Current Opinion in Psychiatry最新文献

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Update on eating disorders and disordered eating behaviors in metabolic bariatric surgery patients. 代谢性减肥手术患者饮食失调和饮食行为紊乱的最新情况。
IF 7.5 2区 医学
Current Opinion in Psychiatry Pub Date : 2024-08-19 DOI: 10.1097/YCO.0000000000000962
Eva Conceição, James E Mitchell, David B Sarwer
{"title":"Update on eating disorders and disordered eating behaviors in metabolic bariatric surgery patients.","authors":"Eva Conceição, James E Mitchell, David B Sarwer","doi":"10.1097/YCO.0000000000000962","DOIUrl":"https://doi.org/10.1097/YCO.0000000000000962","url":null,"abstract":"<p><strong>Purpose of review: </strong>Recent literature suggests a potential causal link between metabolic bariatric surgery (MBS) and an increased risk of eating disorders. However, the available literature offers unclear results regarding the definition of eating problems among MBS patients, their potential impact on weight outcomes, and the efficacy of adjunctive treatment.</p><p><strong>Recent findings: </strong>Although eating disorders may be rare phenomena after surgery, disordered eating behaviors are more common and tend to be more consistently associated with suboptimal weight loss. There also appear to be clear problems when using Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5) criteria to assess eating disorders among MBS patients, particularly for restrictive eating, binge-eating episodes, and the core psychopathology of eating disorders. Finally, preoperative interventions appear to offer effects limited to the presurgery period, and the evidence for the efficacy of postoperative interventions remains limited. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) offer promising benefits for weight loss and the treatment of binge-eating problems, but their potential risks must be carefully managed.</p><p><strong>Summary: </strong>Recognizing the diverse presentations of these problems among individuals undergoing MBS is crucial. Clinical attention should focus on intensive specialized care during the postoperative period for those who develop eating-related problems.</p>","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early intervention for eating disorders. 饮食失调的早期干预。
IF 7.5 2区 医学
Current Opinion in Psychiatry Pub Date : 2024-08-15 DOI: 10.1097/YCO.0000000000000963
Regan Mills, Lucy Hyam, Ulrike Schmidt
{"title":"Early intervention for eating disorders.","authors":"Regan Mills, Lucy Hyam, Ulrike Schmidt","doi":"10.1097/YCO.0000000000000963","DOIUrl":"https://doi.org/10.1097/YCO.0000000000000963","url":null,"abstract":"<p><strong>Purpose of review: </strong>Research on early intervention for eating disorders has started to gain traction and examples of this in practice are increasing. This review summarizes findings over the past 3 years, focusing on the clinical effectiveness of early intervention in practice and the barriers and facilitators to its implementation.</p><p><strong>Recent findings: </strong>Recent developments in early intervention for eating disorders can be divided into three broad themes: research that has examined the efficacy of early intervention pathways in practice, research that has informed understanding of the target patient groups of early intervention (via clinical staging models, e.g.), and research that has suggested new ways to progress early intervention, towards becoming a standard part of best practice care.</p><p><strong>Summary: </strong>Early intervention pathways have shown promising clinical outcomes and are viewed positively by patients, clinicians and other stakeholders. However, more robust trials of their efficacy, effectiveness and cost-effectiveness are needed. Additionally, barriers to early intervention have been identified (e.g. delayed help-seeking); research must now develop and evaluate strategies to address these. Finally, the early intervention models in practice are underpinned partly by clinical staging models for eating disorders, which require further development, especially for eating disorders other than anorexia nervosa.</p>","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness and predictors of psychotherapy in eating disorders: state-of-the-art and future directions. 饮食失调症心理治疗的效果和预测因素:最新进展和未来方向。
IF 7.5 2区 医学
Current Opinion in Psychiatry Pub Date : 2024-08-14 DOI: 10.1097/YCO.0000000000000961
Alessio Maria Monteleone, Giovanni Abbate-Daga
{"title":"Effectiveness and predictors of psychotherapy in eating disorders: state-of-the-art and future directions.","authors":"Alessio Maria Monteleone, Giovanni Abbate-Daga","doi":"10.1097/YCO.0000000000000961","DOIUrl":"https://doi.org/10.1097/YCO.0000000000000961","url":null,"abstract":"<p><strong>Purpose of review: </strong>Psychotherapy is the cornerstone of the multidisciplinary treatment approach for eating disorders. This review examines recent evidence regarding effectiveness, predictors, and mechanisms of change of psychotherapy in eating disorders, providing a road map for clinicians and researchers.</p><p><strong>Recent findings: </strong>Family-based treatments (FBT) are effective in adolescents with anorexia nervosa and bulimia nervosa. Evidence-based psychotherapies for anorexia nervosa have no evidence of superiority compared with treatment as usual (TAU) in adults with anorexia nervosa. Cognitive-behavioural therapy (CBT) is the first-choice psychotherapy recommended for adults with bulimia nervosa and binge-eating disorder (BED). Self-help interventions have some evidence of effectiveness in nonunderweight individuals with eating disorders. Early symptom improvement and adolescent age predict more favourable outcomes.</p><p><strong>Summary: </strong>Evidence-based psychotherapies can be suggested for eating disorders, although follow-up data are needed. Beyond anorexia nervosa, bulimia nervosa, and BED, there is no evidence of psychotherapy effectiveness in other eating disorders. The effectiveness of novel (e.g. 'third-wave') psychotherapies, treatment delivery modality (e.g. internet-delivered), and adjunctive interventions (e.g. virtual reality) needs to be further explored. A broader definition of recovery is recommended, including behavioural, physical, and psychological criteria. Predictors and mechanisms of changes have not been studied enough: quantitative and qualitative studies are needed to promote more tailored and individualized psychotherapy interventions.</p>","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Personality disorders and their association with adverse childhood events. 人格障碍及其与童年不良事件的关系。
IF 7.5 2区 医学
Current Opinion in Psychiatry Pub Date : 2024-08-05 DOI: 10.1097/YCO.0000000000000959
Ştefania Crişan, Diana Nechita
{"title":"Personality disorders and their association with adverse childhood events.","authors":"Ştefania Crişan, Diana Nechita","doi":"10.1097/YCO.0000000000000959","DOIUrl":"https://doi.org/10.1097/YCO.0000000000000959","url":null,"abstract":"<p><strong>Purpose of review: </strong>Theoretical models of personality disorders (PDs) highlight the role of adverse childhood experiences (ACEs) in the development and maintenance of personality pathology. This review presents recent studies on the associations between childhood adversity and PDs, while discussing mechanisms and factors that impact these relationships.</p><p><strong>Recent findings: </strong>Studies point to small to moderate associations between childhood adversity and cluster A, cluster B and cluster C PDs, and some research suggests that childhood adversity could be a predictor for the onset and development of personality pathology. Most research focuses on borderline PD, while research on other PDs is limited. Some mechanisms that explain these associations have been proposed, with the literature investigating emotion dysregulation, dissociation, avoidance or psychosocial dysfunction as mediators.</p><p><strong>Summary: </strong>The consistent associations between ACEs and PDs seems to point that childhood adversity could be a transdiagnostic risk factor for PDs, but research warrants further prospective investigations for causal conclusions, and calls for future research to investigate potential mediators and moderators more thoroughly.</p>","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research and publication gaps on kratom and kratom products: a scoping review of current literature. 关于桔梗和桔梗产品的研究和出版缺口:当前文献的范围界定综述。
IF 6.9 2区 医学
Current Opinion in Psychiatry Pub Date : 2024-07-01 Epub Date: 2024-05-09 DOI: 10.1097/YCO.0000000000000950
Balasingam Vicknasingam, Thiruventhan Karunakaran, Marek C Chawarski
{"title":"Research and publication gaps on kratom and kratom products: a scoping review of current literature.","authors":"Balasingam Vicknasingam, Thiruventhan Karunakaran, Marek C Chawarski","doi":"10.1097/YCO.0000000000000950","DOIUrl":"10.1097/YCO.0000000000000950","url":null,"abstract":"<p><strong>Purpose of review: </strong>Kratom plant, products derived from the plant, and plant phytochemicals are of great interest among researchers, clinicians, and consumers. However, there is a paucity of rigorously collected scientific data on their risk/safety profile and public health impact. This scoping review discusses original research articles published between 2022 and 2023. It focuses on identifying publication gaps on topics related to epidemiology, public health, and risk/safety profiles comparing evidence collected by researchers from Southeast Asia and the West.</p><p><strong>Recent findings: </strong>Our review of the Scopus database identified a total of 55 publications, including clinical case reports and case series reports, surveys, studies enrolling human participants, and publications based on large-scale national surveys or large-scale national or international health system database records.</p><p><strong>Summary: </strong>Overall, there is dearth of reliable data on key epidemiological factors, including the prevalence rates, and on objective and reliable indices of the risk/safety profiles. Rigorous and systematic studies including improved epidemiological surveillance, human laboratory, and controlled clinical studies are urgently needed to advance our understanding of public health consequences of consuming kratom and kratom-derived products and to improve our understanding of their risk/safety profile and additional analytical studies to better inform development of needed regulatory oversight.</p>","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":null,"pages":null},"PeriodicalIF":6.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The nature and characteristics of problem gaming, with a focus on ICD-11 diagnoses. 问题游戏的性质和特点,重点是 ICD-11 诊断。
IF 6.9 2区 医学
Current Opinion in Psychiatry Pub Date : 2024-07-01 Epub Date: 2024-05-06 DOI: 10.1097/YCO.0000000000000949
John B Saunders, Gary Chan, Janni Leung, Daniel Stjepanović, Jason P Connor
{"title":"The nature and characteristics of problem gaming, with a focus on ICD-11 diagnoses.","authors":"John B Saunders, Gary Chan, Janni Leung, Daniel Stjepanović, Jason P Connor","doi":"10.1097/YCO.0000000000000949","DOIUrl":"10.1097/YCO.0000000000000949","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review describes the diagnoses related to problem gaming that are included in ICD-11, published by the WHO in 2022. It summarizes the recent literature on the prevalence of Gaming Disorder, its structure, antecedents and comorbidities, and explores whether the range of diagnoses currently available adequately covers the range of experiences seen with problem gaming.</p><p><strong>Recent findings: </strong>Overall, between 3 and 6% of the population worldwide are reported to have a gaming disorder as defined by ICD-11 or DSM-5. However, most studies are constrained by methodological issues such as nonrepresentative samples and the use of brief questionnaires to determine prevalence. ICD-11 Gaming Disorder is a psychometrically sound diagnosis. There is no diagnosis that currently captures the experience of harm from gaming, where the requirements for the diagnosis of Gaming Disorder are not reached.</p><p><strong>Summary: </strong>There is evidence in support of the proposed new entity of 'Harmful Gaming', which encompasses mental and physical harm/impairment due to a repeated pattern of gaming, but where requirements for the diagnosis of Gaming Disorder are not met. Such a diagnosis would complete the spectrum of diagnoses available for problem or unhealthy gaming, similar to those for unhealthy substance use, and would provide a framework for a public health approach to reducing the overall harm from unhealthy gaming.</p>","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":null,"pages":null},"PeriodicalIF":6.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140897602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacist-prescriber collaborative models of care for opioid use disorder: an overview of recent research. 药剂师与处方医生合作治疗阿片类药物使用障碍的模式:最新研究综述。
IF 6.9 2区 医学
Current Opinion in Psychiatry Pub Date : 2024-07-01 Epub Date: 2024-04-29 DOI: 10.1097/YCO.0000000000000943
Ali Cheetham, Elizabeth Grist, Suzanne Nielsen
{"title":"Pharmacist-prescriber collaborative models of care for opioid use disorder: an overview of recent research.","authors":"Ali Cheetham, Elizabeth Grist, Suzanne Nielsen","doi":"10.1097/YCO.0000000000000943","DOIUrl":"10.1097/YCO.0000000000000943","url":null,"abstract":"<p><strong>Purpose of review: </strong>Collaborative models of care where pharmacists work alongside physicians have been developed for a range of physical health conditions, with benefits including improved patient outcomes and increased access to ongoing care. Opioid agonist treatment (methadone and buprenorphine) is a clinically effective and cost-effective treatment for opioid use disorder that is under-utilized in many countries due to a shortage of prescribers. In recent years, there has been increased interest in the development of collaborative models that utilize pharmacists to overcome barriers to treatment. In this article, we present a narrative review to synthesise recent work in this rapidly developing area.</p><p><strong>Recent findings: </strong>Two key aspects of opioid agonist treatment were identified: Collaborative models have utilized pharmacists to facilitate buprenorphine induction, and collaborative models provide increased capacity for delivering ongoing care in a variety of settings and patient groups where prescriber access is limited. Pharmacists have undertaken direct patient care responsibilities with varying degrees of autonomy, with benefits including a reduction in prescriber workload, and improvements in treatment retention and continuity of care.</p><p><strong>Summary: </strong>Collaborative models in which pharmacists are responsible for buprenorphine induction and ongoing management with methadone and buprenorphine have been shown to reduce demands on prescribers while improving or maintaining patient outcomes, and appear feasible and acceptable in a wide range of outpatient settings.</p>","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":null,"pages":null},"PeriodicalIF":6.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140897589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gradually tapering off antipsychotics: lessons for practice from case studies and neurobiological principles. 逐渐停用抗精神病药物:从案例研究和神经生物学原理中汲取的实践经验。
IF 6.9 2区 医学
Current Opinion in Psychiatry Pub Date : 2024-07-01 Epub Date: 2024-05-09 DOI: 10.1097/YCO.0000000000000940
Mark A Horowitz, Joanna Moncrieff
{"title":"Gradually tapering off antipsychotics: lessons for practice from case studies and neurobiological principles.","authors":"Mark A Horowitz, Joanna Moncrieff","doi":"10.1097/YCO.0000000000000940","DOIUrl":"10.1097/YCO.0000000000000940","url":null,"abstract":"<p><strong>Purpose of review: </strong>There has been an increasing focus on deprescribing in psychiatry recently, particularly of antipsychotic medication, with recognition that not all patients with psychotic disorders require lifelong medication. We summarize some empirical and theoretical papers, and examine case studies to provide instruction on this topic.</p><p><strong>Recent findings: </strong>Recent studies have found that slower tapering (over months or longer) of antipsychotics is associated with a lower relapse rate than quicker tapering (weeks). Case studies presented suggest that the process of reduction is associated with the precipitation or exacerbation of psychotic symptoms and that a slower process of reduction may minimize this effect. This may be because faster reductions cause greater disruption of homeostatic equilibria, provoking psychotic symptoms either as direct withdrawal symptoms or consequences of nonpsychotic withdrawal symptoms (e.g. insomnia) - although not all patients will experience withdrawal symptoms. This suggests that smaller dose reductions, especially at lower doses, made very gradually, may minimize the risk of psychotic symptoms.</p><p><strong>Summary: </strong>Slower tapering of antipsychotics may provide time for adaptations made to the presence of the medications to resolve, thus reducing the disruption to homeostatic equilibrium caused by dose reduction, potentially reducing the risk of relapse. Exacerbation of psychotic symptoms on antipsychotic reduction may not represent evidence of the need for a higher dose of antipsychotic on a long-term basis but may indicate the need for more gradual reduction. Gradual reduction of antipsychotics, especially after long-term use in clinical practice is prudent.</p>","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":null,"pages":null},"PeriodicalIF":6.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11139239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140897517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detecting novel psychoactive substances around the world. 在全球范围内检测新型精神活性物质。
IF 6.9 2区 医学
Current Opinion in Psychiatry Pub Date : 2024-07-01 Epub Date: 2024-04-22 DOI: 10.1097/YCO.0000000000000939
Alberto Salomone, Marco Vincenti
{"title":"Detecting novel psychoactive substances around the world.","authors":"Alberto Salomone, Marco Vincenti","doi":"10.1097/YCO.0000000000000939","DOIUrl":"10.1097/YCO.0000000000000939","url":null,"abstract":"<p><strong>Purpose of review: </strong>The worldwide spread of novel psychoactive substances (NPS) in the illicit drug market and their continuous increase in number and type, for the purpose of bypassing controlled substance legislation, represents a continuing challenge for forensic scientists, clinicians and enforcement authorities. We aim to provide information regarding the most urgent harms related to NPS consumption in different world regions and the current state of the art for NPS analysis.</p><p><strong>Recent findings: </strong>Unfortunately, the identification of NPS in biological samples is controversial, especially when samples are limited, or the drug is promptly and extensively metabolized. This causes a lack of information on their real diffusion in different parts of the world and in different populations. New technologies and instrumental detection of NPS in alternative samples are offering comprehensive information about NPS use.</p><p><strong>Summary: </strong>The lack of detection and underreporting of NPS in biological samples makes it difficult to obtain complete qualitative and quantitative information about NPS prevalence. The most innovative strategies that have been proposed in the last 2 years to assist NPS analysis and possibly facilitate the understanding of the NPS diffusion around the world are presented.</p>","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":null,"pages":null},"PeriodicalIF":6.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Opioid vaccine clinical testing: lessons learned. 阿片类疫苗临床试验:经验教训。
IF 6.9 2区 医学
Current Opinion in Psychiatry Pub Date : 2024-07-01 Epub Date: 2024-05-01 DOI: 10.1097/YCO.0000000000000945
Rachel Luba, Sandra D Comer
{"title":"Opioid vaccine clinical testing: lessons learned.","authors":"Rachel Luba, Sandra D Comer","doi":"10.1097/YCO.0000000000000945","DOIUrl":"10.1097/YCO.0000000000000945","url":null,"abstract":"<p><strong>Purpose of review: </strong>Opioid use disorder (OUD) presents a serious public health concern, with dramatic increases in opioid-overdose mortality in recent years and a small percentage of those with OUD accessing or remaining engaged with available treatments. Efforts are currently underway to identify vaccines targeting opioids, which could provide a novel and complimentary approach. The current review provides an overview of existing literature, practical considerations for designing and conducting clinical trials with vaccines for opioids, and future directions.</p><p><strong>Recent findings: </strong>This review covers the following themes: clinical trial design and selection of endpoints, timepoint selection, practical considerations and lessons learned from the first (ongoing) trial of a vaccine targeting opioids, and future directions.</p><p><strong>Summary: </strong>Efforts to develop and test vaccines targeting OUD are based on a foundation of preclinical work and close collaboration between preclinical and clinical researchers. Efforts to learn from shortcomings of prior clinical trials of vaccines for other substances are essential in designing and testing effective vaccines for OUD. Design and implementation of clinical trials for a vaccine for OUD requires careful balance of participant safety and strategies for retention and efforts to gather viable data to inform future work.</p>","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":null,"pages":null},"PeriodicalIF":6.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140897564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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