Celi Macedo Polo, Tábatta Renata Pereira de Brito, Wanderson Roberto Silva, Daniela Braga Lima, Daniella Pires Nunes, Fábio Antonio Colombo, Ariene Angelini Dos Santos Orlandi, Ligiana Pires Corona
{"title":"Shorter Telomere Length is Associated with Food Insecurity in Older People: A Cross-Sectional Study.","authors":"Celi Macedo Polo, Tábatta Renata Pereira de Brito, Wanderson Roberto Silva, Daniela Braga Lima, Daniella Pires Nunes, Fábio Antonio Colombo, Ariene Angelini Dos Santos Orlandi, Ligiana Pires Corona","doi":"10.2174/0118746098320942240924074044","DOIUrl":"10.2174/0118746098320942240924074044","url":null,"abstract":"<p><strong>Background: </strong>Telomere length has been investigated as a biomarker of biological aging and is associated with several diseases, lifestyle, and socioeconomic factors.</p><p><strong>Objective: </strong>This study aimed to verify whether food insecurity is associated with shorter telomere length in older people.</p><p><strong>Methods: </strong>This is a cross-sectional study carried out in a municipality in the interior of Brazil, with a sample of 440 older people from the community. For telomere length analysis, a blood sample was obtained from each participant, followed by real-time qPCR, and sociodemographic and health information was collected through interviews. Food security/insecurity was measured using the reduced version of the Brazilian Food Insecurity Scale. Descriptive analysis and multiple logistic regression were performed to analyze the factors associated with shorter telomere length, adopting a significance level of 5%.</p><p><strong>Results: </strong>We found that food insecurity was significantly associated with shorter telomere length, regardless of age group, skin color, tabagism, physical activity, milk and dairy consumption, living arrangement, and basic activities of daily life.</p><p><strong>Conclusion: </strong>The findings show the importance of ensuring full access to adequate nutrition for the older population, who are physiologically and socially vulnerable.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"253-266"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13269866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Final Diagnoses of Elderly Emergency Patients Presenting with Weakness and Fatigue in Southeastern Iran.","authors":"Shima Groohi-Sardou, Alireza Dehghani Bahador, Rasoul Raesi, Kiavash Hushmandi, Salman Daneshi","doi":"10.2174/0118746098373552250824195800","DOIUrl":"10.2174/0118746098373552250824195800","url":null,"abstract":"<p><strong>Introduction: </strong>Weakness and fatigue in the elderly present major health challenges, highlighting the need for prompt diagnosis and accurate identification of their causes in emergency departments. This study aimed to investigate the final diagnoses of elderly patients presenting with symptoms of weakness and fatigue in the emergency department.</p><p><strong>Methods: </strong>This cross-sectional study surveyed 200 elderly individuals (aged ≥60) with complaints of weakness and fatigue at Imam Khomeini Hospital in Jiroft, Kerman, Iran, in 2023. The collected data were extracted from patients' medical records using a checklist, and data analysis was performed using SPSS 22 software, employing both descriptive and inferential statistical methods at a significance level of p < 0.05.</p><p><strong>Results: </strong>The mean age of the patients was 78.2 years, with 56% of the patients being female. During hospitalization, 7.5% of the patients died, with 53.33% of these being men. Underlying heart diseases were present in 13.5% of the patients, with 55.6% of those being women. High blood pressure was prevalent in 81% of the patients.</p><p><strong>Discussion: </strong>Infectious diseases were the most common final diagnosis, accounting for 27% of cases, followed by cardiovascular diseases at 18.5%. Among patients with infectious diseases, 85.5% had high blood pressure.</p><p><strong>Conclusion: </strong>The results indicate that weakness and fatigue in elderly patients may signal serious underlying conditions. Additionally, the strong link between high blood pressure and infectious diseases underscores the importance of closely monitoring the overall health of these patients.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"185-192"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Bibliometric Analysis of Research Trends in Aging and Leisure Activities from 2000 to 2023.","authors":"J Mufina Begam, E P Abdul Azeez","doi":"10.2174/0118746098351035241009100118","DOIUrl":"10.2174/0118746098351035241009100118","url":null,"abstract":"<p><strong>Background: </strong>Physical and leisure activities are vital for active aging. Leisure activities among the aging population have received attention from scholars in the recent past. However, the research contributions and trends in this field are unknown. Therefore, a bibliometric analysis was conducted to explore the scholarly contributions in aging and leisure activities to identify the research output trends, assess thematic focuses, and analyze research collaboration patterns.</p><p><strong>Methods: </strong>We extracted data from the Scopus database for the period 2000-2023 and identified 443 articles focusing on aging and leisure activities. Tools, such as bibliographical coupling networks and thematic analysis, were applied using R and Biblioshiny to uncover core themes and connections.</p><p><strong>Results: </strong>There has been a significant increase in research output since 2021, with contributions from numerous authors and countries, particularly the United States and China. Thematic analysis reveals central themes, such as physical activity, successful aging, and cognition.</p><p><strong>Conclusion: </strong>This analysis reveals the evolving nature of scholarly discussions in aging and leisure, highlighting key themes, such as physical activity, cognitive aging, and health promotion. The findings emphasize the growing interest and global collaboration in this interdisciplinary research domain.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"132-146"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amir Bayat, Alireza Sharafshah, Farshid Sefat, Milad Rahimzadegan, Mohammad Raad, Kai-Uwe Lewandrowski
{"title":"New Insights into Colorectal Cancer through the Lens of Precision Oncology and Personalized Medicine: Multi-Omics Helps Aging of Predisposed People.","authors":"Amir Bayat, Alireza Sharafshah, Farshid Sefat, Milad Rahimzadegan, Mohammad Raad, Kai-Uwe Lewandrowski","doi":"10.2174/0118746098348122241024061610","DOIUrl":"10.2174/0118746098348122241024061610","url":null,"abstract":"<p><strong>Background: </strong>Recently, there has been a significant evolution in our understanding of the molecular pathways causing the genesis and progression of cancer via the inter-individual variations. Thus, one-size-fits-all methods for cancer treatment have been replaced by precision oncology (PO) targeting individual cancer symptoms, offering increased effectiveness, and decreased safety concerns and cost load.</p><p><strong>Objective: </strong>The identification of novel actionable indications, rapid, precise, and comprehensive detection of complex phenotypes in every individual, pioneering clinical trial projects with enhanced response feedback, and widespread availability of innovative targeted anticancer management for every patient are vital for the effective implementation of next-generation precision oncology. Additionally, the emergence of precision medicine has altered the perspective of oncologic biomarkers, drug discovery, drug development, and, improvements for cancer patients.</p><p><strong>Method: </strong>This paper narratively reviewed to identify actionable abnormalities, Genomic profiling of tumors employing clinical next-generation sequencing (NGS) from both tumor tissues and liquid biopsies along with the multi-omics strategies as the key component of PO.</p><p><strong>Results: </strong>Our increasing information on tumor biology, specifically microenvironment and heterogeneity- associated data, would improve our understanding of the resistance of targeted drugs and specific mechanisms of action, as well as help enhance existing metastatic colorectal cancer (mCRC) treatment strategies.</p><p><strong>Conclusion: </strong>Collectively, this paper indicated the current and innovative strategies for prognosis, diagnosis, and treatment of various cancer types based on PO overview with a groundbreaking emphasis on CRC suggesting the integrations of multi-omics, highlighting Genomics, and utilizing AL and ML algorithms with targeted therapies. Notably, these findings can help improve the life-span and ageing of the predisposed people.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"193-210"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tomas I Gonzales, Bryant A Seamon, Katie L Boncella, Haniel J Hernandez, Valerie McIntosh, Marc R Blackman, Michael O Harris-Love
{"title":"The Clinical Assessment of Eccentric and Concentric Stepping Kinetics has Utility in Older African American Men with Knee Arthritis.","authors":"Tomas I Gonzales, Bryant A Seamon, Katie L Boncella, Haniel J Hernandez, Valerie McIntosh, Marc R Blackman, Michael O Harris-Love","doi":"10.2174/0118746098312415241112103614","DOIUrl":"10.2174/0118746098312415241112103614","url":null,"abstract":"<p><strong>Introduction: </strong>Stair navigation is physically demanding for individuals with knee osteoarthritis and may result in movement asymmetries that can be quantified using kinetic analysis and force-time parameters. Thus, the purpose of this cross-sectional study was to determine if kinetic force-time parameter asymmetries are present in individuals with knee osteoarthritis and associated with functional outcomes.</p><p><strong>Methods: </strong>Forty-six older male veterans (61.6 ± 5.6 years) participated. More and less involved legs were defined using the Kellgren and Lawrence (KL) scale and self-reported pain. Kinetics were measured with the Neurocom® Step Up and Over test and quantified with the lift-up index, impact index, movement time, and stair-stepping smoothness. Smoothness was calculated from the level of intermittency in acceleration and deceleration during the concentric and eccentric test movements.</p><p><strong>Results: </strong>Smoothness was the only force-time parameter to demonstrate an asymmetry. Greater smoothness values were observed for the less-involved leg (p<0.001, 95% CI: 1.22 to 3.64, d=1.17) and were positively associated with gait speed (more-involved: r=0.47, p<0.01; lessinvolved: r=0.53, p<0.01), Knee Injury and Osteoarthritis Outcome Score (KOOS) Symptom (more-involved: r=0.31, p<0.05; less-involved: r=0.39, p<0.01) and activities of daily living (more-involved: r=0.32, p<0.05; less-involved: r=0.39, p<0.05) subscales, and isokinetic knee extension strength (more-involved: r=0.31, p<0.05; less-involved: r=0.42, p<0.01).</p><p><strong>Conclusion: </strong>Stair-stepping smoothness was diminished in the more involved leg and was associated with worse gait speed, patient-reported outcomes, and knee strength. This observation may reflect compromised motor control associated with decreased strength and greater disease severity in the more-involved leg.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"244-252"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recent Advances in Bioactive Flavonoids-based Nanotherapeutics as Promising Neuroprotectants in Epilepsy.","authors":"Priyabrata Pradhan, Koushik Jana, Somnath Ghosh, Biplab Debnath, Saroj Kumar Rout, Vineet Kumar Rai, Biswakanth Kar, Durga Madhab Kar, Goutam Ghosh, Goutam Rath","doi":"10.2174/0118746098369369250119112935","DOIUrl":"10.2174/0118746098369369250119112935","url":null,"abstract":"<p><strong>Background: </strong>Epilepsy is a prevalent neurological disorder that can be characterized by seizures and can be caused by abnormal electrical impulses in the brain. Various genetic, environmental, age-related, and lifestyle factors are associated with its pathogenesis, which causes neuronal cells to degenerate over time.</p><p><strong>Methodology: </strong>Epilepsy often results from an imbalance between excitatory neurotransmitters, such as glutamate, and inhibitory neurotransmitters, such as GABA. Abnormalities in glutamate receptors like N-methyl-D-aspartate (NMDA), and alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid (AMPA) can lead to excessive neuronal excitation, while dysfunctions in GABA receptors can result in insufficient inhibition, both of which can provoke seizures. Additionally, a variety of receptors and pathways like NF-κB, DAPK, Trκb, COX-2, etc. are associated with the expression of epilepsy. This disorder often faces various limitations in treatment with current anti-epileptic drugs (AEDs), such as drug resistance, adverse effects, and high costs. In context, flavonoids exhibit significant neuroprotective properties in epilepsy through various mechanisms such as antioxidant activity, anti-inflammatory effects, neurotransmitter systems, and receptor modulation.</p><p><strong>Results: </strong>Flavonoids communicate with different signaling pathways and adjust their activities, prompting valuable neuroprotective impacts. Essential flavonoids such as quercetin, rutin, apigenin, luteolin, genistein, fisetin, chrysin, vitexin, naringin, baicalin, catechin, morin, hesperetin, kaempferol, gallic acid, silibinin, wogonin, etc. have shown promising results in channel regulation, reduced oxidative stress and neuroinflammation, and neuronal excitability in experimental models of epilepsy. Given their inherent neuroprotective properties and ability to modulate multiple pathways involved in epilepsy, flavonoids hold considerable promise as multitargeted, accessible, and low-cost alternatives to conventional AEDs. Although there are challenges with target specificity and bioavailability, innovative approaches such as nanotechnology and chemical modifications are being developed to enhance these aspects.</p><p><strong>Conclusion: </strong>Focusing on the mechanisms of action and neuroprotective benefits the paper highlights the promising role of flavonoids and flavonoid-based nanotherapeutics as a beneficial addition to epilepsy treatment strategies.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"18 3","pages":"211-243"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146212565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dewi Shinta Kemala Sari, N. Lipoeto, Hafni Bachtiar, Indra Catri, Nina Kemala Sari, Rima Semiarty
{"title":"Assessing Telemedicine Demand and Viability in Indonesian Geriatric Clinics: A Comprehensive HOT FIT and Sociotechnical Analysis","authors":"Dewi Shinta Kemala Sari, N. Lipoeto, Hafni Bachtiar, Indra Catri, Nina Kemala Sari, Rima Semiarty","doi":"10.2174/0118746098302999240522092726","DOIUrl":"https://doi.org/10.2174/0118746098302999240522092726","url":null,"abstract":"\u0000\u0000The growing elderly population in Indonesia presents challenges for the\u0000healthcare system, prompting the exploration of telemedicine as a solution. However, its effective\u0000implementation in Indonesia faces obstacles.\u0000\u0000\u0000\u0000This research aimed to develop a comprehensive geriatric telemedicine framework in Padang\u0000City by studying multiple stakeholders. We employed qualitative methods, including in-\u0000-depth interviews, across two hospitals, a Health Office, and a Community Health Center, involving\u000018 elderly participants.\u0000\u0000\u0000\u0000The study identified ten key dimensions for geriatric telemedicine services: technology,\u0000Human-Computer Interface (HCI), infrastructure, system workflow, clinical content, people (diverse\u0000roles), organization (ecosystem, service workflow, internal and external regulations), and financing\u0000(social security agency on health and independent). We used the Human-Organization-\u0000Technology Fit and Sociotechnical System approaches for analysis.\u0000\u0000\u0000\u0000The study suggests implications for future implementation and advocates for broader\u0000participant involvement, information technology (IT) studies for system development, and longitudinal\u0000evaluations to assess the impact on elderly health outcomes.\u0000","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"49 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141353461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Atayik, Erdem Atasever, Şeydanur Turgut, U. Çakatay
{"title":"Aging-associated Aberrant Mitochondrial Redox Signaling, Physical\u0000Activity, and Sarcopenia","authors":"M. Atayik, Erdem Atasever, Şeydanur Turgut, U. Çakatay","doi":"10.2174/0118746098315667240606052523","DOIUrl":"https://doi.org/10.2174/0118746098315667240606052523","url":null,"abstract":"\u0000\u0000Aging-related alteration of mitochondrial morphology, impairment in metabolic capacity,\u0000bioenergetics, and biogenesis are closely associated with loss of muscle mass and function. Mitochondrial\u0000Reactive Oxygen Species (ROS) stimulate muscular redox signaling mechanisms.\u0000Bioenergetic integrity of mitochondria and redox signaling dynamics deteriorates in aged skeletal\u0000muscle. Mitochondrial bioenergetic impairment leads to excessive ROS levels and induces the generation\u0000of defective mitochondria. Higher ROS levels may induce senescence or apoptosis. It is\u0000not a resolved issue that mitochondrial dysfunction is either the sole reason or a consequence of\u0000muscle loss (or both). However, Increasing evidence emphasizes that dysregulated mitochondrial\u0000redox signaling has a central role in age-related muscle loss. Nuclear factor erythroid 2-related factor\u00002 (Nrf2) regulates redox signaling pathways with the expression of antioxidant genes. As the\u0000aberrant redox signaling mechanisms in aging skeletal muscle become clearer, new natural and\u0000synthetic Nrf2-modulating substances and integrated daily physical activity alternatives are coming\u0000into view for preventing muscle loss in the elderly. A comprehensive understanding of the relationship\u0000between redox signaling pathways and age-related sarcopenia can help us to prevent sarcopenia\u0000and its frailty effects with an optimized exercise program as an innovative non-pharmacological\u0000therapeutic approach. A further aspect is necessary to consider both individualized physical\u0000training options and alternative Nrf2 signaling modulators. Ameliorating the redox signaling\u0000with physical activity and pharmacological interventions may help to prevent sarcopenia and its\u0000frailty effects.\u0000","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"93 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141352546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}