{"title":"Allicin and its Therapeutic Potential in Diabetes Management: A Comprehensive Review.","authors":"Anmol Saini, Vishakha Saini, Suresh Kumar, Ashwani K Dhingra, Jatin Kumar","doi":"10.2174/0118746098362006250602085308","DOIUrl":null,"url":null,"abstract":"<p><p>It has been known since ancient times that garlic (Allium sativum), a member of the Alliaceae family, is an indispensable component of human food. This compound contains abundant nutrients, minerals, sulphur-containing compounds, essential oils, phenols, and free amino acids. Sugar levels in the blood that are abnormally high are a symptom of diabetes mellitus, in which the body has difficulty appropriately regulating glucose metabolism. Elevated levels of glucose in blood plasma are considered DM. It has been suggested that two primary mechanisms are responsible for the pathogenesis of the disease. One of the main causes of the persistent hyperglycemia linked to diabetes mellitus is the immune system's devastation of pancreatic β-cells, which results in a lack of insulin synthesis. Additionally, endogenous resistance of the body cells to the action of insulin is also a contributing factor. Children who have type 1 diabetes frequently experience symptoms such as polyuria, weight loss, and polydipsia of varying degrees. A comprehensive literature search on the potential benefits of allicin in diabetes mellitus (DM) was conducted using reputable databases such as PubMed, Web of Science, Scopus, and other recognized scientific sources. Furthermore, information on the clinical application of allicin was reviewed and compiled from ClinicalTrials.gov to provide insights into ongoing and completed clinical studies. Allicin is a compound that has the potential to have effects on pancreatic cells, wound healing, promoting insulin secretion, diabetic macroangiopathy, maintaining glucose homeostasis, and diabetic nephropathy. In addition, studies on cell lines that were carried out with different concentrations of allicin demonstrated a significant inhibitory effect on diabetes mellitus. The promising treatment strategy, therapeutic benefits, and inhibitory actions that allicin exhibits on diabetes make it an appealing candidate for additional research and the possibility of its application in the treatment of diabetes mellitus.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current aging science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0118746098362006250602085308","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
It has been known since ancient times that garlic (Allium sativum), a member of the Alliaceae family, is an indispensable component of human food. This compound contains abundant nutrients, minerals, sulphur-containing compounds, essential oils, phenols, and free amino acids. Sugar levels in the blood that are abnormally high are a symptom of diabetes mellitus, in which the body has difficulty appropriately regulating glucose metabolism. Elevated levels of glucose in blood plasma are considered DM. It has been suggested that two primary mechanisms are responsible for the pathogenesis of the disease. One of the main causes of the persistent hyperglycemia linked to diabetes mellitus is the immune system's devastation of pancreatic β-cells, which results in a lack of insulin synthesis. Additionally, endogenous resistance of the body cells to the action of insulin is also a contributing factor. Children who have type 1 diabetes frequently experience symptoms such as polyuria, weight loss, and polydipsia of varying degrees. A comprehensive literature search on the potential benefits of allicin in diabetes mellitus (DM) was conducted using reputable databases such as PubMed, Web of Science, Scopus, and other recognized scientific sources. Furthermore, information on the clinical application of allicin was reviewed and compiled from ClinicalTrials.gov to provide insights into ongoing and completed clinical studies. Allicin is a compound that has the potential to have effects on pancreatic cells, wound healing, promoting insulin secretion, diabetic macroangiopathy, maintaining glucose homeostasis, and diabetic nephropathy. In addition, studies on cell lines that were carried out with different concentrations of allicin demonstrated a significant inhibitory effect on diabetes mellitus. The promising treatment strategy, therapeutic benefits, and inhibitory actions that allicin exhibits on diabetes make it an appealing candidate for additional research and the possibility of its application in the treatment of diabetes mellitus.
自古以来,人们就知道大蒜(Allium sativum)是葱科植物中的一员,是人类不可缺少的食物成分。这种化合物含有丰富的营养物质、矿物质、含硫化合物、精油、酚类物质和游离氨基酸。血糖水平异常高是糖尿病的一种症状,糖尿病患者的身体很难适当地调节葡萄糖代谢。血浆中葡萄糖水平升高被认为是糖尿病。已经提出两种主要机制负责该疾病的发病机制。与糖尿病相关的持续高血糖的主要原因之一是免疫系统对胰腺β细胞的破坏,导致胰岛素合成不足。此外,机体细胞对胰岛素作用的内源性抵抗也是一个促成因素。患有1型糖尿病的儿童经常出现不同程度的多尿、体重减轻和烦渴等症状。利用PubMed、Web of Science、Scopus等知名数据库和其他公认的科学来源,对大蒜素对糖尿病(DM)的潜在益处进行了全面的文献检索。此外,我们还对ClinicalTrials.gov网站上有关大蒜素临床应用的信息进行了审查和汇编,以提供对正在进行和已完成的临床研究的见解。大蒜素是一种对胰腺细胞、伤口愈合、促进胰岛素分泌、糖尿病大血管病变、维持葡萄糖稳态和糖尿病肾病有潜在影响的化合物。此外,用不同浓度的大蒜素对细胞系进行的研究表明,大蒜素对糖尿病有显著的抑制作用。大蒜素对糖尿病的治疗策略、疗效和抑制作用使其成为一个有吸引力的候选者,并有可能在糖尿病的治疗中应用。