{"title":"Comparative study of E-cadherin expression between reticular, erosive oral lichen planus and lichenoid lesions.","authors":"Laleh Maleki, Gholamreza Jahanshahi, Forooz Keshani, Samira Fotoohi Ashiin","doi":"10.4103/drj.drj_447_23","DOIUrl":"10.4103/drj.drj_447_23","url":null,"abstract":"<p><strong>Background: </strong>Accurate and early diagnosis of dysplastic lesions is crucial for successful treatment. A decrease in E-cadherin expression has been observed in dysplastic lesions and tumors. Therefore, the aim of this study was to investigate the expression of E-cadherin, a cell membrane adhesive protein involved in tissue structure and differentiation, in oral reticular lichen planus, erosive lichen planus, and lichenoid lesions.</p><p><strong>Materials and methods: </strong>This descriptive cross-sectional study was conducted on 65 oral samples (20 reticular lichen planus, 20 erosive lichen planus, and 20 lichenoid lesions, with 5 samples of healthy mucosa), to evaluate the expression of E-cadherin using immunohistochemical methods. Data were analyzed using SPSS software (version 25), descriptive statistics, Chi-square tests, and Fisher's exact tests, with a significance threshold set at <i>P</i> < 0.05.</p><p><strong>Results: </strong>The majority of patients were female (72.3%) and primarily in the sixth and seventh decades of life (49.2%). A significant difference was observed between the studied groups regarding staining status (<i>P</i> = 0.038), with erosive lichen planus showing the highest frequency of alterations in E-cadherin expression (45%). In addition, a significant difference was noted between staining status and lesion location (<i>P</i> = 0.004), with the highest frequency of E-cadherin expression changes occurring in buccal mucosal samples (30%).</p><p><strong>Conclusion: </strong>E-cadherin expression in erosive lichen planus is significantly lower than in healthy tissue, reticular lichen planus, and lichenoid lesions. Given the similar reduction observed in squamous cell carcinoma samples, evaluating E-cadherin expression may aid in the early recognition of malignant changes.</p>","PeriodicalId":11016,"journal":{"name":"Dental Research Journal","volume":"22 ","pages":"39"},"PeriodicalIF":0.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12500239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of the effects of Persica and protact mouthwash on gingival healing after crown lengthening surgery - A double-blinded randomized clinical trial.","authors":"Hodis Ehsani, Zahra Tebbi, Tahere Molania, Leila Jabbareh, Tahura Etezadi, Melika Mollaei, Abolfazl Hosseinnataj, Maedeh Salehi","doi":"10.4103/drj.drj_353_24","DOIUrl":"10.4103/drj.drj_353_24","url":null,"abstract":"<p><strong>Background: </strong>Plaque control is one of the main issues after crown lengthening surgery. It is advised to use mouthwashes since mechanical plaque control is not possible due to the presence of the wound. Thus, the present study aims to compare the effectiveness of Persica and Protact mouthwash on gingival healing after crown lengthening surgery.</p><p><strong>Materials and methods: </strong>In this double-blind clinical trial, 33 candidates were randomly divided into three groups (<i>n</i> = 11). The first group used 0.2% chlorhexidine (CHX) mouthwash; the second group used Persica mouthwash; and the third group used Protact mouthwash. Patients were followed for 14 days and changes in their plaque index (PI), gingival index (GI), stain index (SI), tongue taste, and color were recorded. Data were analyzed using SPSS V.22 using the Kruskal-Wallis, Wilcoxon, and Chi-square tests. The significance level was considered to be < 0.05.</p><p><strong>Results: </strong>The PI decreases significantly after 14 days in the CHX group (<i>P</i> = 0.011), however, this difference was not significant in the other two groups. Moreover, the GI and SI were not significantly different in any of the groups (<i>P</i> > 0.05). The changes in the tongue color and taste were only observed in the CHX group and patient dissatisfaction was higher in this group.</p><p><strong>Conclusion: </strong>CHX is the gold standard for patients who have undergone clinical crown lengthening surgery; nevertheless, considering its side effects and bad taste, Persica and Protact herbal mouthwashes can be used in more sensitive and uncooperative individuals.</p>","PeriodicalId":11016,"journal":{"name":"Dental Research Journal","volume":"22 ","pages":"38"},"PeriodicalIF":0.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12500241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of polyethylene and glass fibers on fracture resistance of large MOD composite restorations.","authors":"Niloofar Shadman, Shadi Jahansepas, Arash Tavakoli Rouzbehani","doi":"10.4103/drj.drj_48_25","DOIUrl":"10.4103/drj.drj_48_25","url":null,"abstract":"<p><strong>Background: </strong>Fracture resistance of maxillary premolars with deep MOD cavities restored using resin composite, fibers (Ribbond and Angelus), and cuspal coverage with composite is of importance.</p><p><strong>Materials and methods: </strong>This experimental study divided 55 sound maxillary premolars into five groups. Group 1: intact teeth. MOD cavities with an occlusal depth of 5 mm, an axial depth of 1.5 mm, and a buccolingual width of 3 mm were prepared in the remaining teeth, Group 2: teeth restored with composite by incremental technique (Bisco Aelite Posterior), Group 3: Ribbond fiber, Group 4: Angelus fiber, and Group 5: 2-mm cuspal reduction and coverage with composite. They were subjected to a fracture strength test after 1000 thermocycles and 100,000 chewing cycles. Data were analyzed using analysis of variance, Tukey, and Chi-square tests. A significance level of <i>P</i> < 0.05 was considered.</p><p><strong>Results: </strong>The fracture strength of the control group, cuspal coverage, and Ribbond fiber were significantly higher than the composite group (<i>P</i> = 0.01, <i>P</i> = 0.02, and <i>P</i> = 0.001, respectively). The Angelus fiber also showed marginally higher fracture strength compared to the composite (<i>P</i> = 0.098). The Ribbond fiber exhibited a significantly more favorable failure pattern similar to intact teeth. The difference in failure patterns between the cuspal coverage and Ribbond (<i>P</i> = 0.009) and between the cuspal coverage and control (<i>P</i> = 0.034) was statistically significant.</p><p><strong>Conclusion: </strong>The use of Ribbond fiber, Angelus fiber, and cuspal coverage significantly increased the fracture strength of composite restorations compared to conventional composite in deep MOD of maxillary premolars. In addition, the Ribbond fiber resulted in a more favorable failure pattern, similar to that of intact teeth.</p>","PeriodicalId":11016,"journal":{"name":"Dental Research Journal","volume":"22 ","pages":"40"},"PeriodicalIF":0.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12500238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Microbrush bristle remnants on the bonding surface using different adhesive systems by scanning electron microscope: An <i>in vitro</i> study.","authors":"Shraddha Padwal, Pradeep Shetty, Divya Dudulwar, Kiran Keswani, Vishwajit Lokhande, Manjiri Raje","doi":"10.4103/drj.drj_112_24","DOIUrl":"10.4103/drj.drj_112_24","url":null,"abstract":"<p><strong>Background: </strong>The shelf life of dental restorations relies primarily on the adhesion between tooth and restorative material. Numerous dental adhesive systems have been developed to play a crucial role in enhancing this adhesion. However, the presence of any residues while applying adhesive systems may compromise the adhesive seal, affecting the properties of dental restorations. Thus, this paper aims to assess the presence of microbrush bristle remnants on bonding surfaces using total-etch and self-etch adhesive systems.</p><p><strong>Materials and methods: </strong>In the present experimental <i>in vitro</i> study, 12 extracted permanent maxillary premolar teeth were decoronated and divided into two groups (<i>n</i> = 6). Application of self-etch adhesive system (Seventh generation) was made on the prepared specimens with the help of microbrush (Cotisen) for group I, and total-etch adhesive system (Fifth generation) was applied on the prepared specimens for group II with the same brand of micro brush (Cotisen). Each group received a standardized polymerization process. The bonding surfaces of samples were then analyzed to determine the microbrush bristle remnants. An independent sample <i>t</i>-test was applied to compare the mean bristle remnants between the two groups. <i>P</i> value was set at 0.05 (at a 0.05 level of significance).</p><p><strong>Results: </strong>Self-etch adhesive system had a greater number of microbrush bristle remnants than the total-etch adhesive system, but the difference was not statistically significant.</p><p><strong>Conclusion: </strong>Irrespective of the different adhesive systems being used; microbrush bristle remnants were seen in both groups. Dentists should be cautious to avoid contamination of adhesive surfaces. The presence of bristle remnants might influence the shelf life of the restorations.</p>","PeriodicalId":11016,"journal":{"name":"Dental Research Journal","volume":"22 ","pages":"36"},"PeriodicalIF":0.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12500240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Combined treatment approach: A review of using clear aligners in orthognathic surgery procedures.","authors":"Atefe Ahmadvand, Hossein Ebrahimi, Zahra Amiri, Parisa Besharatizadeh","doi":"10.4103/drj.drj_251_25","DOIUrl":"10.4103/drj.drj_251_25","url":null,"abstract":"<p><strong>Background: </strong>Clear aligner therapy (CAT) was originally introduced for minor orthodontic corrections. However, with technological advances and increasing patient demands for esthetic and comfortable treatments, its application has expanded into more complex cases, including orthognathic surgery. This narrative review explores the use of clear aligners across all phases of orthognathic treatment, such as presurgical, surgical, and postsurgical.</p><p><strong>Materials and methods: </strong>The literature from 2000 to 2025 was analyzed, identifying 34 relevant studies.</p><p><strong>Results: </strong>Findings indicate that CAT can effectively manage dentofacial deformities such as skeletal Class II and III malocclusions, open bites, and craniofacial anomalies when used pre- and/or postoperatively.</p><p><strong>Conclusion: </strong>Clear aligners offer significant advantages in esthetics, oral hygiene, treatment comfort, and quality of life. The combination of surgery and CAT has been demonstrated to reduce treatment time and increase patient satisfaction without compromising skeletal stability. Although there are some limitations, such as concerns about relapse and aligner rigidity in early postoperative phases, the results of occlusal stability, periodontal health, and patient satisfaction are promising. The increasing use of CAT in orthognathic surgery cases, particularly in digitally driven interdisciplinary treatment plans, is supported by this review as an effective and patient-centered alternative to fixed appliances.</p>","PeriodicalId":11016,"journal":{"name":"Dental Research Journal","volume":"22 ","pages":"37"},"PeriodicalIF":0.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12500242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Oral health-related quality of life and its association with oral health literacy and dental caries experience among a group of pregnant women.","authors":"Mojdeh Shahpari, Hajar Shekarchizadeh, Mahsa Sadat Mousavi","doi":"10.4103/drj.drj_193_25","DOIUrl":"10.4103/drj.drj_193_25","url":null,"abstract":"<p><strong>Background: </strong>Oral health plays an important role in the general health of pregnant women and their newborns. Our aim was to assess oral health-related quality of life and its association with oral health literacy and dental caries among a group of Iranian pregnant women.</p><p><strong>Materials and methods: </strong>A cross-sectional study was conducted on 200 pregnant women attending a governmental hospital in Isfahan, Iran, applying a convenient sampling method. Self-administrated questionnaires requested information about demographics, oral health-related quality of life utilizing Oral Health Impact Profile-14 (OHIP-14), and oral health literacy. A senior dental student conducted a clinical examination to record dental caries with Decayed, Missing, and Filled Teeth (DMFT) index. Kolmogorov-Smirnov test, Mann-Whitney <i>U</i>-test, Kruskal-Wallis test, Spearman correlation coefficient, and logistic regression model served for analysis (<i>P</i> < 0.05).</p><p><strong>Results: </strong>The prevalence of oral health impacts on quality of life was 36%. In terms of the severity, the mean score of OHIP-14 was 13.2 ± 9.0 (range: 0-38). The mean score of oral health literacy was 9.7 ± 3.2 (range: 1-16). The mean DMFT was 9.8 ± 5.2. No significant relationship existed between oral health-related quality of life and oral health literacy (<i>P</i> = 0.347). A higher score of OHIP-14 was revealed among participants with higher DMFT index (<i>P</i> = 0.003, <i>r</i> = 0.21). In multivariate analysis, DMFT was independently associated with the likelihood of reporting one or more oral health impacts on quality of life (<i>P</i> < 0.05).</p><p><strong>Conclusions: </strong>Higher caries experience was associated with poorer oral health-related quality of life among pregnant women. Thus, it is recommended to increase quality of life through preventive measures to control the dental caries experience.</p>","PeriodicalId":11016,"journal":{"name":"Dental Research Journal","volume":"22 ","pages":"32"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dental Research JournalPub Date : 2025-08-25eCollection Date: 2025-01-01DOI: 10.4103/drj.drj_234_23
Fatemeh Abbasi, Bahar Abbasi, Mahboubeh Rezazadeh, Ali Ghazalgoo
{"title":"The effect of bromelain-acetaminophen combination on the intensity of endodontic postoperative pain: A randomized clinical trial.","authors":"Fatemeh Abbasi, Bahar Abbasi, Mahboubeh Rezazadeh, Ali Ghazalgoo","doi":"10.4103/drj.drj_234_23","DOIUrl":"10.4103/drj.drj_234_23","url":null,"abstract":"<p><strong>Background: </strong>Despite significant advances in dentistry, postendodontic pain is one of the problems that patients still suffer from. This study aimed to evaluate the effect of bromelain-acetaminophen combination on the reduction of postendodontic pain in teeth with symptomatic irreversible pulpitis.</p><p><strong>Materials and methods: </strong>In this randomized double-blind clinical trial, 60 patients with mandibular first molars with irreversible pulpitis were evaluated. To homogenize the samples, patients who needed endodontic treatment of mandibular first molars with moderate severity were selected according to the American Association of Endodontists case difficulty assessment form. After endodontic treatment, half of the patients were given a placebo and 500 mg acetaminophen every 6 h, and the other half were given 500 mg Anahil capsule and 500 mg acetaminophen every 6 h until the patients' pain was ameliorated. If the patient did not feel pain, they didn't take medication, also we excluded the patients who felt pain for more than 2 days. The Visual Analog Scale (VAS) was used to measure pain before and 6, 12, 24, and 48 h after endodontic treatment. Data were analyzed by SPSS (version 22) software using <i>t</i>-test, Mann-Whitney, and Kaplan-Meyer tests at a 5% error level.</p><p><strong>Results: </strong>The amount of pain decreased more in the experimental group than in the placebo group 6 and 12 h after endodontic treatment, but by controlling the effect of initial pain (<i>P</i> = 0.627), no significant difference was observed between the two groups in the amount of pain (<i>P</i> = 0.875).</p><p><strong>Conclusion: </strong>The bromelain-acetaminophen combination did not have an added value when it comes to controlling postendodontic pain.</p>","PeriodicalId":11016,"journal":{"name":"Dental Research Journal","volume":"22 ","pages":"34"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative evaluation of Papacarie and Carisolv in effective chemomechanical carious dentin removal in primary teeth: A systematic review.","authors":"Mahesh Vilasrao Dadpe, Pooja Balaji Shelke, Yogesh Jagannath Kale, Prasanna Trambakrao Dahake, Shrikant Bhujangrao Kendre, Shrawani Mankar","doi":"10.4103/drj.drj_205_23","DOIUrl":"10.4103/drj.drj_205_23","url":null,"abstract":"<p><strong>Background: </strong>The goal of this study was to assess the techniques used in earlier conducted clinical investigations on the chemomechanical eradication of dentinal caries, as well as to assess the variances in pain perception, the time required for complete caries excavation, and how microbiological analysis compared before and following caries removal in primary teeth for both Papacarie and Carisolv.</p><p><strong>Materials and methods: </strong>An electronic search was conducted utilizing the databases PubMed, Google Scholar, EBSCOhost, Scopus, and the Cochrane Library. The following categories were included during the assessment process: full text randomized and controlled clinical trials published between January 2000 and December 2021 in the English language only. Adolescent and child patients with open dentinal carious lesion in primary teeth were included. The methodology of the seven clinical studies chosen was evaluated.</p><p><strong>Results: </strong>Findings of the study reported that the microbiota in carious dentine was dramatically reduced with the Papacarie therapy, and the pain perception decreased more in the Papacarie group, whereas Carisolv treatment took longer time for complete caries excavation as compared to Papacarie.</p><p><strong>Conclusion: </strong>In conclusion, Papacarie had a beneficial impact by decreasing pain and time taken during caries excavation in primary teeth. The tooth surface treated with Papacarie also demonstrated a reduced bacterial count as compared to Carisolv chemomechanical caries removal approach. Overall, Papacarie and Carisolv are viable minimally invasive and painless techniques for effective caries removal in pediatric patients.</p>","PeriodicalId":11016,"journal":{"name":"Dental Research Journal","volume":"22 ","pages":"33"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Metastasis of follicular carcinoma of the thyroid gland to the mandible: A report of a rare case.","authors":"Pouyan Aminishakib, Alireza Parhiz, Samira Derakhshan, Hossein Borhani","doi":"10.4103/drj.drj_284_24","DOIUrl":"10.4103/drj.drj_284_24","url":null,"abstract":"<p><p>Malignant tumors are able to grow at sites distant from the primary site of origin. Breast, prostate, renal, thyroid, and lung carcinomas commonly metastasize to bone. Jaw metastasis is rare but may occur more often than generally estimated. Follicular carcinomas of the thyroid gland are tumors of follicular cell differentiation that consist of a microfollicular architecture with follicles lined by cuboidal epithelial cells. It is very difficult to diagnose this type of cancer at the preoperative or intraoperative stage of treatment. Here, we report a case of follicular carcinoma of the thyroid gland who was referred due to a mandibular lesion.</p>","PeriodicalId":11016,"journal":{"name":"Dental Research Journal","volume":"22 ","pages":"35"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dental Research JournalPub Date : 2025-07-24eCollection Date: 2025-01-01DOI: 10.4103/drj.drj_499_24
Narges Naghsh, Ahmad Mogharehabed, Elham Amini, Amirhossein Sahebkar
{"title":"Comparison of casein phosphopeptide-amorphous calcium phosphate fluoride paste and a propolis-containing herbal toothpaste in dentinal hypersensitivity: A randomized trial.","authors":"Narges Naghsh, Ahmad Mogharehabed, Elham Amini, Amirhossein Sahebkar","doi":"10.4103/drj.drj_499_24","DOIUrl":"10.4103/drj.drj_499_24","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to compare the efficacy of casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF) and propolis-based herbal toothpaste in the treatment of dentin hypersensitivity (DH).</p><p><strong>Materials and methods: </strong>In this clinical trial, 20 patients (7 men and 13 women) who met the inclusion criteria were randomly divided into two groups. One group received the herbal toothpaste containing propolis (Herbex<sup>®</sup>), while the other received a paste containing CPP-ACPF (GC<sup>®</sup> MI-Paste Plus). Two nonadjacent teeth with DH in two quadrants of each patient were assessed. The pain was determined through the visual analog scale (VAS) in cold and airblast tests before the intervention (baseline) as well as at 15 min, 1, 2, 4, and 8 weeks after the first application. Three-level mixed effect model (repeated measurement, tooth, and patients) was used to analyze the VAS score data. Estimation of fixed effect parameters with standard error and the intraclass correlation coefficient that quantifies the degree to which data at the lower level are correlated were reported. The statistical significance level was determined as <i>P</i> < 0.05.</p><p><strong>Results: </strong>The mean pain intensity score after 8 weeks significantly decreased in the propolis-based toothpaste group (<i>P</i> < 0.001) and CPP-ACPF paste group (<i>P</i> < 0.001) compared with baseline. Betweenn-group comparison in the 8<sup>th</sup> week showed a significantly lower pain score in the propolis-based toothpaste group compared with the CPP-ACPF-containing paste (<i>P</i> = 0.02). However, at other intervals, there were no significant differences between the two groups (<i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>The use of both herbal toothpaste containing propolis and CPP-ACPF-containing paste for 8 weeks effectively reduced DH, with a higher desensitizing effect experienced in the former group.</p>","PeriodicalId":11016,"journal":{"name":"Dental Research Journal","volume":"22 ","pages":"31"},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12334092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}