Current aging science最新文献

{"title":"Challenges of Diagnosis and Management of Burning Mouth Syndrome: A Literature Review.","authors":"Nara Lígia Martins Almeida, Gabriela Moraes Oliveira, Carlos Ferreira Santos, Vanessa Soares Lara, Camila Lopes Cardoso","doi":"10.2174/0118746098279205240812113353","DOIUrl":"10.2174/0118746098279205240812113353","url":null,"abstract":"<p><strong>Background: </strong>Burning Mouth Syndrome (BMS) is defined as an idiopathic orofacial pain with recurrent intraoral burning. It mainly affects middle-aged women in peri- or post-menopause and the elderly, without any identifiable causative lesions and with or without somatosensory alterations. BMS has a complex pathogenesis involving psychogenic factors and deregulated peripheral and central pain, and there is no standard treatment protocol, making its diagnosis and management challenges.</p><p><strong>Objective: </strong>This study was to carry out a review literature on BMS, addressing its identification and therapeutic possibilities.</p><p><strong>Methods: </strong>Review articles and randomized controlled clinical studies whose full text was available, published between 2017 and 2022 in national and international journals, from PubMed and SCIELO databases, WHO manuals and books, were collected. As a search strategy, the keywords \"burning mouth syndrome\", \"treatment\" and \"diagnosis\" were used, totaling 42 papers. Of these, after applying the exclusion criteria, 34 articles were selected.</p><p><strong>Results: </strong>Studies indicate that a comprehensive and thorough anamnesis is essential to exclude secondary factors leading to the correct diagnosis of BMS. In addition, a comprehensive anamnesis directs the best management considering a combination of neuropathic and palliative therapies, which aim to control, eliminate and/or minimize painful symptoms, treating the patient in an individualized way and not the disease itself, since this pathology has no cure.</p><p><strong>Conclusion: </strong>Considering the impact of BMS on quality of life, further studies are needed to expand diagnostic and treatment strategies, aiming to complement existing pharmacological and non-pharmacological treatments, observing the influence that biopsychosocial and neurophysiological mechanisms have on this syndrome.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"102-119"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nicotinamide Adenine Dinucleotide (NAD)-Dependent Protein Deacetylase, Sirtuin, as a Biomarker of Healthy Life Expectancy: A Mini- Review.","authors":"Yodo Sugishita, Yuki Suzuki-Takahashi, Kazuo Yudoh","doi":"10.2174/0118746098319674240827104612","DOIUrl":"10.2174/0118746098319674240827104612","url":null,"abstract":"<p><p>Although a variety of disease-specific biomarkers have been identified for common lifestyle- or aging-related diseases, there are currently no indices available to measure general health or the existence of pre-symptomatic conditions in various types of tissue and organ damage. A rising body of research suggests that sirtuins may have the potential to be used as an index to assess overall health status and the existence of pre-symptomatic illness states. Sirtuins (SIRTs) are nicotinamide adenine dinucleotide (NAD)-dependent deacetylases expressed in a variety of human somatic cells both in health and disease conditions. The activity and expression of SIRTs affect important metabolic pathways, such as cell survival, senescence, proliferation, energy production, stress tolerance, DNA repair, and apoptosis, thereby closely linked to aging and longevity. Given the broad significance of SIRTs in physiological function maintenance, their activity in somatic cells may reflect the early cross-sectional status of tissue damage caused by aging or systemic inflammatory responses that are too early to be detected by disease-specific biomarkers. In this mini-review, we discuss the utility of SIRTs as a surrogate clinical biomarker for health status to evaluate and monitor health life expectancy and the presence of pre-symptomatic illness states.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"95-101"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12376132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Bibliometric Analysis of Research Trends in Aging and Leisure Activities from 2000 to 2023.","authors":"J Mufina Begam, E P Abdul Azeez","doi":"10.2174/0118746098351035241009100118","DOIUrl":"10.2174/0118746098351035241009100118","url":null,"abstract":"<p><strong>Background: </strong>Physical and leisure activities are vital for active aging. Leisure activities among the aging population have received attention from scholars in the recent past. However, the research contributions and trends in this field are unknown. Therefore, a bibliometric analysis was conducted to explore the scholarly contributions in aging and leisure activities to identify the research output trends, assess thematic focuses, and analyze research collaboration patterns.</p><p><strong>Methods: </strong>We extracted data from the Scopus database for the period 2000-2023 and identified 443 articles focusing on aging and leisure activities. Tools, such as bibliographical coupling networks and thematic analysis, were applied using R and Biblioshiny to uncover core themes and connections.</p><p><strong>Results: </strong>There has been a significant increase in research output since 2021, with contributions from numerous authors and countries, particularly the United States and China. Thematic analysis reveals central themes, such as physical activity, successful aging, and cognition.</p><p><strong>Conclusion: </strong>This analysis reveals the evolving nature of scholarly discussions in aging and leisure, highlighting key themes, such as physical activity, cognitive aging, and health promotion. The findings emphasize the growing interest and global collaboration in this interdisciplinary research domain.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"132-146"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clinical Assessment of Eccentric and Concentric Stepping Kinetics has Utility in Older African American Men with Knee Arthritis.","authors":"Tomas I Gonzales, Bryant A Seamon, Katie L Boncella, Haniel J Hernandez, Valerie McIntosh, Marc R Blackman, Michael O Harris-Love","doi":"10.2174/0118746098312415241112103614","DOIUrl":"https://doi.org/10.2174/0118746098312415241112103614","url":null,"abstract":"<p><strong>Introduction: </strong>Stair navigation is physically demanding for individuals with knee osteoarthritis and may result in movement asymmetries that can be quantified using kinetic analysis and force-time parameters. Thus, the purpose of this cross-sectional study was to determine if kinetic force-time parameter asymmetries are present in individuals with knee osteoarthritis and associated with functional outcomes.</p><p><strong>Methods: </strong>Forty-six older male veterans (61.6±5.6 years) participated. More and less involved legs were defined using the Kellgren and Lawrence (KL) scale and self-reported pain. Kinetics were measured with the Neurocom® Step Up and Over test and quantified with the lift-up index, impact index, movement time, and stair-stepping smoothness. Smoothness was calculated from the level of intermittency in acceleration and deceleration during the concentric and eccentric test movements.</p><p><strong>Results: </strong>Smoothness was the only force-time parameter to demonstrate an asymmetry. Greater smoothness values were observed for the less-involved leg (p<0.001, 95% CI: 1.22 to 3.64, d=1.17) and were positively associated with gait speed (more-involved: r=0.47, p<0.01; lessinvolved: r=0.53, p<0.01), Knee Injury and Osteoarthritis Outcome Score (KOOS) Symptom (more-involved: r=0.31, p<0.05; less-involved: r=0.39, p<0.01) and ADL (more-involved: r=0.32, p<0.05; less-involved: r=0.39, p<0.05) subscales, and isokinetic knee extension strength (more-involved: r=0.31, p<0.05; less-involved: r=0.42, p<0.01).</p><p><strong>Conclusion: </strong>Stair-stepping smoothness was diminished in the more involved leg and was associated with worse gait speed, patient-reported outcomes, and knee strength. This observation may reflect compromised motor control associated with decreased strength and greater disease severity in the more-involved leg.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Insights into Colorectal Cancer through the Lens of Precision Oncology and Personalized Medicine: Multi-Omics Helps Aging of Predisposed People.","authors":"Amir Bayat, Alireza Sharafshah, Farshid Sefat, Milad Rahimzadegan, Mohammad Raad, Kai-Uwe Lewandrowski","doi":"10.2174/0118746098348122241024061610","DOIUrl":"10.2174/0118746098348122241024061610","url":null,"abstract":"<p><strong>Background: </strong>Recently, there has been a significant evolution in our understanding of the molecular pathways causing the genesis and progression of cancer via the inter-individual variations. Thus, one-size-fits-all methods for cancer treatment have been replaced by precision oncology (PO) targeting individual cancer symptoms, offering increased effectiveness, and decreased safety concerns and cost load.</p><p><strong>Objective: </strong>The identification of novel actionable indications, rapid, precise, and comprehensive detection of complex phenotypes in every individual, pioneering clinical trial projects with enhanced response feedback, and widespread availability of innovative targeted anticancer management for every patient are vital for the effective implementation of next-generation precision oncology. Additionally, the emergence of precision medicine has altered the perspective of oncologic biomarkers, drug discovery, drug development, and, improvements for cancer patients.</p><p><strong>Method: </strong>This paper narratively reviewed to identify actionable abnormalities, Genomic profiling of tumors employing clinical next-generation sequencing (NGS) from both tumor tissues and liquid biopsies along with the multi-omics strategies as the key component of PO.</p><p><strong>Results: </strong>Our increasing information on tumor biology, specifically microenvironment and heterogeneity- associated data, would improve our understanding of the resistance of targeted drugs and specific mechanisms of action, as well as help enhance existing metastatic colorectal cancer (mCRC) treatment strategies.</p><p><strong>Conclusion: </strong>Collectively, this paper indicated the current and innovative strategies for prognosis, diagnosis, and treatment of various cancer types based on PO overview with a groundbreaking emphasis on CRC suggesting the integrations of multi-omics, highlighting Genomics, and utilizing AL and ML algorithms with targeted therapies. Notably, these findings can help improve the life-span and ageing of the predisposed people.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shorter Telomere Length is Associated with Food Insecurity in Older People: A Cross-Sectional Study.","authors":"Celi Macedo Polo, Tábatta Renata Pereira de Brito, Wanderson Roberto Silva, Daniela Braga Lima, Daniella Pires Nunes, Fábio Antonio Colombo, Ariene Angelini Dos Santos Orlandi, Ligiana Pires Corona","doi":"10.2174/0118746098320942240924074044","DOIUrl":"https://doi.org/10.2174/0118746098320942240924074044","url":null,"abstract":"<p><strong>Background: </strong>Telomere length has been investigated as a biomarker of biological aging and is associated with several diseases, lifestyle, and socioeconomic factors.</p><p><strong>Objective: </strong>This study aimed to verify whether food insecurity is associated with shorter telomere length in older people.</p><p><strong>Methods: </strong>This is a cross-sectional study carried out in a municipality in the interior of Brazil, with a sample of 440 older people from the community. For telomere length analysis, a blood sample was obtained from each participant, followed by real-time qPCR, and sociodemographic and health information was collected through interviews. Food security/insecurity was measured using the reduced version of the Brazilian Food Insecurity Scale. Descriptive analysis and multiple logistic regression were performed to analyze the factors associated with shorter telomere length, adopting a significance level of 5%.</p><p><strong>Results: </strong>We found that food insecurity was significantly associated with shorter telomere length, regardless of age group, skin color, tabagism, physical activity, milk and dairy consumption, living arrangement, and basic activities of daily life.</p><p><strong>Conclusion: </strong>The findings show the importance of ensuring full access to adequate nutrition for the older population, who are physiologically and socially vulnerable.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Telemedicine Demand and Viability in Indonesian Geriatric Clinics: A Comprehensive HOT FIT and Sociotechnical Analysis","authors":"Dewi Shinta Kemala Sari, N. Lipoeto, Hafni Bachtiar, Indra Catri, Nina Kemala Sari, Rima Semiarty","doi":"10.2174/0118746098302999240522092726","DOIUrl":"https://doi.org/10.2174/0118746098302999240522092726","url":null,"abstract":"\u0000\u0000The growing elderly population in Indonesia presents challenges for the\u0000healthcare system, prompting the exploration of telemedicine as a solution. However, its effective\u0000implementation in Indonesia faces obstacles.\u0000\u0000\u0000\u0000This research aimed to develop a comprehensive geriatric telemedicine framework in Padang\u0000City by studying multiple stakeholders. We employed qualitative methods, including in-\u0000-depth interviews, across two hospitals, a Health Office, and a Community Health Center, involving\u000018 elderly participants.\u0000\u0000\u0000\u0000The study identified ten key dimensions for geriatric telemedicine services: technology,\u0000Human-Computer Interface (HCI), infrastructure, system workflow, clinical content, people (diverse\u0000roles), organization (ecosystem, service workflow, internal and external regulations), and financing\u0000(social security agency on health and independent). We used the Human-Organization-\u0000Technology Fit and Sociotechnical System approaches for analysis.\u0000\u0000\u0000\u0000The study suggests implications for future implementation and advocates for broader\u0000participant involvement, information technology (IT) studies for system development, and longitudinal\u0000evaluations to assess the impact on elderly health outcomes.\u0000","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"49 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141353461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aging-associated Aberrant Mitochondrial Redox Signaling, Physical\u0000Activity, and Sarcopenia","authors":"M. Atayik, Erdem Atasever, Şeydanur Turgut, U. Çakatay","doi":"10.2174/0118746098315667240606052523","DOIUrl":"https://doi.org/10.2174/0118746098315667240606052523","url":null,"abstract":"\u0000\u0000Aging-related alteration of mitochondrial morphology, impairment in metabolic capacity,\u0000bioenergetics, and biogenesis are closely associated with loss of muscle mass and function. Mitochondrial\u0000Reactive Oxygen Species (ROS) stimulate muscular redox signaling mechanisms.\u0000Bioenergetic integrity of mitochondria and redox signaling dynamics deteriorates in aged skeletal\u0000muscle. Mitochondrial bioenergetic impairment leads to excessive ROS levels and induces the generation\u0000of defective mitochondria. Higher ROS levels may induce senescence or apoptosis. It is\u0000not a resolved issue that mitochondrial dysfunction is either the sole reason or a consequence of\u0000muscle loss (or both). However, Increasing evidence emphasizes that dysregulated mitochondrial\u0000redox signaling has a central role in age-related muscle loss. Nuclear factor erythroid 2-related factor\u00002 (Nrf2) regulates redox signaling pathways with the expression of antioxidant genes. As the\u0000aberrant redox signaling mechanisms in aging skeletal muscle become clearer, new natural and\u0000synthetic Nrf2-modulating substances and integrated daily physical activity alternatives are coming\u0000into view for preventing muscle loss in the elderly. A comprehensive understanding of the relationship\u0000between redox signaling pathways and age-related sarcopenia can help us to prevent sarcopenia\u0000and its frailty effects with an optimized exercise program as an innovative non-pharmacological\u0000therapeutic approach. A further aspect is necessary to consider both individualized physical\u0000training options and alternative Nrf2 signaling modulators. Ameliorating the redox signaling\u0000with physical activity and pharmacological interventions may help to prevent sarcopenia and its\u0000frailty effects.\u0000","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"93 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141352546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Insight into Acute Disseminated Encephalomyelitis","authors":"Nooreen, Fariha Summayya, Prany Wal, A. Wal, A. Rai, Sudeep Tandon","doi":"10.2174/0118746098294208240429091631","DOIUrl":"https://doi.org/10.2174/0118746098294208240429091631","url":null,"abstract":"\u0000\u0000Acute disseminated encephalomyelitis (ADEM) is a neural and immune-related disorder that occurs when the cerebrospinal system is damaged by extensive swelling. Although manifestation is possible regardless of age, adolescents have a greater probability.\u0000The purpose of the present manuscript is to provide recent advancements and enhance\u0000knowledge of the disease.\u0000\u0000\u0000\u0000The literature search on etiology, pathophysiology, diagnosis and treatment was carried\u0000out using the online databases of SciFinder, Medline, Pubmed, GoogleScholar, Scopus, etc.\u0000\u0000\u0000\u0000Although the cause of ADEM remains unclear, it is believed to be caused by inflammation in those with a genetic sensitivity to environmental stimulation. When people have altered\u0000levels of awareness or multifocal neurological abnormalities, ADEM is a possibility as a diagnosis. The diagnosis of ADEM is dependent on a combination of clinical and radiologic symptoms,\u0000whereas the exclusion of illnesses mimics ADEM; there is no one test that can establish the diagnosis. The inflammation in a child's brain and spinal cord is treated with medication. Prednisone is occasionally given to youngsters for a brief amount of time.\u0000\u0000\u0000\u0000Most children with ADEM improve with high doses of methylprednisolone. Cyclophosphamide is needed by individuals with hypothermia. Most investigations show that 50%-\u000075% of individuals completely recover between the first and sixth month of their condition.\u0000","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"5 5‐6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141381472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Esteem and Body Image in Older Women Practicing Taekwondo with\u0000Low Bone Density: A Randomized Clinical Trial","authors":"D. Linhares, Giullio César Pereira Salustiano Mallen da Silva Silva, Alex Santos Meireles, B. G. Linhares, Luciano Lima dos Santos, Lilliany de Souza Cordeiro, Claudio Joaquim Borba-Pinheiro, R. G. de Souza Vale","doi":"10.2174/0118746098308597240527114223","DOIUrl":"https://doi.org/10.2174/0118746098308597240527114223","url":null,"abstract":"\u0000\u0000Physical exercise can take on a multivariate form, including combat\u0000sports, specifically Taekwondo, a Korean sport characterized by strikes involving the hands and\u0000feet. This sport has been gaining popularity worldwide in recent years and is being practiced by diverse populations, including the older women.\u0000\u0000\u0000\u0000This study aimed to investigate the effects of Taekwondo training on self-esteem and\u0000body image in older women with low bone mineral density (BMD).\u0000\u0000\u0000\u0000This is an experimental research with a two-group design, where assessments were conducted pre- and post during a 12-week intervention period. The sample consisted of 27 inexperienced older women in taekwondo practice, aged between 60 and 70 years, randomly distributed into the experimental group (n=14) and Control Group (n=13). BMD, self-esteem, and body image\u0000were assessed. For the evaluation of self-esteem, the Rosenberg Self-Esteem Scale (RSES) was utilized. For the evaluation of body images, the body image questionnaire was administered.\u0000\u0000\u0000\u0000The results showed that the practice of taekwondo improved (p<0.001) body image in\u0000the variables, including physical condition, body skills, and health, while the variable appearance\u0000showed no difference (p=0.581).\u0000\u0000\u0000\u0000The results of this experimental study indicate an improvement in the self-esteem\u0000and body image of older individuals practicing Taekwondo.\u0000","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"24 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141380118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}