沙格列汀抗糖尿病药胃保留微球的制备与评估

Current Research in Pharmaceutical Sciences Pub Date : 2023-10-08 DOI:10.24092/crps.2023.130302

Purshottam Kumar Thakur, C. K. Tyagi, Neelesh Choubey

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引用次数: 0

摘要

这项研究的目的是开发一种沙克列汀的胃肠保留微球。沙克列汀是一种新型二肽肽酶-4（DPP4）抑制剂类口服活性降糖药。本研究采用乳液溶剂扩散法制备了九种沙克列汀微球制剂，使用的聚合物包括 Eudragit RS 100 和乙基纤维素，药物与聚合物的比例各不相同，并使用聚乙烯醇作为乳液溶剂扩散法的稳定剂。根据浮力百分比和体外药物释放量对配方进行了优化。对制备的微球进行了理化参数评估，结果表明微球的理化参数在一定范围内。关键词：胃复安、沙格列汀、乙基纤维素、漂浮微球、Eudragit RS 100、聚乙烯醇

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FORMULATION AND EVALUATION OF GASTRO-RETENTIVE MICROSPHERE OF SAXAGLIPTIN ANTIDIABETIC AGENT

The objective of this study was to develop a gastro-retentive microsphere of Saxagliptin. Saxagliptin is an orally active hypoglycemic drug of the newdipeptidylpeptidase-4(DPP4) inhibitor class of drug. Nine formulations of Saxagliptin microsphere are prepared by Emulsion solvent diffusion method using polymers like Eudragit RS 100 and Ethyl cellulose at different drug to polymer ratios and Polyvinyl Alcohol as Stabilizing agent by Emulsion Solvent Diffusion Method. The formulations were optimized on the basis of percent buoyancy and in vitro drug release. The prepared microspheres were evaluated for physicochemical parameters and found to be within range. KEYWORDS: Gastro retentive, Saxagliptin, Ethyl cellulose, Floating microsphere, Eudragit RS 100, Polyvinyl alcohol

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Current Research in Pharmaceutical Sciences

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