Current aging science最新文献

{"title":"Revolutionizing Neurodegenerative Disease Management: The Synergy of AI and Pharmacy.","authors":"Krishnaveni Manubolu, Raveesha Peeriga","doi":"10.2174/0118746098375978250820220024","DOIUrl":"10.2174/0118746098375978250820220024","url":null,"abstract":"<p><p>Neurodegenerative diseases, including Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis (ALS), represent major healthcare challenges worldwide. Despite advances in diagnosis and treatment, these conditions remain incurable, and there is a need for more effective management strategies. The integration of artificial intelligence (AI) in healthcare has emerged as a promising solution, offering new approaches to diagnosis, personalized treatment, and patient care. This paper explores the potential of AI to revolutionize the management of neurodegenerative diseases, with a focus on its synergistic role in pharmacy. By leveraging AI in drug discovery, personalized treatment plans, and clinical decision-making, AI can enhance therapeutic outcomes and improve patient quality of life. The study reviews the current landscape of AI applications in neurodegenerative disease management, with a focus on pharmacy-related interventions. The review includes AI-driven approaches in genomics, biomarkers, drug repurposing, and clinical trials. It also examines AI's role in optimizing pharmaceutical care, improving medication adherence, and tailoring treatments based on individual genetic profiles. AI has demonstrated its capability to analyze vast datasets, from genetic information to clinical records, to identify novel drug targets and predict patient responses to specific therapies. The use of AI in precision medicine has enabled more accurate diagnosis and has facilitated the development of personalized treatments for neurodegenerative diseases. Additionally, AI tools are enhancing medication management by providing personalized therapy adjustments and improving adherence. AI offers transformative potential for the future of neurodegenerative disease management. Its integration into pharmacy practice promises more effective, individualized treatments, accelerating drug discovery, and optimizing patient care. As AI technologies continue to advance, their role in managing complex neurological disorders will become increasingly vital.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"285-302"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peptide Regulation of Ageing: From Experiment to Practice.","authors":"A V Arutjunyan, I G Popovich, L S Kozina, G A Ryzhak","doi":"10.2174/0118746098346230250116065407","DOIUrl":"https://doi.org/10.2174/0118746098346230250116065407","url":null,"abstract":"<p><p>The article presents an analysis of the results of many years of research devoted to the study of biological activity of peptide bioregulators at the molecular, cellular and tissue levels, as well as at the level of the organism. The study of peptide efficacy and analysis of their mechanism of action allowed the famous Russian gerontologist Vladimir Khavinson to propose the concept of peptide regulation of gene expression and protein synthesis. He developed and introduced the technology of obtaining active peptide preparations from animal tissues and also synthesized short peptides with targeted tissue-specific action, which are also capable of regulating gene activity and protein synthesis in cells. It has been established that they stimulate cell proliferation and differentiation, can have immunomodulatory effects, and inhibit apoptosis, thus restoring tissue functions in various pathologies. It is extremely important to study the effect of peptides on the stabilization of cell metabolism and prevention of premature aging, which may contribute to the species limited life. The review presents the results of experimental and clinical studies of peptide drugs in ageing, as well as the prospects of their use for the prevention and treatment of a number of cardiovascular, oncological, neurological, neurodegenarative, and other age-associated diseases.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"19 1","pages":"30-41"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective and Antioxidant Study of <i>Cyanobacteria Arthrospira</i>.","authors":"Krishna Chandra Panda, Rajaram Das, B V V Ravi Kumar, J Sruti","doi":"10.2174/0118746098365217250828003543","DOIUrl":"10.2174/0118746098365217250828003543","url":null,"abstract":"<p><p>The search for novel neuroprotective and antioxidant agents is crucial in combating neurodegenerative diseases and oxidative stress-related disorders. This study explores the neuroprotective and antioxidant properties of Arthrospira (commonly known as Spirulina), a cyanobacterium renowned for its rich nutritional profile and potential health benefits. Arthrospira has gained attention for its high content of bioactive compounds, including phycocyanin, carotenoids, and essential fatty acids, 60% protein, 8% fats, 15-25% Carbohydrates, minerals, vitamins, and pigments which are thought to contribute to its therapeutic and nutritional effects. In this research, Arthrospira was evaluated for its neuroprotective and antioxidant capabilities through a series of in vitro and in vivo experiments. The study utilized cell-based assays to assess the ability of Arthrospira extracts to protect neuronal cells from oxidative damage induced by various stressors, including hydrogen peroxide and glutamate. Additionally, the study employed animal models to further investigate the effects of Arthrospira on cognitive function and oxidative stress in vivo. The findings revealed that Arthrospira extracts exhibited significant antioxidant activity, as demonstrated by their ability to neutralize free radicals and reduce oxidative stress markers in neuronal cells. In vitro assays showed that Arthrospira enhanced cellular viability and reduced markers of oxidative damage, such as malondialdehyde (MDA) and reactive oxygen species (ROS). These results suggest that Arthrospira possesses potent antioxidant properties that can mitigate oxidative stress and protect neuronal cells. In vivo studies using rodent models further confirmed the neuroprotective effects of Arthrospira. Animals supplemented with Arthrospira showed improved cognitive performance in behavioral tests, including memory and learning tasks. Additionally, histological analysis revealed a reduction in neuroinflammation and neuronal damage in the brains of Arthrospira-treated animals. Biochemical assays supported these findings, indicating a decrease in oxidative stress markers and an increase in endogenous antioxidant enzyme activities.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"267-284"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontotemporal Dementia, Current Diagnosis and Treatment Emphasis on Natural Products: A Review.","authors":"Zulfa Nooreen, Fariha Sumayya, Pranay Wal, Awani Kumar Rai, Sudeep Tandon","doi":"10.2174/0118746098343389250131050235","DOIUrl":"10.2174/0118746098343389250131050235","url":null,"abstract":"<p><strong>Introduction: </strong>Frontotemporal dementia (FTD) refers to a spectrum of brain illnesses that mostly affects the frontal and temporal lobes. These regions are commonly related to personality, behaviour, and communication. It is brought on by aberrant protein aggregates, genetics and mutation. FTD most frequently affect people between the ages of 45 and 65 but can also affect young and elderly people. It is estimated that 1.0 to 15.4 per 100,000 members of the population can be affected by FTD in the near future. About 20,000 to 30,000 cases of FTD were reported in the USA alone in 2016. Presently, no specific pharmaceutical treatments for FTD have been authorized by the US Food and Drug Administration.</p><p><strong>Methods: </strong>The present review demonstrates the risk factors, pathogenesis, pathophysiology, diagnostic criteria and treatment of FTD using a number of synthetic and natural drugs to treat the disease and focuses on natural products used to manage the disease. The literature search was done by online databases of SciFinder, Medline, Pubmed, GoogleScholar and Scopus.</p><p><strong>Results: </strong>Various pharmacological and non-pharmacological interventions have been recorded to treat the disease. Primary treatment is a temporary reduction in the symptoms and progression of the disease. Curcumin, glycyrrhiza, Quercetin, Bacopa monnieri, Panax ginseng, galantamine and many more are recorded for this activity.</p><p><strong>Discussion: </strong>Herbal remedies and Phytoconstituents, either alone or in combination, could serve as excellent therapies for dementia with fewer adverse effects. Anticholinesterase, anti-inflammatory, antioxidant compounds are gaining interest in the management of FTD.</p><p><strong>Conclusion: </strong>Herbal extract and compounds are helpful in management of the disease with their specific mode of action.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"42-58"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarkers for Chronic Kidney Disease: An Updated Review of Innovative Detection Approaches.","authors":"Zahra Tolou-Ghamari","doi":"10.2174/0118746098380113250707112707","DOIUrl":"10.2174/0118746098380113250707112707","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic kidney disease (CKD) is a progressive and incurable condition that impairs kidney function over time. Affecting approximately 13% of the global population, CKD poses a substantial economic burden on healthcare systems and significantly reduces both the quality and duration of life for affected individuals. The overview of innovative methods will facilitate the identification and documentation of novel biomarkers associated with kidney diseases.</p><p><strong>Aim: </strong>This review summarizes the findings of previous studies associated with novel therapeutic approaches and biomarkers for the early detection of CKD.</p><p><strong>Materials and methods: </strong>All relevant databases were searched for published articles on the topic of interest from the beginning of the study period up to April 2025, using the following search terms: \"Chronic Kidney Disease,\" \"Conventional Biomarkers,\" and \"Novel Biomarkers.\" We also reviewed the reference lists of eligible studies, previous review articles, and registered clinical trials. A total of 101 manuscripts were included in this evaluation.</p><p><strong>Results: </strong>To comprehensively understand the diverse changes resulting from the complex pathomechanisms of CKD, the use of a combination of biomarkers is recommended. Relying solely on creatinine levels, estimated glomerular filtration rate (eGFR), and proteinuria may be insufficient for accurate diagnosis. However, for the diagnosis, monitoring of progression, and assessment of disease severity, direct measurement of glomerular filtration rate (GFR) remains the most reliable and optimal approach. Glomerular, tubular, and tissue integrity of endothelial and epithelial cells in the nephron could be representative of morphophysiological changes associated with CKD. Albumin and creatinine are not sufficient for clinical application in the early detection of CKD. The published articles reported urea/BUN, creatinine, and cystatin C as the functional biomarkers. Injury biomarkers included: proteinuria, hematuria, creatinine (when > 40% kidney parenchyma is damaged), cystatin C, podocytes, podocalyxin, Nephrin, Podocin, CR1, CD80, synaptopodin, GLEPP-1, CD59, WT1, and CD59. For CKD progression, measuring DKK3, CKD273, hL-FABP, Fetuin-A, and Scd25 might offer valuable information.</p><p><strong>Conclusion: </strong>Different biomarkers should be deliberated regarding the early detection of CKD based on their sensitivity, efficacy, specificity, and, of course, cost benefits for both patients and health system decision makers, which confer relevance.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"322-330"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual Approaches for Parkinson's Disease: Role of the Dopaminergic and Non-Dopaminergic Therapies.","authors":"Brijesh Kumar Duvey, Ravneet Singh Sumbel, Abhishek, Devkant Sharma, Anurag Bhargava, Vishnu Mittal, Anjali Sharma","doi":"10.2174/0118746098382353251012173313","DOIUrl":"https://doi.org/10.2174/0118746098382353251012173313","url":null,"abstract":"<p><p><p> Introduction: Parkinson's Disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms, primarily due to the degeneration of dopaminergic neurons. This review aims to explore the therapeutic landscape of PD, focusing on dopaminergic and non-dopaminergic treatment strategies, as well as recent advancements and future directions in managing the disease. </p><p> Methods: A comprehensive literature review was conducted using databases such as PubMed, Science Direct, and Scopus, covering studies published up to 2025. The review focused on epidemiological trends, pathophysiological mechanisms, diagnostic approaches, and pharmacological and non-pharmacological therapies related to PD. </p><p> Results: PD affects approximately 1-2% of individuals over 60 years of age, with its prevalence expected to rise globally. Motor symptoms such as bradykinesia, rigidity, and tremor are wellrecognized, but non-motor symptoms remain underdiagnosed. Dopaminergic therapies, including levodopa and dopamine agonists, are effective in symptom management but are associated with long-term complications. Non-dopaminergic approaches, such as MAO-B inhibitors, amantadine, anticholinergics, and deep brain stimulation, offer additional symptom control. Emerging strategies include gene therapy, immunotherapy, and neuroprotective agents targeting disease modification. </p><p> Discussion: While current treatments provide symptomatic relief, they do not halt disease progression. A multidimensional therapeutic approach combining dopaminergic and nondopaminergic strategies is necessary. Advances in molecular genetics and biomarker discovery hold promise for early diagnosis and personalized treatment. However, the need for more targeted, disease-modifying therapies remains a major challenge. </p><p> Conclusion: This review underscores the importance of integrating traditional and emerging therapies for comprehensive PD management. Future research should focus on genetic insights, early detection, and innovative therapeutics to improve patient outcomes and quality of life.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145511971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral and Psychological Symptoms of Dementia: A Review of its Management in Sub-Saharan Africa.","authors":"Marian Esther Miller","doi":"10.2174/0118746098386183251001145157","DOIUrl":"https://doi.org/10.2174/0118746098386183251001145157","url":null,"abstract":"<p><p>Dementia has been highlighted as one of the key diagnoses among elderly people. This study seeks to review the management of behavioral and psychological symptoms of dementia in Sub-Saharan Africa. A comprehensive review was carried out with the aid of online research journal websites as well as other in-context articles. While conducting this study, the keywords in the search query were directed towards managing behavioral and psychological symptoms of dementia in Sub-Saharan Africa. Areas noted in relation to this study were understanding the effects on management of behavioral and psychological symptoms of dementia in Sub-Saharan Africa. It was discovered that 88% of the population of Ghana and 90% of the population of South Africa do not have an idea about dementia. Health professionals in sub-Saharan Africa are not provided with the knowledge they need to take care of dementia patients. There is a high prevalence rate of dementia in Africa, with a probability of having over 200% rate in dementia due to the rise of the older generation. There is a need to address the education of dementia before the management of the behavioral and psychological symptoms of dementia can be curbed. Until that is that Africa will constantly be in a cycle of being at the verge of breakthrough in addressing the management of dementia and coming back to the root cause, which is health education.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145480739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Calculated Serum Osmolality Equation for Older Adults.","authors":"Sommapan Rueanthip, Jiraporn Sri-On, Phudit Buaprasert, Thitiwan Paksopis, Rasida Ruangsiri","doi":"10.2174/0118746098307108240612053852","DOIUrl":"https://doi.org/10.2174/0118746098307108240612053852","url":null,"abstract":"<p><strong>Background: </strong>Hypertonic Dehydration (HD) is the term used for the loss of bodily water in older adults and is linked to a number of morbidities, such as urolithiasis, ischemic stroke, urinary tract infections, venous thromboembolism, morbidity, and death.</p><p><strong>Objective: </strong>This study aimed to develop and validate a new calculated serum osmolality equation for older adults and to compare its accuracy with five previously published equations.</p><p><strong>Methods: </strong>This was a prospective diagnosis accuracy study conducted between September 1, 2019, and August 31, 2020, including older adults aged 60 years and above living in Bangkok, Thailand. We measured serum osmolarity by automatic osmometer using the freezing point depression method. For the training group, we developed a new calculated serum osmolality equation from blood glucose, Blood Urea Nitrogen (BUN), and serum electrolytes. In the validation group, we validated the accuracy of the calculated serum osmolarity equation (index test) compared to the measured serum osmolality (reference standard test). We evaluated the agreement between the reference standard test and index test with the Bland-Altman method and concordance correlation coefficient. We determined the mean difference, accuracy, and precision between the index test and five previously published equations with reference standard test.</p><p><strong>Results: </strong>We included 586 participants in this study (410 in the training group and 176 in the validation group). Multiple linear regression analysis revealed a significant association among blood glucose, sodium, BUN, and serum osmole. Our new equation corresponded to osmolality estimate = 1.3x(Na+ + BUN) + 0.9xglucose + 86 mOsm/kg. We used the dataset from 176 participants and calculated the mean difference for the index test and compared it with five previously published equations. The index test exhibited a mean difference of -0.5 (95% CI; -1.2-0.2) mOsm/kg, which was similar to that of the previous eq. 2 and eq. 3. and had great accuracy (0.98) and good precision (0.76), while equation 3 exhibited the highest accuracy (0.99) and precision (0.77). Additionally, the new equation's Area Under the Receiving Operating Characteristics (AUROC) curve was 0.87 (95% CI 0.80-0.94), indicating a very good ability to forecast HD (serum osmolality > 300 mOsm/kg as the gold standard). The AUROC curve of the index test did not differ from that of the others.</p><p><strong>Conclusion: </strong>In this work, we have developed a new serum osmolality equation able to predict hypertonic dehydration in Thai community-dwelling older adults aged 60 years and above, but not in general. An external validation study should be conducted.</p>.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145353995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unravelling the Association between FOXO3a and Cancer Cell Senescence: An Insight into its Role and Biological Pathway.","authors":"Remizar Alpaddli, Novi Silvia Hardiany, Septelia Inawati Wanandi","doi":"10.2174/0118746098365760250903112703","DOIUrl":"https://doi.org/10.2174/0118746098365760250903112703","url":null,"abstract":"<p><p>This review explores the intricate relationship between FOXO3a and cellular senescence in cancer, highlighting its complex and context-dependent function. FOXO3a, a transcription factor commonly known as a tumor suppressor, exhibits paradoxical roles in cancer biology. This review describes FOXO3a's dual functions in promoting tumor suppression and progression, its interplay with senescence pathways, and its impact on cancer cell phenotypes. Senescence is also known to be a tumor suppressor and a barrier against malignancies. However, persistent senescence has been found to create an adverse effect due to cancer progression and therapeutic endeavors. The review also discusses the potential of senescence management and FOXO3a modulation as novel therapeutic strategies in cancer treatment. Recent advancements in proteomics research, including FOXO3a's interactions with microRNAs, post-translational modifications, and protein-protein interactions, are also elaborated. This paper concludes by emphasizing the need to understand the role of FOXO3a in cancer biology and its potential as a biomarker and therapeutic target.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid Cosmeceutical Innovations for Aging Skin: Bridging Functional Skincare and Therapeutic Benefits through Multifunctional Formulations.","authors":"Shikha Baghel Chauhan, Indu Singh, Manisha Singh, Mohit Singh","doi":"10.2174/0118746098369285250902044905","DOIUrl":"https://doi.org/10.2174/0118746098369285250902044905","url":null,"abstract":"<p><p>A new generation of hybrid cosmetics has come into existence, providing an efficient means to achieve both skincare and aesthetic objectives with only one product. These cosmetics incorporate ingredients from natural and synthetic sources, making use of cutting-edge technologies to improve efficacy, sustainability, and customer pleasure. This review paper will focus on the effects of hybrid cosmetics on different types of skin cells, the technologies employed, and the role of ingredients like botanical extracts, marine-based active ingredients, and synthetic compounds in the cosmetic formulations, in order to provide improved skincare benefits. Various technologies like nanotechnology, encapsulation technique, transdermal patches, electroporation, and iontophoresis are analyzed for their role in enhancing efficacy and sustainability. Hybrid cosmetics containing natural ingredients of marine origin, like Laminaria japonica and Pseudopterogorgia elisabethae, as well as botanical extracts like Resveratrol, provide safe, ecofriendly, and sustainable cosmetics, whereas synthetically derived compounds that are used in the cosmetic industry, like Hyaluronic acid and Niacinamide, provide quick action and targeted delivery. The findings of this review suggest novel dual approaches for developing a range of hybrid products to meet the increasing needs of consumers, as well as techniques for improving stability and efficacy. Using natural ingredients aligns with the growing trend toward sustainability in cosmetics. Synthetic ingredients have been developed for precise delivery, rapid action, and affordability. However, by implementing appropriate strategies for technology and ingredient selection, consumers' demands for effective products can be met.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}