Current aging science最新文献_第5页

Therapeutic Approaches to Increase the Survival Rate of Cancer Patientsin the Younger and Older Population 提高老年癌症患者存活率的治疗方法

Current aging science Pub Date : 2023-12-07 DOI: 10.2174/0118746098241507231127114248

Tharrun Paul, Kanagaraj Palaniyandi, Dhanavathy Gnanasampanthapandian

{"title":"Therapeutic Approaches to Increase the Survival Rate of Cancer Patients\u0000in the Younger and Older Population","authors":"Tharrun Paul, Kanagaraj Palaniyandi, Dhanavathy Gnanasampanthapandian","doi":"10.2174/0118746098241507231127114248","DOIUrl":"https://doi.org/10.2174/0118746098241507231127114248","url":null,"abstract":"\u0000\u0000Various developments have been observed in the treatment of cancer patients, such as\u0000higher survival rates and better treatment outcomes. However, expecting similar outcomes in\u0000older patients remains a challenge. The main reason for this conclusion is the exclusion of older\u0000people from clinical trials for cancer drugs, as well as other factors, such as comorbidity, side\u0000effects, age-related frailties and their willingness to undergo multiple treatments. However, the\u0000discovery of new techniques and drug combinations has led to a significant improvement in the\u0000survival of the elderly population after the onset of the disease. On the other hand, cancer treatments have not become more complex for the younger population when compared to the older\u0000population, as the younger population tends to respond well to treatment trials and their physiological conditions are stable in response to treatments. In summary, this review correlates recent\u0000cancer treatment strategies and the corresponding responses and survival outcomes of older and\u0000younger patients.\u0000","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"42 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138592341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Relationship Between Sarcopenia And Proteinuria, What Do We Know? 肥胖症与蛋白尿之间的关系，我们知道些什么？

Current aging science Pub Date : 2023-11-15 DOI: 10.2174/0118746098232969231106091204

O. Gungor, Sena Ulu, A. Inci, Kenan Topal, Kamyar Kalantar-Zadech

引用次数: 0

Relationship of Self-Reported Physical Activity with Cognition in Middle-Aged Adults 中年人自我描述的体育活动与认知的关系

Current aging science Pub Date : 2023-11-14 DOI: 10.2174/0118746098273724231107092608

Srinivasa Rao Pachava, S. Shenoy

{"title":"Relationship of Self-Reported Physical Activity with Cognition in Middle-Aged Adults","authors":"Srinivasa Rao Pachava, S. Shenoy","doi":"10.2174/0118746098273724231107092608","DOIUrl":"https://doi.org/10.2174/0118746098273724231107092608","url":null,"abstract":"The increasing prevalence of age-related cognitive decline highlights the importance of physical activity for cognitive health. Regular exercise has been associated with improved mental health and reduced risk of cognitive decline. This study investigated the connection between self-reported physical activity and cognitive function in middle-aged adults. This cross-sectional study included 56 Indian adults aged 30-55, selected based on a health screening questionnaire. Participants reported their physical activity using the International Physical Activity Questionnaire-Short Form (IPAQ-SF), which categorized them into low, moderate, and high activity levels. Cognitive functions, including visual memory, executive function, and attention, were assessed using the Cambridge Neuropsychological Automated Testing Battery (CANTAB). Results were statistically analyzed for relationships between cognitive domains and physical activity parameters using Pearson’s correlation and linear regression analysis. The study showed a significant positive correlation of attention with moderate and vigorous physical activity, while sedentary behavior negatively impacted attention. Linear regression showed that attention is affected by moderate-intensity activity whereas executive function and visual memory are affected by age. This study supports the view that moderate and vigorous intensity activities may positively affect attention in middle-aged adults highlighting the benefits of physical activity.","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"28 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139276150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesenchymal Stromal Cells Nanovesicles Carry microRNA with Nephroprotective Proprieties Regardless of Aging 间充质基质细胞纳米囊泡携带具有肾保护特性的 microRNA，与年龄无关

Current aging science Pub Date : 2023-11-14 DOI: 10.2174/0118746098272926231107061047

M. Convento, Andreia Silva de Oliveira, M. Boim, Fernanda Teixeira Borges

{"title":"Mesenchymal Stromal Cells Nanovesicles Carry microRNA with Nephroprotective Proprieties Regardless of Aging","authors":"M. Convento, Andreia Silva de Oliveira, M. Boim, Fernanda Teixeira Borges","doi":"10.2174/0118746098272926231107061047","DOIUrl":"https://doi.org/10.2174/0118746098272926231107061047","url":null,"abstract":"Containing information molecules from their parent cells and inclining to fuse with targeted cells, bone marrow mesenchymal stromal cells-derived extracellular vesicles (MSCs-EV) are valuable in nanomedicine. The effects of aging on the paracrine mechanism and in the production and action of MSCs-EV and their cargos of miR-26a and siRNA-26a for the treatment of tubular renal cells under nephrotoxicity injury remain unelucidated. The purpose of this study was to evaluate MSCs-EV of different ages and their ability to deliver the cargos of miR-26a and siRNA-26ª to target renal tubular cells affected by nephrotoxicity injury. In a model of gentamicin-induced nephrotoxicity, renal tubular cells treated with MSCs-EV expressing or not expressing microRNA-26a were analyzed. Western blotting was utilized to evaluate cell cycle markers, and MTT assay was utilized to evaluate auto-renovation capacity. Tubular cells under nephrotoxicity injury showed decreased proliferative capacity, but the treatment in the tubular renal cells under nephrotoxicity injury with MSCs-EV expressing microRNA-26a showed nephroprotective effects, regardless of EV age. While the treatment with EV-mediated siRNA-26a failed to preserve the nephroprotective effects equally, regardless of age. Mesenchymal stromal cell nanovesicles carry microRNA with nephroprotective proprieties regardless of aging.","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"36 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139277398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acknowledgement to Reviewers 审稿人致谢

Current aging science Pub Date : 2023-11-01 DOI: 10.2174/187460981603230711150633

引用次数: 0

Meet the Section Editor 见栏目编辑

Current aging science Pub Date : 2023-11-01 DOI: 10.2174/187460981603230711115039

Aurel Popa-Wagner

引用次数: 0

How do "Young-old" Adults Project their Self? A Study of Self-defining Future Projections in Normal Ageing. “年轻的老年人”如何表现他们的自我?正常老龄化中自我定义未来预测的研究。

Current aging science Pub Date : 2023-01-01 DOI: 10.2174/1874609816666230330092556

Alain Fritsch, Virginie Voltzenlogel, Christine Cuervo-Lombard

{"title":"How do \"Young-old\" Adults Project their Self? A Study of Self-defining Future Projections in Normal Ageing.","authors":"Alain Fritsch, Virginie Voltzenlogel, Christine Cuervo-Lombard","doi":"10.2174/1874609816666230330092556","DOIUrl":"https://doi.org/10.2174/1874609816666230330092556","url":null,"abstract":"Background: Self-defining future projections (SDFP) are mental representations of plausible and highly significant future events that provide core information of one's understanding of self.Objective: We explored SDFPs in a large sample of older adults and aimed to target the interrelations between the main dimensions of SDFPs. Moreover, correlations between these dimensions and clinical and cognitive variables were examined.Methods: We recruited 87 young-old adults (60-75 years) with normal cognitive functioning who were asked to generate three SDFPs.Results: We found integrative meaning as a salient dimension and older individuals preferentially generated projections containing leisure or relationship events. Anxiety and self-esteem were correlated with integrative meaning and high executive functioning was found to be protective towards the simulation of future events containing dependence and death or end-of-life events.Conclusion: This study will contribute to the understanding of personal goals and identity in normal ageing.","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"16 3","pages":"199-210"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10453506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Long-term Study of NeuroAid (MLC601, MLC901) in Patients with Alzheimer's Disease; An Extension 8-year Follow-up Study. NeuroAid (MLC601、MLC901)治疗阿尔茨海默病患者的长期研究延长8年随访研究。

Current aging science Pub Date : 2023-01-01 DOI: 10.2174/1874609816666230224111759

Hossein Pakdaman, Ali Amini Harandi, Koroush Gharagozli, Fatemeh Siavoshi, Siavash Shirzadeh Barough, Ehsan Sharifipour, Akram Esfandani, Saba Ilkhani, Fatemeh Sadat Tabatabaei, Seyed Ali Sobhanian

{"title":"A Long-term Study of NeuroAid (MLC601, MLC901) in Patients with Alzheimer's Disease; An Extension 8-year Follow-up Study.","authors":"Hossein Pakdaman, Ali Amini Harandi, Koroush Gharagozli, Fatemeh Siavoshi, Siavash Shirzadeh Barough, Ehsan Sharifipour, Akram Esfandani, Saba Ilkhani, Fatemeh Sadat Tabatabaei, Seyed Ali Sobhanian","doi":"10.2174/1874609816666230224111759","DOIUrl":"https://doi.org/10.2174/1874609816666230224111759","url":null,"abstract":"Background: MLC601 and MLC901 showed neuroprotective and neuroregenerative properties and positive results in the treatment of dementia and cognitive impairment. This study aimed to investigate the long-term benefits of monotherapy with MLC601 and MLC901 in patients with Alzheimer's disease (AD).Methods: In this study, patients with AD, diagnosed by DSM-IV criteria, were enrolled. Patients have received MLC601 for four years, and their regimen has changed to MLC901 for another four years. Recruited patients were followed to assess the efficacy and safety first of MLC601 and MLC901. Mini-Mental State Examination (MMSE) and Alzheimer's Disease Assessment Scale- Cognitive Subscale (ADAS-Cog) were used to assess cognitive function. Safety was evaluated by monitoring adverse events (AEs) and abnormal findings in physical examinations or lab tests.Results: At the end of the trial, the changes in the mean (±SD) MMSE and ADAS-Cog scores were 5.1 (3.09) and 12.5 (10.89), respectively. Both scores showed a significant change in repeated measure analysis, with the ADAS-Cog score indicating a higher change than the MMSE score (P < 0.001).Conclusion: For more than eight years, we studied monotherapy with NeuroAid (MLC601, MLC901) in patients with AD. The study contributes further to the long-term safety and efficacy data of MLC in patients with AD.","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"16 3","pages":"234-239"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10095635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Moderate Physical Activity Reduces the Odds of Sarcopenia in Community- dwelling Older Women: A Cross-sectional Study. 适度的体育活动减少社区老年妇女肌肉减少症的几率:一项横断面研究。

Current aging science Pub Date : 2023-01-01 DOI: 10.2174/1874609816666230330171930

José Augusto Gonçalves Marini, Pedro Pugliesi Abdalla, Lucimere Bohn, Jorge Mota, Michael Duncan, André Pereira Dos Santos, Dalmo Roberto Lopes Machado

{"title":"Moderate Physical Activity Reduces the Odds of Sarcopenia in Community- dwelling Older Women: A Cross-sectional Study.","authors":"José Augusto Gonçalves Marini, Pedro Pugliesi Abdalla, Lucimere Bohn, Jorge Mota, Michael Duncan, André Pereira Dos Santos, Dalmo Roberto Lopes Machado","doi":"10.2174/1874609816666230330171930","DOIUrl":"https://doi.org/10.2174/1874609816666230330171930","url":null,"abstract":"Introduction: The time spent in different physical activity (PA) intensities is associated with sarcopenia risk for community-dwelling older women.Aim: To evaluate the role of sitting time and physical activity (PA) level as predictors of sarcopenia odds.Methods: In a cross-sectional study, physically independent older women (n = 67) performed the six-minute walk test to identify functional limitation (≤ 400 m). Sedentary time (as sitting time) and PA (light, moderate and vigorous) were obtained with the International Physical Activity Questionnaire (IPAQ). Sarcopenia was diagnosed as recommended by the Society of Sarcopenia, Cachexia and Wasting Disorders (SCWD). Sarcopenia odds (low muscle mass and functional limitation) was predicted by binary logistic regression, considering the weekly sitting time and PA as independent variables.Results: Sarcopenia prevalence was 7.5% (n = 5), with functional limitation present in 38.8% (n = 26), and low muscle mass in 22.4% (n = 15). The predictive model (p = 0.014) involved moderate PA as the only significant predictor (OR = 0.999; p = 0.005; 95% CI: 0.998-1.000) of functional limitation. Moderate PA prevents sarcopenia odds. Each weekly hour of moderate PA decreased sarcopenia odds by 6%.Conclusion: Time spent in moderate PA can prevent sarcopenia.","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"16 3","pages":"219-226"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10096171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Population Ageing in Lower and Middle-income Countries: Policy Landscape of Southeast Asian Countries. 中低收入国家的人口老龄化:东南亚国家的政策格局。

Current aging science Pub Date : 2023-01-01 DOI: 10.2174/1874609816666230516150701

Paolo Miguel Manalang Vicerra

{"title":"Population Ageing in Lower and Middle-income Countries: Policy Landscape of Southeast Asian Countries.","authors":"Paolo Miguel Manalang Vicerra","doi":"10.2174/1874609816666230516150701","DOIUrl":"https://doi.org/10.2174/1874609816666230516150701","url":null,"abstract":"Populations are ageing at varying rates of development. Countries with developed economies have experienced such changes to their population structures. Examinations have been conducted with regard to how respective societies can accommodate the said changes in their health and social systems, but this research mostly focuses on more developed regions rather than lowerincome countries. This paper discussed the experience of ageing populations in developing economies, which comprise the majority of the global older population. They display a vastly different experience from high-income countries, especially when viewed within the level of world regions. The cases presented here were from Southeast Asian countries in order to have a wide range of examples in terms of differences in country-income categories. In lower and middle-income countries, there are older adults who: continue working as their primary income source, are nonmembers of pension systems, and provide intergenerational support rather than only receiving it. The COVID-19 pandemic situation was also included here, as policies were reformed to address current needs that highlighted the challenging situation of older adults. The populations of countries that have yet to age substantially, especially those in the least-developed regions, can utilise this paper's recommendations in order to prepare for changes in the age structures of their societies.","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"16 3","pages":"188-193"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10099197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0