{"title":"γ-奥氮杂醇负载型niosomes的开发与表征","authors":"Shubham Sharma, Budhram Saharan, Jinendra Sardiya, Vishvas Pathak","doi":"10.24092/crps.2023.130303","DOIUrl":null,"url":null,"abstract":"Over the past several years, treatment of infectious diseases and immunization has undergone a revolutionary shift. Noisome are vesicles composed of non-ionic surfactants, which are biodegradable, relatively nontoxic, more stable and inexpensive, an alternative to liposomes. Noisome are of nonionic multilamellar vesicular structure of surface-active agents, which is similar to liposomes. This article highlights Ƴ-oryzanol (Oz) exert their antioxidant activity and often associated with lowering level of cholesterol, anti-inflammatory, anti-diabetic and anti-cancer effects. All reformulation studies were performed. The thin-film hydration technique was used for encapsulation of OZ in noisome. More than 85 % entrapment of Oz was achieved. Nearly 90 % drug was released within 24 hours. Formulation was found sterilized. Formulation was found stable after 5 weeks. KEYWORDS: Niosomes, Gamma Oryzanol, Liposomes, Antioxidant","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"16 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"DEVELOPMENT AND CHARACTERIZATION OF GAMMA ORYZANOL LOADED NIOSOMES\",\"authors\":\"Shubham Sharma, Budhram Saharan, Jinendra Sardiya, Vishvas Pathak\",\"doi\":\"10.24092/crps.2023.130303\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Over the past several years, treatment of infectious diseases and immunization has undergone a revolutionary shift. Noisome are vesicles composed of non-ionic surfactants, which are biodegradable, relatively nontoxic, more stable and inexpensive, an alternative to liposomes. Noisome are of nonionic multilamellar vesicular structure of surface-active agents, which is similar to liposomes. This article highlights Ƴ-oryzanol (Oz) exert their antioxidant activity and often associated with lowering level of cholesterol, anti-inflammatory, anti-diabetic and anti-cancer effects. All reformulation studies were performed. The thin-film hydration technique was used for encapsulation of OZ in noisome. More than 85 % entrapment of Oz was achieved. Nearly 90 % drug was released within 24 hours. Formulation was found sterilized. Formulation was found stable after 5 weeks. KEYWORDS: Niosomes, Gamma Oryzanol, Liposomes, Antioxidant\",\"PeriodicalId\":11053,\"journal\":{\"name\":\"Current Research in Pharmaceutical Sciences\",\"volume\":\"16 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-10-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Research in Pharmaceutical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.24092/crps.2023.130303\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Research in Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24092/crps.2023.130303","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
DEVELOPMENT AND CHARACTERIZATION OF GAMMA ORYZANOL LOADED NIOSOMES
Over the past several years, treatment of infectious diseases and immunization has undergone a revolutionary shift. Noisome are vesicles composed of non-ionic surfactants, which are biodegradable, relatively nontoxic, more stable and inexpensive, an alternative to liposomes. Noisome are of nonionic multilamellar vesicular structure of surface-active agents, which is similar to liposomes. This article highlights Ƴ-oryzanol (Oz) exert their antioxidant activity and often associated with lowering level of cholesterol, anti-inflammatory, anti-diabetic and anti-cancer effects. All reformulation studies were performed. The thin-film hydration technique was used for encapsulation of OZ in noisome. More than 85 % entrapment of Oz was achieved. Nearly 90 % drug was released within 24 hours. Formulation was found sterilized. Formulation was found stable after 5 weeks. KEYWORDS: Niosomes, Gamma Oryzanol, Liposomes, Antioxidant
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