网状、糜烂性口腔扁平苔藓与类苔藓病变中E-cadherin表达的比较研究。

Q2 Dentistry
Dental Research Journal Pub Date : 2025-09-24 eCollection Date: 2025-01-01 DOI:10.4103/drj.drj_447_23
Laleh Maleki, Gholamreza Jahanshahi, Forooz Keshani, Samira Fotoohi Ashiin
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引用次数: 0

摘要

背景:准确和早期诊断发育不良病变是成功治疗的关键。在发育不良病变和肿瘤中观察到E-cadherin表达减少。因此,本研究旨在探讨e -钙粘蛋白(一种参与组织结构和分化的细胞膜粘附蛋白)在口腔网状扁平苔藓、糜烂性扁平苔藓和类地衣病变中的表达。材料和方法:本研究采用描述性横断面研究方法对65份口腔标本(20份网状扁平苔藓、20份糜烂性扁平苔藓和20份类苔藓病变,5份健康粘膜标本)进行免疫组织化学方法评价E-cadherin的表达。数据分析采用SPSS软件(版本25)、描述性统计、卡方检验和Fisher精确检验,显著性阈值P < 0.05。结果:大多数患者为女性(72.3%),主要集中在六、七十岁(49.2%)。实验组之间的染色状况有显著差异(P = 0.038),侵蚀性扁平地衣中E-cadherin表达改变的频率最高(45%)。此外,染色状态和病变部位之间存在显著差异(P = 0.004),颊粘膜样品中E-cadherin表达变化的频率最高(30%)。结论:E-cadherin在糜烂性扁平苔藓组织中的表达明显低于健康组织、网状扁平苔藓组织和扁平苔藓样病变组织。鉴于在鳞状细胞癌样本中观察到类似的减少,评估E-cadherin表达可能有助于早期识别恶性变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative study of E-cadherin expression between reticular, erosive oral lichen planus and lichenoid lesions.

Background: Accurate and early diagnosis of dysplastic lesions is crucial for successful treatment. A decrease in E-cadherin expression has been observed in dysplastic lesions and tumors. Therefore, the aim of this study was to investigate the expression of E-cadherin, a cell membrane adhesive protein involved in tissue structure and differentiation, in oral reticular lichen planus, erosive lichen planus, and lichenoid lesions.

Materials and methods: This descriptive cross-sectional study was conducted on 65 oral samples (20 reticular lichen planus, 20 erosive lichen planus, and 20 lichenoid lesions, with 5 samples of healthy mucosa), to evaluate the expression of E-cadherin using immunohistochemical methods. Data were analyzed using SPSS software (version 25), descriptive statistics, Chi-square tests, and Fisher's exact tests, with a significance threshold set at P < 0.05.

Results: The majority of patients were female (72.3%) and primarily in the sixth and seventh decades of life (49.2%). A significant difference was observed between the studied groups regarding staining status (P = 0.038), with erosive lichen planus showing the highest frequency of alterations in E-cadherin expression (45%). In addition, a significant difference was noted between staining status and lesion location (P = 0.004), with the highest frequency of E-cadherin expression changes occurring in buccal mucosal samples (30%).

Conclusion: E-cadherin expression in erosive lichen planus is significantly lower than in healthy tissue, reticular lichen planus, and lichenoid lesions. Given the similar reduction observed in squamous cell carcinoma samples, evaluating E-cadherin expression may aid in the early recognition of malignant changes.

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来源期刊
Dental Research Journal
Dental Research Journal Dentistry-Dentistry (all)
CiteScore
1.70
自引率
0.00%
发文量
70
审稿时长
52 weeks
期刊介绍: Dental Research Journal, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online journal with Bimonthly print on demand compilation of issues published. The journal’s full text is available online at http://www.drjjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal will cover technical and clinical studies related to health, ethical and social issues in field of Dentistry. Articles with clinical interest and implications will be given preference.
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