Current aging science最新文献

{"title":"Establishing Cut-off Points for the Cornell Scale to Enhance Depression Diagnosis in Parkinson's Disease Patients: A Study in the Vietnamese Healthcare Context.","authors":"Thanh-Nghiep Pham-Tran, Manh Xuan Bui, Nghia Trung Tran, Vu Hoang Anh Nguyen","doi":"10.2174/0118746098370198250322165956","DOIUrl":"https://doi.org/10.2174/0118746098370198250322165956","url":null,"abstract":"<p><strong>Background: </strong>Major Depressive Disorder (MDD) often coexists with Parkinson's Disease (PD), significantly affecting the quality of life. Depression in Parkinson's disease patients is frequently neglected due to an emphasis on motor symptoms, resulting in underdiagnosis. The Cornell Scale for Depression in Dementia (CS) demonstrates potential as a screening instrument for identifying depression in Parkinson's disease patients, while research on its use in Vietnam is scarce.</p><p><strong>Aims: </strong>This study aims to calculate the Area Under the Receiver Operating Characteristic (AUROC) curve and identify optimal cut-off points for the CS in diagnosing depression in patients with Parkinson's disease.</p><p><strong>Methods: </strong>In this cross-sectional study conducted at Nguyen Tri Phuong Hospital from February to September 2022, 54 patients with Parkinson's disease were examined for major depressive disorder according to DSM-5 criteria and evaluated using the CS. Reliability was assessed by inter-rater reliability testing. The diagnostic performance was assessed by calculating sensitivity, specificity, positive and negative predictive values, and the Area Under the Receiver Operating Characteristic (AUROC) curve.</p><p><strong>Results: </strong>The CS exhibited significant reliability (Cronbach's alpha = 0.91; ICC = 0.91) and diagnostic precision (AUROC = 0.968). An ideal cut-off score of 9 was determined, exhibiting a sensitivity of 88.5% and a specificity of 89.3%. The results indicated cut-off scores of 6 and 11 for excluding or diagnosing depression, respectively, affirming the CS as a versatile and efficient screening instrument for patients with Parkinson's disease.</p><p><strong>Conclusion: </strong>The CS is a dependable and valid screening tool for identifying depression in Vietnamese PD patients, enabling early detection and intervention.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontotemporal Dementia, Current Diagnosis and Treatment Emphasis on Natural Products: A Review.","authors":"Zulfa Nooreen, Fariha Sumayya, Pranay Wal, Awani Kumar Rai, Sudeep Tandon","doi":"10.2174/0118746098343389250131050235","DOIUrl":"https://doi.org/10.2174/0118746098343389250131050235","url":null,"abstract":"<p><strong>Background: </strong>Frontotemporal dementia (FTD) refers to a spectrum of brain illnesses that mostly affects the frontal and temporal lobes. These regions are commonly related to personality, behaviour, and communication. It is brought on by aberrant protein aggregates, genetics and mutation. FTD most frequently affect people between the ages of 45 and 65 but can also affect young and elderly people. It is estimated that 1.0 to 15.4 per 100,000 members of the population can be affected by FTD in the near future. About 20,000 to 30,000 cases of FTD were reported in the USA alone in 2016. Presently, no specific pharmaceutical treatments for FTD have been authorized by the US Food and Drug Administration. Nowadays, various biomarkers are available for the correct diagnosis of the disease.</p><p><strong>Method: </strong>The present review demonstrates the risk factors, pathogenesis, pathophysiology, diagnostic criteria and treatment of FTD using a number of synthetic and natural drugs to treat the disease and focuses on natural products used to manage the disease. The literature search was done by online databases of SciFinder, Medline, Pubmed, GoogleScholar and Scopus.</p><p><strong>Conclusion: </strong>Various pharmacological and non-pharmacological interventions have been recorded to treat the disease. Primary treatment is a temporary reduction in the symptoms and progression of the disease. Anticholinesterase, anti-inflammatory, antioxidant compounds are gaining interest in the management of FTD. Herbal remedies and Phytoconstituents, either alone or in combination, could serve as excellent therapies for dementia with fewer adverse effects.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-silico Comparative Analysis of TOP3B Protein Mammals Species with Emphasis on Heterocephalus glaber and Homo sapiens.","authors":"Yuhan Ye, Muhammed Asim Ali, Yifei Zhu, Athar Hussain","doi":"10.2174/0118746098338510250222054836","DOIUrl":"https://doi.org/10.2174/0118746098338510250222054836","url":null,"abstract":"<p><strong>Introduction/background: </strong>TOP3B (Topoisomerase III-Beta) is a DNA topoisomerase enzyme essential for managing DNA topology during various cellular processes. TOP3B knockout mice typically develop but have a shorter lifespan; however, the exact role of TOP3B is not fully understood. This study aims to investigate the diversity of TOP3B across various mammalian species, with a particular focus on comparing the naked mole-rat (Heterocephalus glaber), known for its exceptional longevity and genomic stability, and humans (Homo sapiens).</p><p><strong>Materials and methods: </strong>The study analyzed 30 putative TOP3B genes across 23 mammalian species, including Heterocephalus glaber (Hgl), Octodon degus (Ode), Pongo abelii (Pab), Trachypithecus francoisi (Tfr), Cavia porcellus (Cpo), Aotus nancymaae (Ana) and Homo sapiens (Hsa). Further deep in-silico analysis was done by covering structural and functional delivery analysis.</p><p><strong>Results: </strong>Database searches revealed the presence of two transcript isoforms, X1 and X3, in the naked mole-rat (NMR) and three isoforms in humans (Hsa), while most other species exhibited one to two isoforms. Analyses of conserved domain architecture and de novo motifs indicated noticeable differences in the domain and motif patterns between the NMR and human isoforms. Additionally, multiple sequence alignment identified several mutations at critical sites in the NMR's TOP3B protein, including A46D and G47S, and five other unnamed mutations that may contribute to genomic stability. Evolutionary analyses showed that the TOP3B sequences of the NMR are closely related to those of Cavia porcellus (guinea pig) and Octodon degus (Degus). Furthermore, protein-protein interaction network analyses, along with pathway and molecular docking studies, revealed significant diversity in the interaction patterns of TOP3B between the NMR and humans.</p><p><strong>Discussion: </strong>The structural diversity and conserved-site mutations in Hgl's TOP3B protein suggest a potential role in promoting genomic stability and extending lifespan. These unique structural features may contribute to the Heterocephalus glaber's exceptional resistance to genomic instability and aging, offering insights into potential longevity mechanisms.</p><p><strong>Conclusion: </strong>These findings suggest that structure variations and mutations in NMR's TOP3B protein are associated with enhanced genomic stability, which may underlie its remarkable lifespan. This study provides preliminary insights into the potential function of TOP3B in genomic maintenance across species, particularly in aging and longevity.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytoextracts as Natural Anti-Aging Agents: Mechanisms and Strategies for Skin Rejuvenation.","authors":"Vishakha Devi, Geeta Deswal, Ajmer Singh Grewal, Anjali Sharma, Kumar Guarve","doi":"10.2174/0118746098363055250218040726","DOIUrl":"https://doi.org/10.2174/0118746098363055250218040726","url":null,"abstract":"<p><strong>Introduction: </strong>Skin aging is a complex biological process driven by intrinsic factors, such as genetics and cellular metabolism, and extrinsic factors, including environmental stressors like UV radiation, pollution, and lifestyle choices. These factors result in visible signs of aging, such as wrinkles, reduced skin elasticity, and pigmentation.</p><p><strong>Objective: </strong>This review presents the recent findings on phytoextracts as natural anti-aging agents, highlighting their bioactive compounds, mechanisms of action, and applications in skin rejuvenation.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in databases including Scopus, PubMed, and Web of Science, focusing on articles published from 2000 to 2023. Search terms such as \"phytoextracts and skin aging,\" \"natural antioxidants and collagen synthesis,\" and \"bioactive compounds and skin rejuvenation\" were used. Inclusion criteria involved peer-reviewed studies on phytoextracts with experimental evidence of anti-aging effects, focusing on human and in-vitro models. Exclusion criteria included non-English articles, review papers without experimental data, and studies unrelated to skin aging. Recent research articles focusing on skin aging mechanisms and the efficacy of phytoextracts were identified. Particular attention was given to the antioxidant, anti-inflammatory, and collagen-boosting properties of phytoextracts.</p><p><strong>Results: </strong>This study provides novel insights into the mechanisms through which phytoextracts counteract oxidative stress, inflammation, and extracellular matrix degradation. Notable examples include the role of resveratrol in activating longevity genes, curcumin in reducing UVinduced damage, and ginseng in improving skin elasticity. These compounds were found to exhibit potent anti-aging mechanisms through their antioxidant activity and collagen-boosting effects. Advanced delivery technologies, such as nanocarriers, enhance the efficacy of these bioactives.</p><p><strong>Conclusion: </strong>Phytoextracts demonstrate significant potential in combating skin aging by reducing oxidative stress and inflammation, and enhancing collagen production. While the results are promising, further clinical studies are required to validate their long-term efficacy and safety in skin aging management.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Different Body Mass Index Does Not Impact Physical Health in Older Adults without Sedentary Behavior: A Cross-Sectional Study.","authors":"Patchareeya Amput, Sirima Wongphon","doi":"10.2174/0118746098294790240510063241","DOIUrl":"10.2174/0118746098294790240510063241","url":null,"abstract":"<p><strong>Aims and objective: </strong>This study aimed to compare and determine the correlation of BMI on physical health, including muscle strength, balance, and cardiorespiratory fitness in older adults without sedentary behavior.</p><p><strong>Methods: </strong>A total of 65 older adults without sedentary behavior were recruited and divided into 3 groups on the basis of body mass index (BMI): normal weight (n= 22/group), overweight (<i>n</i>= 22/- group), and obese (<i>n</i>= 21/group). All the older adults were evaluated for upper limb muscle strength using the handgrip strength test, lower limb muscle strength using the sit-to-stand (STS10) test, balance ability using the time up and go (TUG) test, and cardiorespiratory fitness using the 6-minute walk test (6MWT).</p><p><strong>Results: </strong>The handgrip strength test, STS10 test, and distance of 6MWT showed no difference among the groups (p> 0.05). However, overweight group had a significantly longer duration for the TUG test when compared to normal weight, while obese group had a significantly longer duration for the TUG test when compared with overweight and normal weight groups (p< 0.01). In addition, BMI was positively correlated with the duration of the TUG test. Whereas, the handgrip strength test, STS10 test, and distance of 6MWT were not correlated with BMI.</p><p><strong>Conclusion: </strong>The BMI does not impact upper and lower limb muscle strength or the cardiorespiratory fitness test, except for the ability to balance in older adults without sedentary behavior.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"39-46"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gait Characteristics over the Six-minute Walk Test in Older Women of a Specific Portuguese Community: A Cross-Sectional Study.","authors":"Jullyanne Silva, Tiago Atalaia, Rodrigo Martins, Joao Abrantes, Pedro Aleixo","doi":"10.2174/0118746098315374240508094923","DOIUrl":"10.2174/0118746098315374240508094923","url":null,"abstract":"<p><strong>Introduction and objective: </strong>There is limited research on the changes that can occur in the gait biomechanical parameters of older adults over long-distance walking. Thus, this study aimed to evaluate the gait characteristics of older women of a specific Portuguese community over the six-minute walk test (6MWT) along with gait spatial and temporal parameters and angular kinematics of the lower limb joints.</p><p><strong>Materials and methods: </strong>Twenty-six older women voluntarily participated. Each woman performed the 6MWT, and during this, their spatial and temporal parameters were collected through plantar pressure data (100Hz) and angular kinematics through an inertial sensor system (100Hz). The 6MWT was divided into four intervals, and the Friedman test was used to compare them. The median age of the women was calculated, and the Mann-Whitney test was used to compare women above and below the median age value.</p><p><strong>Results: </strong>An increase in gait speed, stance phase, and double stance phase along the intervals was observed, as well as larger angular displacements of the hip, knee, and ankle (p<0.05). Women below or above the median age value also yielded these behaviours. Gait speed, cadence, stride length, and step length were higher in women below the median age value, while stride and step duration were lower (p<0.05).</p><p><strong>Conclusion: </strong>Older women yielded changes in gait spatial and temporal parameters along the 6MWT, as well as larger angular displacements of the lower limb joints. Older women (compared to younger ones) yielded lower gait speed, cadence, stride length, and step length, higher stance and double stance phases, and shorter angular displacements of the lower limb joints.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"59-72"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart Seizure Detection System: Machine Learning Based Model in Healthcare IoT.","authors":"Naresh Rana, Tanishk Thakur, Shruti Jain","doi":"10.2174/0118746098298618240429102237","DOIUrl":"10.2174/0118746098298618240429102237","url":null,"abstract":"<p><strong>Background: </strong>Epilepsy, the tendency to have recurrent seizures, can have various causes, including brain tumors, genetics, stroke, brain injury, infections, and developmental disorders. Epileptic seizures are usually transient events. They normally leave no trace after the postictal recovery period has passed.</p><p><strong>Aims: </strong>An electroencephalogram (EEG) can only detect brain activity during the recording. It will be detected if an epileptogenic focus or generalized abnormality is active during the recording.</p><p><strong>Objective: </strong>This work demonstrated a smart seizure detection system for Healthcare IoT, which is a challenging problem of EEG data analysis.</p><p><strong>Method: </strong>The study suggested an integrated methodology in recognition of the drawbacks of manual identification and the significant negative effects of uncontrollable seizures on patients' lives.</p><p><strong>Result: </strong>The research shows remarkable accuracy, up to 100% in some experiments, by combining classifier ensembles like Decision Trees, Logistic Regression, and Support Vector Machine with different signal processing techniques like Discrete Wavelet Transform, Hjorth Parameters, and statistical features. The results were compared using the kNN classifier, other datasets and other state-of-the-art techniques.</p><p><strong>Conclusion: </strong>Healthcare IoT is further utilized by the methodology, which takes a comprehensive approach using classifier ensembles and signal processing approaches resulting in real-time data to help them make better decisions. This demonstrates how well the suggested method works for smart seizure detection, which is a crucial development for better patient outcomes.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"29-38"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Mutation in the CACNA1F Gene Found by Whole Exome Sequencing (WES) and <i>In Silico</i> Analysis in an Iranian Family with Consanguineous Relationships.","authors":"Vahid Omarmeli, Marjan Assefi, Kai-Uwe Lewandrowski, Alireza Sharafshah, Hanieh Faizmahdavi, Parichehr Darabi, Amir Amiri, Nasrin Mansouri","doi":"10.2174/0118746098307079240507063045","DOIUrl":"10.2174/0118746098307079240507063045","url":null,"abstract":"<p><strong>Background: </strong>X-linked mutations are highly important in clinical diagnosis, and at least 533 disorders are related to the genes located on the X chromosome.</p><p><strong>Case presentation: </strong>A 21-year-old Caucasian woman with a 24-year-old Caucasian man as her fiancé referred Clinical genetic lab for premarital genetic counseling (carrier screening). None of them had any abnormal manifestations. Following genetic counseling, Whole Exome Sequencing (WES) test performed to find the possible pathogenic mutations. Also, after drawing the couple's pedigree, candidate mutations were examined in the woman's parents as well as her uncles. Additionally, <i>in silico</i> investigations were performed through SWISS-MODEL, MolProbity, ProSA, Py- Mol, and FATCAT tools. The most important mutation diagnosed in the woman (R1362Q in the 35th exon of CACNA1F), was observed in her mother and her two uncles. The mutation was also screened in both her father and her fiancé, but they had no mutations. After medical examinations of carriers, there was no sign of any eye impairment. Other mutations were TCTN2 (c.1613-2A>G), TARS (p.K319E), SPEG (p.E3020K), CPS1 (p.A1180V), MYO3A (p.I736M), NNT (p.R968Q), MED23 (p.K406T). Bioinformatics analyses indicated no alteration in the mutant structure of CACNA1F (Q1362) compared with the normal structure (R1362).</p><p><strong>Conclusion: </strong>Conclusively, the current study emphasizes the non-pathogenic effect of missense mutation R1362Q in the 35th exon of CACNA1F in association with ocular diseases. This will ensure the reports of this mutation as healthy instead of uncertain in the literature and databanks.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"80-85"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Connecting the Dots: Gender, Sexuality, and Societal Influences on Cognitive Aging and Alzheimer's Disease.","authors":"Swati Verma, Sarvesh Paliwal, Debashish Paramanick, Chaitanay Vinayak Narayan, Manasvi Saini","doi":"10.2174/0118746098299754240530111755","DOIUrl":"10.2174/0118746098299754240530111755","url":null,"abstract":"<p><p>Alzheimer's disease (AD) has many etiologies and the impact of gender on AD changes throughout time. As a consequence of advancements in precision medical procedures and methodology, Alzheimer's disease is now better understood and treated. Several risk factors may be addressed to lower one's chances of developing Alzheimer's disease or associated dementia (ADRD). The presence of amyloid-α protein senile plaques, intracellular tau protein neurofibrillary tangles (NfTs), neurodegeneration, and neuropsychiatric symptoms (NPS) characterizes Alzheimer's disease. NPS is common in persons with Alzheimer's disease dementia, although its presentation varies widely. Gender differences might explain this clinical variability. The fundamental goal of this review is to 1) emphasize the function of old age, sex, and gender in the development of Alzheimer's disease, dementia, and ADRD, and 2) explain the importance of sexual hormones, education, and APOE (Apolipoprotein E) status. This is a narrative summary of new ideas and concepts on the differences in the chance of developing dementia or Alzheimer's disease between men and women. A more thorough examination of risk and protective variables in both men and women might hasten research into the epidemiology of neurological illnesses such as dementia and Alzheimer's disease. Similarly, future preventive efforts should target men and women separately.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"14-28"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141426577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clinical Assessment of Eccentric and Concentric Stepping Kinetics has Utility in Older African American Men with Knee Arthritis.","authors":"Tomas I Gonzales, Bryant A Seamon, Katie L Boncella, Haniel J Hernandez, Valerie McIntosh, Marc R Blackman, Michael O Harris-Love","doi":"10.2174/0118746098312415241112103614","DOIUrl":"https://doi.org/10.2174/0118746098312415241112103614","url":null,"abstract":"<p><strong>Introduction: </strong>Stair navigation is physically demanding for individuals with knee osteoarthritis and may result in movement asymmetries that can be quantified using kinetic analysis and force-time parameters. Thus, the purpose of this cross-sectional study was to determine if kinetic force-time parameter asymmetries are present in individuals with knee osteoarthritis and associated with functional outcomes.</p><p><strong>Methods: </strong>Forty-six older male veterans (61.6±5.6 years) participated. More and less involved legs were defined using the Kellgren and Lawrence (KL) scale and self-reported pain. Kinetics were measured with the Neurocom® Step Up and Over test and quantified with the lift-up index, impact index, movement time, and stair-stepping smoothness. Smoothness was calculated from the level of intermittency in acceleration and deceleration during the concentric and eccentric test movements.</p><p><strong>Results: </strong>Smoothness was the only force-time parameter to demonstrate an asymmetry. Greater smoothness values were observed for the less-involved leg (p<0.001, 95% CI: 1.22 to 3.64, d=1.17) and were positively associated with gait speed (more-involved: r=0.47, p<0.01; lessinvolved: r=0.53, p<0.01), Knee Injury and Osteoarthritis Outcome Score (KOOS) Symptom (more-involved: r=0.31, p<0.05; less-involved: r=0.39, p<0.01) and ADL (more-involved: r=0.32, p<0.05; less-involved: r=0.39, p<0.05) subscales, and isokinetic knee extension strength (more-involved: r=0.31, p<0.05; less-involved: r=0.42, p<0.01).</p><p><strong>Conclusion: </strong>Stair-stepping smoothness was diminished in the more involved leg and was associated with worse gait speed, patient-reported outcomes, and knee strength. This observation may reflect compromised motor control associated with decreased strength and greater disease severity in the more-involved leg.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}