Current medicinal chemistry最新文献

{"title":"Recent Progress in Curcumin: Extraction, Purification, and Bioactivity.","authors":"Hong-Mei Cao, Pei-Hong Zhao, Yi-Tao Zhao, Jiao-Jiao Fang, Ya-Nan Wang, Xin Chen","doi":"10.2174/0109298673353286241219061902","DOIUrl":"https://doi.org/10.2174/0109298673353286241219061902","url":null,"abstract":"<p><p>Curcumin is a natural plant pigment that has been widely used in food production, drug development, and textile engineering. Gaining a deep understanding of the biological activities of curcumin and obtaining high-purity curcumin are of vital importance for basic research and applications of curcumin. In this review, we summarize recent advances in curcumin, mainly focusing on the methods of extracting and purifying curcumin from turmeric as well as applications based on biological activity. We systematically describe the advantages and disadvantages of traditional and modern extraction technologies. The usual purification methods include conventional methods (such as macroporous resin column chromatography and silica gel column chromatography, etc.) and auxiliary modern technologies (such as high-speed countercurrent chromatography and supercritical fluid chromatography). In terms of biological activity, the phenolic hydroxy group and methoxy group of curcumin are closely related to its antioxidant activity, endowing it with strong antibacterial, anti-inflammatory, and antitumor properties. Moreover, the development direction based on its multiple biological activities is also discussed.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress of Microneedles in Vaccine Delivery.","authors":"Xinyu Qiao, Derun Liu, Wentao Pan, Meilin He, Fanda Meng","doi":"10.2174/0109298673336874241129081141","DOIUrl":"https://doi.org/10.2174/0109298673336874241129081141","url":null,"abstract":"<p><p>Large-scale infectious diseases have become a significant threat to human health and safety. The successful invention of vaccines is the most powerful means for preventing infectious diseases and has greatly improved global human health. Even during the pandemic of COVID-19, which has affected the world, vaccines have played an irreplaceable role. Microneedles (MNs) punctured the stratum corneum and formed microchannels in the skin allowing the vaccine to be efficiently recognized by the abundant antigen-presenting cells (APCs) in the skin to form specific immunity. Compared with traditional vaccination methods, MN transdermal immunization has the advantages of painlessness, easy storage, and efficient immune response. In this review, we summarize the types of vaccines, types of MNs, research progress and clinical research status of MN-based vaccines. We also cover various technologies for vaccine encapsulation, stable delivery of MN vaccines, and a wide range of potential clinical applications. We also outline the future development prospects of the MN system onboard to achieve better clinical benefits.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Therapeutic Potential of Plumbagin: Its Current Applications in Cancer and Neuropsychiatric Disorders.","authors":"Tingting Jiang, Dongsheng Zhou, Jiahui Wang, Haitao Huang, Chong Zhang, Jianguo Yan, Yali Zhou","doi":"10.2174/0109298673345583241226093530","DOIUrl":"https://doi.org/10.2174/0109298673345583241226093530","url":null,"abstract":"<p><p>Plumbagin (PL) is an important natural active ingredient in traditional Chinese medicine derived from the Plumbago zeylanica L. It possesses a variety of biological activities, such as anti-inflammatory, anticancer, antioxidant, antimicrobial, and neuroprotective properties, and has great potential for utilization in disease treatment and prevention. Cancer and neurological and psychiatric diseases are two major categories of diseases that currently threaten the physical and mental health of human beings, and their increasing incidence is causing a serious economic burden to all humanity. Based on the physical and chemical properties and pharmacokinetics of plumbagin, this study will focus on summarizing the application research status of plumbagin in cancer, neurological, and psychiatric diseases and analyze the molecular targets and action pathways of its therapeutic efficacy. This study will also briefly summarize the application of plumbagin in other diseases, as well as the existing problems and future development direction of plumbagin in clinical application, aiming to provide new perspectives and strategies for the development of new drugs and the treatment of existing diseases.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ononin's Antagonistic Activity towards TRPV1: Insights from Molecular Dynamics and Capsaicin-Evoked Calcium Response in DRG Neurons.","authors":"Fadi G Saqallah, Manal A Abbas, Belal O Al-Najjar, Aya Y Al-Kabariti, Muhammad Yusuf, Omar A Abdulwahed, Noor A Barakat, Mohammad Alsalem","doi":"10.2174/0109298673331246241023095720","DOIUrl":"https://doi.org/10.2174/0109298673331246241023095720","url":null,"abstract":"<p><strong>Background: </strong>The search for effective painkillers has led to intensive research, with a particular focus on the transient receptor potential vanilloid-1 (TRPV1) channel as a possible target.</p><p><strong>Methods: </strong>One promising candidate is ononin, which is investigated for its binding with TRPV1 through a 200-ns molecular dynamic simulation and analysed via root-meansquare deviation (RMSD), root-mean-square fluctuation (RMSF), hydrogen-bond interactions, radius of gyration (RadGyr), and MM-PBSA energy calculations. The results were further validated experimentally via calcium imaging studies.</p><p><strong>Results: </strong>Molecular dynamics revealed that the ononin-TRPV1 complex achieved stable binding within a remarkably short time of approximately 38 ns while maintaining the degree of compactness of the receptor throughout a 200 ns simulation period. In contrast, the capsazepine-TRPV1 complex displayed more significant structural deviations during the whole simulation. Moreover, MM-PBSA energy calculations showed a relatively strong binding affinity between ononin and TRPV1, mainly attributed to favourable hydrophobic interactions. Pre-incubation of dorsal root ganglia (DRG) neurons with ononin (1 and 10 μM) or capsazepine (10 μM) for 4 min prior to stimulation with capsaicin significantly reduced capsaicin-evoked calcium responses. No significant difference between capsazepine and ononin was found at a concentration of 10 μM.</p><p><strong>Conclusion: </strong>Overall, this research demonstrates the potential of ononin as a potential antagonist for developing analgesics targeting TRPV1. Hence, and to our best knowledge, this study represents the first report of ononin's antagonistic activity towards TRPV1.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thymoquinone-loaded Nanosized Ethosomal-based Hydrogels: Their Preparation, Characterization, in Vitro, Ex Vivo, and Antimicrobial Evaluation against Staphylococcus aureus.","authors":"Pratibha Pathak, Waleed H Almalki, Nabil K Alruwaili, Abdulaziz Alzahrani, Salem Salman Almujri, Abdulrahman Alhamyani, Abdulmalik Saleh Alfawaz Altamimi, Ankit Sahoo, Tanuja Singh, Md Abul Barkat, Vikas Kumar, Amita Verma, Mahfoozur Rahman","doi":"10.2174/0109298673341004250101104428","DOIUrl":"https://doi.org/10.2174/0109298673341004250101104428","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Thymoquinone (TQ) is found in the seeds of Nigella sativa. It has immunomodulatory, antibacterial, anti-inflammatory, antioxidant, astringent, antifungal, and antihistaminic properties, making it a highly valuable compound of interest. However, the use of it as a therapeutic drug is highly challenging because of its poor solubility, low bioavailability, and short-term stability.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;The present study focused on a nanosized ethosome formulation of thymoquinone with potent antimicrobial activity against Staphylococcus aureus.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study aimed to develop nanosized TQ-loaded ethosome-based hydrogels and evaluate their antimicrobial effects. The methods included UV‒VIS spectrophotometer analysis, solubility studies, preparation of TQ-loaded ethosomes, thermodynamic stability, in vitro drug release, characterization, preparation of ethosome- based hydrogels, ex vivo skin permeation, skin drug retention, and antimicrobial studies against S. aureus.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;UV‒VIS analysis revealed that thymoquinone (TQ) demonstrated a maximum absorbance peak at λmax 254 nm. TQ has the highest solubility in ethanol (60 mg/mL) and soy lecithin (65 mg/mL). TQ solubility in PBS 7.4 (75 mg/mL) with ethanol (50:50% w/v) was found to be crucial for determining in vitro and ex vivo drug release. Ethosomes were developed using soy lecithin (1.5-4.5% w/w), cholesterol (0.20-0.42% w/w), and ethanol (30-47% w/w) across ten formulations (E1-E10). These ethosomes were further evaluated for physical stability. Formulations E6-E10, with optimal concentrations of soy lecithin, cholesterol, and high ethanol, showed thermodynamic stability for up to 6 weeks. These materials were selected for further study because of their stability and in vitro drug release. E6 resulted in the greatest drug release and permeation due to the optimal lipid, cholesterol, and higher ethanol concentrations. E6, with a particle size of 114.8 nm, a PDI of 0.247, and a zeta potential of -0.497 mV, showed optimal stability and drug encapsulation, and the TEM results confirmed the presence of spherical vesicles. The addition of carbopol-940 (1% w/w) resulted in the formation of a gel, enhancing the topical application and sustained release of the drug. Compared with the TQCG hydrogel, the E6 hydrogel showed superior TQ permeation and flux over 24 hours. The first-order model fits the release kinetics, confirming the suitability of the E6 hydrogel for further study. The E6 hydrogel retained 3.6 times more drugs than TQ-CG, enhancing skin penetration and drug delivery. The TQ-loaded ethosome (E6 in D3) demonstrated the second-highest antimicrobial action, followed by the E6 hydrogel [D2], with the Clinsol gel as a control [C] showing the maximum inhibition against S. aureus. The efficacy of E6 is likely due to better diffusion. The slower diffusion of the hydrogel provides sustained action, making it effect","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oridonin Suppresses the Malignant Progression of Lung Cancer by Targeting S100A11.","authors":"Yulin Luo, Jingjing Li, Yao Chen, Yan Huang, Qi Luo, Qiang Luo, Qingqing Huang, Gang Huang, Mingming Jin","doi":"10.2174/0109298673352893241228015939","DOIUrl":"https://doi.org/10.2174/0109298673352893241228015939","url":null,"abstract":"<p><strong>Background: </strong>Lung cancer (LC) is the second most lethal cancer and efficient treatments are missing. Our understanding of the underlying pathogenic mechanisms remains limited. Oridonin is a compound extracted from the Chinese herb Rabdosia rubescens with anticancer properties. Nevertheless, its effects on LC and the underlying mechanisms remain unknown.</p><p><strong>Methods: </strong>In the current research, A549 and Hcc1833 cells were treated with different doses of oridonin, and cell proliferation and migration were detected using CCK8, EdU, Transwell, and wound healing assays. A subcutaneous tumor and caudal vein metastasis model was generated to verify the inhibitory effects of oridonin on Hcc1833 tumor growth and metastasis in vivo. Proteomics analyses then were performed to examine the regulatory mechanism. LiP-SMap combined with microscale thermophoresis and molecular docking analyses were used to validate the relationship between oridonin and S100A11.</p><p><strong>Result: </strong>Data showed that oridonin suppressed cell proliferation and migration depending on dose and suppressed tumor growth and invasion. LiP-SMap and molecular docking analyses confirmed that oridonin interacted with the Asn-53 residue of S100A11, which inhibited the activation of oridonin. S100A11 overexpression reversed the inhibitory effects of oridonin on cell proliferation and migration.</p><p><strong>Conclusion: </strong>In conclusion, the data indicate that oridonin suppresses LC malignant progression by targeting S100A11.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming Alzheimer's Treatment: Unveiling New Potential with Drug Repurposing Strategies.","authors":"Ashish Sriram Mishra, Manimaran Vasantham, Bhavna Ghosh, Sivakumar Ponnurengam Malliappan","doi":"10.2174/0109298673341391241231054936","DOIUrl":"https://doi.org/10.2174/0109298673341391241231054936","url":null,"abstract":"<p><p>Alzheimer's disease (AD) remains a significant challenge in neurology, marked by progressive cognitive decline and neurodegeneration. Despite extensive research efforts, effective treatments are still lacking. Traditional drug discovery is often slow and costly, frequently resulting in limited success. Drug repurposing, which identifies new therapeutic uses for existing medications, has emerged as a promising approach to expedite AD treatment development. This review examines the potential of drug repurposing to transform AD therapy by utilizing the established safety profiles and known mechanisms of current drugs. We explore various repurposed drugs under investigation for AD, originally intended for cardiovascular, metabolic, and psychiatric conditions. Detailed discussions include how these drugs provide neuroprotective benefits by inhibiting amyloid-beta aggregation, reducing tau phosphorylation, and modulating neuroinflammation. Additionally, we emphasize the benefits of drug repurposing, such as shortened development timelines, lower costs, and increased chances of clinical success. By integrating current research findings, this review offers a thorough overview of the most promising repurposed drug candidates and their potential impact on AD treatment strategies. It stresses the importance of innovative approaches in AD research and calls for greater investment in drug repurposing initiatives. Through these strategies, we aim to accelerate the availability of effective treatments, providing renewed hope and a brighter future for those affected by this devastating disease.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Advancements, Immunotherapy, Targeted and Conventional Therapies, Biopsy, Colposcopy, and Pap Smear Integration in the Management of Cervical Cancer.","authors":"Siddhi Wargantiwar, Sankha Bhattacharya, Abhishek Kanugo","doi":"10.2174/0109298673337745241123054840","DOIUrl":"https://doi.org/10.2174/0109298673337745241123054840","url":null,"abstract":"<p><p>Cervical cancer remains a significant global health concern, making it essential to investigate new treatment options continuously. This page provides an overview of the latest advancements and best practices in detection and intervention, including Pap smears, colposcopy, biopsy, immunotherapy, targeted therapies, chemotherapy, radiation therapy, and surgery. Surgical techniques such as radical hysterectomy and minimally invasive procedures have advanced to enhance patient outcomes and quality of life. Simultaneously, radiation therapy methods have been refined to maximize tumour control while reducing adverse effects. Chemotherapy remains vital, with new drugs and combination regimens demonstrating improved tolerance and efficacy. Immunotherapy, notably immune checkpoint inhibitors, has shown promise in advanced stages of cervical cancer. Additionally, targeted therapies that focus on specific biochemical pathways offer the potential for personalized treatment approaches. This review critically assesses ongoing research, evaluates existing data, and emphasizes the opportunities and challenges of each therapeutic approach. Ultimately, integrating these diverse treatment strategies is the key to enhancing patient outcomes.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Prospects for Necroptosis in Inflammatory Diseases: A Bibliometric Analysis.","authors":"Ya Ting Tan, Mei Juan Wang, Shu Chao Wang","doi":"10.2174/0109298673336964250103060730","DOIUrl":"https://doi.org/10.2174/0109298673336964250103060730","url":null,"abstract":"<p><strong>Background: </strong>Necroptosis is a modifiable form of cell death mainly dependent on RIPK3 and MLKL. The association between necroptosis and inflammation has been a key focus of research. An increasing number of studies have shown that necroptosis plays an important role in inflammatory diseases, such as inflammatory bowel disease.</p><p><strong>Methods: </strong>Articles published up to 2023 were searched on the Web of Science. VOSviewer, CiteSpace, Gephi, and Microsoft Office Excel were used for bibliometric analysis and visualisation. In addition, journal impact factors and journal partitions were obtained through the Web of Science.</p><p><strong>Results: </strong>A total of 3011 articles were included in this study. The number of publications and citations in the field increased year by year. China had the highest number of publications. Cell Death & Disease published the most papers in the field. P. Vandenabeele is one of the most important scholars in this field. The most cited reference was \"Molecular Mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death\".We found substantial evidence that acute kidney injury, sepsis, cancer, and other diseases are closely related to necroptosis. In addition, we found that inhibitors of necroptosis have great potential in the treatment of inflammatory diseases.</p><p><strong>Conclusion: </strong>This is the first bibliometric analysis of studies related to necroptosis in inflammatory diseases. Our results provide an overview of basic and influential research, providing a basis for the identification of valuable research directions. Furthermore, this work offers general insight into the role of necroptosis in inflammatory human diseases.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SQSTM1/P62 Mediates the Effects of CPNE3 on the Epithelialmesenchymal Transition and Migratory Inhibition of Lung Adenocarcinoma Cells.","authors":"Yanping Li, You Li, Liming Xu, Guangming Yang, Huansi Zhou, Mingjing Jin, Kai Yu, Chunhua Lu","doi":"10.2174/0109298673340242250102104725","DOIUrl":"https://doi.org/10.2174/0109298673340242250102104725","url":null,"abstract":"<p><strong>Introduction: </strong>Copine-3 (CPNE3) is a conservative calcium-dependent phospholipid-binding protein belonging to the copines protein family. CPNE3 has been implicated in the development and progression of several diseases, including cancer.</p><p><strong>Method: </strong>Herein, we investigated the molecular mechanisms through which CPNE3 regulates the migration of lung adenocarcinoma (LUAD) cells in vitro. Western blotting and immunohistochemical assays showed that CPNE3 is widely distributed in LUAD tissues and cell lines and that CPNE3 downregulation promotes the migration of human LUAD A549 cells.</p><p><strong>Results: </strong>Stable isotope labelling with amino acids in cell culture, which is a quantitative proteomics approach coupled with bioinformatic analyses, revealed that CPNE3 regulates SQSTM1/p62 and vimentin expression, indicating that CPNE3 may mediate epithelial-mesenchymal transition (EMT). CPNE3 silencing by siRNA upregulated vimentin levels but downregulated E-cadherin levels in the A549 cells.</p><p><strong>Conclusion: </strong>Furthermore, SQSTM1/p62 knockdown enhanced migratory ability and EMT progression in CPNE3-silenced A549 cells. Overall, CPNE3 knockdown was found to promote EMT by inhibiting SQSTM1/p62 signalling and facilitating cell migration. Our findings highlight the role of CPNE3 as a tumour suppressor, providing deeper insights into its carcinogenic roles in LUAD.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}