FORMULATION OF ANTI-ACNE GEL OF MORINGA OLIEFERA LEAVES POWDER ETHANOLIC EXTRACT AS AN INHIBITOR OF BACTERIA

Current Research in Pharmaceutical Sciences Pub Date : 2023-07-07 DOI:10.24092/crps.2023.130203

Bhavesh Gupta, Neha Chopra, S. Dubey, Prasann Kohli, Mohammad Ibrahim Zaidi, A. Chauhan

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Abstract

Acne (Acne vulgaris) is the most common disorder which is a chronic inflammatory disease. That cause acne by one of the bacteria is staphylococcus epidermis. Moringa oleifera leaves contain flavonoid, alkaloid and phenolic compound which have inhibit acne growth. The purpose of the study is the compression of bacteriostatic ability of the extracts and gel for formula that can fulfills the physical properties of good gel moringa leaves. Moringa leaves were extracted with maceration method using ethanol 70% in three days. HPMC 4000 as a polymer were used extract was added with variation concentration of 5,10,15% physical evaluation test of gel was organoleptic, homogeneity, PH, viscosity, adhesion, and spread tests for 4 weeks. In-vitro bacteriostatic activity test with 1% Clindamycin gel a positive control and polymer gel negative control. The results that variation concentrations of ethanol extract of moringa leaves affected the physical properties of gel including viscosity PH, adhesion and spread ability. KEYWORDS: Moringa oleifera, Acne vulgaris, clindamycin, HPMC4000

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以辣木叶粉末乙醇提取物为抑菌剂的抗痤疮凝胶的研制

痤疮(痤疮寻常)是最常见的疾病，是一种慢性炎性疾病。引起痤疮的细菌之一是表皮葡萄球菌。辣木叶含有类黄酮、生物碱和酚类化合物，具有抑制痤疮生长的作用。研究的目的是压缩辣木叶提取物和凝胶的抑菌能力，以获得符合辣木叶凝胶物性的配方。用70%乙醇浸泡法提取辣木叶，提取时间为3天。以HPMC 4000为聚合物，分别加入浓度为5%、10%、15%的萃取物，进行4周的感官、均匀性、PH、粘度、黏附、扩散等物理评价试验。体外抑菌活性试验，1%克林霉素凝胶为阳性对照，聚合物凝胶为阴性对照。结果表明，辣木叶乙醇提取物浓度的变化对凝胶的粘度、PH值、黏附力和扩散能力等物理性能有影响。关键词:辣木，寻常痤疮，克林霉素，HPMC4000

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Current Research in Pharmaceutical Sciences

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