Current aging science最新文献

{"title":"Aging-associated Aberrant Mitochondrial Redox Signaling, Physical\u0000Activity, and Sarcopenia","authors":"M. Atayik, Erdem Atasever, Şeydanur Turgut, U. Çakatay","doi":"10.2174/0118746098315667240606052523","DOIUrl":"https://doi.org/10.2174/0118746098315667240606052523","url":null,"abstract":"\u0000\u0000Aging-related alteration of mitochondrial morphology, impairment in metabolic capacity,\u0000bioenergetics, and biogenesis are closely associated with loss of muscle mass and function. Mitochondrial\u0000Reactive Oxygen Species (ROS) stimulate muscular redox signaling mechanisms.\u0000Bioenergetic integrity of mitochondria and redox signaling dynamics deteriorates in aged skeletal\u0000muscle. Mitochondrial bioenergetic impairment leads to excessive ROS levels and induces the generation\u0000of defective mitochondria. Higher ROS levels may induce senescence or apoptosis. It is\u0000not a resolved issue that mitochondrial dysfunction is either the sole reason or a consequence of\u0000muscle loss (or both). However, Increasing evidence emphasizes that dysregulated mitochondrial\u0000redox signaling has a central role in age-related muscle loss. Nuclear factor erythroid 2-related factor\u00002 (Nrf2) regulates redox signaling pathways with the expression of antioxidant genes. As the\u0000aberrant redox signaling mechanisms in aging skeletal muscle become clearer, new natural and\u0000synthetic Nrf2-modulating substances and integrated daily physical activity alternatives are coming\u0000into view for preventing muscle loss in the elderly. A comprehensive understanding of the relationship\u0000between redox signaling pathways and age-related sarcopenia can help us to prevent sarcopenia\u0000and its frailty effects with an optimized exercise program as an innovative non-pharmacological\u0000therapeutic approach. A further aspect is necessary to consider both individualized physical\u0000training options and alternative Nrf2 signaling modulators. Ameliorating the redox signaling\u0000with physical activity and pharmacological interventions may help to prevent sarcopenia and its\u0000frailty effects.\u0000","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"93 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141352546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Insight into Acute Disseminated Encephalomyelitis","authors":"Nooreen, Fariha Summayya, Prany Wal, A. Wal, A. Rai, Sudeep Tandon","doi":"10.2174/0118746098294208240429091631","DOIUrl":"https://doi.org/10.2174/0118746098294208240429091631","url":null,"abstract":"\u0000\u0000Acute disseminated encephalomyelitis (ADEM) is a neural and immune-related disorder that occurs when the cerebrospinal system is damaged by extensive swelling. Although manifestation is possible regardless of age, adolescents have a greater probability.\u0000The purpose of the present manuscript is to provide recent advancements and enhance\u0000knowledge of the disease.\u0000\u0000\u0000\u0000The literature search on etiology, pathophysiology, diagnosis and treatment was carried\u0000out using the online databases of SciFinder, Medline, Pubmed, GoogleScholar, Scopus, etc.\u0000\u0000\u0000\u0000Although the cause of ADEM remains unclear, it is believed to be caused by inflammation in those with a genetic sensitivity to environmental stimulation. When people have altered\u0000levels of awareness or multifocal neurological abnormalities, ADEM is a possibility as a diagnosis. The diagnosis of ADEM is dependent on a combination of clinical and radiologic symptoms,\u0000whereas the exclusion of illnesses mimics ADEM; there is no one test that can establish the diagnosis. The inflammation in a child's brain and spinal cord is treated with medication. Prednisone is occasionally given to youngsters for a brief amount of time.\u0000\u0000\u0000\u0000Most children with ADEM improve with high doses of methylprednisolone. Cyclophosphamide is needed by individuals with hypothermia. Most investigations show that 50%-\u000075% of individuals completely recover between the first and sixth month of their condition.\u0000","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"5 5‐6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141381472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Esteem and Body Image in Older Women Practicing Taekwondo with\u0000Low Bone Density: A Randomized Clinical Trial","authors":"D. Linhares, Giullio César Pereira Salustiano Mallen da Silva Silva, Alex Santos Meireles, B. G. Linhares, Luciano Lima dos Santos, Lilliany de Souza Cordeiro, Claudio Joaquim Borba-Pinheiro, R. G. de Souza Vale","doi":"10.2174/0118746098308597240527114223","DOIUrl":"https://doi.org/10.2174/0118746098308597240527114223","url":null,"abstract":"\u0000\u0000Physical exercise can take on a multivariate form, including combat\u0000sports, specifically Taekwondo, a Korean sport characterized by strikes involving the hands and\u0000feet. This sport has been gaining popularity worldwide in recent years and is being practiced by diverse populations, including the older women.\u0000\u0000\u0000\u0000This study aimed to investigate the effects of Taekwondo training on self-esteem and\u0000body image in older women with low bone mineral density (BMD).\u0000\u0000\u0000\u0000This is an experimental research with a two-group design, where assessments were conducted pre- and post during a 12-week intervention period. The sample consisted of 27 inexperienced older women in taekwondo practice, aged between 60 and 70 years, randomly distributed into the experimental group (n=14) and Control Group (n=13). BMD, self-esteem, and body image\u0000were assessed. For the evaluation of self-esteem, the Rosenberg Self-Esteem Scale (RSES) was utilized. For the evaluation of body images, the body image questionnaire was administered.\u0000\u0000\u0000\u0000The results showed that the practice of taekwondo improved (p<0.001) body image in\u0000the variables, including physical condition, body skills, and health, while the variable appearance\u0000showed no difference (p=0.581).\u0000\u0000\u0000\u0000The results of this experimental study indicate an improvement in the self-esteem\u0000and body image of older individuals practicing Taekwondo.\u0000","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"24 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141380118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gait Characteristics over the Six-minute Walk Test in Older Women of a Specific Portuguese Community: A Cross-Sectional Study.","authors":"Jullyanne Silva, Tiago Atalaia, Rodrigo Martins, João Abrantes, Pedro Aleixo","doi":"10.2174/0118746098315374240508094923","DOIUrl":"https://doi.org/10.2174/0118746098315374240508094923","url":null,"abstract":"<p><strong>Introduction and objective: </strong>There is limited research on the changes that can occur in the gait biomechanical parameters of older adults over long-distance walking. Thus, this study aimed to evaluate the gait characteristics of older women of a specific Portuguese community over the six-minute walk test (6MWT) along with gait spatial and temporal parameters and angular kinematics of the lower limb joints.</p><p><strong>Materials and methods: </strong>Twenty-six older women voluntarily participated. Each woman performed the 6MWT, and during this, their spatial and temporal parameters were collected through plantar pressure data (100Hz) and angular kinematics through an inertial sensor system (100Hz). The 6MWT was divided into four intervals, and the Friedman test was used to compare them. The median age of the women was calculated, and the Mann-Whitney test was used to compare women above and below the median age value.</p><p><strong>Results: </strong>An increase in gait speed, stance phase, and double stance phase along the intervals was observed, as well as larger angular displacements of the hip, knee, and ankle (p<0.05). Women below or above the median age value also yielded these behaviours. Gait speed, cadence, stride length, and step length were higher in women below the median age value, while stride and step duration were lower (p<0.05).</p><p><strong>Conclusion: </strong>Older women yielded changes in gait spatial and temporal parameters along the 6MWT, as well as larger angular displacements of the lower limb joints. Older women (compared to younger ones) yielded lower gait speed, cadence, stride length, and step length, higher stance and double stance phases, and shorter angular displacements of the lower limb joints.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Different Body Mass Index Does Not Impact Physical Health in Older Adults without Sedentary Behavior: A Cross-Sectional Study.","authors":"Patchareeya Amput, Sirima Wongphon","doi":"10.2174/0118746098294790240510063241","DOIUrl":"https://doi.org/10.2174/0118746098294790240510063241","url":null,"abstract":"<p><strong>Aims and objective: </strong>This study aimed to compare and determine the correlation of BMI on physical health, including muscle strength, balance, and cardiorespiratory fitness in older adults without sedentary behavior.</p><p><strong>Methods: </strong>A total of 65 older adults without sedentary behavior were recruited and divided into 3 groups on the basis of body mass index (BMI): normal weight (n= 22/group), overweight (n= 22/- group), and obese (n= 21/group). All the older adults were evaluated for upper limb muscle strength using the handgrip strength test, lower limb muscle strength using the sit-to-stand (STS10) test, balance ability using the time up and go (TUG) test, and cardiorespiratory fitness using the 6-minute walk test (6MWT).</p><p><strong>Results: </strong>The handgrip strength test, STS10 test, and distance of 6MWT showed no difference among the groups (p> 0.05). However, overweight group had a significantly longer duration for the TUG test when compared to normal weight, while obese group had a significantly longer duration for the TUG test when compared with overweight and normal weight groups (p< 0.01). In addition, BMI was positively correlated with the duration of the TUG test. Whereas, the handgrip strength test, STS10 test, and distance of 6MWT were not correlated with BMI.</p><p><strong>Conclusion: </strong>The BMI does not impact upper and lower limb muscle strength or the cardiorespiratory fitness test, except for the ability to balance in older adults without sedentary behavior.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Mutation in the CACNA1F Gene Found by Whole Exome Sequencing (WES) and In Silico Analysis in an Iranian Family with Consanguineous Relationships.","authors":"Vahid Omarmeli, Marjan Assefi, Kai-Uwe Lewandrowski, Alireza Sharafshah, Hanieh Faizmahdavi, Parichehr Darabi, Amir Amiri, Nasrin Mansouri","doi":"10.2174/0118746098307079240507063045","DOIUrl":"10.2174/0118746098307079240507063045","url":null,"abstract":"<p><strong>Background: </strong>X-linked mutations are highly important in clinical diagnosis, and at least 533 disorders are related to the genes located on the X chromosome.</p><p><strong>Case presentation: </strong>A 21-year-old Caucasian woman with a 24-year-old Caucasian man as her fiancé referred Clinical genetic lab for premarital genetic counseling (carrier screening). None of them had any abnormal manifestations. Following genetic counseling, Whole Exome Sequencing (WES) test performed to find the possible pathogenic mutations. Also, after drawing the couple's pedigree, candidate mutations were examined in the woman's parents as well as her uncles. Additionally, in silico investigations were performed through SWISS-MODEL, MolProbity, ProSA, Py- Mol, and FATCAT tools. The most important mutation diagnosed in the woman (R1362Q in the 35th exon of CACNA1F), was observed in her mother and her two uncles. The mutation was also screened in both her father and her fiancé, but they had no mutations. After medical examinations of carriers, there was no sign of any eye impairment. Other mutations were TCTN2 (c.1613-2A>G), TARS (p.K319E), SPEG (p.E3020K), CPS1 (p.A1180V), MYO3A (p.I736M), NNT (p.R968Q), MED23 (p.K406T). Bioinformatics analyses indicated no alteration in the mutant structure of CACNA1F (Q1362) compared with the normal structure (R1362).</p><p><strong>Conclusion: </strong>Conclusively, the current study emphasizes the non-pathogenic effect of missense mutation R1362Q in the 35th exon of CACNA1F in association with ocular diseases. This will ensure the reports of this mutation as healthy instead of uncertain in the literature and databanks.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart Seizure Detection System: Machine Learning Based Model in Healthcare IoT.","authors":"Naresh Rana, Tanishk Thakur, Shruti Jain","doi":"10.2174/0118746098298618240429102237","DOIUrl":"https://doi.org/10.2174/0118746098298618240429102237","url":null,"abstract":"<p><strong>Aims: </strong>Epilepsy, the tendency to have recurrent seizures, can have various causes, including brain tumors, genetics, stroke, brain injury, infections, and developmental disorders. Epileptic seizures are usually transient events. They normally leave no trace after the postictal recovery period has passed.</p><p><strong>Background: </strong>An electroencephalogram (EEG) can only detect brain activity during the recording. It will be detected if an epileptogenic focus or generalized abnormality is active during the recording.</p><p><strong>Objective: </strong>This work demonstrated a smart seizure detection system for Healthcare IoT, which is a challenging problem of EEG data analysis.</p><p><strong>Method: </strong>The study suggested an integrated methodology in recognition of the drawbacks of manual identification and the significant negative effects of uncontrollable seizures on patients' lives.</p><p><strong>Result: </strong>The research shows remarkable accuracy, up to 100% in some experiments, by combining classifier ensembles like Decision Trees, Logistic Regression, and Support Vector Machine with different signal processing techniques like Discrete Wavelet Transform, Hjorth Parameters, and statistical features. The results were compared using the kNN classifier, compared with other datasets and other state-of-the-art techniques.</p><p><strong>Conclusion: </strong>Healthcare IoT is further utilized by the methodology, which takes a comprehensive approach using classifier ensembles and signal processing approaches resulting in real-time data to help them make better decisions. This demonstrates how well the suggested method works for smart seizure detection, which is a crucial development for better patient outcomes.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loneliness, Psychological Well-being, Depression, and Social Participation in the Older Persons: Rural and Urban Differences.","authors":"Zeynep Gümüş Demir, Mahmut Yılmaz","doi":"10.2174/0118746098297063240409070531","DOIUrl":"https://doi.org/10.2174/0118746098297063240409070531","url":null,"abstract":"INTRODUCTION\u0000The purpose of this study is to compare the loneliness, psychological well- being, depression, and social participation of elderly people living in Turkish society between rural and urban areas. The sample group of the study, in which a correlational survey model was used, consisted of 610 elderly adults.\u0000\u0000\u0000METHOD\u0000The study population consists of two groups: the first group consists of individuals over 65 years of age living in the city (Istanbul) (n= 291), and the second group consists of individuals over 65 years of age living in rural areas (rural areas of Ordu) (n= 319). Socio-demographic Information Form, Loneliness in the Elderly Scale, Geriatric Depression Scale, Psychological Well-Being in the Elderly Scale, and Social Inclusion Scale were applied online. Statistical analyses of the study were conducted using SPSS 27.00, and the Independent Samples t-test and ANOVA test were used.\u0000\u0000\u0000RESULTS\u0000According to the findings of this study, statistically significant results were found in psychological well-being, social inclusion, social relations, loneliness and depression, and place of residence. It was observed that the social isolation and social acceptance levels of those living in urban areas were higher than those living in rural areas. Social, loneliness, and depression scores of those living in the village/town were found to be higher than those living in the city centre. Furthermore, the social relationship scores of those living in the village/town were found to be higher than those living in the city centre.\u0000\u0000\u0000CONCLUSION\u0000The increasing elderly population worldwide has become an issue that requires global measures. Place of residence is one of the factors thought to affect older people's health and well- being. It is thought that the study data will contribute to new policies that will ensure the protection and promotion of elderly health and those working in this field. In addition, the study, which provides information about Turkish culture, will also enable intercultural comparisons.","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"169 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140693521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Dietary Restriction on PGC-1α Regulation in the Development of Age-associated Diseases.","authors":"Shefilyn Widjaja, R. Antarianto, N. Hardiany","doi":"10.2174/0118746098301226240402051508","DOIUrl":"https://doi.org/10.2174/0118746098301226240402051508","url":null,"abstract":"Ageing is the most significant risk factor for a number of non-communicable diseases, manifesting as cognitive, metabolic, and cardiovascular diseases. Although multifactorial, mitochondrial dysfunction and oxidative stress have been proposed to be the driving forces of ageing. Peroxisome proliferator-activated receptor γ coactivator α (PGC-1α) is a transcriptional coactivator central to various metabolic functions, of which mitochondrial biogenesis is the most prominent function. Inducible by various stimuli, including nutrient limitations, PGC-1α is a molecule of interest in the maintenance of mitochondrial function and, therefore, the prevention of degenerative diseases. This review involves a literature search for articles retrieved from PubMed using PGC-1α, ageing, and dietary restriction as keywords. Dietary restriction has been shown to promote tissue-specific PGC-1α expression. Both dietary restriction and PGC-1α upregulation have been shown to prolong the lifespans of both lower and higher-level organisms; the incidence of non-communicable diseases also decreased in fasting mammals. In conclusion, dietary interventions may delay ageing by regulating healthy mitochondria in various organs, presenting the possibility of a new primary prevention for many age-related diseases.","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140721045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RNA-based Therapies for Aging and Cancer, What Known so Far?","authors":"S. Pathak, Antara Banerjee","doi":"10.2174/187460981701240229094013","DOIUrl":"https://doi.org/10.2174/187460981701240229094013","url":null,"abstract":"<jats:sec>\u0000<jats:title />\u0000<jats:p />\u0000</jats:sec>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"105 51","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140090243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}