Current Research in Pharmaceutical Sciences最新文献

{"title":"DEVELOPMENT AND CHARACTERIZATION OF SELF-HEALING TRANSDERMAL PATCH OF LIDOCAINE FOR THE MANAGEMENT OF PAIN","authors":"P. P, Neha Chopra, A. Chaudhuri, Harshit Kumar, Anshu Gurjar, Nidhi Sharma","doi":"10.24092/crps.2023.130204","DOIUrl":"https://doi.org/10.24092/crps.2023.130204","url":null,"abstract":"Pain management is a significant challenge due to the side effects associated with commonly prescribed medications like NSAIDs and opioids. Local anesthetics, such as lidocaine, offer an alternative with fewer side effects when formulated in topical patches. Transdermal delivery systems, including heated patches, enhance drug absorption and provide targeted pain relief. This research paper aims to develop and characterize a self-heating transdermal patch of lidocaine for pain management. The drug sample of lidocaine was characterized using UV-visible spectrophotometric analysis, melting point determination, and differential scanning calorimetry. The results confirmed the purity of the drug sample. Pre-formulation studies were conducted to determine the solubility and partition coefficient of lidocaine, as well as drug-excipient interaction studies. The formulation of the lidocaine transdermal patch included the selection of excipients such as solvents, adhesives, solubilizers, and permeation enhancers. The patch was developed in three trial batches, with the final batch prepared using a drug-in-adhesive type approach. The developed patch was evaluated for physical characteristics, solvent residual content, rolling ball test, shear strength, drug crystallization, drug content, and in-vitro permeation. The results of the evaluation showed that the developed lidocaine transdermal patch had the desired physical characteristics, uniform thickness, good folding endurance, and appropriate solvent residual content. It exhibited satisfactory rolling ball test and shear strength. Microscopic examination confirmed the absence of drug crystallization. The drug content of the patch was determined to be within the desired range, and the in-vitro permeation study demonstrated successful drug release through the dialysis membrane. In conclusion, the development and characterization of a self-heating transdermal patch of lidocaine for pain management provide a promising approach for effective and targeted pain relief. The patch formulation demonstrated suitable physical properties, drug content, and permeation characteristics, suggesting its potential as an alternative pain management solution. KEYWORDS: Lidocaine, transdermal patch, pain management, self-heating, drug delivery","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91331930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A REVIEW ARTICLE ON CURRENT PHARMACOLOGICAL STATUS OF CARDIOPROTECTIVE PLANT","authors":"Sarita Yadav, B. Yadav, Nandini Chaudhary, Rajneesh Kumar, Ravi Yadav, S. Pandey","doi":"10.24092/crps.2023.130103","DOIUrl":"https://doi.org/10.24092/crps.2023.130103","url":null,"abstract":"Cardiovascular diseases involve abnormalities of the heart and blood vessels, such as coronary heart disease, hypertension, and cerebrovascular disease, and are the main cause of the increase in mortality rate in the world. Herbal plants tend to be very useful to prevent cardiovascular disease. The phytoconstituents of herbal medicinal plants like tannins, alkaloids, saponins, flavonoids, and glycosides that have the ability to prevent cardiovascular diseases. Examples such as Nerium oleander, Amaranthus viridis, Ginkgo biloba, Daucus carota, Gingerol, Tinospora cordifolia etc. Many studies investigated the cardioprotective effect of these natural products against experimentally-induced myocardial damage, and their results revealed that their potential phytochemicals exhibited significant antioxidant, anti-apoptotic, anti-inflammatory, anti-atherosclerotic activities. The review highlights the promising mechanisms and probable applications of various herbal plants, and their phytochemicals in the prevention and treatment of cardiovascular diseases. The cardioprotective plants contain a wide- variety of bioactive compound involve with diosgenin, isoflavones, sulforaphane, carotinized, catechin and quercetin are increasing the cardio protection and decreases the chances of cardiac abnormalities. KEYWORDS: Cardiovascular diseases, herbal products, phytochemicals, cardioprotective plant, Trichopus zeylanicus, cardiotoxicity","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"247 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73515152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CROCIN AS NEUROPROTECTIVE AGONIST IN OXIDATIVE DAMAGE AND COGNITIVE DYSFUNCTION INDUCED BY ALUMINIUM CHLORIDE AND COLCHICINE IN RODENTS","authors":"Deepak Tomar, M. M, Dhananjay Taumar, A. A, M. M, P. Jain, Khushi Goel, Amulya Jindal","doi":"10.24092/crps.2023.130105","DOIUrl":"https://doi.org/10.24092/crps.2023.130105","url":null,"abstract":"The main constituent of saffron, Crocus sativus L., is called Crocin (CR). Water-soluble carotenoids in CR possesses anti-inflammatory, analgesic, anti-edematous, as well as anti-oxidant properties, as well as to increase the number of microtubules in sheep brain microtubules and to have neuroprotective effects. For example, Alzheimer's disease (AD), where the harm of hippocampal as well as cortical neurons results in memory as well as cognitive impairment, as well as amyotrophic lateral sclerosis (ALS), where weakness in muscle is brought on by the degeneration of spinal, bulbar, as well as cortical motor neurons, are disorders which are characterized by the progressive and irreversible loss of neurons. In the current investigation, we evaluated CR's ability to protect neurons from the oxidative harm that Colchicine (Col) and Aluminum chloride (ALCL) induce. GSH level, SOD, besides catalase reduced in the Col model's Col-treated group but was practically returned to normal in the group that received CR. When given CR instead of Col, the levels of MDA, acetylcholine esterase, and nitric oxide returned to nearly normal levels. However, in the Morris water maze test, CR significantly reduces the time it takes to reach the platform (escape latency time), indicating learning and cognitive improvement. Corresponding to this, in the passive avoidance test, the transfer delay time did not significantly increase in the CR-treated group but it did in the Col-treated group. Similar outcomes in the aluminium chloride model were attained. Thus, the present study comes to the conclusion that CR can be utilized to treat oxidative stress and illnesses linked to cognitive dysfunction, such as AD as well as Parkinson’s diseases shown against rodents resultantly. KEYWORDS: Crocin, Aluminium Chloride, Alzheimer’s disease, oxidative stress, Neurodegeneration","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"118 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87967972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SIMULTANEOUS DETERMINATION OF PHYTONADIONE AND ITS DEGRADANTS BY HPLC IN INJECTABLE EMULSION FORMULATION USED TO TREAT VKDB IN NEWBORNS","authors":"M. Ullah, Md. Sohel Rana, MD. Shahnowaj Bhuiyan","doi":"10.24092/crps.2023.130104","DOIUrl":"https://doi.org/10.24092/crps.2023.130104","url":null,"abstract":"Phytonadione, also known as Phytomenadione or Vitamin K1 is used as an Injectable emulsion is used to Newborns for the precautionary treatment for Vitamin K Deficiency Bleeding (VKDB) during birth. In the current study, A Gradient, Sensitive & Cost effective HPLC method has been developed to determine and quantify the degradants of Phytonadione and Benzyl Alcohol into Phytonadione Injectable Emulsion. The chromatographic separation was performed by GL Sciences Inert sustain HP™ C18 (250 × 4.6 mm, 3.0 μ) column. The degradants were well separated by a gradient program started with the mixture of 25 mM Ammonium Acetate in water as buffer, pH 3.5 and Methanol in the ratio of 40: 60 V/V at the flow rate of 1.0 mL min­­‑1 and UV detection was performed at 254 nm. The degradation products from Phytonadione and Benzyl Alcohol were well resolved from the main peaks and its other impurities by the developed method. The method was validated by complying specificity/selectivity, linearity, limit of detection (LOD), limit of quantification (LOQ), accuracy and precision following ICH Q2 (R1). The developed method in this study could be applied for the analysis of routine quality control related substances of Phytonadione Injectable Emulsion, since there is no official monograph. KEYWORDS: Phytomenadione, Vitamin K, Method validation, Impurities, Degradants.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84761622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMPROVEMENT OF DISSOLUTION RATE OF REPAGLINIDE BY UTILIZING SOLID DISPERSION TECHNIQUE","authors":"Mahendra Patel, A. Indurkhya, M. Khan","doi":"10.24092/crps.2023.130107","DOIUrl":"https://doi.org/10.24092/crps.2023.130107","url":null,"abstract":"The recent study's objective was to prepare and evaluate the Repaglinide (RG) solid dispersion. RG is poorly water soluble, BCS class II drug. Repaglinide solid dispersion (RG-SD) was prepared by solvent evaporation method using different proportion of PVP K30. The prepared RG-SD was evaluated for solubility studies, drug content, in vitro dissolution, DSC studies and XRD studies. DSC and XRD studies results indicate that RG exists in amorphous form in solid dispersion. The solubility of pure RG was enhanced from 34.41±0.68 to 370.3±1.52 μg/mL in distilled water at 370 C. RG-SD (RG:PVP K30) (1:10) showed high burst release (65%) in the first 30 min. Current research concludes that Repaglinide solid dispersions using PVP-K30 (1:10) as a carrier in solid dispersions showed promising results in enhancement of repaglinide properties. KEYWORDS: Repaglinide, Solid Dispersion, PVK K30, Dissolution Rate, Solvent evaporation","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78676931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A CONCISE REVIEW ON SPANSULES: A NEW METHOD OF DRUG DELIVERY","authors":"Abhilasha Bhadoriya, Trupti Shukla","doi":"10.24092/crps.2023.130102","DOIUrl":"https://doi.org/10.24092/crps.2023.130102","url":null,"abstract":"Spansules are considered as an Advanced Drug Delivery System because they allow for controlled and sustained release of medication over an extended period of time. This type of delivery system can provide a constant plasma drug concentration over a wide range of time, which can improve treatment outcomes and reduce the risk of side effects. In addition to providing sustained release, Spansules can also be used to deliver multiple drugs in a single dosage form. The multi-drug regimen capability of Spansules is also beneficial, as it allows for the delivery of multiple drugs in a single dosage form. This can improve patient compliance with their medication regimen, simplify dosing, and reduce the risk of drug interactions. This can be particularly useful in cases where a patient requires treatment with multiple medications to manage a complex medical condition. Spansules can act as biphasic release drug delivery system that can be used to provide both immediate and sustained release of medication. These systems can be useful in cases where a patient requires rapid relief of symptoms followed by ongoing management over a longer period of time. Overall, Spansules are a versatile and effective drug delivery system that can provide several benefits to patients and healthcare providers. KEYWORDS: Spansules, Biphasic, Controlled release, Sustained release, Drug","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87901993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DEVELOPMENT AND CHARACTERIZATION OF TRANDOLAPRIL IMMEDIATE RELEASE TABLETS USING DIFFERENT SUPERDISINTEGRATING AGENTS","authors":"ARPNA INDURKHYA, MAHENDRA PATEL, MASHEER AHMED KHAN","doi":"10.24092/crps.2023.130106","DOIUrl":"https://doi.org/10.24092/crps.2023.130106","url":null,"abstract":"A potent non-sulfhydryl prodrug, trandolapril is transformed into the active substance, trandolaprilat, in the liver. For obese individuals with mild-to-moderate essential hypertension, Trandolapril is effective and safe. The elimination t1/2 of trandolapril and trandolaprilat are approximately 6 hours and 16–24 hours, respectively. The goal of present work is to develop the Trandolapril immediate release tablet using various superdisintegrants. Crospovidone, Sodium starch glycolate and Croscarmellose sodium in concentrations of 2%, 4%, and 6% were used as superdisintegrating agents for the optimization. Direct compression technique was used to make nine formulations (IRTR 1 to IRTR 9). The powder blends of all batches were evaluated for different parameters to know the powder flow characteristics and it was found that the powder blend had excellent flow and compressibility characteristics. Then, compressed tablets were tested for quality control parameters as per the IP. In formulation IRTR1-IRTR9, disintegration time was observed 30.23 to 71.67 Sec and more than 70% drug was released in 30 min. Thus, based on evaluation results, it is concluded that formulation of immediate release (IR) tablets of Trandolapril were successfully developed. Minimum disintegration time 30.23 seconds 90.56% drug release in 30 min was obtained with IRTR3. KEYWORDS: Trandolapril, Immediate release, Crospovidone, Sodium starch glycolate, crocarmellose sodium","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"104 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135693597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HERBAL COMPONENTS AS AN ADVANTAGEOUS REMEDY FOR PIMPLE AND ACNE IN FACE-WASH: A SYSTEMIC REVIEW","authors":"Naman Agarwal, A. A., Amulya Jindal","doi":"10.24092/crps.2023.130101","DOIUrl":"https://doi.org/10.24092/crps.2023.130101","url":null,"abstract":"erbal formulations are in high demand on the global market. The human epidermis is the most vulnerable organ in the body to infections and disease-causing microbes. It also acts as the majorly responsible body part for respiration. As a result, it needs a great deal of care and protection. Many skin issues can occur throughout puberty due to internal component imbalances and hormone imbalances. The most prevalent skin condition is acne. The most commonly afflicted areas are the face and neck. The removal of oil from the face is a preventative measure. This will need proper cleaning and washing. Antibiotic gels and anti-acne washes or masks containing synthetic medicines are presently available on the market. Unfortunately, in addition to treating illnesses and killing infections, these medicines may have adverse effects. Various studies have demonstrated the effectiveness of herbal-based compositions for cleansing and oil removal. As a result of this necessity, we came up with the notion of using herbs and various plant derived components markedly useful in the various treatments of skin-related conditions. The characteristics of various face wash and their efficacy are reviewed in the current study comprehensively. The main objective of this study is the comparison of Ingredients used in various formulations of face wash like Neem, Aloe vera, Belpatra, Curry, Haldi, Lemon, Indian madder, Sweet flag, Lodhra, Gelling agent, Preservative, Neutralizer, Humectants, Vehicle, Perfume, Chelating agent, on the basis of evaluation and effective development of emerging techniques used in the markedly available face wash which reportedly proven as an advantageous measure of treatment.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85776631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RISK FACTORS OR PREDICTORS OF DEVELOPING CIPROFLOXACIN, TRIMETHOPRIM/SULFAMETHOXAZOLE AND THIRD GENERATION CEPHALOSPORIN RESISTANCE IN ESCHERICHIA COLI INFECTIONS: A SYSTEMATIC REVIEW AND META-ANALYSIS","authors":"Deshwal Pr, Reddy Ns, F. R., A. M, T. P","doi":"10.24092/crps.2022.120402","DOIUrl":"https://doi.org/10.24092/crps.2022.120402","url":null,"abstract":"The Centers for Disease Control and Prevention (CDC) estimates that by 2050, ten million people a year could be dying as a result of Anti-Microbial Resistance (AMR). An increase in resistance has been observed for trimethoprim/sulfamethoxazole followed by ciprofloxacin and third-generation cephalosporins in the management of Escherichia coli infections. To identify risk factors for ciprofloxacin (Cip-REC), trimethoprim/sulfamethoxazole (TMP/SMX-REC,) and third-generation cephalosporin (TGC-REC) resistance in Escherichia coli infection relative to controls patients. A systematic search of MEDLINE/PubMed and Embase databases identified case-control, cohort, and cross-sectional studies on risk factors for Cip-REC, TMP/SMX-REC, and TGC-REC-infected patients. A random-effects model was used to pool odds ratios (ORs) of developing resistant E. coli infection. This study was registered with PROSPERO (CRD42022297043). A total of 23 studies were included (9891 participants). Overall, 22, 8, and 11 risk factors were identified for developing Cip-REC, TMP/SMX-REC, and TGC-REC infections respectively. The prior antibiotic use [OR=3.19] reported high pooled ORs for Cip-REC infection. TMP/SMX-REC infection was associated with genitourinary abnormalities [OR=2.91]. Further analysis unveiled potential factors for TGC-REC infection; prior history of admission [OR=3.14] and hemodialysis [OR=2.20]. Prior antibiotic usage, genitourinary disorders, and admission history increase the risk of Cip-REC, TMP/SMX-REC, and TGC-REC infections. Modifiable risk factors may help prevent resistant E. coli infection. KEYWORDS: Escherichia coli, Ciprofloxacin, Trimethoprim, Sulfamethoxazole, Third Generation Cephalosporin","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86973985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IN SILICO STUDY OF PHYTOCONSTITUENTS OF MORINGA OLEIFERA AGAINST TREHALOSE–6–PHOSPHATE PHOSPHATASE (TPP) ENZYMES","authors":"P. Bhatnagar, Neha Dangi","doi":"10.24092/crps.2022.120404","DOIUrl":"https://doi.org/10.24092/crps.2022.120404","url":null,"abstract":"Numerous pathogenic microorganisms use the enzymes trehalose-6-phosphate phosphatase (TPP) to biosynthesize the sugar trehalose from trehalose-6-phosphate (T6P) as part of their infection and proliferation processes. In order to build new generation candidate medications to inhibit TPP using in silico approaches, the current work is being done. The majority of the 10 phytochemicals from Moringa oleifera that were used in docking studies with the 3D model of TPP had good binding affinities to the enzyme, with campesterol and stigmat-4-en-3-one showing the highest affinities (Binding energies of - 7.8 kcal/mole and -8.0 kcal/mole, respectively), when compared to the commonly used commercial drug isoniazid (Binding energy of –6.0 kcal/mole).The active site of TPP sequences, which coordinates Mg2+ and is necessary for catalysis, has been discovered to bind to phytochemical leads during docking. Binding poses and distance measurement of TPP-phytochemical complexes of 5-Hydroxymethylfurfural, Citronellol, Xylitol, 2,4-Di-tert-butylphenol, Palmitoleic acid, cis-Vaccenic acid, Phytol, Cyclopentane, 1,1-[3-(2-cyclopentylethyl)-1,5-pentanediyl]bis-, Campesterol and Stigmat-4-en-3-one reveals that the lead phytochemicals were in close proximity with most of the active site amino acids (distance range from 1.88 to 3.77 Aº). This demonstrates the close affinity between the enzyme and the leads, which may open the door to the development of new generation medications to treat diseases caused by pathogenic microorganisms that produce TPP. KEYWORDS: Trehalose–6–phosphate phosphatase, Binding affinity, In silico, Phytochemical, Moringa oleifera","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89984109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}