Current aging science最新文献

{"title":"Top Three Healthcare Trends in Orthopaedics Affecting Musculoskeletal Care in the Elderly.","authors":"Morgan P Lorio, Kai-Uwe Lewandrowski, Kenneth Blum","doi":"10.2174/0118746098309054240721180720","DOIUrl":"10.2174/0118746098309054240721180720","url":null,"abstract":"<p><p>Several trends toward patient-centered multi-care models employing translational research strategies are currently emerging in orthopaedics. These align seamlessly with epigenetics discussions in pain, a clinical approach to pain management that prioritizes tailoring healthcare to individual needs, preferences, and circumstances. Recognizing the unique genetic and epigenetic factors influencing pain perception, healthcare providers can integrate personalized insights into their patient-centered approach, offering more targeted and effective pain management strategies tailored to each individual's experience. Custom 3D-printing technologies may also become increasingly relevant to more effectively and reliably treat painful degenerative structural abnormalities. They are expected to go hand-in-hand with the precision medicine redefinition of musculoskeletal care. More effective analysis of surgeons' clinical decision-making and patients' perception of high-value orthopaedic care is needed. Shared Decision Making (SDM) is critical to identifying the best solution for each patient and improving stakeholders' understanding of factors influencing the diverse prioritizing values of surgical or non-surgical treatments by payers, systems, and other providers. Identifying high-value orthopaedic surgeries via effective SDM in orthopedic surgery requires more than just presenting patients with information. The Rasch analysis of patient expectations can provide this nuanced approach that involves understanding patient values, addressing misconceptions, and aligning surgical recommendations with patient-specific goals. Optimizing orthopaedic treatment within the patient-centered framework can drive innovation in reimbursement policies that support the field more broadly. Research on separating high-value from low-value orthopaedic procedures may likely impact healthcare decision- makers' resource allocation.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"87-94"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncovering the Healing Power of Stem Cells: Harnessing Regenerative Therapies for Alzheimer's Disease.","authors":"Shima Mehrabadi","doi":"10.2174/0118746098334856250106055739","DOIUrl":"10.2174/0118746098334856250106055739","url":null,"abstract":"<p><p>Alzheimer's disease is a progressive neurodegenerative disorder with no known treatment. Recent advances in regenerative medicine, including stem cell therapies, hold promise for treating Alzheimer's disease and slowing its progression. This review explores the various types of stem cells, such as neural and mesenchymal stem cells, and how they can be harnessed for Alzheimer's treatment. It also discusses the potential mechanisms of action, including neurogenesis, anti-inflammatory and anti-apoptotic effects, and the secretion of various biologically active molecules by stem cells.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"18 3","pages":"175-184"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146212533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoxia-reoxygenation Extends the Lifespan of <i>Caenorhabditis elegans via</i> SKN-1- and DAF-16A-Dependent Stress Hormesis.","authors":"Ferbian Milas Siswanto, Maria Dara Novi Handayani, Rita Dewi Firmasyah, Jojor Lamsihar Manalu, Adriyan Pramono","doi":"10.2174/0118746098292667240914024812","DOIUrl":"10.2174/0118746098292667240914024812","url":null,"abstract":"<p><strong>Aims: </strong>To study the role of hypoxia-reoxygenation and anoxia-starvation on the lifespan of <i>C. elegans</i> and elucidate the mechanism at molecular levels.</p><p><strong>Background: </strong>Increasing evidence indicates that reactive oxygen species (ROS) act as signaling molecules that promote health. Hormesis occurs when a moderate stress level induces a beneficial adaptive response, protecting organisms against subsequent exposure to severe stress. <i>Caenorhabditis elegans</i> is a widely used model organism to study aging and displays a broad hormetic ability to couple with stress. To date, only few methods are available to induce stress hormesis in <i>C. elegans</i>.</p><p><strong>Objectives: </strong>The objectives of this study were to explore the effects of hypoxia-reoxygenation and anoxia-starvation on the lifespan of <i>C. elegans</i>, exploring the involvement of ROS and oxidative stress-related pathways, and examining the hormetic property of H/R.</p><p><strong>Methods: </strong>The <i>C. elegans</i> were cultured in hypoxic conditions (1% O₂) with OP50 bacteria for 24 h followed by reoxygenation (20% O₂) (H/R) or in anoxic conditions (0% O₂; 100% N₂) without OP50 bacteria for 24 h followed by reoxygenation (20% O₂) and food supplementation (A/S). Survivals were plotted and estimated for probability with Kaplan-Meier analysis.</p><p><strong>Results: </strong>The H/R extended the lifespan of <i>C. elegans</i>, and H/R-pretreated worms showed improved resistance toward A/S compared to naïve worms. The <i>C. elegans</i> SKN-1 and DAF-16 are important oxidative stress response factors homologous to mammalian Nrf2 and FOXO3, respectively. Mutations in SKN-1 and DAF-16 blocked H/R-induced life extension. Next, H/R treatment in <i>C. elegans</i> activated both SKN-1 and DAF-16, as indicated by the upregulation of putative target genes of SKN-1 (<i>gcs-1</i> and <i>gss-1</i>) and DAF-16 (<i>sod-3</i>). Moreover, pre-treatment with antioxidants (N-acetylcysteine, chlorogenic acid, and sulforaphane) reduced ROS levels and diminished the lifespan extension effect of H/R, indicating their dependency on ROS.</p><p><strong>Conclusion: </strong>These results provide evidence that H/R is beneficial for lifespan and stress resistance by activating the adaptive cellular response pathway (SKN-1 and DAF-16A) toward oxidative stress.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"163-173"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart Seizure Detection System: Machine Learning Based Model in Healthcare IoT.","authors":"Naresh Rana, Tanishk Thakur, Shruti Jain","doi":"10.2174/0118746098298618240429102237","DOIUrl":"10.2174/0118746098298618240429102237","url":null,"abstract":"<p><strong>Background: </strong>Epilepsy, the tendency to have recurrent seizures, can have various causes, including brain tumors, genetics, stroke, brain injury, infections, and developmental disorders. Epileptic seizures are usually transient events. They normally leave no trace after the postictal recovery period has passed.</p><p><strong>Aims: </strong>An electroencephalogram (EEG) can only detect brain activity during the recording. It will be detected if an epileptogenic focus or generalized abnormality is active during the recording.</p><p><strong>Objective: </strong>This work demonstrated a smart seizure detection system for Healthcare IoT, which is a challenging problem of EEG data analysis.</p><p><strong>Method: </strong>The study suggested an integrated methodology in recognition of the drawbacks of manual identification and the significant negative effects of uncontrollable seizures on patients' lives.</p><p><strong>Result: </strong>The research shows remarkable accuracy, up to 100% in some experiments, by combining classifier ensembles like Decision Trees, Logistic Regression, and Support Vector Machine with different signal processing techniques like Discrete Wavelet Transform, Hjorth Parameters, and statistical features. The results were compared using the kNN classifier, other datasets and other state-of-the-art techniques.</p><p><strong>Conclusion: </strong>Healthcare IoT is further utilized by the methodology, which takes a comprehensive approach using classifier ensembles and signal processing approaches resulting in real-time data to help them make better decisions. This demonstrates how well the suggested method works for smart seizure detection, which is a crucial development for better patient outcomes.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"29-38"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gait Characteristics over the Six-minute Walk Test in Older Women of a Specific Portuguese Community: A Cross-Sectional Study.","authors":"Jullyanne Silva, Tiago Atalaia, Rodrigo Martins, Joao Abrantes, Pedro Aleixo","doi":"10.2174/0118746098315374240508094923","DOIUrl":"10.2174/0118746098315374240508094923","url":null,"abstract":"<p><strong>Introduction and objective: </strong>There is limited research on the changes that can occur in the gait biomechanical parameters of older adults over long-distance walking. Thus, this study aimed to evaluate the gait characteristics of older women of a specific Portuguese community over the six-minute walk test (6MWT) along with gait spatial and temporal parameters and angular kinematics of the lower limb joints.</p><p><strong>Materials and methods: </strong>Twenty-six older women voluntarily participated. Each woman performed the 6MWT, and during this, their spatial and temporal parameters were collected through plantar pressure data (100Hz) and angular kinematics through an inertial sensor system (100Hz). The 6MWT was divided into four intervals, and the Friedman test was used to compare them. The median age of the women was calculated, and the Mann-Whitney test was used to compare women above and below the median age value.</p><p><strong>Results: </strong>An increase in gait speed, stance phase, and double stance phase along the intervals was observed, as well as larger angular displacements of the hip, knee, and ankle (p<0.05). Women below or above the median age value also yielded these behaviours. Gait speed, cadence, stride length, and step length were higher in women below the median age value, while stride and step duration were lower (p<0.05).</p><p><strong>Conclusion: </strong>Older women yielded changes in gait spatial and temporal parameters along the 6MWT, as well as larger angular displacements of the lower limb joints. Older women (compared to younger ones) yielded lower gait speed, cadence, stride length, and step length, higher stance and double stance phases, and shorter angular displacements of the lower limb joints.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"59-72"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Sarcopenic Obesity in Elderly Population: A Meta-Analysis.","authors":"Viviane Locatelli Rupolo, Taiana Lemos Camargo, Isabele Rejane de Oliveira Maranhao Pureza, Mileni Vanti Beretta, Anderson Garcez","doi":"10.2174/0118746098331277241101025928","DOIUrl":"10.2174/0118746098331277241101025928","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenic obesity (SO) is characterized by the simultaneous presence of both obesity and sarcopenia in the same individual, and it is associated with adverse health outcomes such as falls, hospitalization, functional disability, and mortality. This study aimed to provide a comprehensive analysis of the prevalence of SO in the elderly population through a systematic review and meta-analysis of the scientific literature.</p><p><strong>Methods: </strong>A systematic search was conducted in the PubMed, Embase, Web of Science, and LILACS databases for observational studies published up to July 2023 on the prevalence of SO in individuals aged 65 years or older. Data were collected from the selected and included articles, including general study information, demographic characteristics of the samples, methods, and results. The quality of the studies was assessed using the Newcastle-Ottawa Scale (NOS) criteria. A random-effects model was applied for the quantitative synthesis (meta-analysis) of combined prevalence data, and the I-squared index (I²) was used to assess heterogeneity. Publication bias was evaluated using a funnel plot and Egger's test.</p><p><strong>Results: </strong>A total of 37 articles meeting the eligibility criteria were selected and included in this meta-analysis. Heterogeneity among the studies was observed, along with evidence of publication bias. Most studies were classified as having a high risk of bias. The pooled prevalence of SO in the elderly was 10% (95% CI: 8%-12%; I²: 99.10%, p<0.001). A similar result was observed after stratification by sex, with a prevalence of 10% in both men (95% CI: 8%-12%; I²: 97.46%, p<0.001) and women (95% CI: 8%-12%; I²: 98.72%, p<0.001). Subgroup and sensitivity analyses revealed that the study setting, criteria used for the diagnosis of obesity, and the risk of bias in the studies were potential factors contributing to the heterogeneity in the prevalence of SO in the elderly.</p><p><strong>Conclusions: </strong>This meta-analysis indicated a significant prevalence of SO among the elderly population, with no difference by sex, highlighting SO as a substantial health problem in this population. These findings underscore the importance of interventions to reduce the occurrence of SO in the elderly.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"18 2","pages":"147-162"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Mutation in the CACNA1F Gene Found by Whole Exome Sequencing (WES) and <i>In Silico</i> Analysis in an Iranian Family with Consanguineous Relationships.","authors":"Vahid Omarmeli, Marjan Assefi, Kai-Uwe Lewandrowski, Alireza Sharafshah, Hanieh Faizmahdavi, Parichehr Darabi, Amir Amiri, Nasrin Mansouri","doi":"10.2174/0118746098307079240507063045","DOIUrl":"10.2174/0118746098307079240507063045","url":null,"abstract":"<p><strong>Background: </strong>X-linked mutations are highly important in clinical diagnosis, and at least 533 disorders are related to the genes located on the X chromosome.</p><p><strong>Case presentation: </strong>A 21-year-old Caucasian woman with a 24-year-old Caucasian man as her fiancé referred Clinical genetic lab for premarital genetic counseling (carrier screening). None of them had any abnormal manifestations. Following genetic counseling, Whole Exome Sequencing (WES) test performed to find the possible pathogenic mutations. Also, after drawing the couple's pedigree, candidate mutations were examined in the woman's parents as well as her uncles. Additionally, <i>in silico</i> investigations were performed through SWISS-MODEL, MolProbity, ProSA, Py- Mol, and FATCAT tools. The most important mutation diagnosed in the woman (R1362Q in the 35th exon of CACNA1F), was observed in her mother and her two uncles. The mutation was also screened in both her father and her fiancé, but they had no mutations. After medical examinations of carriers, there was no sign of any eye impairment. Other mutations were TCTN2 (c.1613-2A>G), TARS (p.K319E), SPEG (p.E3020K), CPS1 (p.A1180V), MYO3A (p.I736M), NNT (p.R968Q), MED23 (p.K406T). Bioinformatics analyses indicated no alteration in the mutant structure of CACNA1F (Q1362) compared with the normal structure (R1362).</p><p><strong>Conclusion: </strong>Conclusively, the current study emphasizes the non-pathogenic effect of missense mutation R1362Q in the 35th exon of CACNA1F in association with ocular diseases. This will ensure the reports of this mutation as healthy instead of uncertain in the literature and databanks.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"80-85"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Connecting the Dots: Gender, Sexuality, and Societal Influences on Cognitive Aging and Alzheimer's Disease.","authors":"Swati Verma, Sarvesh Paliwal, Debashish Paramanick, Chaitanay Vinayak Narayan, Manasvi Saini","doi":"10.2174/0118746098299754240530111755","DOIUrl":"10.2174/0118746098299754240530111755","url":null,"abstract":"<p><p>Alzheimer's disease (AD) has many etiologies and the impact of gender on AD changes throughout time. As a consequence of advancements in precision medical procedures and methodology, Alzheimer's disease is now better understood and treated. Several risk factors may be addressed to lower one's chances of developing Alzheimer's disease or associated dementia (ADRD). The presence of amyloid-α protein senile plaques, intracellular tau protein neurofibrillary tangles (NfTs), neurodegeneration, and neuropsychiatric symptoms (NPS) characterizes Alzheimer's disease. NPS is common in persons with Alzheimer's disease dementia, although its presentation varies widely. Gender differences might explain this clinical variability. The fundamental goal of this review is to 1) emphasize the function of old age, sex, and gender in the development of Alzheimer's disease, dementia, and ADRD, and 2) explain the importance of sexual hormones, education, and APOE (Apolipoprotein E) status. This is a narrative summary of new ideas and concepts on the differences in the chance of developing dementia or Alzheimer's disease between men and women. A more thorough examination of risk and protective variables in both men and women might hasten research into the epidemiology of neurological illnesses such as dementia and Alzheimer's disease. Similarly, future preventive efforts should target men and women separately.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"14-28"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141426577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges of Diagnosis and Management of Burning Mouth Syndrome: A Literature Review.","authors":"Nara Lígia Martins Almeida, Gabriela Moraes Oliveira, Carlos Ferreira Santos, Vanessa Soares Lara, Camila Lopes Cardoso","doi":"10.2174/0118746098279205240812113353","DOIUrl":"10.2174/0118746098279205240812113353","url":null,"abstract":"<p><strong>Background: </strong>Burning Mouth Syndrome (BMS) is defined as an idiopathic orofacial pain with recurrent intraoral burning. It mainly affects middle-aged women in peri- or post-menopause and the elderly, without any identifiable causative lesions and with or without somatosensory alterations. BMS has a complex pathogenesis involving psychogenic factors and deregulated peripheral and central pain, and there is no standard treatment protocol, making its diagnosis and management challenges.</p><p><strong>Objective: </strong>This study was to carry out a review literature on BMS, addressing its identification and therapeutic possibilities.</p><p><strong>Methods: </strong>Review articles and randomized controlled clinical studies whose full text was available, published between 2017 and 2022 in national and international journals, from PubMed and SCIELO databases, WHO manuals and books, were collected. As a search strategy, the keywords \"burning mouth syndrome\", \"treatment\" and \"diagnosis\" were used, totaling 42 papers. Of these, after applying the exclusion criteria, 34 articles were selected.</p><p><strong>Results: </strong>Studies indicate that a comprehensive and thorough anamnesis is essential to exclude secondary factors leading to the correct diagnosis of BMS. In addition, a comprehensive anamnesis directs the best management considering a combination of neuropathic and palliative therapies, which aim to control, eliminate and/or minimize painful symptoms, treating the patient in an individualized way and not the disease itself, since this pathology has no cure.</p><p><strong>Conclusion: </strong>Considering the impact of BMS on quality of life, further studies are needed to expand diagnostic and treatment strategies, aiming to complement existing pharmacological and non-pharmacological treatments, observing the influence that biopsychosocial and neurophysiological mechanisms have on this syndrome.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"102-119"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nicotinamide Adenine Dinucleotide (NAD)-Dependent Protein Deacetylase, Sirtuin, as a Biomarker of Healthy Life Expectancy: A Mini- Review.","authors":"Yodo Sugishita, Yuki Suzuki-Takahashi, Kazuo Yudoh","doi":"10.2174/0118746098319674240827104612","DOIUrl":"10.2174/0118746098319674240827104612","url":null,"abstract":"<p><p>Although a variety of disease-specific biomarkers have been identified for common lifestyle- or aging-related diseases, there are currently no indices available to measure general health or the existence of pre-symptomatic conditions in various types of tissue and organ damage. A rising body of research suggests that sirtuins may have the potential to be used as an index to assess overall health status and the existence of pre-symptomatic illness states. Sirtuins (SIRTs) are nicotinamide adenine dinucleotide (NAD)-dependent deacetylases expressed in a variety of human somatic cells both in health and disease conditions. The activity and expression of SIRTs affect important metabolic pathways, such as cell survival, senescence, proliferation, energy production, stress tolerance, DNA repair, and apoptosis, thereby closely linked to aging and longevity. Given the broad significance of SIRTs in physiological function maintenance, their activity in somatic cells may reflect the early cross-sectional status of tissue damage caused by aging or systemic inflammatory responses that are too early to be detected by disease-specific biomarkers. In this mini-review, we discuss the utility of SIRTs as a surrogate clinical biomarker for health status to evaluate and monitor health life expectancy and the presence of pre-symptomatic illness states.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"95-101"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12376132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}