Current aging science最新文献

{"title":"COVID-19 and Brain Aging: What are the Implications of Immunosenescence?","authors":"Gabriela Serafim Keller,&nbsp;Eduarda Behenck Medeiros,&nbsp;Maria Laura Cecconi Dos Santos,&nbsp;Adrielly Vargas Lidio,&nbsp;Ewa Kucharska,&nbsp;Josiane Budni","doi":"10.2174/1874609816666221228103320","DOIUrl":"https://doi.org/10.2174/1874609816666221228103320","url":null,"abstract":"<p><p>The human lifespan is increasing, and mankind is aging. It is estimated that, until the year 2050, this population worldwide will reach 22% of the total world population. Along with aging, the human immunologic system changes, a process called immunosenescence or even inflammaging. The aging immune system increases mortality and morbidity in the elderly mainly because it loses its capacity to react against internal and external aggressions. There is a decrease in B and T lymphocytes and CD4+ lymphocytes lose the CD28 protein expression that is needed for costimulation, leading to reduced response to viral infections. This could be responsible for more deleterious consequences of coronavirus disease infection in the elderly. Besides that, the human brain ages, being more susceptible to damage and viral infections, such as COVID-19 infection. There are several pathways that could explain the susceptibility to the COVID-19 infection in the elderly brain, one of them is binding to ACE 2 receptors in cerebral cells through the spike protein. It has been reported that glial cells and neurons, in addition to endothelial and arterial smooth muscle cells in the brain, express the ACE 2 receptor, which would justify the neurological symptoms and consequences of the disease. This infection can have several clinical manifestations such as hemorrhagic stroke, delirium and long-term cognitive complaints, such as brain fog, polyneuropathies, short time memory complaints and insomnia. Although none of the studies could prove that there is a long-term neuronal damage, there are clinical sequelae that should be taken into account and more studies are necessary to know the consequences of the infection in the elderly brain.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"16 2","pages":"89-96"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9502381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral, Sociodemographic, and Sleep Correlates of Symptoms of Depression amongst Older Brazilian Females According to Age: A Cross- Sectional Network Analysis.","authors":"Lucimere Bohn,&nbsp;Pedro Pugliesi Abdalla,&nbsp;Sitong Chen,&nbsp;Elzier Sampaio de Queiroz Neto,&nbsp;Dalmo Roberto Lopes Machado,&nbsp;Jorge Mota,&nbsp;Clarice Martins Lucena","doi":"10.2174/1874609816666230119125104","DOIUrl":"https://doi.org/10.2174/1874609816666230119125104","url":null,"abstract":"<p><strong>Background: </strong>Examining the interrelationships between symptoms of depression and sociodemographic and behavioral correlates is challengeful using traditional regression analysis.</p><p><strong>Objective: </strong>to identify the sociodemographic, movement behaviors, and sleep correlates that contribute the most to symptoms of depression in Brazilian older females, using a network analysis approach.</p><p><strong>Methods: </strong>This cross-sectional study analyzed 1019 older females from Brazil. Data (sociodemographic, height (meters), weight (kilograms), symptoms of depression, physical activity, sleep) were self-reported via phone calls. The relationships between symptoms of depression and their correlates were assessed using the Network Analysis (qgraph package of the Rstudio) for entire sample and age groups (60-69; 70-79 and 80+ years old).</p><p><strong>Results: </strong>60-69 and 70-79 groups have more weekly home exits, with aging \"single, widowed or divorced\" was progressively higher, and \"married or stable union\" and Overweight/obesity were progressively fewer (p < 0.05). 60-69 have more education years and fewest medicaments use. Sleep compliance (for the entire sample), body mass index (for the 60-69), compliance with moderate to vigorous physical activity (for the 70-79), and educational level (for 80+) were the variables with the highest expected influence values (p < 0.05) on symptoms of depression (1.370; 1.388; 1.129; and 1.354, respectively).</p><p><strong>Conclusion: </strong>Symptoms of depression vary throughout the aging process and thus determine that intervention strategies encompass these specific factors according to each age group. Poor sleep behavior has a strong positive association with symptoms of depression. This result highlights that health professionals must be aware of the importance of sleep to mitigate the worsening of depression among older Brazilian females.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"16 2","pages":"143-152"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9502411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Education and Physical Activity in Executive Function Performance of Adult Population.","authors":"Namrata Sharma,&nbsp;Shweta Shenoy","doi":"10.2174/1874609816666230214100557","DOIUrl":"https://doi.org/10.2174/1874609816666230214100557","url":null,"abstract":"<p><strong>Background: </strong>Executive function performance has been extensively studied in extreme age groups, but the middle age population, where a decline could begin, is still under investigation. The role of factors like education and physical activity that might influence cognitive performance is not well understood.</p><p><strong>Objective: </strong>The study aimed to examine the influence of age, education, and physical activity on executive function performance and the interaction effects between these factors on two subpopulations of adults, i.e., young adults and middle-aged adults.</p><p><strong>Methods: </strong>92 adults, 46 young adults (N = 24.4 ± 2.7 years, 25 postgraduates and 21 PhDs) and 46 middle-aged adults (N = 48.08 ± 5.79 years, 28 postgraduates and 18 PhDs), were included. Each subject performed Delayed Matching of Sample (DMS), Spatial Working Memory (SWM), and Multitasking (MTT) test on CANTAB. Physical activity levels were reported through IPAQ.</p><p><strong>Results: </strong>Results indicated age to have a major influence on DMS, SWM, and MTT performance; however, education was only found to influence SWM. MTT and SWM performance was found to be lower in middle-aged adults in comparison to young adults. On comparison of test scores between highly active and moderately active groups of middle-aged adults, no differences were found; however, in young adults, MTT correct scores (p < 0.05) were significantly higher in the highly active group in comparison to their counterparts. Interaction between age and level of education revealed better retrieval in middle-aged adults with higher education in comparison to their counterparts.</p><p><strong>Conclusion: </strong>In comparison to younger counterparts, executive function performance deteriorated around the middle ages. Education was found to play a protective role in executive abilities slowing during middle age. Also, physical activity may play some role in executive function performance.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"16 2","pages":"153-165"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9504495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic Inflammation in Sarcopenia Alter Functional Capacity in Thai Community-dwelling Older People: A Preliminary Observational Study.","authors":"Kornanong Yuenyongchaiwat,&nbsp;Chareeporn Akekawatchai","doi":"10.2174/1874609815666220513141300","DOIUrl":"10.2174/1874609815666220513141300","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenia is linked to the loss of muscle mass in older adults, leading to impaired functional capacity and quality of life. In addition, this finding was recognized as an agerelated chronic inflammatory process. We aimed to determine the relationship between sarcopenia, functional capacity, and inflammatory biomarkers and subsequent prediction of inflammatory biomarkers in older adults.</p><p><strong>Methods: </strong>A total of 126 women and men aged ≥ 60 years were enrolled. Participants were required to complete a handgrip dynamometer, 6-meter walk test, and bioimpedance analysis. Diagnosis was based on the definition of sarcopenia from the Asian Working Group for Sarcopenia 2019. Prior to performing a 6-minute walking test (i.e., functional capacity testing), blood samples were drawn for a C-reactive protein (CRP) test.</p><p><strong>Results: </strong>A total of 12.70% were categorized as having sarcopenia. Significant differences in CRP and functional capacity between the sarcopenia and non-sarcopenia groups were found (p <.05). Older people with high CRP levels had significantly reduced functional capacity and slow gait speed.</p><p><strong>Conclusions: </strong>Poor functional capacity was associated with increased CRP levels, which might be due to the development of age-related inflammation. Older patients with sarcopenia may be at higher risk for functional decline.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"15 3","pages":"274-281"},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10639292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fear of Falling and Functional Mobility in Elders with Diabetic Peripheral Neuropathy in Coastal Karnataka, India: A Hospital-Based Study.","authors":"Garima Gupta,&nbsp;G Arun Maiya,&nbsp;Shyamasunder N Bhat,&nbsp;Manjunatha H Hande,&nbsp;Lisa Dillon,&nbsp;Lisa Keay","doi":"10.2174/1874609815666220324153104","DOIUrl":"https://doi.org/10.2174/1874609815666220324153104","url":null,"abstract":"<p><strong>Background: </strong>Aging with diabetic neuropathy is likely to predispose people to falls. Despite being a high-risk population, estimates of falls and their associated factors are poorly documented in elderly diabetic neuropathy patients living in coastal Karnataka, India.</p><p><strong>Objective: </strong>To investigate fear of falling and functional mobility, as an approximate measure of clinical fall risk, and explore the associated risk factors in elderly diabetic neuropathy patients living in coastal Karnataka, India.</p><p><strong>Methods: </strong>A hospital-based cross-sectional study was conducted on 316 elders aged 60 to 80 with diabetic neuropathy. A detailed diabetic foot evaluation was done. Self-reported fear of fall and functional mobility was measured using the Falls Efficacy Scale- International and Timed Up and Go test, respectively, with published cut-points. Additionally, a recall of 12 months of fall history was recorded.</p><p><strong>Results: </strong>Descriptive analysis showed that self-reported fear of fall and below-average functional mobility was present in 39% and 49% of the elders with diabetic neuropathy, respectively. Spearman's correlational analysis revealed that self-reported fall concerns and functional mobility are significantly interdependent. Regression analysis suggested female gender, the severity of neuropathy, and previous falls as significant modifiers for fear of falls and poor functional mobility.</p><p><strong>Conclusion: </strong>Half of the elders (49%) with diabetic neuropathy have poor functional mobility and 39% have a fear of falling. Improving physical function and addressing fall concerns of elders with diabetic neuropathy can result in greater confidence to participate in everyday activities and contribute to their better health. Hence, early fall risk identification is recommended for providing better health care to these individuals.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"252-258"},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40325702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WITHDRAWN: Pathway Linking Emotional Suppression to Depression and Anxiety in Cancer Patients undergoing Chemotherapy: The Mediating Role of Ego-strength","authors":"Rasoul Heshmati, Chris Lo, Maryam Parnian Khooy, Elaheh Naseri","doi":"10.2174/1874609815666220804123152","DOIUrl":"10.2174/1874609815666220804123152","url":null,"abstract":"<p><p>This article has been withdrawn from the journal “Current Aging Science”, after noticing that it is already published in another\u0000journal, “Journal of Mental Health and Aging (2022) Volume 6, Issue 1”. The corresponding author is requested for an explanation\u0000of this violation. However, this paper still appears on the website of the journal \"Journal of Mental Health and Aging\" even\u0000after the author’s confirmation that they have withdrawn it from that journal.</p><p><p>Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.</p><p><p>The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php.</p><p><strong>Bentham science disclaimer: </strong>It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously\u0000submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere\u0000must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting\u0000the article for publication the authors agree that the publishers have the legal right to take appropriate action against the\u0000authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright\u0000of their article is transferred to the publishers if and when the article is accepted for publication.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40694344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet the Editorial Board Member","authors":"Yadollah Abolfathi Momtaz","doi":"10.2174/187460981502220518122926","DOIUrl":"https://doi.org/10.2174/187460981502220518122926","url":null,"abstract":"<jats:sec>\u0000<jats:title />\u0000<jats:p />\u0000</jats:sec>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85355679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of Heart Rate and Blood Pressure Responses to Active Standing in Healthy Adults.","authors":"Caitríona Quinn, A. Monaghan, T. Foran, R. Kenny, J. Gormley","doi":"10.2174/1874609815666220419102648","DOIUrl":"https://doi.org/10.2174/1874609815666220419102648","url":null,"abstract":"OBJECTIVES\u0000This review outlines the normal heart rate and blood pressure response to active standing, the physiological mechanisms governing these, and the effect of ageing on the responses.\u0000\u0000\u0000METHOD\u0000A literature search was conducted to identify articles investigating the normal heart rate and/or blood pressure response to standing.\u0000\u0000\u0000RESULTS\u0000Heart rate when standing increases and then decreases and recovers to baseline. Blood pressure responses are inverse. Skeletal muscle contraction and the baroreceptor reflex drive this. With ageing, heart rate response attenuates and the initial blood pressure response increases.\u0000\u0000\u0000DISCUSSION\u0000Normal heart rate and blood pressure responses are attributed to the baroreceptor reflex and skeletal muscle contraction. Decreased muscle strength and baroreceptor sensitivity are associated with ageing, suggesting a possible benefit in improving skeletal muscle strength to maintain an efficient response. Understanding these responses and their variation with ageing is clinically relevant and may be beneficial in improving rehabilitation outcomes.","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"1996 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78607509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric properties of the Persian version of the UCLA geriatrics attitudes scale (UCLA-GAS).","authors":"N. Zanjari, Yadollah Abolfathi Momtaz, Tayebe Abdollahi","doi":"10.2174/1874609815666220419104512","DOIUrl":"https://doi.org/10.2174/1874609815666220419104512","url":null,"abstract":"AIMS\u0000The attitudes toward older patients are considered the main factor in providing health services.\u0000\u0000\u0000BACKGROUND\u0000There is a lack of a proper short scale to measure attitudes toward older patients among healthcare professionals.\u0000\u0000\u0000OBJECTIVE\u0000The present study was to assess the psychometric properties of the UCLA Geriatric Attitude scale (UCLA-GAS) among a sample of Iranian healthcare professionals.\u0000\u0000\u0000METHODS\u0000The method of this study was cross-sectional for psychometric evaluation. The sample included 232 healthcare professionals in Mazandaran city. Study participants were selected by cluster random sampling technique. Psychometric evaluation of the UCLA-GAS assessed through content and construct validity. Content validity was evaluated based on the content validity index (CVI) and construct validity investigated using exploratory and confirmatory factor analysis. Also, convergent validity was assessed using the Kogan's Attitudes Toward Older People Scale (KAOPS) questionnaire. Cronbach's alpha was used to evaluate internal consistency reliability and stability was assessed using test-retest.\u0000\u0000\u0000RESULTS\u0000Regarding the content validity, CVI and modified Kappa statistic for all items were >0.79 and shows all items where relevant to the UCLA-GAS in the Iranian context. The three dimensions of the UCLA-GAS extracted from factor analysis were labeled: 1- medical/economic burden (6 items) 2- appreciate attitude (5 items), 3- resource allocation (3 items). CFA revealed that the UCLA-GAS structure model was a validated model (CMIN = 2.312, GFI = 0.913, CFI = 0.902, RMSEA = 0.075). The scale had a significant and positive correlation with KAOPS questionnaire. Also, The Cronbach's alpha of the scale was 0.78 and intra-class correlation coefficient (ICC), for total instrument was reported as 0.93 (95% CI: 0.87-0.98) and demonstrated good reliability of the instrument.\u0000\u0000\u0000CONCLUSION\u0000The result shows the UCLA-GAS is a valid and reliable scale for measuring attitude toward older patient among healthcare professionals. This study recommends using Iranian UCLA-GAS in future research and policy-making.","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"530 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72436497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth Hormone Stimulates Murine Macrophage Migration During Aging.","authors":"K. Borbely, Aldilane L X Marques, Felipe Lima Porto, Beatriz Santana Mendonça, S. Smaniotto, Maria Danielma dos Santos Reis","doi":"10.2174/1874609815666220415132815","DOIUrl":"https://doi.org/10.2174/1874609815666220415132815","url":null,"abstract":"BACKGROUND\u0000Age-related impairments in macrophage functions have important consequences for the health of the elderly population. The aging process is also accompanied by a reduction in several hormones, including growth hormone (GH). Previous studies have shown that this hormone can affect macrophage activity in young individuals, however, the biological effects of GH stimulation on macrophages during aging have not yet been elucidated.\u0000\u0000\u0000OBJECTIVE\u0000The aim of this work was to investigate the in vitro effects of GH on peritoneal macrophages from aged mice.\u0000\u0000\u0000METHODS\u0000Peritoneal macrophages isolated from young (4 months-old) and old (12-15 months-old) mice were treated in vitro with 100 ng/mL of GH for 24 hours. After treatment, cells were analysed for cell morphology, reactive oxygen species (ROS) production, expression of integrins, cell adhesion to extracellular matrix molecules and migration in transwell chambers.\u0000\u0000\u0000RESULTS\u0000Although GH-treated cells from old mice decreased ROS production, we did not observe the effects of GH on macrophage morphology or macrophage phagocytic activity in young and old-derived cell cultures. Macrophages from old mice increased adhesion to laminin and fibronectin substrates, as did cells obtained from young mice treated with GH, but no change was observed in the expression of integrin receptors. Furthermore, cells from old mice increased migration compared to young mice and a significant increase in macrophage migration was observed under GH stimulation.\u0000\u0000\u0000CONCLUSION\u0000Our results showed that GH can interfere with the motility of macrophages from old mice, advancing our understanding of the interactions between the immune and neuroendocrine systems during aging.","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73801406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}