retentive microsphere of Saxagliptin. Saxagliptin is an orally active hypoglycemic drug of the newdipeptidylpeptidase-4(DPP4) inhibitor class of drug. Nine formulations of Saxagliptin microsphere are prepared by Emulsion solvent diffusion method using polymers like Eudragit RS 100 and Ethyl cellulose at different drug to polymer ratios and Polyvinyl Alcohol as Stabilizing agent by Emulsion Solvent Diffusion Method. The formulations were optimized on the basis of percent buoyancy and in vitro drug release. The prepared microspheres were evaluated for physicochemical parameters and found to be within range. KEYWORDS: Gastro retentive, Saxagliptin, Ethyl cellulose, Floating microsphere, Eudragit RS 100, Polyvinyl alcohol","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139321796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A REVIEW ON NATURAL COLOURANTS USED IN COSMETICS","authors":"Vigneshwaran Lv, Amritha Pp, K. Farsana, K. T, S. V, A. Tk","doi":"10.24092/crps.2023.130201","DOIUrl":"https://doi.org/10.24092/crps.2023.130201","url":null,"abstract":"Colour plays a vital role in marketing any product such as cosmetics, food additives, pharmaceutical products etc. It gives the attractiveness for a product. Colour also helps to get the attention of the customers. Early days synthetic dyes were used as colorants in these products. The carcinogenic effect and the toxic effect of the synthetic dyes made the impact and thirst on the use of natural dyes. Natural dyes are obtained from the pigments produced by the microorganisms and the phytochemicals produced by the plants. Animal pigments are rarely used as colorants. The synthetic colorant in cosmetic industry is now replaced by the natural pigments. The colours obtained from the natural sources possess various properties like anti-cancer and so on. Some of the phytochemicals such as anthocyanins are used as colorant and also as antioxidant. Hence the natural colorants are used as a nutritional one and also it maintains in improving the health. KEYWORDS: Cosmetics, Colourants, Pigments, Phytochemicals, Antioxidant","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84370137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANTIOXIDANT AND ANTIDIABETIC ACTIVITY OF DECALEPIS HAMILTONII LEAVES EXTRACT","authors":"Ashok Kumar, Sattwik Das, N. Sharma","doi":"10.24092/crps.2023.130202","DOIUrl":"https://doi.org/10.24092/crps.2023.130202","url":null,"abstract":"In most nations, diabetes mellitus is a serious and rising health issue. The goal of the study was to compare the antidiabetic effects of leaves extracts of Decalepis hamiltonii in normal and diabetic rats induced with alloxan. Using 120 mg/kg of alloxan monohydrate, diabetes was induced. In order to considerably lower blood glucose levels in both normal and alloxan-induced diabetic rats, D. hamiltonii methanolic extract was given at doses of 200 mg and 400 mg, along with glibenclamide at a dose of 7 mg/kg bwt. Additionally, the injection of the extract dramatically reduced the levels of AST, ALT, triglycerides, and total blood cholesterol while simultaneously raising the amount of liver glycogen. In order to perform the oral glucose tolerance test (OGTT), separate groups were given doses of D. hamiltonii methanolic extract (200 mg, 400 mg), and glibenclamide (7.5 mg), which effectively reduced blood sugar levels following an oral glucose load at all time points. These findings indicate that diabetic rats' blood glucose levels were successfully lowered by the methanolic extract of D. hamiltonii leaves. The antioxidant potential of the leaves was measured using various in vitro assays. The methanolic extracts showed high antioxidant activity measured as scavenging of DPPH, superoxide and hydroxyl radicals. The antioxidant activity did not correlate with the phenolic content of the extracts. These results demonstrate the antioxidant potency of the leaves extracts which could be the basis for its alleged health promoting potential of D. hamiltonii. The leaves of D. hamiltonii could serve as a new source of natural antioxidants or nutraceuticals with potential applications to reducing the level of oxidative stress and related health benefits. KEYWORDS: Decalepis hamiltonii, Antidiabetic, Antioxidant, Alloxan, AST, OGTT","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89203917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FORMULATION OF ANTI-ACNE GEL OF MORINGA OLIEFERA LEAVES POWDER ETHANOLIC EXTRACT AS AN INHIBITOR OF BACTERIA","authors":"Bhavesh Gupta, Neha Chopra, S. Dubey, Prasann Kohli, Mohammad Ibrahim Zaidi, A. Chauhan","doi":"10.24092/crps.2023.130203","DOIUrl":"https://doi.org/10.24092/crps.2023.130203","url":null,"abstract":"Acne (Acne vulgaris) is the most common disorder which is a chronic inflammatory disease. That cause acne by one of the bacteria is staphylococcus epidermis. Moringa oleifera leaves contain flavonoid, alkaloid and phenolic compound which have inhibit acne growth. The purpose of the study is the compression of bacteriostatic ability of the extracts and gel for formula that can fulfills the physical properties of good gel moringa leaves. Moringa leaves were extracted with maceration method using ethanol 70% in three days. HPMC 4000 as a polymer were used extract was added with variation concentration of 5,10,15% physical evaluation test of gel was organoleptic, homogeneity, PH, viscosity, adhesion, and spread tests for 4 weeks. In-vitro bacteriostatic activity test with 1% Clindamycin gel a positive control and polymer gel negative control. The results that variation concentrations of ethanol extract of moringa leaves affected the physical properties of gel including viscosity PH, adhesion and spread ability. KEYWORDS: Moringa oleifera, Acne vulgaris, clindamycin, HPMC4000","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86908115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}