Current aging science最新文献

{"title":"Phytoextracts as Natural Anti-Aging Agents: Mechanisms and Strategies for Skin Rejuvenation.","authors":"Vishakha Devi, Geeta Deswal, Ajmer Singh Grewal, Anjali Sharma, Kumar Guarve","doi":"10.2174/0118746098363055250218040726","DOIUrl":"https://doi.org/10.2174/0118746098363055250218040726","url":null,"abstract":"<p><strong>Introduction: </strong>Skin aging is a complex biological process driven by intrinsic factors, such as genetics and cellular metabolism, and extrinsic factors, including environmental stressors like UV radiation, pollution, and lifestyle choices. These factors result in visible signs of aging, such as wrinkles, reduced skin elasticity, and pigmentation.</p><p><strong>Objective: </strong>This review presents the recent findings on phytoextracts as natural anti-aging agents, highlighting their bioactive compounds, mechanisms of action, and applications in skin rejuvenation.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in databases including Scopus, PubMed, and Web of Science, focusing on articles published from 2000 to 2023. Search terms such as \"phytoextracts and skin aging,\" \"natural antioxidants and collagen synthesis,\" and \"bioactive compounds and skin rejuvenation\" were used. Inclusion criteria involved peer-reviewed studies on phytoextracts with experimental evidence of anti-aging effects, focusing on human and in-vitro models. Exclusion criteria included non-English articles, review papers without experimental data, and studies unrelated to skin aging. Recent research articles focusing on skin aging mechanisms and the efficacy of phytoextracts were identified. Particular attention was given to the antioxidant, anti-inflammatory, and collagen-boosting properties of phytoextracts.</p><p><strong>Results: </strong>This study provides novel insights into the mechanisms through which phytoextracts counteract oxidative stress, inflammation, and extracellular matrix degradation. Notable examples include the role of resveratrol in activating longevity genes, curcumin in reducing UVinduced damage, and ginseng in improving skin elasticity. These compounds were found to exhibit potent anti-aging mechanisms through their antioxidant activity and collagen-boosting effects. Advanced delivery technologies, such as nanocarriers, enhance the efficacy of these bioactives.</p><p><strong>Conclusion: </strong>Phytoextracts demonstrate significant potential in combating skin aging by reducing oxidative stress and inflammation, and enhancing collagen production. While the results are promising, further clinical studies are required to validate their long-term efficacy and safety in skin aging management.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variability in Exercise is Linked to Improved Age-related Dysfunctions, Suggesting a Potential Role for the Constrained-Disorder Principle-based Second-Generation Artificial Intelligence System.","authors":"Ehud Rinott, Tal Sigawi, Noa Hurvitz, Narmine Elkhateeb, Lilah Rinsky-Halivni, Yaron Ilan","doi":"10.2174/0118746098339043241219060015","DOIUrl":"https://doi.org/10.2174/0118746098339043241219060015","url":null,"abstract":"<p><strong>Objective: </strong>Regular physical activity (PA) promotes mental and physical health. Nevertheless, inactivity is a worldwide pandemic, and methods to augment exercise benefits are required. The constrained disorder principle (CDP) characterizes biological systems based on their inherent variability. Therefore, we aimed to investigate the association between intra-individual variability in PA and disability among non-athlete adults.</p><p><strong>Methods: </strong>In this retrospective analysis of the longitudinal SHARE survey, we included non-disabled adults aged >50 with at least six visits over 14 years. Self-reported PA frequency was documented bi- to triennially. Low PA intensity was defined as vigorous PA frequency less than once a week. Stable PA was described as an unchanged PA intensity in all consecutive middle observations. The primary outcome was defined as a physical limitation in everyday activities at the end of the survey. Secondary outcomes were cognitive functions, including short-term memory, longterm memory, and verbal fluency.</p><p><strong>Results: </strong>The study included 2,049 non-disabled adults with a mean age of 53 and 49.1% women. In the initially high PA intensity group, variability in PA was associated with increased physical disability prevalence (23.3% vs. 33.2%, stablevs.unstable PA; P<0.01; adjusted P<0.01). In the initially low PA intensity group, variability was associated with a reduced physical disability (45.6% vs. 33.3%, stablevs.unstable PA; P=0.02; adjusted P=0.03). There were no statistically significant differences in cognitive parameters between the groups. Among individuals with the same low PA intensity at the beginning and end of follow-up, variability was associated with reduced physical disability (56.9% vs. 36.5%, stablevs.unstable PA; P=0.02; adjusted P=0.04) and improved short- -term memory (score change: -0.28 vs. +0.29, stablevs.unstable PA; P=0.05).</p><p><strong>Conclusion: </strong>Incorporating variability into PA regimens of inactive adults may enhance their physical and cognitive benefits.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Different Body Mass Index Does Not Impact Physical Health in Older Adults without Sedentary Behavior: A Cross-Sectional Study.","authors":"Patchareeya Amput, Sirima Wongphon","doi":"10.2174/0118746098294790240510063241","DOIUrl":"10.2174/0118746098294790240510063241","url":null,"abstract":"<p><strong>Aims and objective: </strong>This study aimed to compare and determine the correlation of BMI on physical health, including muscle strength, balance, and cardiorespiratory fitness in older adults without sedentary behavior.</p><p><strong>Methods: </strong>A total of 65 older adults without sedentary behavior were recruited and divided into 3 groups on the basis of body mass index (BMI): normal weight (n= 22/group), overweight (<i>n</i>= 22/- group), and obese (<i>n</i>= 21/group). All the older adults were evaluated for upper limb muscle strength using the handgrip strength test, lower limb muscle strength using the sit-to-stand (STS10) test, balance ability using the time up and go (TUG) test, and cardiorespiratory fitness using the 6-minute walk test (6MWT).</p><p><strong>Results: </strong>The handgrip strength test, STS10 test, and distance of 6MWT showed no difference among the groups (p> 0.05). However, overweight group had a significantly longer duration for the TUG test when compared to normal weight, while obese group had a significantly longer duration for the TUG test when compared with overweight and normal weight groups (p< 0.01). In addition, BMI was positively correlated with the duration of the TUG test. Whereas, the handgrip strength test, STS10 test, and distance of 6MWT were not correlated with BMI.</p><p><strong>Conclusion: </strong>The BMI does not impact upper and lower limb muscle strength or the cardiorespiratory fitness test, except for the ability to balance in older adults without sedentary behavior.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"39-46"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Top Three Healthcare Trends in Orthopaedics Affecting Musculoskeletal Care in the Elderly.","authors":"Morgan P Lorio, Kai-Uwe Lewandrowski, Kenneth Blum","doi":"10.2174/0118746098309054240721180720","DOIUrl":"10.2174/0118746098309054240721180720","url":null,"abstract":"<p><p>Several trends toward patient-centered multi-care models employing translational research strategies are currently emerging in orthopaedics. These align seamlessly with epigenetics discussions in pain, a clinical approach to pain management that prioritizes tailoring healthcare to individual needs, preferences, and circumstances. Recognizing the unique genetic and epigenetic factors influencing pain perception, healthcare providers can integrate personalized insights into their patient-centered approach, offering more targeted and effective pain management strategies tailored to each individual's experience. Custom 3D-printing technologies may also become increasingly relevant to more effectively and reliably treat painful degenerative structural abnormalities. They are expected to go hand-in-hand with the precision medicine redefinition of musculoskeletal care. More effective analysis of surgeons' clinical decision-making and patients' perception of high-value orthopaedic care is needed. Shared Decision Making (SDM) is critical to identifying the best solution for each patient and improving stakeholders' understanding of factors influencing the diverse prioritizing values of surgical or non-surgical treatments by payers, systems, and other providers. Identifying high-value orthopaedic surgeries via effective SDM in orthopedic surgery requires more than just presenting patients with information. The Rasch analysis of patient expectations can provide this nuanced approach that involves understanding patient values, addressing misconceptions, and aligning surgical recommendations with patient-specific goals. Optimizing orthopaedic treatment within the patient-centered framework can drive innovation in reimbursement policies that support the field more broadly. Research on separating high-value from low-value orthopaedic procedures may likely impact healthcare decision- makers' resource allocation.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"87-94"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoxia-reoxygenation Extends the Lifespan of <i>Caenorhabditis elegans via</i> SKN-1- and DAF-16A-Dependent Stress Hormesis.","authors":"Ferbian Milas Siswanto, Maria Dara Novi Handayani, Rita Dewi Firmasyah, Jojor Lamsihar Manalu, Adriyan Pramono","doi":"10.2174/0118746098292667240914024812","DOIUrl":"10.2174/0118746098292667240914024812","url":null,"abstract":"<p><strong>Aims: </strong>To study the role of hypoxia-reoxygenation and anoxia-starvation on the lifespan of <i>C. elegans</i> and elucidate the mechanism at molecular levels.</p><p><strong>Background: </strong>Increasing evidence indicates that reactive oxygen species (ROS) act as signaling molecules that promote health. Hormesis occurs when a moderate stress level induces a beneficial adaptive response, protecting organisms against subsequent exposure to severe stress. <i>Caenorhabditis elegans</i> is a widely used model organism to study aging and displays a broad hormetic ability to couple with stress. To date, only few methods are available to induce stress hormesis in <i>C. elegans</i>.</p><p><strong>Objectives: </strong>The objectives of this study were to explore the effects of hypoxia-reoxygenation and anoxia-starvation on the lifespan of <i>C. elegans</i>, exploring the involvement of ROS and oxidative stress-related pathways, and examining the hormetic property of H/R.</p><p><strong>Methods: </strong>The <i>C. elegans</i> were cultured in hypoxic conditions (1% O₂) with OP50 bacteria for 24 h followed by reoxygenation (20% O₂) (H/R) or in anoxic conditions (0% O₂; 100% N₂) without OP50 bacteria for 24 h followed by reoxygenation (20% O₂) and food supplementation (A/S). Survivals were plotted and estimated for probability with Kaplan-Meier analysis.</p><p><strong>Results: </strong>The H/R extended the lifespan of <i>C. elegans</i>, and H/R-pretreated worms showed improved resistance toward A/S compared to naïve worms. The <i>C. elegans</i> SKN-1 and DAF-16 are important oxidative stress response factors homologous to mammalian Nrf2 and FOXO3, respectively. Mutations in SKN-1 and DAF-16 blocked H/R-induced life extension. Next, H/R treatment in <i>C. elegans</i> activated both SKN-1 and DAF-16, as indicated by the upregulation of putative target genes of SKN-1 (<i>gcs-1</i> and <i>gss-1</i>) and DAF-16 (<i>sod-3</i>). Moreover, pre-treatment with antioxidants (N-acetylcysteine, chlorogenic acid, and sulforaphane) reduced ROS levels and diminished the lifespan extension effect of H/R, indicating their dependency on ROS.</p><p><strong>Conclusion: </strong>These results provide evidence that H/R is beneficial for lifespan and stress resistance by activating the adaptive cellular response pathway (SKN-1 and DAF-16A) toward oxidative stress.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"163-173"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart Seizure Detection System: Machine Learning Based Model in Healthcare IoT.","authors":"Naresh Rana, Tanishk Thakur, Shruti Jain","doi":"10.2174/0118746098298618240429102237","DOIUrl":"10.2174/0118746098298618240429102237","url":null,"abstract":"<p><strong>Background: </strong>Epilepsy, the tendency to have recurrent seizures, can have various causes, including brain tumors, genetics, stroke, brain injury, infections, and developmental disorders. Epileptic seizures are usually transient events. They normally leave no trace after the postictal recovery period has passed.</p><p><strong>Aims: </strong>An electroencephalogram (EEG) can only detect brain activity during the recording. It will be detected if an epileptogenic focus or generalized abnormality is active during the recording.</p><p><strong>Objective: </strong>This work demonstrated a smart seizure detection system for Healthcare IoT, which is a challenging problem of EEG data analysis.</p><p><strong>Method: </strong>The study suggested an integrated methodology in recognition of the drawbacks of manual identification and the significant negative effects of uncontrollable seizures on patients' lives.</p><p><strong>Result: </strong>The research shows remarkable accuracy, up to 100% in some experiments, by combining classifier ensembles like Decision Trees, Logistic Regression, and Support Vector Machine with different signal processing techniques like Discrete Wavelet Transform, Hjorth Parameters, and statistical features. The results were compared using the kNN classifier, other datasets and other state-of-the-art techniques.</p><p><strong>Conclusion: </strong>Healthcare IoT is further utilized by the methodology, which takes a comprehensive approach using classifier ensembles and signal processing approaches resulting in real-time data to help them make better decisions. This demonstrates how well the suggested method works for smart seizure detection, which is a crucial development for better patient outcomes.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"29-38"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gait Characteristics over the Six-minute Walk Test in Older Women of a Specific Portuguese Community: A Cross-Sectional Study.","authors":"Jullyanne Silva, Tiago Atalaia, Rodrigo Martins, Joao Abrantes, Pedro Aleixo","doi":"10.2174/0118746098315374240508094923","DOIUrl":"10.2174/0118746098315374240508094923","url":null,"abstract":"<p><strong>Introduction and objective: </strong>There is limited research on the changes that can occur in the gait biomechanical parameters of older adults over long-distance walking. Thus, this study aimed to evaluate the gait characteristics of older women of a specific Portuguese community over the six-minute walk test (6MWT) along with gait spatial and temporal parameters and angular kinematics of the lower limb joints.</p><p><strong>Materials and methods: </strong>Twenty-six older women voluntarily participated. Each woman performed the 6MWT, and during this, their spatial and temporal parameters were collected through plantar pressure data (100Hz) and angular kinematics through an inertial sensor system (100Hz). The 6MWT was divided into four intervals, and the Friedman test was used to compare them. The median age of the women was calculated, and the Mann-Whitney test was used to compare women above and below the median age value.</p><p><strong>Results: </strong>An increase in gait speed, stance phase, and double stance phase along the intervals was observed, as well as larger angular displacements of the hip, knee, and ankle (p<0.05). Women below or above the median age value also yielded these behaviours. Gait speed, cadence, stride length, and step length were higher in women below the median age value, while stride and step duration were lower (p<0.05).</p><p><strong>Conclusion: </strong>Older women yielded changes in gait spatial and temporal parameters along the 6MWT, as well as larger angular displacements of the lower limb joints. Older women (compared to younger ones) yielded lower gait speed, cadence, stride length, and step length, higher stance and double stance phases, and shorter angular displacements of the lower limb joints.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"59-72"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Sarcopenic Obesity in Elderly Population: A Meta-Analysis.","authors":"Viviane Locatelli Rupolo, Taiana Lemos Camargo, Isabele Rejane de Oliveira Maranhao Pureza, Mileni Vanti Beretta, Anderson Garcez","doi":"10.2174/0118746098331277241101025928","DOIUrl":"10.2174/0118746098331277241101025928","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenic obesity (SO) is characterized by the simultaneous presence of both obesity and sarcopenia in the same individual, and it is associated with adverse health outcomes such as falls, hospitalization, functional disability, and mortality. This study aimed to provide a comprehensive analysis of the prevalence of SO in the elderly population through a systematic review and meta-analysis of the scientific literature.</p><p><strong>Methods: </strong>A systematic search was conducted in the PubMed, Embase, Web of Science, and LILACS databases for observational studies published up to July 2023 on the prevalence of SO in individuals aged 65 years or older. Data were collected from the selected and included articles, including general study information, demographic characteristics of the samples, methods, and results. The quality of the studies was assessed using the Newcastle-Ottawa Scale (NOS) criteria. A random-effects model was applied for the quantitative synthesis (meta-analysis) of combined prevalence data, and the I-squared index (I²) was used to assess heterogeneity. Publication bias was evaluated using a funnel plot and Egger's test.</p><p><strong>Results: </strong>A total of 37 articles meeting the eligibility criteria were selected and included in this meta-analysis. Heterogeneity among the studies was observed, along with evidence of publication bias. Most studies were classified as having a high risk of bias. The pooled prevalence of SO in the elderly was 10% (95% CI: 8%-12%; I²: 99.10%, p<0.001). A similar result was observed after stratification by sex, with a prevalence of 10% in both men (95% CI: 8%-12%; I²: 97.46%, p<0.001) and women (95% CI: 8%-12%; I²: 98.72%, p<0.001). Subgroup and sensitivity analyses revealed that the study setting, criteria used for the diagnosis of obesity, and the risk of bias in the studies were potential factors contributing to the heterogeneity in the prevalence of SO in the elderly.</p><p><strong>Conclusions: </strong>This meta-analysis indicated a significant prevalence of SO among the elderly population, with no difference by sex, highlighting SO as a substantial health problem in this population. These findings underscore the importance of interventions to reduce the occurrence of SO in the elderly.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"18 2","pages":"147-162"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Mutation in the CACNA1F Gene Found by Whole Exome Sequencing (WES) and <i>In Silico</i> Analysis in an Iranian Family with Consanguineous Relationships.","authors":"Vahid Omarmeli, Marjan Assefi, Kai-Uwe Lewandrowski, Alireza Sharafshah, Hanieh Faizmahdavi, Parichehr Darabi, Amir Amiri, Nasrin Mansouri","doi":"10.2174/0118746098307079240507063045","DOIUrl":"10.2174/0118746098307079240507063045","url":null,"abstract":"<p><strong>Background: </strong>X-linked mutations are highly important in clinical diagnosis, and at least 533 disorders are related to the genes located on the X chromosome.</p><p><strong>Case presentation: </strong>A 21-year-old Caucasian woman with a 24-year-old Caucasian man as her fiancé referred Clinical genetic lab for premarital genetic counseling (carrier screening). None of them had any abnormal manifestations. Following genetic counseling, Whole Exome Sequencing (WES) test performed to find the possible pathogenic mutations. Also, after drawing the couple's pedigree, candidate mutations were examined in the woman's parents as well as her uncles. Additionally, <i>in silico</i> investigations were performed through SWISS-MODEL, MolProbity, ProSA, Py- Mol, and FATCAT tools. The most important mutation diagnosed in the woman (R1362Q in the 35th exon of CACNA1F), was observed in her mother and her two uncles. The mutation was also screened in both her father and her fiancé, but they had no mutations. After medical examinations of carriers, there was no sign of any eye impairment. Other mutations were TCTN2 (c.1613-2A>G), TARS (p.K319E), SPEG (p.E3020K), CPS1 (p.A1180V), MYO3A (p.I736M), NNT (p.R968Q), MED23 (p.K406T). Bioinformatics analyses indicated no alteration in the mutant structure of CACNA1F (Q1362) compared with the normal structure (R1362).</p><p><strong>Conclusion: </strong>Conclusively, the current study emphasizes the non-pathogenic effect of missense mutation R1362Q in the 35th exon of CACNA1F in association with ocular diseases. This will ensure the reports of this mutation as healthy instead of uncertain in the literature and databanks.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"80-85"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Connecting the Dots: Gender, Sexuality, and Societal Influences on Cognitive Aging and Alzheimer's Disease.","authors":"Swati Verma, Sarvesh Paliwal, Debashish Paramanick, Chaitanay Vinayak Narayan, Manasvi Saini","doi":"10.2174/0118746098299754240530111755","DOIUrl":"10.2174/0118746098299754240530111755","url":null,"abstract":"<p><p>Alzheimer's disease (AD) has many etiologies and the impact of gender on AD changes throughout time. As a consequence of advancements in precision medical procedures and methodology, Alzheimer's disease is now better understood and treated. Several risk factors may be addressed to lower one's chances of developing Alzheimer's disease or associated dementia (ADRD). The presence of amyloid-α protein senile plaques, intracellular tau protein neurofibrillary tangles (NfTs), neurodegeneration, and neuropsychiatric symptoms (NPS) characterizes Alzheimer's disease. NPS is common in persons with Alzheimer's disease dementia, although its presentation varies widely. Gender differences might explain this clinical variability. The fundamental goal of this review is to 1) emphasize the function of old age, sex, and gender in the development of Alzheimer's disease, dementia, and ADRD, and 2) explain the importance of sexual hormones, education, and APOE (Apolipoprotein E) status. This is a narrative summary of new ideas and concepts on the differences in the chance of developing dementia or Alzheimer's disease between men and women. A more thorough examination of risk and protective variables in both men and women might hasten research into the epidemiology of neurological illnesses such as dementia and Alzheimer's disease. Similarly, future preventive efforts should target men and women separately.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"14-28"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141426577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}