Current aging science最新文献

{"title":"Revolutionizing Therapeutic Approaches Against Pathophysiology of Alzheimer's Disease: A Therapeutic Review.","authors":"Manita Saini, Seema Rohilla, Rakesh Kumar","doi":"10.2174/0118746098376646250715094707","DOIUrl":"10.2174/0118746098376646250715094707","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a multifactorial neuron-degenerative old age illness, which deteriorates the neuronal cells of the brain ultimately leading to dementia, decreased thinking ability and intricacy in performing daily routine activities. In most of the cases, AD is suspected to be caused by a combination of numerous factors, like environmental, genetic and lifestyle affecting the brain functioning. The present permitted treatments include N-methyl-Daspartate (NMDA) receptor antagonists, cholinesterase inhibitors, and their combinations, which provide only momentary and symptomatic relief. Nowadays, clinical research is interested, in the pathology of Alzheimer's disease to target the metabolism of abnormal tau protein, removal of beta-amyloid inflammatory response, the cholinergic neuron, and free radical damage, and treatments that can either stop or modify the course, of AD. Globally, efforts are continued to search new targets to invent new options for the treatment of AD. The present review critically discusses about various treatment strategies for the patients presented with AD. Moreover, herbal drug and new drug candidates, along with nanoformulations for the treatments of AD and the role of AI-based technology in searching therapy for AD have been delineated in the present article. We concluded that preventing amyloid-β (Aβ) synthesis, enhancing the removal of Aβ deposition, or preventing Aβ aggregation can suppress AD. Moreover, herbal medicines have become an attractive alternative to cure this disease with numerous beneficial effects with little side effects. Novel approaches using AI are therefore required to create treatments with novel targets that may not only cure symptoms but also prevent disease development at an early stage to improve the quality of patients' lives.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"303-321"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When Cysts Mislead: A Case Report of Ovarian Cyst Resembling Giant Ureterocele after Hysterectomy.","authors":"Naina Kumar, Immanuel Pradeep, Annapurna Srirambhatla, Mishu Mangla","doi":"10.2174/0118746098365660250423075122","DOIUrl":"10.2174/0118746098365660250423075122","url":null,"abstract":"<p><strong>Introduction: </strong>Women undergoing hysterectomy without oophorectomy face a risk of needing re-surgery for new adnexal conditions. Additionally, large ovarian cysts in posthysterectomy patients can complicate diagnoses, often mimicking conditions, like mesenteric cysts, massive ascites, or giant hydronephrosis.</p><p><strong>Case presentation: </strong>A 54-year-old para four and live four (P4L4) post-hysterectomy woman presented to the gynecological outpatient department with complaints of lower abdominal and back pain lasting seven days, along with difficulty urinating and burning during micturition. Her initial outside imaging, including a CECT and CT-urogram, suggested a grade three or four ureterocele, with potential differentials, such as megaureter and vesicoureteric reflux. However, upon clinical examination and further evaluation using MRI, it was found to be a large left-sided ovarian cyst of 13.8x9.5x11.3 cm causing hydroureteronephrosis (left>right). Her intraoperative findings revealed a large predominantly, tense cystic lesion of size 13x12 cm, completely occupying the lower pelvis in the midline, and it was densely adherent to the bladder and omentum anteriorly, and to the bowel posteriorly and on sides. Subsequent histopathological examination confirmed it as a mucinous cystadenoma of the ovary.</p><p><strong>Conclusion: </strong>Large ovarian masses in post-hysterectomy patients present significant diagnostic and management challenges as they can mimic a range of conditions. This underscores the need for a multidisciplinary approach to improve diagnostic accuracy and optimize patient outcomes.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"378-386"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanotechnology-Based Approaches for Combating Skin Aging: A Comprehensive Review.","authors":"Mitali, Mukesh Kumar Singh, Arun Kumar Mishra","doi":"10.2174/0118746098384581250904035955","DOIUrl":"10.2174/0118746098384581250904035955","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The aging of skin is a multifaceted biological phenomenon influenced by both intrinsic and extrinsic factors. As awareness among the public increases, there is a growing interest in natural ingredients and cutting-edge cosmetic solutions that enhance skin appearance and mitigate the aging process. Nanotechnology has emerged as a significant field within cosmeceuticals, providing innovative solutions that overcome the limitations of conventional cosmetic formulations by enhancing delivery, stability, and targeted efficacy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This review synthesized contemporary research on nanotechnology-driven approaches utilized in anti-aging skincare. A comprehensive search of scientific databases, including Pub- Med, Scopus, and Google Scholar, was performed to identify research articles and review papers using keywords, such as \"nanotechnology\", \"skin aging\", \"anti-aging cosmetics\", \"nanocarriers\", and \"bioactive compounds\". The emphasis was placed on studies that highlight nanosized delivery systems and their mechanisms in addressing issues related to skin aging.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Bioactive compounds targeting anti-aging, such as antioxidants (including ascorbic acid, alpha-tocopherol, lipoic acid, and coenzyme Q10) and plant extracts (such as green tea, turmeric, and resveratrol), were successfully integrated into nanocarrier systems. These systems, comprising lipid nanoparticles, polymeric carriers, nanoemulsions, dendrimers, and fullerenes, demonstrate improved penetration, stability, and controlled release compared to traditional formulations, thereby enhancing the effectiveness of active ingredients in addressing signs of aging.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion: &lt;/strong&gt;Nanotechnology-driven skincare has demonstrated enhanced delivery, stability, and bioavailability of anti-aging compounds, addressing limitations of conventional formulations. Nanosized carriers improve penetration and controlled release, optimizing the functional benefits of antioxidants and botanical extracts. However, concerns related to safety, toxicity, and regulatory compliance require further investigation. Sustainable nanocarrier development and interdisciplinary collaborations will be essential for balancing efficacy with safety. Continued research will be crucial to establishing standardized guidelines and ensuring the successful commercialization of nano-based anti-aging cosmetics.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Nanotechnology presents significant potential for the development of effective antiaging cosmetic products. The use of nanosized delivery systems significantly enhances the efficacy of active ingredients, providing a viable alternative to traditional formulations. Nonetheless, challenges related to safety, toxicity, regulatory compliance, and long-term clinical application must be addressed in future research to facilitate the successful commercialization of these products. Additionally, future ","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"331-348"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In-silico</i> Comparative Analysis of TOP3B Protein Mammals Species with Emphasis on <i>Heterocephalus glaber</i> and <i>Homo sapiens</i>.","authors":"Yuhan Ye, Muhammed Asim Ali, Yifei Zhu, Athar Hussain","doi":"10.2174/0118746098338510250222054836","DOIUrl":"10.2174/0118746098338510250222054836","url":null,"abstract":"<p><strong>Introduction: </strong>TOP3B (Topoisomerase III-Beta) is a DNA topoisomerase enzyme essential for managing DNA topology during various cellular processes. TOP3B knockout mice typically develop but have a shorter lifespan; however, the exact role of TOP3B is not fully understood. This study aims to investigate the diversity of TOP3B across various mammalian species, with a particular focus on comparing the naked mole-rat (Heterocephalus glaber), known for its exceptional longevity and genomic stability, and humans (Homo sapiens).</p><p><strong>Methods: </strong>The study analyzed 30 putative TOP3B genes across 23 mammalian species, including Heterocephalus glaber (Hgl), Octodon degus (Ode), Pongo abelii (Pab), Trachypithecus francoisi (Tfr), Cavia porcellus (Cpo), Aotus nancymaae (Ana) and Homo sapiens (Hsa). Further deep in-silico analysis was done by covering structural and functional delivery analysis.</p><p><strong>Results: </strong>Database searches revealed the presence of two transcript isoforms, X1 and X3, in the naked mole-rat (NMR) and three isoforms in humans (Hsa), while most other species exhibited one to two isoforms. Analyses of conserved domain architecture and de novo motifs indicated noticeable differences in the domain and motif patterns between the NMR and human isoforms. Additionally, multiple sequence alignment identified several mutations at critical sites in the NMR's TOP3B protein, including A46D and G47S, and five other unnamed mutations that may contribute to genomic stability. Evolutionary analyses showed that the TOP3B sequences of the NMR are closely related to those of Cavia porcellus (guinea pig) and Octodon degus (Degus). Furthermore, protein-protein interaction network analyses, along with pathway and molecular docking studies, revealed significant diversity in the interaction patterns of TOP3B between the NMR and humans.</p><p><strong>Discussion: </strong>The structural diversity and conserved-site mutations in Hgl's TOP3B protein suggest a potential role in promoting genomic stability and extending lifespan. These unique structural features may contribute to the Heterocephalus glaber's exceptional resistance to genomic instability and aging, offering insights into potential longevity mechanisms.</p><p><strong>Conclusion: </strong>These findings suggest that structure variations and mutations in NMR's TOP3B protein are associated with enhanced genomic stability, which may underlie its remarkable lifespan. This study provides preliminary insights into the potential function of TOP3B in genomic maintenance across species, particularly in aging and longevity.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"74-88"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subtle Intrusion: Minimal Serous Uterine Carcinoma in an Asymptomatic Postmenopausal Patient-A Case Report.","authors":"Naina Kumar, Seetu Palo, Ashutosh Rath, Mishu Mangla, Pooja Rathod","doi":"10.2174/0118746098347939250407050519","DOIUrl":"10.2174/0118746098347939250407050519","url":null,"abstract":"<p><strong>Introduction: </strong>Minimal serous uterine cancers (MUSCs) represent a distinct subset of endometrial malignancies characterized by early-stage presentation and unique histopathological features. These tumors typically manifest as intraepithelial or superficial serous carcinomas confined to endometrial polyps without myometrial invasion or lymphovascular involvement. MUSCs are predominantly diagnosed in postmenopausal women and are associated with favorable prognosis.</p><p><strong>Case presentation: </strong>The present case report briefs the finding of a 60-year-old woman presenting to the gynecological outpatient department for a routine gynaecological check-up. She was a known case of type II diabetes mellitus, hypertension, and asthma. She had no history of postmenopausal bleeding or vaginal discharge. Incidentally, on per speculum examination, a polyp of 2x3 cm was seen protruding through the cervical opening (cervical os). Her transvaginal ultrasound revealed a postmenopausal uterus with a thickened endometrium of 10mm. Her histopathology report of dilatation and curettage with polypectomy revealed serous carcinoma against the background of atrophic endometrium. The patient was managed with staging laparotomy with Wertheim's hysterectomy with bilateral pelvic lymph node dissection, omentectomy, and parietal peritoneum biopsy. Her final histopathology report revealed Stage 1A1 MUSC with atrophic endometrium.</p><p><strong>Conclusion: </strong>The case report highlights the clinical significance of recognizing MUSC as an early- stage variant of endometrial cancer. Postmenopausal women, vulnerable to uterine serous carcinoma, require comprehensive sampling of all endometrial biopsies, curettings, and endometrial polyps to ensure early detection and accurate staging.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"101-107"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing Cut-off Points for the Cornell Scale to Enhance Depression Diagnosis in Parkinson's Disease Patients: A Study in the Vietnamese Healthcare Context.","authors":"Thanh-Nghiep Pham-Tran, Manh Xuan Bui, Nghia Trung Tran, Vu Hoang Anh Nguyen","doi":"10.2174/0118746098370198250322165956","DOIUrl":"10.2174/0118746098370198250322165956","url":null,"abstract":"<p><strong>Introduction: </strong>Major Depressive Disorder (MDD) often coexists with Parkinson's Disease (PD), significantly affecting the quality of life. Depression in Parkinson's disease patients is frequently neglected due to an emphasis on motor symptoms, resulting in underdiagnosis. The Cornell Scale for Depression in Dementia (CS) demonstrates potential as a screening instrument for identifying depression in Parkinson's disease patients, while research on its use in Vietnam is scarce.</p><p><strong>Methods: </strong>In this cross-sectional study conducted at Nguyen Tri Phuong Hospital from February to September 2022, 54 patients with Parkinson's disease were examined for major depressive disorder according to DSM-5 criteria and evaluated using the CS. Reliability was assessed by inter-rater reliability testing. The diagnostic performance was assessed by calculating sensitivity, specificity, positive and negative predictive values, and the Area Under the Receiver Operating Characteristic (AUROC) curve.</p><p><strong>Results: </strong>The CS exhibited significant reliability (Cronbach's alpha = 0.91; ICC = 0.91) and diagnostic precision (AUROC = 0.968). An ideal cut-off score of 9 was determined, exhibiting a sensitivity of 88.5% and a specificity of 89.3%. The results indicated cut-off scores of 6 and 11 for excluding or diagnosing depression, respectively, affirming the CS as a versatile and efficient screening instrument for patients with Parkinson's disease.</p><p><strong>Discussion: </strong>This scale has demonstrated reliability across studies, although the optimal cut-off points may vary slightly. It is suitable for community screening, outpatient preliminary diagnosis, or descriptive epidemiological surveys-allowing clinicians to select the most appropriate threshold based on specific clinical needs.</p><p><strong>Conclusion: </strong>The CS is a dependable and valid screening tool for identifying depression in Vietnamese PD patients, enabling early detection and intervention.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"66-73"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytoextracts as Natural Anti-Aging Agents: Mechanisms and Strategies for Skin Rejuvenation.","authors":"Vishakha Devi, Geeta Deswal, Ajmer Singh Grewal, Anjali Sharma, Kumar Guarve","doi":"10.2174/0118746098363055250218040726","DOIUrl":"10.2174/0118746098363055250218040726","url":null,"abstract":"<p><strong>Introduction/objective: </strong>Skin aging is a complex biological process driven by intrinsic factors, such as genetics and cellular metabolism, and extrinsic factors, including environmental stressors like UV radiation, pollution, and lifestyle choices. These factors result in visible signs of aging, such as wrinkles, reduced skin elasticity, and pigmentation. This review presents the recent findings on phytoextracts as natural anti-aging agents, highlighting their bioactive compounds, mechanisms of action, and applications in skin rejuvenation.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in databases including Scopus, PubMed, and Web of Science, focusing on articles published from 2000 to 2023. Search terms such as \"phytoextracts and skin aging,\" \"natural antioxidants and collagen synthesis,\" and \"bioactive compounds and skin rejuvenation\" were used. Inclusion criteria involved peer-reviewed studies on phytoextracts with experimental evidence of anti-aging effects, focusing on human and in-vitro models. Exclusion criteria included non-English articles, review papers without experimental data, and studies unrelated to skin aging. Recent research articles focusing on skin aging mechanisms and the efficacy of phytoextracts were identified. Particular attention was given to the antioxidant, anti-inflammatory, and collagen-boosting properties of phytoextracts.</p><p><strong>Results: </strong>This study provides novel insights into the mechanisms through which phytoextracts counteract oxidative stress, inflammation, and extracellular matrix degradation. Notable examples include the role of resveratrol in activating longevity genes, curcumin in reducing UVinduced damage, and ginseng in improving skin elasticity. These compounds were found to exhibit potent anti-aging mechanisms through their antioxidant activity and collagen-boosting effects. Advanced delivery technologies, such as nanocarriers, enhance the efficacy of these bioactives.</p><p><strong>Conclusion: </strong>Phytoextracts demonstrate significant potential in combating skin aging by reducing oxidative stress and inflammation, and enhancing collagen production. While the results are promising, further clinical studies are required to validate their long-term efficacy and safety in skin aging management.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"1-16"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variability in Exercise is Linked to Improved Age-related Dysfunctions, Suggesting a Potential Role for the Constrained-Disorder Principle-based Second-Generation Artificial Intelligence System.","authors":"Ehud Rinott, Tal Sigawi, Noa Hurvitz, Narmine Elkhateeb, Lilah Rinsky-Halivni, Yaron Ilan","doi":"10.2174/0118746098339043241219060015","DOIUrl":"10.2174/0118746098339043241219060015","url":null,"abstract":"<p><strong>Objective: </strong>Regular physical activity (PA) promotes mental and physical health. Nevertheless, inactivity is a worldwide pandemic, and methods to augment exercise benefits are required. The constrained disorder principle (CDP) characterizes biological systems based on their inherent variability. Therefore, we aimed to investigate the association between intra-individual variability in PA and disability among non-athlete adults.</p><p><strong>Methods: </strong>In this retrospective analysis of the longitudinal SHARE survey, we included non-disabled adults aged >50 with at least six visits over 14 years. Self-reported PA frequency was documented bi- to triennially. Low PA intensity was defined as vigorous PA frequency less than once a week. Stable PA was described as an unchanged PA intensity in all consecutive middle observations. The primary outcome was defined as a physical limitation in everyday activities at the end of the survey. Secondary outcomes were cognitive functions, including short-term memory, longterm memory, and verbal fluency.</p><p><strong>Results: </strong>The study included 2,049 non-disabled adults with a mean age of 53 and 49.1% women. In the initially high PA intensity group, variability in PA was associated with increased physical disability prevalence (23.3% vs. 33.2%, stable vs. unstable PA; P<0.01; adjusted P<0.01). In the initially low PA intensity group, variability was associated with a reduced physical disability (45.6% vs. 33.3%, stable vs. unstable PA; P=0.02; adjusted P=0.03). There were no statistically significant differences in cognitive parameters between the groups. Among individuals with the same low PA intensity at the beginning and end of follow-up, variability was associated with reduced physical disability (56.9% vs. 36.5%, stable vs. unstable PA; P=0.02; adjusted P=0.04) and improved short-term memory (score change: -0.28 vs. +0.29, stable vs. unstable PA; P=0.05).</p><p><strong>Conclusion: </strong>Incorporating variability into PA regimens of inactive adults may enhance their physical and cognitive benefits.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"89-100"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-Driven Innovations in Hearing Health: A Review of Artificial Intelligence Applications in Audiology and Hearing Technologies.","authors":"S Chitra Thara, K Vidhya Lekshmi, N Venkateswaramurthy","doi":"10.2174/0118746098352524250123050156","DOIUrl":"https://doi.org/10.2174/0118746098352524250123050156","url":null,"abstract":"<p><p>Hearing loss is a prevalent condition affecting over 500 million people globally, with projections estimating more than 700 million cases by 2050. Artificial Intelligence (AI) holds transformative potential in audiology, enhancing diagnostic, therapeutic, and rehabilitation outcomes. This review explores the applications of AI in hearing aids, cochlear implants, sign language recognition, and tele-audiology. A comprehensive literature review was conducted using PubMed, Google Scholar, and other academic databases. Relevant studies on AI-driven advancements in audiology were analyzed, focusing on hearing aid technologies, cochlear implants, diagnostics, and tele-audiology platforms. AI technologies significantly enhance hearing aids through real-time personalization and adaptive algorithms. Cochlear implants leverage AI for improved speech recognition and listening comfort. AI-powered sign language systems facilitate communication through real-time gestureto- text conversions, while tele-audiology expands care access using AI-enabled platforms. Diagnostic advancements include AI-enhanced audiometric testing and otoscopy. AI is revolutionizing hearing healthcare by providing personalized, efficient, and accessible solutions. Its integration into audiology represents a paradigm shift, offering significant improvements in patient outcomes and quality of life.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"19 1","pages":"17-29"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Biofeedback in Improving Vertigo Management in Older Adults. A Controlled Clinical Study in Italy.","authors":"Buizza Chiara, Ghilardi Alberto, Franco Elena","doi":"10.2174/0118746098379252250702070309","DOIUrl":"10.2174/0118746098379252250702070309","url":null,"abstract":"<p><strong>Introduction: </strong>Vertigo significantly impacts the psychosocial functioning in older persons, limiting their ability to carry out daily activities. In older adults, the effects of vertigo are even more severe than in younger populations, as it negatively impacts gait and balance, increasing the risk of falls. This, in turn, has a profound effect on their independence and overall quality of life. Despite the importance of providing integrated treatment, only a few psychological interventions have been proposed for older people. The aim of this study is to evaluate the effectiveness of biofeedback in decreasing the emotional, functional, and physical effects of vertigo in a sample of 190 older outpatients over a 3-month follow-up period.</p><p><strong>Methods: </strong>This is a controlled clinical study involving 190 persons of an outpatients of a Medical Centre, aged over 65 years. All patients received treatment as usual; in addition, the experimental group participated in a brief biofeedback training, using Procomp Infinity by Thought Technology Ltd. No biofeedback booster sessions were provided to the experimental group during the 3- month follow-up. Changes in vertigo severity were assessed using the Dizziness Handicap Inventory (DHI).</p><p><strong>Results: </strong>Repeated ANOVA measures showed that older patients treated with biofeedback reported a reduction in DHI scores after three months, reflecting a decrease in the subjective perception of the disabling impacts of dizziness on their daily living.</p><p><strong>Discussion: </strong>These findings support the effectiveness of integrating biofeedback training into the standard care protocol for older patients living with vertigo. Biofeedback treatment has reduced the effects of dizziness and instability on the day-to-day activities in these patients. Through biofeedback training, these patients learned valuable strategies to manage their symptoms, using techniques such as muscle relaxation and breath control to mitigate the arousal and heightened alertness associated with vertigo episodes. Biofeedback empowered these patients, fostering in them a sense of autonomy and self-efficacy in managing their condition.</p><p><strong>Conclusion: </strong>Despite these promising results, future research should delve deeper into the underlying mechanisms of vertigo in older persons, examining psychological factors and exploring potential correlations with other common comorbidities in this population, such as cardiovascular issues and cognitive decline. Understanding these interconnections will be crucial for developing more comprehensive and effective treatment strategies for older patients with vertigo.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"19 3","pages":"360-368"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}