Mehrdad Abdinian, Mohammad Amin Tavakoli Hranadi, Mohammad Hossein Manouchehri Naeini
{"title":"Evaluating the effect of amalgam fillings on caries detection in cone-beam computed tomography images.","authors":"Mehrdad Abdinian, Mohammad Amin Tavakoli Hranadi, Mohammad Hossein Manouchehri Naeini","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Dental caries stands as one of the most prevalent dental concerns, with early diagnosis being pivotal in clinical dentistry. Cone-beam computed tomography (CBCT) emerges as a widely utilized modality for dental caries identification, owing to its significant advantages. However, there remains a considerable knowledge gap regarding the efficacy of CBCT scans in detecting dental caries. In line with the as low as reasonably achievable principle, this study endeavors to evaluate the impact of amalgam fillings on the precision of occlusal caries detection in CBCT.</p><p><strong>Materials and methods: </strong>This <i>in vitro</i> study employed a set of 102 extracted human teeth samples. Among these, six molar teeth were used to create mesial-occlusal-distal amalgam restorations. The remaining teeth were placed in the dental sockets of a dry human skull to restore proximal contacts. CBCT images were obtained and examined by two observers, while histopathological examination was conducted using a stereomicroscope. Comparative analysis of CBCT images and histopathological data was performed using the McNemar test in SPSS software (α = 0.05).</p><p><strong>Results: </strong>The McNemar test results indicated that the nonrestoration group showed greater sensitivity and lower specificity in CBCT imaging than the amalgam-restored tooth group.</p><p><strong>Conclusion: </strong>The findings suggested that the CBCT technique did not demonstrate effectiveness in diagnosing dental caries around amalgam restorations.</p>","PeriodicalId":11016,"journal":{"name":"Dental Research Journal","volume":"21 ","pages":"54"},"PeriodicalIF":0.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anil Tanaji Patil, Tanaya Rajeev Kulkarni, B Sandhyarani, Sujatha Paranna, Renuka Bhurke, Ankita Annu
{"title":"The effect of nano-hydroxyapatite and casein phosphopeptide-amorphous calcium phosphate with and without laser irradiation on the microhardness and surface morphology of demineralized primary enamel: An <i>in vitro</i> experimental study.","authors":"Anil Tanaji Patil, Tanaya Rajeev Kulkarni, B Sandhyarani, Sujatha Paranna, Renuka Bhurke, Ankita Annu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Various topical gels, varnishes, and fluoride gels are being used by dentists for the treatment of White spot lesions (WSLs). The remineralizing effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), nano-hydroxyapatite (nHAp), and lasers has been proven earlier. This study was designed to evaluate the remineralizing effect of nHAp and CPP-ACP with and without erbium-doped yttrium aluminum garnet (Er: YAG) laser irradiation on demineralized primary enamel. The aim of this study was to evaluate the effect of CPP-ACP and nHAp with and without Er:YAG laser irradiation on the microhardness and surface morphology of demineralized primary enamel.</p><p><strong>Materials and methods: </strong>The present study is an experimental <i>in vitro</i> study. Fifty extracted primary incisors were selected for the study. Following cleaning and sectioning, teeth were embedded in acrylic. The tooth models were divided into four groups randomly - Group 1 (CPP-ACP), Group 2 (nHAp), Group 3 (CPP-ACP + laser), and Group 4 (nHAp + laser). The baseline, postdemineralization, and postremineralization Vickers hardness testing was performed. One sample from each group was analyzed by scanning electron microscopy. Descriptive statistics such as frequencies and percentages for categorical data, mean and standard deviation for numerical data were depicted. The normality of numerical data was checked using the Shapiro-Wilk test. The level of significance was kept at 5%. Intergroup comparison (>2 groups) was done using one-way analysis of variance followed by pair-wise comparison using the <i>post hoc</i> test.</p><p><strong>Results: </strong>There was a statistically significant increase in surface microhardness in each group after remineralization. The highest increase in microhardness value was seen in Group 4 (nHAp + laser) followed by Group 3 (CPP-ACP + laser) and the least in Group 1 (CPP-ACP). Similar observations were made in scanning electron microscopic images. This indicated that nHAp has a comparable, if not better ability for remineralization than CPP-ACP. The remineralizing capacity of both the remineralizing agents was seen to be improved in this study when simultaneous laser application was employed.</p><p><strong>Conclusion: </strong>Currently, the evidence supporting the efficacy of nHAp dentifrices and laser in primary teeth is limited. Additional long-term <i>in vivo</i> studies employing standardized protocols and large sample sizes are necessary to draw definitive findings about the effect of remineralizing agents and lasers on primary enamel.</p>","PeriodicalId":11016,"journal":{"name":"Dental Research Journal","volume":"21 ","pages":"47"},"PeriodicalIF":0.0,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abhishek Purohit, Abhinav Singh, Bharathi M Purohit
{"title":"Structure equation modeling in oral health research: A review of applications and considerations.","authors":"Abhishek Purohit, Abhinav Singh, Bharathi M Purohit","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This review provides an overview of structure equation modeling (SEM) and its applications in dental research. SEM is a statistical technique that allows researchers to examine the relationships between variables and is useful for analyzing data from a wide range of research designs, including cross-sectional, longitudinal, and experimental studies. The process involves specifying a theoretical model, testing the model with data, and evaluating the model fit. It has been used in dental research to investigate a wide range of topics, including dental diseases, oral health-related quality of life, and dental anxiety. SEM is particularly useful in modeling the relationships between various risk factors and dental diseases and also has the potential to provide a deeper understanding of the multifactorial nature of dental diseases such as periodontitis, dental caries, and oral cancer. Moreover, the insights provided can aid in the development of effective strategies for the prevention and treatment of dental diseases. It is a powerful statistical tool that can be used by dental researchers to gain a better understanding of the intricate interplay of factors that underlie dental diseases and other oral health-related outcomes.</p>","PeriodicalId":11016,"journal":{"name":"Dental Research Journal","volume":"21 ","pages":"49"},"PeriodicalIF":0.0,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correlation between clinicopathological indices and expression of cluster of differentiation 24 and cluster of differentiation 44 biomarkers in oral epithelial dysplasia and oral squamous cell carcinoma patients: A follow-up study.","authors":"Narges Ghazi, Nasrollah Saghravanian, Kazem Anvari, Majid Mirhashemi, Mohammadhadi Erfanian","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Oral squamous cell carcinoma (OSCC) is the most common oral cavity cancer and may occur following oral epithelial dysplasia (OED). Cancer stem cells (CSCs) can self-renew and multi-directionally differentiate to promote tumorigenesis with high expression of cluster of differentiation (CD) 24 and CD44 markers. CSCs play a pivotal role in tumor development, drug resistance, and relapse after treatment. We aimed to evaluate the correlation between both marker expressions and clinicopathological indices in OED and OSCC patients.</p><p><strong>Materials and methods: </strong>In this follow-up study, we could access 37 patients, including 12 OEDs and 25 OSCCs (Grade I: <i>n</i> = 9, Grade II: <i>n</i> = 8, and Grade III: <i>n</i> = 8). Data were analyzed using SPSS software (version 26) and log-rank tests, Fisher's exact test, Chi-square, and one-way ANOVA. <i>P</i> < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>There was no significant difference in the expression of CD24 and CD44 markers between the study groups (<i>P</i> > 0.05) and the expression of both markers and clinicopathological indices in the study groups (<i>P</i> > 0.05). The mean and standard deviation of overall survival (OS) were 54.46 ± 43.08 with a range of 6-193 months, and they were 8.24 ± 15.34 months with a range of 0-70 months for disease-free survival (DFS) in patients, respectively. The average of DFS in Grade I was significantly lower than the OED (<i>P</i> = 0.002) and Grade II (<i>P</i> = 0.039) groups. The OS average in the Grade I (<i>P</i> = 0.014) and Grade III (<i>P</i> = 0.004) groups was statistically lower than the OED group.</p><p><strong>Conclusion: </strong>Although more than half of the patients demonstrated high expression of both markers, there was no statistically significant difference between them and clinicopathological indices.</p>","PeriodicalId":11016,"journal":{"name":"Dental Research Journal","volume":"21 ","pages":"50"},"PeriodicalIF":0.0,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Comparative immunohistochemical analysis of epithelial-mesenchymal transition biomarkers in odontogenic keratocyst, dentigerous cyst, and radicular cyst.","authors":"Hamideh Kadeh, Nahid Esmaeilzadeh Ashini","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Odontogenic keratocyst (OKC) is one of the common odontogenic cysts with aggressive clinical behavior and a high recurrence rate. Epithelial-mesenchymal transition (EMT) is a process, in which the epithelial cell loses its epithelial characteristics and acquires mesenchymal features. Since the evidence for the involvement of EMT in the development of OKC is still limited, the present study aimed to investigate the immunohistochemical expression of EMT-related proteins (E-cadherin and N-cadherin) in OKC and compare them to radicular cyst (RC) and dentigerous cyst (DC).</p><p><strong>Materials and methods: </strong>In this descriptive analytical study, 75 paraffin blocks, including 25 DCs, 25 OKC, and 25 RCs, were selected. Immunohistochemical staining was performed to determine the expression and staining intensity of E-cadherin and N-cadherin proteins. The specimens were examined under an optical microscope, and the data were analyzed using the Kruskal-Wallis test in SPSS statistical software (version 23) with a significance level of 5%.</p><p><strong>Results: </strong>The expression of N-cadherin in OKC was higher than that in other cysts; nonetheless, there was no statistically significant difference (<i>P</i> = 0.331). The staining intensity of N-cadherin was weak in most cases, and this difference was not statistically significant (<i>P</i> = 0.252). E-cadherin expression in OKC was significantly lower than that in radicular and DCs (<i>P</i> = 0.003). In addition, the staining intensity of E-cadherin in OKC was weak and moderate (<i>P</i> = 0.003).</p><p><strong>Conclusion: </strong>In this study, we observed an increase in the expression of N-cadherin in OKC. In addition, the protein expression levels of E-cadherin in OKC were significantly lower compared to DC and RC. Therefore, it appears that the EMT process likely occurs in OKC and may contribute to its local aggressive behavior.</p>","PeriodicalId":11016,"journal":{"name":"Dental Research Journal","volume":"21 ","pages":"46"},"PeriodicalIF":0.0,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mehdi Shahabinejad, Siavash Bagheri Shirvan, Golnaz Fatemi, Farnaz Mohajer Tehran
{"title":"Comparative analysis of PDL1 and cluster of differentiation 68 marker expression in oral squamous cell carcinoma patients: Correlation with depth of invasion and immunofluorescence through immunohistochemistry.","authors":"Mehdi Shahabinejad, Siavash Bagheri Shirvan, Golnaz Fatemi, Farnaz Mohajer Tehran","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Over the past 5 years, the use of immune checkpoint inhibitors in the treatment of head-and-neck squamous cell carcinoma (HNSCC) has increased. Both programmed death-ligand 1 (PD-L1) and cluster of differentiation 68 (CD68) are overexpressed in various carcinomas. Consequently, evaluating the expression of CD68 and PD-L1 in HNSCC lesions may lead to detecting a possible marker for HNSCC. This study aimed to evaluate the expression of PDL1 and CD68 markers in a patient with oral squamous cell carcinoma (OSCC) and examine its relationship with depth of invasion (DOI) and immunofluorescence (IF) through immunohistochemistry.</p><p><strong>Materials and methods: </strong>This cross-sectional study was conducted in the School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran, Department of Oral and Maxillofacial Pathology. Thirty-four paraffin blocks and demographic information of 15 female and 19 male OSCC patients were collected. Following sample preparations, immunohistochemical staining was performed. Subsequently, each tissue section was analyzed for tumor-infiltrating lymphocytes by CD68 marker and PD-L1 expression. Data analysis was conducted using SPSS software (version 25). Chi-square, Shapiro-Wilk, and independent <i>t</i>-analytical tests were employed for statistical assessments. <i>P</i> < 0.05 was remarked as statistically significant.</p><p><strong>Results: </strong>CD68 and PDL1 expression in the squamous cell carcinoma (SCC) group was higher than the control group (<i>P</i> < 0.001). There was an increasing expression of PDL1 and CD68 as the grade of the disease progressed (<i>P</i> < 0.001 for each), as well as an increasing expression of IF and DOI.</p><p><strong>Conclusion: </strong>The expression levels of CD68 and PDL1 were elevated in SCC tissues in comparison to the unaffected, healthy parts of the tissue section.</p>","PeriodicalId":11016,"journal":{"name":"Dental Research Journal","volume":"21 ","pages":"48"},"PeriodicalIF":0.0,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maryam Mehrabkhani, Razie Khanmohammdi, Hosein Nematollahi, Nikoo Rajabi, Ali Gheidari
{"title":"Influence of temperament on children's cooperation during dental treatment.","authors":"Maryam Mehrabkhani, Razie Khanmohammdi, Hosein Nematollahi, Nikoo Rajabi, Ali Gheidari","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The etiologies of childhood dental fear/dental behavior management problems have been extensively studied, especially the role of children's temperaments. This study aimed to evaluate the effect of temperament and its associated variables on the anxiety and cooperation level of preschool children in a dental clinic.</p><p><strong>Materials and methods: </strong>This cross-sectional study involved 103, 4-6-year-old patients (39 boys and 64 girls). The children's parents or guardians completed the Child Fear Survey Schedule (CFSS) Dental Subscale and the Malhotra temperament questionnaire before the treatment. Patients' anxiety and cooperation levels were then assessed through three distinct treatment stages of fluoride therapy, injection of local anesthesia, and drilling, by applying the Venham anxiety and clinical cooperation scales. The data were analyzed using analysis of variance, Mann-Whitney, Kruskal-Wallis, and Chi-square tests. The significance level of 0.05 was deemed relevant in the analysis.</p><p><strong>Results: </strong>A significant correlation was established between the mean of CFSS and the variety of temperament (<i>P</i> = 0.001). Anxiety and uncooperative behavior during injection and drilling were strongly related to lower sociability scores. Furthermore, higher anxiety during the drilling stage was related to higher impulsivity scores.</p><p><strong>Conclusion: </strong>The evaluation of children's anxiety and cooperation in dental clinics heavily relies on temperament and certain related factors, such as sociability. These variables serve as crucial benchmarks in understanding and assessing the psychological state of children during dental procedures.</p>","PeriodicalId":11016,"journal":{"name":"Dental Research Journal","volume":"21 ","pages":"45"},"PeriodicalIF":0.0,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pardis Sheibani, Ghazaleh Ahmadizenous, Behnaz Esmaeili, Ali Bijani
{"title":"Effect of computer-aided design/computer-aided manufacturing bleach shade ceramic thickness on its light transmittance and microhardness of light-cured resin cement.","authors":"Pardis Sheibani, Ghazaleh Ahmadizenous, Behnaz Esmaeili, Ali Bijani","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to measure light transmittance (LT) through various thicknesses of computer-aided design/computer-aided manufacturing bleach shade ceramics and to assess the Vickers microhardness (VMH) of underlying light-cured resin cement.</p><p><strong>Materials and methods: </strong>In this <i>in vitro</i> study, a total of 90 ceramic discs (VITA Mark II [VM], VITA Suprinity, and CELTRA Duo) were prepared in 0.5, 1, and 1.5 mm thicknesses. To measure LT, the Valo light-curing unit was placed in direct contact with the ceramics on the radiometer. The average LT was recorded after three measurements. In addition, 90 specimens of light-cured resin cement (Allcem Veneer) were cured in Teflon molds (0.5 mm in depth) beneath ceramic pieces. Ten specimens of resin cement were also cured without the presence of ceramic as a control group. VMH of the cement specimens was reported. The data were analyzed by one-way analysis of variance and multiple comparison tests (α =0.05) in SPSS version 17.</p><p><strong>Results: </strong>In each ceramic group, LT was negatively related to ceramic thickness (<i>P</i> < 0.05). At a thickness of 1.5 mm among all ceramic types, the VMH of resin cement was significantly decreased (<i>P</i> < 0.05). In all thicknesses, the VMH of resin cement was lower significantly than the control group, except for the thickness of 0.5 mm of VM.</p><p><strong>Conclusion: </strong>According to the results of this study, light-cured cement is not a suitable option for cementing the studied bleach shade ceramics. Furthermore, the thickness of the ceramic has a significant effect on LT (<i>P</i> < 0.05), unlike VMH.</p>","PeriodicalId":11016,"journal":{"name":"Dental Research Journal","volume":"21 ","pages":"44"},"PeriodicalIF":0.0,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prospects of artificial intelligence in dentistry.","authors":"Zohreh Afshari, Abbasali Khademi, Pedram Iranmanesh","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11016,"journal":{"name":"Dental Research Journal","volume":"21 ","pages":"35"},"PeriodicalIF":0.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of preoperative systemic capsaicin on tooth sensitivity after in-office bleaching: A pilot study.","authors":"Pouran Samimi, Marzie Kachuie, Abbas Jafarian, Maryam Montazeri Shahtouri, Maryam Khoroushi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Tooth bleaching sensitivity (TBS) after bleaching procedures is a common problem. This study was undertaken to determine the effect of preoperative systemic capsaicin on tooth sensitivity (TS) after in-office bleaching procedures.</p><p><strong>Materials and methods: </strong>Thirty participants received the treatment in this clinical trial. The subjects were randomly assigned to two groups (<i>n</i> = 15). Placebo and 0.25% capsaicin were administered three times daily for 24 h, with the first dose being administrated 1 h before the bleaching procedure. The subjects underwent two bleaching sessions at a 2-week interval by applying 40% hydrogen peroxide gel on six upper anterior teeth. A visual analog scale (VAS) was used to evaluate TS. Data were analyzed with SPSS 24. Statistical analyses were carried out with the Wilcoxon test and paired <i>t</i>-test. Statistical significance was set at <i>P</i> ≤ 0.05.</p><p><strong>Results: </strong>In the capsaicin group, there was a significant increase in TBS between the immediate and 1-h postoperative intervals and a significant decrease between 1- and 24-h postoperative intervals (<i>P</i> = 0.01 and <i>P</i> = 0.000, respectively). In the placebo group, there was a significant decrease between immediate and 24-h and between 1- and 24-h postoperative intervals (<i>P</i> = 0.007, <i>P</i> = 0.02). Milder TS was detected in the placebo group 24 h after bleaching (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Under the limitations of this study, preoperative use of systemic capsaicin did not significantly affect TS after the in-office bleaching procedure.</p>","PeriodicalId":11016,"journal":{"name":"Dental Research Journal","volume":"21 ","pages":"36"},"PeriodicalIF":0.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}