Current aging science最新文献_第6页

Mitoresilience: Hormesis, Psycho-physical Resilience, Mitochondria and Heart Rate Variability as Relevant Interplaying Elements in Longevity Medicine. 线粒体恢复力:激效，心理-生理恢复力，线粒体和心率变异性是长寿医学中相关的相互作用因素。

Current aging science Pub Date : 2023-01-01 DOI: 10.2174/1874609815666220606140754

A Cavezzi, R Colucci, G d' Errico

{"title":"Mitoresilience: Hormesis, Psycho-physical Resilience, Mitochondria and Heart Rate Variability as Relevant Interplaying Elements in Longevity Medicine.","authors":"A Cavezzi, R Colucci, G d' Errico","doi":"10.2174/1874609815666220606140754","DOIUrl":"https://doi.org/10.2174/1874609815666220606140754","url":null,"abstract":"Psycho-biological resilience is considered one of the most important factors in the epigenetics of aging. Cell senescence exhibits a series of possible biochemical derangements concerning mitochondria, proteasome, genome and membranes. Research has shown that resilience can be acquired through hormesis, a set of conservative and adaptive processes based on biphasic doseresponse to specific mild stressors, such as fasting, intake of polyphenols, exercising, physical and chemical stress and mental engagement. These stimuli were shown to elicit beneficial cellular metabolic pathways, such as sirtuin activation, mechanistic target of rapamycin and insulin growth factor- 1 downregulation, nuclear related factor 2 upregulation and autophagy. The complex of these resilience-building processes plays a documented role in longevity. Mitochondria are regarded as one of the core actors of aging processes and represent the main target of hormetic approaches [mitohormesis]; furthermore, the influence of the mind on mitochondria, and thus on the balance of health and disease has been recently established, leading to the so-called mitochondria psychobiology. Hence, psychologic and physical stress that reflects on these organelles may be regarded as a relevant factor in cell senescence, and thus the proposed \"mitoresilience\" denomination may be pertinent within the biomedical science of aging. Finally, the quantification of individual resilience is becoming increasingly important in aging science, and the investigation of the autonomic nervous system through heart rate variability (HRV) proved to be a valid method to quantify this parameter. In conclusion, an integrated approach targeting hormetic pathways to improve psychophysical resilience (namely mitoresilience), supported by the monitoring of HRV, may represent a valuable option in longevity medicine.","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"16 1","pages":"25-32"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9277197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sarcopenic Obesity and Its Impact on Quality of Life: A Concise Review. 肌肉减少型肥胖及其对生活质量的影响:一个简明的综述。

Current aging science Pub Date : 2023-01-01 DOI: 10.2174/1874609816666230525161020

Mangalam Kumari, Archana Khanna

引用次数: 0

Cocoa Flavanols and the Aging Brain. 可可黄烷醇与大脑老化。

Current aging science Pub Date : 2023-01-01 DOI: 10.2174/1874609815666220819145845

Robert Lalonde, Catherine Strazielle

引用次数: 2

Improvement of Health and Morphofunctional Status of Law Enforcement Officers of Older Age Groups during the Organized Motor Activities. 老年人执法人员在有组织的运动活动中健康和形态功能状况的改善。

Current aging science Pub Date : 2023-01-01 DOI: 10.2174/1874609816666230327140631

Oleksandr Lutskyi, Ivan Okhrimenko, Maryna Halych, Viktoriia Lytvyn, Olena Kudermina, Maksym Hrebeniuk, Ihor Bloshchynskyi

{"title":"Improvement of Health and Morphofunctional Status of Law Enforcement Officers of Older Age Groups during the Organized Motor Activities.","authors":"Oleksandr Lutskyi, Ivan Okhrimenko, Maryna Halych, Viktoriia Lytvyn, Olena Kudermina, Maksym Hrebeniuk, Ihor Bloshchynskyi","doi":"10.2174/1874609816666230327140631","DOIUrl":"https://doi.org/10.2174/1874609816666230327140631","url":null,"abstract":"Background: With age, there is a tendency for the health of law enforcement officers to deteriorate. This especially applies to instructor officers, whose professional activity is characterized by a significant decrease in the volume of motor activity, overloading of the intellectual sphere, and high neuro-emotional stress.Objective: The aim of the research is to investigate the influence of recreational and healthpromoting training sessions with physical exercise on the health, physical development, and functional status of instructor officers of older age groups.Methods: 62 instructor officers (aged 40-45) of various academic disciplines took part in the research. The instructors of the experimental group (EG, n = 30) were engaged in physical exercises in accordance with the authors' program of recreational and health-promoting training sessions; the instructors of the control group (CG, n = 32) attended the training sessions according to the existing physical training program.Results: It was found that at the end of the experiment, the studied indicators of the EG instructor officers were significantly better than those of the CG ones, according to the indicators of body weight, Quetelet index, the vital capacity of lungs, vital index, strength index, heart rate, arterial blood pressure, Robinson index, and level of physical health.Conclusion: It was established that systematic recreational and health-promoting training sessions have a positive effect on the health level of the instructor officers of older age groups. This will allow them to carry out instructional activities at a high professional level and ensure resistance to adverse factors of professional activities.","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"16 3","pages":"227-233"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10099450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aging: Change in SIRT1 and Enzymatic Profile Promotes a Decrease in the Antioxidant Capacity of Resveratrol in Human Leukocytes In Vitro. 衰老:SIRT1和酶谱的变化促进了体外人类白细胞白藜芦醇抗氧化能力的下降。

Current aging science Pub Date : 2023-01-01 DOI: 10.2174/1874609815666220511143843

Filipe Nogueira Franco, Luciana de Cassia Cardoso, Bárbara Néllita Moura Silva, Glaucy Rodrigues de Araújo, Miriam Martins Chaves

{"title":"Aging: Change in SIRT1 and Enzymatic Profile Promotes a Decrease in the Antioxidant Capacity of Resveratrol in Human Leukocytes In Vitro.","authors":"Filipe Nogueira Franco, Luciana de Cassia Cardoso, Bárbara Néllita Moura Silva, Glaucy Rodrigues de Araújo, Miriam Martins Chaves","doi":"10.2174/1874609815666220511143843","DOIUrl":"https://doi.org/10.2174/1874609815666220511143843","url":null,"abstract":"Background: One of the most studied theories about aging comes from the accumulation of free radical generation, leading to oxidative stress. Resveratrol (RSV) is a polyphenolic compound that has been shown to act as an antioxidant in medical practice.Objective: To verify the antioxidant action of resveratrol (and its correlation with aging) in leukocytes from donors of different ages, mainly through the analysis of the three main enzymes of the antioxidant complex and the analysis of the SIRT1 signaling pathway.Methods: Luminol-dependent chemiluminescence assay was used to evaluate ROS and SIRT1. Antioxidant enzymes were evaluated by commercial kits. *p<0.05.Results: In all age groups, there was a reduction in reactive oxygen species (ROS) in cells stimulated with RSV. There was a positive correlation between its antioxidant effect and donor age. In younger individuals (20-39 years old), there was an increase in catalase activity in cells exposed to RSV. In the older groups (40-59 years old and 60-80 years old), RSV was able to increase the activity of the enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx). Through the analysis of SIRT1 it was possible to observe a silencing of the pathway in leukocytes treated with RSV during aging.Conclusion: RSV showed antioxidant activity in all age groups, although more pronounced in younger individuals. One of the mechanisms of action of the RSV is due to the increase in the activity of antioxidant enzymes, which varies according to the individual's age, especially through the modulation of important antioxidant pathways.","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"16 1","pages":"56-64"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9278020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Meet the Editorial Board Member 认识编辑委员会成员

Current aging science Pub Date : 2023-01-01 DOI: 10.2174/187460981601230106142555

B. Yulug

引用次数: 0

Prediction of Risk of Frailty Among Institutionalized Older Adults in India. 印度机构老年人衰弱风险的预测。

Current aging science Pub Date : 2023-01-01 DOI: 10.2174/1874609815666220415130737

Nisha Kulal, Girish N, Vaishali K

{"title":"Prediction of Risk of Frailty Among Institutionalized Older Adults in India.","authors":"Nisha Kulal, Girish N, Vaishali K","doi":"10.2174/1874609815666220415130737","DOIUrl":"https://doi.org/10.2174/1874609815666220415130737","url":null,"abstract":"Background: Frailty is a state of age-related physiological vulnerability resulting from impaired homeostatic reserve and a reduced capacity of the individual to withstand stress and an independent predictor of deleterious health outcomes among the aged. Early identification of people who are at risk for frailty is vital in preventing and minimizing its socio-economic consequences in low-resource countries like India. However, risk factors for frailty among Indian institutionalized older adults have been seldom explored.Objective: The objective of this study is to develop a prediction model for the risk of frailty among institutionalized older adults.Methods: This study adopted a case-control design, wherein institutionalized adults were categorized into frail and non-frail, using Fried's criteria. Individuals above 55 years of age who could follow instructions without severe motor and cognitive impairment and terminal illness were recruited from nine conveniently selected institutions. Socio-demographic, lifestyle, behavioral, and physical performance factors were evaluated by including hundred participants.Results: Among the fourteen independent variables, age, cognition, income, functional mobility, polypharmacy and presence of more than 3 comorbidities were significant in univariate analysis. But adjusted odds ratio showed a statistical significance for low educational status, low income, poor functional mobility, and presence of more than 3 co-morbidities only, hence they were used for developing the prediction model.Conclusion: Low education status, low income, poor functional mobility, and presence of more than 3 comorbidities were found to have a significant association with the risk of frailty. A model has been developed to predict the risk and early identification of frailty among institutionalized older adults.","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"16 1","pages":"33-39"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9277992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nursing Home Residence, Overweight and Cognitive Status are Related to Falls in Older Adults: A Cross-sectional Study. 养老院居住、超重和认知状况与老年人跌倒有关:一项横断面研究。

Current aging science Pub Date : 2023-01-01 DOI: 10.2174/1874609815666221007105647

Oliveira A C P, Lopes P B, Lara J P R, Moreira N B, Pereira G P, Rodacki A L F

{"title":"Nursing Home Residence, Overweight and Cognitive Status are Related to Falls in Older Adults: A Cross-sectional Study.","authors":"Oliveira A C P, Lopes P B, Lara J P R, Moreira N B, Pereira G P, Rodacki A L F","doi":"10.2174/1874609815666221007105647","DOIUrl":"https://doi.org/10.2174/1874609815666221007105647","url":null,"abstract":"Background: Nursing home residents are likely to differ from community older adults when their gait parameters are compared, as nursing home residents present more falls.Aim: The study aim was to identify the main fall (occurrence predictors) (anthropometrics, functional and gait-related parameters) between older adults living in community and nursing homes during self-selected (SSWS) and fast walking speeds (FWS).Methods: A hundred and sixty-five older adults were selected from the community (n = 92) and nursing home (n = 73) with and without fall history. They were assessed for fall history, functionality, cognitive status, and several gait parameters in SSWS and FWS conditions.Results: Fallers differed from non-fallers in the SSWS, while such differences were not evidenced during the FWS. Cadence and stride width did not differ when living backgrounds were compared. Nursing home residents walked slower than their non-institutionalized peers, regardless of fall history or walking speed. Besides, binary logistic regression analysis showed that living in a nursing home, age, body mass index (BMI), mini-mental state examination (MMSE), and step width were related to falls in the SSWS. On the other hand, living in a nursing home, having a larger BMI and having low MMSE scores were fall predictors in the FWS.Conclusion: Fall occurrence can be identified by factors related to living in nursing homes, cognitive status, BMI, and gait parameters, at the SSWS. Cognitive status and BMI are related to falls in the FWS for those living in nursing homes.","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"16 2","pages":"125-132"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9870568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environment Intensifies Imbalance and Fear of Falling: Comparing Urban and Rural Aging Communities. 环境加剧失衡与坠落恐惧:城乡老龄化社区比较。

Current aging science Pub Date : 2023-01-01 DOI: 10.2174/1874609816666230503094432

Mahin Nazari, Tayebeh Rakhshani, Ali Khani Jeihooni, Abedin Bakht Abnoos, Abdolrahim Asadollahi

{"title":"Environment Intensifies Imbalance and Fear of Falling: Comparing Urban and Rural Aging Communities.","authors":"Mahin Nazari, Tayebeh Rakhshani, Ali Khani Jeihooni, Abedin Bakht Abnoos, Abdolrahim Asadollahi","doi":"10.2174/1874609816666230503094432","DOIUrl":"https://doi.org/10.2174/1874609816666230503094432","url":null,"abstract":"Background: The relationship between environmental diversity and the health status of older adults has been less considered in studies. This study seeks to investigate the causal relationship among the environment, falling, fear of falling, and the imbalance of older adults in southern Iran in 2021.Objective: The investigation into the relationship between environmental pollution to the imbalance and fear of falling, especially in comparing urban and rural aging societies is the aim of current study.Methods: In a cross-sectional study, 489 older samples from rural and urban areas were chosen randomly and their experience of falling, fear of falling, imbalance, and IADL were examined. The ordinal and nominal logistic regression and ANOVA were performed using IBM-SPSS.Results: With a mean age of 71.8 (SD = 8.3), older participants have long time chronic disease (69.6%) and falling experience twice a year (42.7%). The values of effect size indicated the high effectiveness of settlement in explaining IADL, health situation, experience and fear of falling, and imbalance (Eta squared > 30). The odds ratio for being in the urban settlement was 5.51, indicating the imbalance score increased by approximately 5.52 times.Conclusion: Imbalance in older people leads to the fear and experience of falling. This imbalance is strongly influenced by the environment. Urban pollution can contribute to this problem. Future studies on aging need to focus on environmental pollution and diversity in the experience of falling and imbalance.","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"16 3","pages":"211-218"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10101785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Multifactorial Balance Rehabilitation Program on Risk of Falls and Functional Fitness in Older Adults with Diabetic Peripheral Neuropathy. 多因素平衡康复计划对老年糖尿病周围神经病变患者跌倒风险和功能健康的影响。

Current aging science Pub Date : 2023-01-01 DOI: 10.2174/1874609816666230306150844

Garima Gupta, G Arun Maiya, Shyamasunder N Bhat, H Manjunatha Hande

{"title":"Effect of Multifactorial Balance Rehabilitation Program on Risk of Falls and Functional Fitness in Older Adults with Diabetic Peripheral Neuropathy.","authors":"Garima Gupta, G Arun Maiya, Shyamasunder N Bhat, H Manjunatha Hande","doi":"10.2174/1874609816666230306150844","DOIUrl":"https://doi.org/10.2174/1874609816666230306150844","url":null,"abstract":"Background: Increasing age and the added disadvantage of diabetic peripheral neuropathy (DPN) put the individual at a higher risk of falls and reduced functional fitness. However, there is a dearth of literature on multifactorial balance intervention, especially targeting the needs of older adults with DPN.Objective: The current study aimed to determine the effect of a multifactorial balance rehabilitation program on fall risk and functional fitness in older adults with DPN.Methods: In this pre-post experimental study, 30 independently ambulating older adults (71.2 ± 4.70 years) with DPN, who were at risk of falling (timed up and go score ≥ 9.4 seconds), were recruited. Along with the standard care, all the participants received 12 weeks of the multifactorial balance rehabilitation program.Results: Fall risk using the Fullerton Advanced Balance scale and functional fitness using the Senior Fitness Test were measured at baseline and after 12 weeks of the intervention. The intervention reduced the risk of falling score significantly (MD = 6.17, p < .001). All six parameters of functional fitness improved after 12 weeks of intervention. The improvement in lower limb strength (MD = 1.53 times), upper limb strength (MD = 2.48 times), endurance (MD = 16.07 seconds), lower limb flexibility (MD = 2.02 inches), upper limb flexibility (MD = 1.47 inches), and dynamic balance (MD = 1.53 seconds) was statistically significant at p < 0.05.Conclusion: This study provided encouraging evidence about the potential of multifactorial balance rehabilitation to reduce the risk of falling and improve functional fitness in older adults with DPN.","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"16 3","pages":"240-247"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10110305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0