Current Opinion in Psychiatry最新文献

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Eating disorders in Southern Africa: an update on prevalence, recognition, and clinical implications. 南部非洲饮食失调:流行、认识和临床意义的最新情况。
IF 5.9 2区 医学
Current Opinion in Psychiatry Pub Date : 2026-09-11 DOI: 10.1097/YCO.0000000000001116
Lot Sternheim, Hans W Hoek, Bernou Melisse
{"title":"Eating disorders in Southern Africa: an update on prevalence, recognition, and clinical implications.","authors":"Lot Sternheim, Hans W Hoek, Bernou Melisse","doi":"10.1097/YCO.0000000000001116","DOIUrl":"https://doi.org/10.1097/YCO.0000000000001116","url":null,"abstract":"<p><strong>Purpose of review: </strong>Recent publications call for research on eating disorders in Southern Africa. However, research is scarce, dated and heavily relies on unvalidated self-reports conducted mainly among young, urban women. This narrative review deliberate challenges in recognizing and identifying eating disorder pathology in Southern African populations and discusses research and clinical implications.</p><p><strong>Recent findings: </strong>The prevalence in Southern Africa is 0.7%, and 0.5-4.7% for the named eating disorders. Cultural, linguistic, and dietary practices may obscure recognition of eating disorder pathology. Evidence on body image concerns is mixed, suggesting that these differ from Western contexts. Interactions between ethnicity and broader socio-cultural factors remain underexplored. These gaps highlight the need for contextually relevant research and for co-developing interventions with local researchers, clinicians, and individuals with lived experience.</p><p><strong>Summary: </strong>The comprehension of eating disorder pathology in Southern African populations remains limited. Understanding and including linguistic, socio-cultural and socio-economic factors is essential. Qualitative research offers an important starting point to explore body image, disordered eating thoughts and behaviors, and underlying mechanisms in these populations.</p>","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148944359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic health in severe mental illness: bridging the mortality gap - a narrative review. 严重精神疾病的代谢健康:弥合死亡率差距-叙述性回顾。
IF 5.9 2区 医学
Current Opinion in Psychiatry Pub Date : 2026-09-09 DOI: 10.1097/YCO.0000000000001121
Kousar Ishaq, Gerardo A Zavala, Najma Siddiqi
{"title":"Metabolic health in severe mental illness: bridging the mortality gap - a narrative review.","authors":"Kousar Ishaq, Gerardo A Zavala, Najma Siddiqi","doi":"10.1097/YCO.0000000000001121","DOIUrl":"https://doi.org/10.1097/YCO.0000000000001121","url":null,"abstract":"<p><strong>Purpose of review: </strong>People with severe mental illness (SMI) continue to experience a marked mortality gap, driven largely by preventable cardiometabolic conditions. This review examines recent advances in metabolic health that move the field beyond monitoring towards earlier, more proactive, and better integrated interventions.</p><p><strong>Recent findings: </strong>Recent pharmacological evidence supports metformin's role in mitigating antipsychotic-induced weight gain, and also supports glucagon-like peptide-1 receptor agonists as effective treatments for established obesity and dysglycaemia in SMI. Evidence for behavioural interventions suggests that meaningful improvement, including remission of metabolic syndrome, is achievable when interventions are sufficiently intensive, tailored, and embedded within routine care, rather than delivered as low-intensity education alone. Updated clinical guidance endorses a \"screen and intervene\" approach and promotes integrated models of mental and physical healthcare, but major implementation gaps remain, particularly in low- and middle-income settings. Finally, emerging genetic and biological evidence indicates that metabolic dysfunction may be partly intrinsic to SMI, underscoring the clinical relevance of metabolic psychiatry.</p><p><strong>Summary: </strong>Metabolic health in SMI should now be considered a core therapeutic target. The central challenge is not only recognising the problem, but also implementing effective metabolic interventions, at scale, across diverse, often siloed, care settings.</p>","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of inflammation in neurodevelopment and childhood psychiatric disorders. 炎症在神经发育和儿童精神疾病中的作用。
IF 5.9 2区 医学
Current Opinion in Psychiatry Pub Date : 2026-09-02 DOI: 10.1097/YCO.0000000000001122
Alexandra U Zezulin, Jonathan Posner
{"title":"The role of inflammation in neurodevelopment and childhood psychiatric disorders.","authors":"Alexandra U Zezulin, Jonathan Posner","doi":"10.1097/YCO.0000000000001122","DOIUrl":"https://doi.org/10.1097/YCO.0000000000001122","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review examines how prenatal inflammation may contribute to psychiatric and neurodevelopmental disorders, with a focus on maternal immune activation, microglial programming, and epigenetic mechanisms.</p><p><strong>Recent findings: </strong>Recent studies have found that inflammation during pregnancy is associated with changes in brain development and neurodevelopmental outcomes in children. Animal research indicates that maternal immune activation can cause long-lasting changes in gene expression, neural circuitry, and microglial activity. Two-hit models suggest that prenatal inflammation may prime microglia, making the brain more vulnerable to later stress, infections, or adversity. Interventions that target microglia, reduce inflammation, or provide enriched environments may reduce downstream behavioral and neurodevelopmental effects.</p><p><strong>Summary: </strong>Inflammation in early life may increase the risk of psychiatric disorders by altering placental signals, fetal brain development, and neuroimmune regulation. Preventing inflammation during pregnancy and reducing stress and adversity after birth may help protect against later mental health problems.</p>","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bipolar disorder and the risk of developing dementia - a systematic review and meta-analysis. 双相情感障碍和发展为痴呆的风险——一项系统回顾和荟萃分析。
IF 5.9 2区 医学
Current Opinion in Psychiatry Pub Date : 2026-09-01 Epub Date: 2026-05-20 DOI: 10.1097/YCO.0000000000001100
Lars Vedel Kessing, Klaus Munkholm
{"title":"Bipolar disorder and the risk of developing dementia - a systematic review and meta-analysis.","authors":"Lars Vedel Kessing, Klaus Munkholm","doi":"10.1097/YCO.0000000000001100","DOIUrl":"10.1097/YCO.0000000000001100","url":null,"abstract":"<p><strong>Purpose of review: </strong>To present an up-to-date systematic review and meta-analysis on the risk of dementia in patients with bipolar disorder.</p><p><strong>Recent findings: </strong>We included 22 studies investigating the risk of developing dementia among patients with bipolar disorder of which 21 studies provided data for the meta-analysis, comprising a total of 185 306 patients with bipolar disorder and 10 702 744 participants without bipolar disorder. Random effects meta-analysis showed an increased risk of being diagnosed with dementia in patients diagnosed with bipolar disorder [odds ratio (OR): 3.13 (95% CI: 2.40-4.09), I2  = 99.8%, 21 studies]. In a secondary analysis excluding studies with overlapping populations, the pooled effect estimate was OR = 2.60 (95% CI 1.76-3.85, I2  = 99.9%, 11 studies). The evidence was uncertain due to substantial and unexplained between-study heterogeneity, methodological limitations, and risk of bias in the included studies.</p><p><strong>Summary: </strong>Patients with bipolar disorder have an increased risk of developing dementia, but the evidence is uncertain.</p>","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":" ","pages":"390-399"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bipolar disorder in later life: lifestyle and physical health. 老年生活中的双相情感障碍:生活方式和身体健康。
IF 5.9 2区 医学
Current Opinion in Psychiatry Pub Date : 2026-09-01 Epub Date: 2026-02-10 DOI: 10.1097/YCO.0000000000001079
Osvaldo P Almeida
{"title":"Bipolar disorder in later life: lifestyle and physical health.","authors":"Osvaldo P Almeida","doi":"10.1097/YCO.0000000000001079","DOIUrl":"10.1097/YCO.0000000000001079","url":null,"abstract":"<p><strong>Purpose of review: </strong>To review the association between bipolar disorder in later life, lifestyle measures and physical health.</p><p><strong>Recent findings: </strong>Unhealthy lifestyle behaviours are more frequent among individuals with than without bipolar disorder, and recent retrospective cohort studies using the UK Biobank and Primary Care Clinical Practice Research Datalink have produced results suggesting that hazardous lifestyles may individually and together increase the risk of incident bipolar disorder, including later in life. In addition, new investigations using data from the GAGE-BD consortium and the Australian Pharmaceutical Benefits Scheme suggest that physical health morbidities are generally more prevalent among older women than men with bipolar disorder.</p><p><strong>Summary: </strong>The findings of recent studies indicate that bipolar disorder is associated with unhealthy or hazardous lifestyles and that the association between them may be reciprocal. Lifestyle behaviours seem to have additive effects on physical morbidity, and this may help guide the introduction of harm-minimisation interventions. Bipolar disorder is also associated with high physical health burden, which seems to be more pronounced in women than men. The reasons behind such sex-discrepancy are unclear.</p>","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":" ","pages":"385-389"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147364114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rethinking mental disorders in COVID-19: evidence from prepandemic longitudinal data. 重新思考COVID-19中的精神障碍:来自大流行前纵向数据的证据
IF 5.9 2区 医学
Current Opinion in Psychiatry Pub Date : 2026-09-01 Epub Date: 2026-07-07 DOI: 10.1097/YCO.0000000000001103
Diana Czepiel, Els van der Ven, Marit Sijbrandij, Hans W Hoek
{"title":"Rethinking mental disorders in COVID-19: evidence from prepandemic longitudinal data.","authors":"Diana Czepiel, Els van der Ven, Marit Sijbrandij, Hans W Hoek","doi":"10.1097/YCO.0000000000001103","DOIUrl":"10.1097/YCO.0000000000001103","url":null,"abstract":"<p><strong>Purpose of review: </strong>To synthesize longitudinal evidence of mental health outcomes, including prepandemic symptom measurements, among individuals with preexisting mental disorders during the COVID-19 pandemic.</p><p><strong>Recent findings: </strong>Symptom exacerbation commonly occurred in bulimia nervosa, binge-eating disorder, substance use disorders and in obsessive-compulsive psychopathology related to contamination, while symptom improvement was consistently observed in bipolar disorders. In autism spectrum, schizophrenia spectrum and posttraumatic stress disorders, contrasting symptom patterns were reported, possibly reflecting differences in preexisting demographic and clinical profiles and contextual influences. Symptoms in depressive and anxiety disorders, anorexia nervosa and obsessive-compulsive psychopathology unrelated to contamination remained largely stable. Across most disorders, individuals with chronic mental disorders or higher prepandemic symptom levels more frequently showed stable or improving trajectories than those with milder presentations or recent-onset disorders.</p><p><strong>Summary: </strong>Given the small number of methodologically diverse studies, definitive statements regarding differential impact of the pandemic across disorders or underlying mechanisms remain premature. Nevertheless, current evidence does not indicate a generalised deterioration in individuals with preexisting mental disorders, including those with the highest prepandemic symptom burden. While some disorder-specific differences emerged, likely reflecting interactions between contextual changes and preexisting disorder processes, the overall picture is more nuanced than frequently portrayed in pandemic-related literature.</p>","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":" ","pages":"375-384"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13566447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148519977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lifestyle and psychotherapy interventions for older adults with bipolar disorder. 老年双相情感障碍患者的生活方式和心理治疗干预。
IF 5.9 2区 医学
Current Opinion in Psychiatry Pub Date : 2026-09-01 Epub Date: 2026-04-30 DOI: 10.1097/YCO.0000000000001092
Paula Villela Nunes, Luisa de Siqueira Rotenberg, Lucas Melo Neves, Beny Lafer
{"title":"Lifestyle and psychotherapy interventions for older adults with bipolar disorder.","authors":"Paula Villela Nunes, Luisa de Siqueira Rotenberg, Lucas Melo Neves, Beny Lafer","doi":"10.1097/YCO.0000000000001092","DOIUrl":"10.1097/YCO.0000000000001092","url":null,"abstract":"<p><strong>Purpose of review: </strong>Bipolar disorder (BD) in older adults presents unique clinical challenges, and nonpharmacological interventions are an important component of comprehensive care, with more favorable side-effect profiles. This review synthesizes recent evidence on lifestyle and psychotherapy interventions for older adults with BD.</p><p><strong>Recent findings: </strong>Evidence derives predominantly from observational studies, with few interventional trials. Lifestyle analysis - largely from large-scale biobank cohorts - identifies smoking, sleep dysregulation, sedentary behavior, suboptimal diet, and weight extremes as modifiable risk factors associated with BD onset and course. Despite guideline recommendations, cognitive behavioral therapy for insomnia remains underutilized in BD. In psychotherapy, recovery-oriented and strengths-based models, including Recovery-focused Therapy and Functional Remediation for older adults, show feasibility and acceptability, with a randomized trial underway. Physical activity research is severely limited by absence of interventional studies in older adults with BD, with available evidence indicating that cognitive function and sedentary behavior may be bidirectionally associated.</p><p><strong>Summary: </strong>Lifestyle and psychotherapy interventions for older adults with BD remain limited by paucity of interventional evidence, particularly for this age group. Integrated, age-sensitive, and recovery-oriented approaches hold promise. Future research must prioritize trials that include older adults and address lifestyle factors and their impact on course, cognition and psychosocial functioning.</p>","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":" ","pages":"425-431"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroimaging in older-age bipolar disorder. 老年双相情感障碍的神经影像学研究。
IF 5.9 2区 医学
Current Opinion in Psychiatry Pub Date : 2026-09-01 Epub Date: 2026-06-20 DOI: 10.1097/YCO.0000000000001104
Florindo Stella, Rodolfo B Ladeira, Orestes V Forlenza
{"title":"Neuroimaging in older-age bipolar disorder.","authors":"Florindo Stella, Rodolfo B Ladeira, Orestes V Forlenza","doi":"10.1097/YCO.0000000000001104","DOIUrl":"10.1097/YCO.0000000000001104","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review summarizes neuroimaging studies designed to investigate cortical and subcortical brain changes in older adults with bipolar disorder (OABD). The imaging modalities discussed in the review include structural MRI, functional MRI (fMRI), diffusion tensor imaging (DTI) addressing white-matter microstructure, and functional and molecular neuroimaging with PET (18-F-FDG-PET, amyloid-PET, and tau-PET).</p><p><strong>Recent findings: </strong>Although limited, the neuroimaging evidence in OABD points to cortical thinning, reduced gray matter volume, subcortical alterations, and decreased fractional anisotropy in white-matter tracts. Studies also report a 'brain age gap' in bipolar disorder, in which predicted brain age (as per neuroimaging scans) exceeds chronological age.</p><p><strong>Summary: </strong>Neuroimaging research in OABD remains limited by methodological heterogeneity, including variable imaging protocols, differences in episode severity and frequency, the effects of pharmacological treatment and neurobiological changes associated with disease chronicity. These factors restrict comparability and generalizability across studies.</p>","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":" ","pages":"432-437"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Repetitive transcranial magnetic stimulation treatment for obsessive-compulsive disorder. 反复经颅磁刺激治疗强迫症。
IF 5.9 2区 医学
Current Opinion in Psychiatry Pub Date : 2026-09-01 Epub Date: 2026-06-20 DOI: 10.1097/YCO.0000000000001107
Monika Klírová, Andrej Stančák, Tomáš Novák, Odile A van den Heuvel
{"title":"Repetitive transcranial magnetic stimulation treatment for obsessive-compulsive disorder.","authors":"Monika Klírová, Andrej Stančák, Tomáš Novák, Odile A van den Heuvel","doi":"10.1097/YCO.0000000000001107","DOIUrl":"10.1097/YCO.0000000000001107","url":null,"abstract":"<p><strong>Purpose of review: </strong>Repetitive transcranial magnetic stimulation (rTMS) and its modifications have emerged as promising interventions for obsessive-compulsive disorder (OCD). Although growing evidence supports the safety and clinical efficacy of rTMS, substantial heterogeneity in study designs and stimulation protocols continues to hinder the development of uniform, consensus-based guidelines.</p><p><strong>Recent findings: </strong>Large-scale clinical trials capable of definitively establishing the effectiveness of existing rTMS protocols are still lacking. However, available findings from smaller randomized controlled trials and (network) meta-analyses suggest moderate efficacy for various rTMS targets and protocols. Accelerated protocols may shorten time to response, though comparative evidence of their efficacy remains limited. In the absence of clear clinical predictors, research is increasingly focused on personalized treatment protocols and biomarker-informed prediction of response. Also, integrated treatment approaches, with accumulating evidence supporting the combination of rTMS with psychotherapy or pharmacotherapy, seem promising.</p><p><strong>Summary: </strong>rTMS shows promise as an adjunctive treatment for OCD. Large, well designed clinical trials are required to establish the most effective target and stimulation parameters and to verify long-term outcomes. Personalized targeting guided by neural predictors, as well as the integration of rTMS into broader therapeutic strategies, may enhance treatment efficacy.</p>","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":" ","pages":"364-374"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13566475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological maintenance treatment in older age bipolar disorder. 老年双相情感障碍的药物维持治疗。
IF 5.9 2区 医学
Current Opinion in Psychiatry Pub Date : 2026-09-01 Epub Date: 2026-06-10 DOI: 10.1097/YCO.0000000000001101
Debbie Zittema, Annemieke Dols
{"title":"Pharmacological maintenance treatment in older age bipolar disorder.","authors":"Debbie Zittema, Annemieke Dols","doi":"10.1097/YCO.0000000000001101","DOIUrl":"10.1097/YCO.0000000000001101","url":null,"abstract":"<p><strong>Purpose of review: </strong>The current review discusses the most recent developments in pharmacological maintenance treatment of older age bipolar disorder.</p><p><strong>Recent findings: </strong>Older age bipolar disorder (OABD) applies to patients with bipolar disorder aged 50 years and over, a threshold reflecting the association between bipolar disorder and premature aging. Although medication effective in younger age bipolar disorder (YABD) are generally assumed to remain effective in older adults, the disease course becomes more complex in time and age-related changes in pharmacokinetics and pharmacodynamics require careful consideration. Despite the growing aging population, research targeting OABD remains limited. Therefore, the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE-BD) was initiated by the ISBD (International Society for Bipolar Disorder) OABD taskforce in 2016. Several recent studies on pharmacological maintenance therapy originated from this initiative and are discussed in this narrative review alongside other recent findings. However, no intervention studies have been published in the last 18 months, and the current evidence base largely consists of prospective cohort studies and cross-sectional data.</p><p><strong>Summary: </strong>When looking at maintenance therapy in OABD, lithium remains first line of treatment but with an adjusted lower therapeutic range. Lithium therapy should not be withheld due to concerns of future kidney function decline.</p>","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":" ","pages":"400-405"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13566370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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