Current medicinal chemistry最新文献_第10页

Lipids and Inflammation: Novel Molecular Targets and Therapeutic Implications 脂质与炎症：新的分子靶点和治疗意义

IF 4.1 4区医学

Current medicinal chemistry Pub Date : 2024-09-18 DOI: 10.2174/0109298673311105240902053715

Laura Torlai Triglia, FILIPPO LUCA GURGOGLIONE, Federico Barocelli, Michele Bianconcini, Giampaolo Niccoli

{"title":"Lipids and Inflammation: Novel Molecular Targets and Therapeutic Implications","authors":"Laura Torlai Triglia, FILIPPO LUCA GURGOGLIONE, Federico Barocelli, Michele Bianconcini, Giampaolo Niccoli","doi":"10.2174/0109298673311105240902053715","DOIUrl":"https://doi.org/10.2174/0109298673311105240902053715","url":null,"abstract":"Atherosclerotic cardiovascular disease represents the most common cause of death worldwide. Altered cholesterol metabolism and inflammation are major cardiovascular risk factors that underpin atherosclerotic plaque growth and destabilization. While initial evidence considered dyslipidemia and inflammation as independent atherogenic actors, growing evidence has revealed that several molecular mechanisms implicated in cholesterol metabolism participate in multiple inflammatory signalling pathways. In particular, proprotein convertase subtilisin/kexin type 9, adenosine monophosphate-activated protein kinase pathway, oxidized low-density lipoproteins, and lipoprotein (a) have been demonstrated to share concurrent atherogenic and inflammatory properties. Novel lipid-lowering therapies targeting these molecular pathways have been implemented. Mechanistic and clinical studies have addressed their hypolipidemic potential and explored their role in atherosclerosis-related vascular inflammation, and ongoing randomized clinical trials are investigating their prognostic role. The purpose of this review was to dive into the signalling pathways linking cholesterol metabolism and inflammation and outline the current evidence on the anti-inflammatory activities of the novel lipid-lowering drugs.","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":"1 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research, Development and Pharmacological Activity of Sinomenine and Its Derivatives. 西诺明及其衍生物的研究、开发和药理活性。

IF 3.5 4区医学

Current medicinal chemistry Pub Date : 2024-09-18 DOI: 10.2174/0109298673323738240830055548

Tieqiang Zong, Jinfeng Sun, Zhengyu Hu, Long Jin, Lantian Cui, Yongkang Xue, Wei Zhou, Gao Li

{"title":"Research, Development and Pharmacological Activity of Sinomenine and Its Derivatives.","authors":"Tieqiang Zong, Jinfeng Sun, Zhengyu Hu, Long Jin, Lantian Cui, Yongkang Xue, Wei Zhou, Gao Li","doi":"10.2174/0109298673323738240830055548","DOIUrl":"https://doi.org/10.2174/0109298673323738240830055548","url":null,"abstract":"In this manuscript, the resource distribution, pharmacological activity, pharma-cokinetics of sinomenine and the structure, synthesis, biological activity and mechanism of sinomenine derivatives reported from 2000 to December 2023 were reviewed. The lit-erature was retrieved through Web of Science, PubMed, Science Direct, SciFiner Scholar and other websites. Sinomenine belongs to isoquinoline alkaloids and was extracted from the Chinese herb Sinomenium acutum root. In Asian countries such as China and Japan, it is commonly prescribed as a treatment for rheumatoid arthritis. In addition, sinomenine also has sedative, analgesic, anti-inflammatory, immunosuppressive, neuroprotective, an-ti-drug dependence, anti-tumor and other biological activities. Sinomenine limited its ap-plication prospects because of its large dosage, poor epidermal permeability and short half-life. To overcome these defects, new sinomenine derivatives have been synthesized. Based on the comprehensive analysis of relevant literature at home and abroad, this paper reviews the recent progress in the study of sinomenine's pharmacological effects and structural modifications. Future research on sinomenine will focus on improving its thera-peutic effect, and developing new drug preparations and structural modifications. It is hoped that this review will help to better understand the research progress of sinomenine and provide constructive suggestions for further research of sinomenine.","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in the Linkers of Drug Conjugates 药物共轭连接体的最新进展

IF 4.1 4区医学

Current medicinal chemistry Pub Date : 2024-09-18 DOI: 10.2174/0109298673320170240829110110

Shirui Deng, Xiaoan Wen, Jinzheng Wang

引用次数: 0

Foam Cells: The Origin of Formation and Target for Plant-derived Bioactive Compounds 泡沫细胞：泡沫细胞的形成起源和植物生物活性化合物的靶标

IF 4.1 4区医学

Current medicinal chemistry Pub Date : 2024-09-18 DOI: 10.2174/0109298673316025240829105311

Siarhei A. Dabravolski, Vasily N. Sukhorukov, Victor Y. Glanz, Elizaveta M. Pleshko, Nikolay A. Orekhov, Alexander N. Orekhov

{"title":"Foam Cells: The Origin of Formation and Target for Plant-derived Bioactive Compounds","authors":"Siarhei A. Dabravolski, Vasily N. Sukhorukov, Victor Y. Glanz, Elizaveta M. Pleshko, Nikolay A. Orekhov, Alexander N. Orekhov","doi":"10.2174/0109298673316025240829105311","DOIUrl":"https://doi.org/10.2174/0109298673316025240829105311","url":null,"abstract":"Foam cells play a crucial role in the initiation and progression of atherosclerosis, a condition marked by the development and growth of plaques that narrow blood vessel lumens. This narrowing can prevent normal blood flow and, in severe cases, lead to plaque rupture and blood clot formation, which can cause stroke or myocardial infarction. The origin of foam cells is diverse, arising from monocytes, vascular smooth muscle cells, stem/progenitor cells, and dendritic and endothelial cells. In their attempt to eliminate excess lipoproteins and cholesterol, foam cells inadvertently contribute to plaque development and rupture. Cholesterol uptake, efflux, and esterification are the major processes regulating foam cell formation. Advances in technology, such as the identification of cell-surface markers for lineage tracing and single-cell RNA sequencing, have unveiled diverse molecular mechanisms involved in the formation of foam cells from different origins, offering new insights into plaque formation and potential targets for anti-foam cell therapies. In this review, we focus on recent studies exploringthe inhibitory effects of medicinal plants and their bioactive components on foam cell formation. Various mechanisms are explored, including the inhibition of cholesterol uptake and the up-regulation of cholesterol efflux, as well as the suppression of inflammatory and adhesion activities. Emphasizing a cellular target-based therapeutic approach, this review envisions the development of innovative plant-based medications for atherosclerosis treatment.","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":"209 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Circadian Rhythm-related Signature to Predict Prognosis, Immunei Infiltration, and Drug Response in Breast Cancer. 预测乳腺癌预后、免疫浸润和药物反应的昼夜节律相关特征。

IF 3.5 4区医学

Current medicinal chemistry Pub Date : 2024-09-13 DOI: 10.2174/0109298673320179240803071001

Mingyu Chu, Jing Huang, Qianyu Wang, Yaqun Fang, Dina Cui, Yucui Jin

{"title":"A Circadian Rhythm-related Signature to Predict Prognosis, Immunei Infiltration, and Drug Response in Breast Cancer.","authors":"Mingyu Chu, Jing Huang, Qianyu Wang, Yaqun Fang, Dina Cui, Yucui Jin","doi":"10.2174/0109298673320179240803071001","DOIUrl":"https://doi.org/10.2174/0109298673320179240803071001","url":null,"abstract":"Purpose: Circadian rhythm genes (CRRGs) play essential roles in cancer occurrence and development. However, the prognostic significance of CRRGs in breast cancer (BC) has not been fully elucidated. Our study aimed to develop a prognostic gene signature based on CRRGs that can accurately and stably predict the prognosis of BC.Methods: The transcriptome data and clinical information for BC patients were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. A consensus unsupervised clustering analysis was carried out to investigate the roles of CRRGs in BC. A CRRGs-related prognostic risk model was established by using logistic least absolute shrinkage and selection operator (LASSO) Cox regression and univariate Cox regression analyses. Kaplan-Meier (KM) curves analysis, time-dependent receptor operation characteristics (ROC) curves analysis, and nomogram were plotted to evaluate the predictive efficacy of the model. The relevance of risk score to the immune cell infiltration, tumor burden mutation (TMB), and therapeutic response was assessed.Results: A risk model comprising six CRRGs (SLC44A4, SLC16A6, TPRG1, FABP7, GLYATL2, and FDCSP) was constructed and validated, demonstrating a good predictor of BC. The low-risk group displayed a higher number of immune activities and immune checkpoint expression and a lower burden of tumor mutation. Additionally, drug sensitivity analysis demonstrated the prognostic signature may serve as a potential chemosensitivity predictor.Conclusion: We established 6 CRRGs-related risk signatures for the prognosis of BC, which is of great value in predicting the prognosis of patients with BC and guiding the treatment for BC.","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomedicine in Management of Cerebral Infarction and Brain Cancer: Role of Inflammation. 纳米药物治疗脑梗塞和脑癌：炎症的作用

IF 3.5 4区医学

Current medicinal chemistry Pub Date : 2024-09-13 DOI: 10.2174/0109298673306668240829144324

Vikas Kumar, Fahad Al-Abbasi, Firoz Anwar, Jonathan A Lal

{"title":"Nanomedicine in Management of Cerebral Infarction and Brain Cancer: Role of Inflammation.","authors":"Vikas Kumar, Fahad Al-Abbasi, Firoz Anwar, Jonathan A Lal","doi":"10.2174/0109298673306668240829144324","DOIUrl":"https://doi.org/10.2174/0109298673306668240829144324","url":null,"abstract":"Introduction: Cerebral infarction, the blockage of blood vessels in the brain, is generally an age-related illness. Factors such as unhealthy diets, stressful behaviours and decreased environmental consistency with physiological barriers also contribute to increased casualties. Long-term brain function reconstruction and successful drug therapy are needed. The most frequent malignant brain tumour, glioblastoma, has been linked to variations in mitochondrial ROS, chaperone-mediated autophagy, and the interaction between lncRNA (BC200) and miRNA. Glioblastoma stem cells express high levels of ATP/P2X7 receptors, promoting survival by activating M2 muscarinic receptors.Areas covered: This expert opinion provides an overview of the latest experimental drug therapies aimed at protecting against and restoring cerebral stroke.Expert opinion: Nanomedicine overcomes the challenges associated with traditional therapy and physiological obstacles in the treatment of cerebral infarction by improving stroke management, including diagnosis, imaging, and treatment, addressing a diverse range of associated factors.","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in the Treatment of Chronic Wounds. 慢性伤口的治疗趋势。

IF 3.5 4区医学

Current medicinal chemistry Pub Date : 2024-09-13 DOI: 10.2174/0109298673312649240829103906

Rohit Sharma, Jan Hruska, Lukas Peter, Kristina Randlova, Kamil Kuca

{"title":"Trends in the Treatment of Chronic Wounds.","authors":"Rohit Sharma, Jan Hruska, Lukas Peter, Kristina Randlova, Kamil Kuca","doi":"10.2174/0109298673312649240829103906","DOIUrl":"https://doi.org/10.2174/0109298673312649240829103906","url":null,"abstract":"Chronic wounds remain one of the significant burdens to health across the world, mainly in view of diabetes and its natural consequences. This category of lesions includes pressure ulcers, vascular diseases, and surgery-related wounds, which affect millions and pose a major challenge to the healthcare industry. The paper reviews the various physiological mechanisms of wound healing, factors that impede it, and some new treatments emerging at this moment. In contrast, current developments include surgical and non-surgical alternatives like topical dressings, medicated formulations, and skin substitutes. Advanced wound care today covers tissue-engineered skin substitutes, 3D-printed wound dressings, topical medicated formulations, and growth factor-based therapies. These are non-invasive, biocompatible methods that are cost-effective, userfriendly, and more conducive to natural healing than traditional therapies. Hydrogel dressings have high water content to create a moist environment that encourages healing. They also reflect excellent physicochemical and biological properties, which enhance autolytic debridement and reduction of pain due to the moisture retention, biocompatibility, and non-toxicity conferred. Tissue-engineered skin substitutes, comprising allogeneic or autologous cells, wound-healing enhancement bioengineered allogeneic cellular therapies are like the natural skin and encourage regeneration. 3D printing allows the production of customized dressings to aid in better treatment. Newer therapies, including bioengineered allogeneic cellular therapies and fish skin grafting, require more clinical trials to confirm safety and efficacy. With such innovations in wound healing technologies and therapies, the future looks quite promising in managing chronic wounds, enhancing healing, reducing healthcare expenditure, and promoting a better quality of life for patients.","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in Energy Dynamics in Arsenic Exposure Based Neurotoxicity: A Comprehensive Review. 基于砷暴露的神经毒性的能量动力学变化：全面回顾。

IF 3.5 4区医学

Current medicinal chemistry Pub Date : 2024-09-13 DOI: 10.2174/0109298673315956240829094938

Anuj Choudhary, Ruchi Pandey, Debiprasad Padhy, Dipak Rathod, Krishna Murti, Vivek Dave, Sameer Dhingra, Mahesh Rachamalla, Nitesh Kumar

{"title":"Changes in Energy Dynamics in Arsenic Exposure Based Neurotoxicity: A Comprehensive Review.","authors":"Anuj Choudhary, Ruchi Pandey, Debiprasad Padhy, Dipak Rathod, Krishna Murti, Vivek Dave, Sameer Dhingra, Mahesh Rachamalla, Nitesh Kumar","doi":"10.2174/0109298673315956240829094938","DOIUrl":"https://doi.org/10.2174/0109298673315956240829094938","url":null,"abstract":"Background: The by-product of naturally occurring rock, soil with different agricultural and industrial processes contaminated groundwater with a toxic metalloid- Arsenic (As3+), which results in different toxicities within the human body and in developing fetus.Aim: The present study emphasizes evaluating the presence of oxidative stress and excessive generation of reactive oxygen species (ROS) resulting in mitochondrial dysfunction and caspase activation followed by apoptosis due to arsenic-induced neurotoxicity along with epigenetic modifications at different molecular targets.Methods: Published articles available on PubMed and Scopus were studied and summarized.Results: The precise mechanism causing arsenic-induced neurotoxicity at a critical stage of brain development is still unknown, while increased oxidative stress led to mitochondrial dysfunctions which are known to play a prominent role in this. AMPK acts as a metabolic checkpoint and restores ATP levels through a different anabolic pathway in energy starvation. At the same time, arsenic-induced AMPK activation leads to autophagy and neuronal cell death.Conclusion: This review summarized the molecular mechanisms involved in arsenic-induced neurotoxicity, which can help develop suitable future ameliorative and therapeutic strategies.","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, Synthesis, and Docking of Novel Tropane Hybrids as Potent Hsp90 Inhibitors with Potential Anti-Breast Cancer Activity. 作为具有潜在抗乳腺癌活性的强效 Hsp90 抑制剂的新型托烷杂交化合物的设计、合成和对接。

IF 3.5 4区医学

Current medicinal chemistry Pub Date : 2024-09-13 DOI: 10.2174/0109298673313163240829094557

Eman M H Abbas, Rehab Sabour, Norah A Alsaiari, Hanadi Y Medrasi, Asmaa F Kassem, Thoraya A Farghaly

{"title":"Design, Synthesis, and Docking of Novel Tropane Hybrids as Potent Hsp90 Inhibitors with Potential Anti-Breast Cancer Activity.","authors":"Eman M H Abbas, Rehab Sabour, Norah A Alsaiari, Hanadi Y Medrasi, Asmaa F Kassem, Thoraya A Farghaly","doi":"10.2174/0109298673313163240829094557","DOIUrl":"https://doi.org/10.2174/0109298673313163240829094557","url":null,"abstract":"Background and objective: Breast cancer is the most common form of cancer in women and is the leading cause of cancer-related deaths among women globally. In this study, we aimed to synthesize a series of tropane derivatives to investigate their Hsp90 inhibitory activity as well as their cytotoxic impact on breast cancer cells (MCF- 7 and MDA-MB-231).Methods: Novel fused-tropane derivatives were created and produced as inhibitors of Hsp90, taking inspiration from XL888, a tropane medication used for treating cancer. The target compounds were screened in vitro to determine their ability to inhibit the activity of Hsp90.Results: All tropane derivatives displayed a good submicromolar inhibition of Hsp90 with IC50 values ranging from 52.64 to 76.05 nM, relative to XL888 reference medication (IC50 = 27.78 nM). Among all the compounds examined, tropane derivative 5 exhibited the highest level of Hsp90 inhibitory action, with an IC50 value of 52.64 nM. Furthermore, the cytotoxic activity of all compounds was evaluated against two breast cancer cell lines, namely MCF-7 and MDA-MB-231. Tropane derivative 5 exhibited greater potency than doxorubicin against both cell lines. In addition, it demonstrated a safety profile significantly superior to that of doxorubicin when tested on normal human cells (WI-38 cells), thereby confirming its exceptional level of safety. The western blotting analysis demonstrated a 2.4-fold reduction in Hsp90 expression in MCF-7 cells. Furthermore, the molecular docking analysis has provided additional evidence for the capacity of compound 5 to effectively bind with the target Hsp90 enzyme.Conclusion: We have succeeded in synthesizing novel tropane hybrids exhibiting significant anti-Hsp90 action, similar to XL888 analogues.","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the Mechanism Underlying Radiotherapy Resistance Caused by Oligodendroglia Cells in Glioblastoma by Applying the Single-cell RNA Sequencing Technology. 应用单细胞RNA测序技术分析胶质母细胞瘤中少突胶质细胞导致放疗耐药的机制

IF 3.5 4区医学

Current medicinal chemistry Pub Date : 2024-09-12 DOI: 10.2174/0109298673337314240911053946

Qinghua Yuan, Weida Gao, Mian Guo, Bo Liu

{"title":"Analysis of the Mechanism Underlying Radiotherapy Resistance Caused by Oligodendroglia Cells in Glioblastoma by Applying the Single-cell RNA Sequencing Technology.","authors":"Qinghua Yuan, Weida Gao, Mian Guo, Bo Liu","doi":"10.2174/0109298673337314240911053946","DOIUrl":"https://doi.org/10.2174/0109298673337314240911053946","url":null,"abstract":"Background: Glioblastoma (GBM) is an aggressive malignancy. The inherent resistance of GBM to radiotherapy poses great challenges for clinical treatment.Objectives: The primary objective of this study is to explore the molecular mechanisms of radiotherapy resistance in GBM and identify the key influencing factors that contribute to this phenomenon.Methods: The single-cell RNA sequencing (scRNA-seq) data of GBM were downloaded from the Gene Expression Omnibus (GEO) database. Cells were clustered using the Seurat R package, and the clusters were annotated using the CellMarker database. Pseudotime analysis was conducted using Monocle2. Marker scores were calculated based on the RNA-seq data of GBM from the UCSC database, and the enrichment of Hallmark gene sets was measured with the AUCell package. Furthermore, the most frequently mutated genes were identified using the simple nucleotide variation data from The Cancer Genome Atlas (TCGA) applying the maftools package.Results: This study identified two oligodendrocyte subsets (ODC3 and ODC4) as radiotherapy-resistant groups in GBM. Enrichment and Pseudotime analysis revealed that the inflammatory response and immune activation pathways were enriched in ODC3, while the cell division and interferon response pathways were enriched in ODC4. The enrichment scores of hallmark gene sets further confirmed that ODC3 and ODC4 subpopulations developed radiotherapy resistance via distinct molecular mechanisms. Analysis of gene mutation frequencies showed that TP53 exhibited the most significant change in mutation frequency, indicating that it was an important risk factor involved in radiotherapy resistance in GBM.Conclusion: We identified two ODC subpopulations that exhibited resistance to radiotherapy, providing a new perspective and potential targets for personalized treatment strategies for GBM.","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0