Current aging science最新文献

{"title":"When Cysts Mislead: A Case Report of Ovarian Cyst Resembling Giant Ureterocele after Hysterectomy.","authors":"Naina Kumar, Immanuel Pradeep, Annapurna Srirambhatla, Mishu Mangla","doi":"10.2174/0118746098365660250423075122","DOIUrl":"https://doi.org/10.2174/0118746098365660250423075122","url":null,"abstract":"<p><strong>Background: </strong>Women undergoing hysterectomy without oophorectomy face a risk of needing re-surgery for new adnexal conditions. Additionally, large ovarian cysts in posthysterectomy patients can complicate diagnoses, often mimicking conditions, like mesenteric cysts, massive ascites, or giant hydronephrosis.</p><p><strong>Case presentation: </strong>A 54-year-old para four and live four (P4L4) post-hysterectomy woman presented to the gynecological outpatient department with complaints of lower abdominal and back pain lasting seven days, along with difficulty urinating and burning during micturition. Her initial outside imaging, including a CECT and CT-urogram, suggested a grade three or four ureterocele, with potential differentials, such as megaureter and vesicoureteric reflux. However, upon clinical examination and further evaluation using MRI, it was found to be a large left-sided ovarian cyst of 13.8x9.5x11.3 cm causing hydroureteronephrosis (left>right). Her intraoperative findings revealed a large predominantly, tense cystic lesion of size 13x12 cm, completely occupying the lower pelvis in the midline, and it was densely adherent to the bladder and omentum anteriorly, and to the bowel posteriorly and on sides. Subsequent histopathological examination confirmed it as a mucinous cystadenoma of the ovary.</p><p><strong>Conclusion: </strong>Large ovarian masses in post-hysterectomy patients present significant diagnostic and management challenges as they can mimic a range of conditions. This underscores the need for a multidisciplinary approach to improve diagnostic accuracy and optimize patient outcomes.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subtle Intrusion: Minimal Serous Uterine Carcinoma in an Asymptomatic Postmenopausal Patient-A Case Report.","authors":"Naina Kumar, Seetu Palo, Ashutosh Rath, Mishu Mangla, Pooja Rathod","doi":"10.2174/0118746098347939250407050519","DOIUrl":"https://doi.org/10.2174/0118746098347939250407050519","url":null,"abstract":"<p><strong>Introduction: </strong>Minimal serous uterine cancers (MUSCs) represent a distinct subset of endometrial malignancies characterized by early-stage presentation and unique histopathological features. These tumors typically manifest as intraepithelial or superficial serous carcinomas confined to endometrial polyps without myometrial invasion or lymphovascular involvement. MUSCs are predominantly diagnosed in postmenopausal women and are associated with favorable prognosis.</p><p><strong>Case presentation: </strong>The present case report briefs the finding of a 60-year-old woman presenting to the gynecological outpatient department for a routine gynaecological check-up. She was a known case of type II diabetes mellitus, hypertension, and asthma. She had no history of postmenopausal bleeding or vaginal discharge. Incidentally, on per speculum examination, a polyp of 2x3 cm was seen protruding through the cervical opening (cervical os). Her transvaginal ultrasound revealed a postmenopausal uterus with a thickened endometrium of 10mm. Her histopathology report of dilatation and curettage with polypectomy revealed serous carcinoma against the background of atrophic endometrium. The patient was managed with staging laparotomy with Wertheim's hysterectomy with bilateral pelvic lymph node dissection, omentectomy, and parietal peritoneum biopsy. Her final histopathology report revealed Stage 1A1 MUSC with atrophic endometrium.</p><p><strong>Conclusion: </strong>The case report highlights the clinical significance of recognizing MUSC as an early- stage variant of endometrial cancer. Postmenopausal women, vulnerable to uterine serous carcinoma, require comprehensive sampling of all endometrial biopsies, curettings, and endometrial polyps to ensure early detection and accurate staging.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cachexia: Unraveling its Complex Pathophysiology and Novel Therapeutic Approaches.","authors":"Kiran Dudhat, Misari Vanpariya, Rahul Kumar Sah","doi":"10.2174/0118746098355767250325074021","DOIUrl":"https://doi.org/10.2174/0118746098355767250325074021","url":null,"abstract":"<p><p>Cachexia is a complex, multifactorial syndrome marked by progressive weight loss, muscle wasting, and metabolic disturbances. It presents significant challenges in clinical practice and contributes to 20% of all cancer-related deaths. While cachexia is commonly linked to cancer, it is also associated with a range of chronic conditions, including chronic heart failure, chronic kidney disease, and autoimmune disorders. Additionally, cachexia is not limited to cancer. Still, it can also occur in end-stage or chronic diseases such as AIDS, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, tuberculosis, and gastrointestinal diseases. This article aims to explore the intricate pathophysiological mechanisms underlying cachexia and discuss emerging therapeutic strategies for its management. This comprehensive review of the literature and clinical studies explores the intricate interactions between inflammation, disrupted metabolism, hormonal imbalances, and immune dysfunction in cachexia. Furthermore, this review highlights the importance of early detection and intervention in improving the devastating consequences of cachexia on patient outcomes. Finally, this review presents the latest advancements in therapeutic approaches, including pharmacological interventions, nutritional support, exercise regimens, and novel targeted therapies, while underscoring the need for multidisciplinary and personalized treatment strategies.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing Cut-off Points for the Cornell Scale to Enhance Depression Diagnosis in Parkinson's Disease Patients: A Study in the Vietnamese Healthcare Context.","authors":"Thanh-Nghiep Pham-Tran, Manh Xuan Bui, Nghia Trung Tran, Vu Hoang Anh Nguyen","doi":"10.2174/0118746098370198250322165956","DOIUrl":"https://doi.org/10.2174/0118746098370198250322165956","url":null,"abstract":"<p><strong>Background: </strong>Major Depressive Disorder (MDD) often coexists with Parkinson's Disease (PD), significantly affecting the quality of life. Depression in Parkinson's disease patients is frequently neglected due to an emphasis on motor symptoms, resulting in underdiagnosis. The Cornell Scale for Depression in Dementia (CS) demonstrates potential as a screening instrument for identifying depression in Parkinson's disease patients, while research on its use in Vietnam is scarce.</p><p><strong>Aims: </strong>This study aims to calculate the Area Under the Receiver Operating Characteristic (AUROC) curve and identify optimal cut-off points for the CS in diagnosing depression in patients with Parkinson's disease.</p><p><strong>Methods: </strong>In this cross-sectional study conducted at Nguyen Tri Phuong Hospital from February to September 2022, 54 patients with Parkinson's disease were examined for major depressive disorder according to DSM-5 criteria and evaluated using the CS. Reliability was assessed by inter-rater reliability testing. The diagnostic performance was assessed by calculating sensitivity, specificity, positive and negative predictive values, and the Area Under the Receiver Operating Characteristic (AUROC) curve.</p><p><strong>Results: </strong>The CS exhibited significant reliability (Cronbach's alpha = 0.91; ICC = 0.91) and diagnostic precision (AUROC = 0.968). An ideal cut-off score of 9 was determined, exhibiting a sensitivity of 88.5% and a specificity of 89.3%. The results indicated cut-off scores of 6 and 11 for excluding or diagnosing depression, respectively, affirming the CS as a versatile and efficient screening instrument for patients with Parkinson's disease.</p><p><strong>Conclusion: </strong>The CS is a dependable and valid screening tool for identifying depression in Vietnamese PD patients, enabling early detection and intervention.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontotemporal Dementia, Current Diagnosis and Treatment Emphasis on Natural Products: A Review.","authors":"Zulfa Nooreen, Fariha Sumayya, Pranay Wal, Awani Kumar Rai, Sudeep Tandon","doi":"10.2174/0118746098343389250131050235","DOIUrl":"https://doi.org/10.2174/0118746098343389250131050235","url":null,"abstract":"<p><strong>Background: </strong>Frontotemporal dementia (FTD) refers to a spectrum of brain illnesses that mostly affects the frontal and temporal lobes. These regions are commonly related to personality, behaviour, and communication. It is brought on by aberrant protein aggregates, genetics and mutation. FTD most frequently affect people between the ages of 45 and 65 but can also affect young and elderly people. It is estimated that 1.0 to 15.4 per 100,000 members of the population can be affected by FTD in the near future. About 20,000 to 30,000 cases of FTD were reported in the USA alone in 2016. Presently, no specific pharmaceutical treatments for FTD have been authorized by the US Food and Drug Administration. Nowadays, various biomarkers are available for the correct diagnosis of the disease.</p><p><strong>Method: </strong>The present review demonstrates the risk factors, pathogenesis, pathophysiology, diagnostic criteria and treatment of FTD using a number of synthetic and natural drugs to treat the disease and focuses on natural products used to manage the disease. The literature search was done by online databases of SciFinder, Medline, Pubmed, GoogleScholar and Scopus.</p><p><strong>Conclusion: </strong>Various pharmacological and non-pharmacological interventions have been recorded to treat the disease. Primary treatment is a temporary reduction in the symptoms and progression of the disease. Anticholinesterase, anti-inflammatory, antioxidant compounds are gaining interest in the management of FTD. Herbal remedies and Phytoconstituents, either alone or in combination, could serve as excellent therapies for dementia with fewer adverse effects.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-silico Comparative Analysis of TOP3B Protein Mammals Species with Emphasis on Heterocephalus glaber and Homo sapiens.","authors":"Yuhan Ye, Muhammed Asim Ali, Yifei Zhu, Athar Hussain","doi":"10.2174/0118746098338510250222054836","DOIUrl":"https://doi.org/10.2174/0118746098338510250222054836","url":null,"abstract":"<p><strong>Introduction/background: </strong>TOP3B (Topoisomerase III-Beta) is a DNA topoisomerase enzyme essential for managing DNA topology during various cellular processes. TOP3B knockout mice typically develop but have a shorter lifespan; however, the exact role of TOP3B is not fully understood. This study aims to investigate the diversity of TOP3B across various mammalian species, with a particular focus on comparing the naked mole-rat (Heterocephalus glaber), known for its exceptional longevity and genomic stability, and humans (Homo sapiens).</p><p><strong>Materials and methods: </strong>The study analyzed 30 putative TOP3B genes across 23 mammalian species, including Heterocephalus glaber (Hgl), Octodon degus (Ode), Pongo abelii (Pab), Trachypithecus francoisi (Tfr), Cavia porcellus (Cpo), Aotus nancymaae (Ana) and Homo sapiens (Hsa). Further deep in-silico analysis was done by covering structural and functional delivery analysis.</p><p><strong>Results: </strong>Database searches revealed the presence of two transcript isoforms, X1 and X3, in the naked mole-rat (NMR) and three isoforms in humans (Hsa), while most other species exhibited one to two isoforms. Analyses of conserved domain architecture and de novo motifs indicated noticeable differences in the domain and motif patterns between the NMR and human isoforms. Additionally, multiple sequence alignment identified several mutations at critical sites in the NMR's TOP3B protein, including A46D and G47S, and five other unnamed mutations that may contribute to genomic stability. Evolutionary analyses showed that the TOP3B sequences of the NMR are closely related to those of Cavia porcellus (guinea pig) and Octodon degus (Degus). Furthermore, protein-protein interaction network analyses, along with pathway and molecular docking studies, revealed significant diversity in the interaction patterns of TOP3B between the NMR and humans.</p><p><strong>Discussion: </strong>The structural diversity and conserved-site mutations in Hgl's TOP3B protein suggest a potential role in promoting genomic stability and extending lifespan. These unique structural features may contribute to the Heterocephalus glaber's exceptional resistance to genomic instability and aging, offering insights into potential longevity mechanisms.</p><p><strong>Conclusion: </strong>These findings suggest that structure variations and mutations in NMR's TOP3B protein are associated with enhanced genomic stability, which may underlie its remarkable lifespan. This study provides preliminary insights into the potential function of TOP3B in genomic maintenance across species, particularly in aging and longevity.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytoextracts as Natural Anti-Aging Agents: Mechanisms and Strategies for Skin Rejuvenation.","authors":"Vishakha Devi, Geeta Deswal, Ajmer Singh Grewal, Anjali Sharma, Kumar Guarve","doi":"10.2174/0118746098363055250218040726","DOIUrl":"https://doi.org/10.2174/0118746098363055250218040726","url":null,"abstract":"<p><strong>Introduction: </strong>Skin aging is a complex biological process driven by intrinsic factors, such as genetics and cellular metabolism, and extrinsic factors, including environmental stressors like UV radiation, pollution, and lifestyle choices. These factors result in visible signs of aging, such as wrinkles, reduced skin elasticity, and pigmentation.</p><p><strong>Objective: </strong>This review presents the recent findings on phytoextracts as natural anti-aging agents, highlighting their bioactive compounds, mechanisms of action, and applications in skin rejuvenation.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in databases including Scopus, PubMed, and Web of Science, focusing on articles published from 2000 to 2023. Search terms such as \"phytoextracts and skin aging,\" \"natural antioxidants and collagen synthesis,\" and \"bioactive compounds and skin rejuvenation\" were used. Inclusion criteria involved peer-reviewed studies on phytoextracts with experimental evidence of anti-aging effects, focusing on human and in-vitro models. Exclusion criteria included non-English articles, review papers without experimental data, and studies unrelated to skin aging. Recent research articles focusing on skin aging mechanisms and the efficacy of phytoextracts were identified. Particular attention was given to the antioxidant, anti-inflammatory, and collagen-boosting properties of phytoextracts.</p><p><strong>Results: </strong>This study provides novel insights into the mechanisms through which phytoextracts counteract oxidative stress, inflammation, and extracellular matrix degradation. Notable examples include the role of resveratrol in activating longevity genes, curcumin in reducing UVinduced damage, and ginseng in improving skin elasticity. These compounds were found to exhibit potent anti-aging mechanisms through their antioxidant activity and collagen-boosting effects. Advanced delivery technologies, such as nanocarriers, enhance the efficacy of these bioactives.</p><p><strong>Conclusion: </strong>Phytoextracts demonstrate significant potential in combating skin aging by reducing oxidative stress and inflammation, and enhancing collagen production. While the results are promising, further clinical studies are required to validate their long-term efficacy and safety in skin aging management.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variability in Exercise is Linked to Improved Age-related Dysfunctions, Suggesting a Potential Role for the Constrained-Disorder Principle-based Second-Generation Artificial Intelligence System.","authors":"Ehud Rinott, Tal Sigawi, Noa Hurvitz, Narmine Elkhateeb, Lilah Rinsky-Halivni, Yaron Ilan","doi":"10.2174/0118746098339043241219060015","DOIUrl":"https://doi.org/10.2174/0118746098339043241219060015","url":null,"abstract":"<p><strong>Objective: </strong>Regular physical activity (PA) promotes mental and physical health. Nevertheless, inactivity is a worldwide pandemic, and methods to augment exercise benefits are required. The constrained disorder principle (CDP) characterizes biological systems based on their inherent variability. Therefore, we aimed to investigate the association between intra-individual variability in PA and disability among non-athlete adults.</p><p><strong>Methods: </strong>In this retrospective analysis of the longitudinal SHARE survey, we included non-disabled adults aged >50 with at least six visits over 14 years. Self-reported PA frequency was documented bi- to triennially. Low PA intensity was defined as vigorous PA frequency less than once a week. Stable PA was described as an unchanged PA intensity in all consecutive middle observations. The primary outcome was defined as a physical limitation in everyday activities at the end of the survey. Secondary outcomes were cognitive functions, including short-term memory, longterm memory, and verbal fluency.</p><p><strong>Results: </strong>The study included 2,049 non-disabled adults with a mean age of 53 and 49.1% women. In the initially high PA intensity group, variability in PA was associated with increased physical disability prevalence (23.3% vs. 33.2%, stablevs.unstable PA; P<0.01; adjusted P<0.01). In the initially low PA intensity group, variability was associated with a reduced physical disability (45.6% vs. 33.3%, stablevs.unstable PA; P=0.02; adjusted P=0.03). There were no statistically significant differences in cognitive parameters between the groups. Among individuals with the same low PA intensity at the beginning and end of follow-up, variability was associated with reduced physical disability (56.9% vs. 36.5%, stablevs.unstable PA; P=0.02; adjusted P=0.04) and improved short- -term memory (score change: -0.28 vs. +0.29, stablevs.unstable PA; P=0.05).</p><p><strong>Conclusion: </strong>Incorporating variability into PA regimens of inactive adults may enhance their physical and cognitive benefits.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Different Body Mass Index Does Not Impact Physical Health in Older Adults without Sedentary Behavior: A Cross-Sectional Study.","authors":"Patchareeya Amput, Sirima Wongphon","doi":"10.2174/0118746098294790240510063241","DOIUrl":"10.2174/0118746098294790240510063241","url":null,"abstract":"<p><strong>Aims and objective: </strong>This study aimed to compare and determine the correlation of BMI on physical health, including muscle strength, balance, and cardiorespiratory fitness in older adults without sedentary behavior.</p><p><strong>Methods: </strong>A total of 65 older adults without sedentary behavior were recruited and divided into 3 groups on the basis of body mass index (BMI): normal weight (n= 22/group), overweight (<i>n</i>= 22/- group), and obese (<i>n</i>= 21/group). All the older adults were evaluated for upper limb muscle strength using the handgrip strength test, lower limb muscle strength using the sit-to-stand (STS10) test, balance ability using the time up and go (TUG) test, and cardiorespiratory fitness using the 6-minute walk test (6MWT).</p><p><strong>Results: </strong>The handgrip strength test, STS10 test, and distance of 6MWT showed no difference among the groups (p> 0.05). However, overweight group had a significantly longer duration for the TUG test when compared to normal weight, while obese group had a significantly longer duration for the TUG test when compared with overweight and normal weight groups (p< 0.01). In addition, BMI was positively correlated with the duration of the TUG test. Whereas, the handgrip strength test, STS10 test, and distance of 6MWT were not correlated with BMI.</p><p><strong>Conclusion: </strong>The BMI does not impact upper and lower limb muscle strength or the cardiorespiratory fitness test, except for the ability to balance in older adults without sedentary behavior.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"39-46"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gait Characteristics over the Six-minute Walk Test in Older Women of a Specific Portuguese Community: A Cross-Sectional Study.","authors":"Jullyanne Silva, Tiago Atalaia, Rodrigo Martins, Joao Abrantes, Pedro Aleixo","doi":"10.2174/0118746098315374240508094923","DOIUrl":"10.2174/0118746098315374240508094923","url":null,"abstract":"<p><strong>Introduction and objective: </strong>There is limited research on the changes that can occur in the gait biomechanical parameters of older adults over long-distance walking. Thus, this study aimed to evaluate the gait characteristics of older women of a specific Portuguese community over the six-minute walk test (6MWT) along with gait spatial and temporal parameters and angular kinematics of the lower limb joints.</p><p><strong>Materials and methods: </strong>Twenty-six older women voluntarily participated. Each woman performed the 6MWT, and during this, their spatial and temporal parameters were collected through plantar pressure data (100Hz) and angular kinematics through an inertial sensor system (100Hz). The 6MWT was divided into four intervals, and the Friedman test was used to compare them. The median age of the women was calculated, and the Mann-Whitney test was used to compare women above and below the median age value.</p><p><strong>Results: </strong>An increase in gait speed, stance phase, and double stance phase along the intervals was observed, as well as larger angular displacements of the hip, knee, and ankle (p<0.05). Women below or above the median age value also yielded these behaviours. Gait speed, cadence, stride length, and step length were higher in women below the median age value, while stride and step duration were lower (p<0.05).</p><p><strong>Conclusion: </strong>Older women yielded changes in gait spatial and temporal parameters along the 6MWT, as well as larger angular displacements of the lower limb joints. Older women (compared to younger ones) yielded lower gait speed, cadence, stride length, and step length, higher stance and double stance phases, and shorter angular displacements of the lower limb joints.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"59-72"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}