Current medicinal chemistry最新文献

{"title":"New Frontiers in Cancer Treatment.","authors":"Rafael Coveñas","doi":"10.2174/0109298673542331260821045101","DOIUrl":"https://doi.org/10.2174/0109298673542331260821045101","url":null,"abstract":"","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Olfactory Receptor Dysfunction Induced by Fenton and Fenton-Like Reactions: Linking Molecular Damage to Behavior.","authors":"Khatuna Dondoladze","doi":"10.2174/0109298673485458260810061255","DOIUrl":"https://doi.org/10.2174/0109298673485458260810061255","url":null,"abstract":"<p><p>When inhaled, environmental toxins enter not only the respiratory system but also the olfactory system. Metallic compounds in the environment form various free radicals through Fenton reactions and Fenton-like reactions. These free radicals damage the olfactory system in various ways. Reactive oxygen species generated during Fenton and Fenton-like reactions damage olfactory G protein-coupled receptors, disrupting the receptor's coupling to GOₗf and cAMP- and IP3/Ca2+-dependent signaling. The cascade of reactions involves ion channels, mitochondria, enzymes, lipids, proteins, DNA, and antioxidant defense mechanisms, including Nrf2-dependent transcriptional programs, glutathione, and others. Essentially, Fenton and Fenton-like reactions both generate free radicals; however, the reactive hydroxyl radical (•OH) generated in the classical Fenton reaction rapidly and locally damages neuronal cell and receptor structural molecules, whereas Fenton-like reactions, through surface-mediated, prolonged ROS production, cause progressive, chronic damage that differentially alters GPCR-GOₗf signaling and neuronal function; the study of these mechanisms is essential for assessing oxidative neurotoxicity of the olfactory system. This review discusses damage to olfactory receptor structures by radicals generated during Fenton and Fenton-like reactions, the characteristics of these chemical reactions, and the corresponding behavioral clinical changes.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunotherapy, Gene Therapy and Big Data Analysis in Burns, Trauma and Cosmetic Surgery.","authors":"Peng Wang, Zexin Zhang, Yingjun Su","doi":"10.2174/0109298673537793260819070550","DOIUrl":"https://doi.org/10.2174/0109298673537793260819070550","url":null,"abstract":"","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Updates on the Neuroprotective Effects of Nobiletin in Neurological Disorders: From Molecular Targets to Clinical Prospects.","authors":"Leila Mohammadi, Tourandokht Baluchnejadmojarad, Mehrdad Roghani","doi":"10.2174/0109298673467257260821042739","DOIUrl":"https://doi.org/10.2174/0109298673467257260821042739","url":null,"abstract":"<p><strong>Background: </strong>Neurological disorders are a significant and increasing public health concern due to their multifactorial pathogenesis, progressive clinical course, and limited long-term effectiveness of current therapeutic strategies. Recent experimental and clinical studies have increasingly focused on bioactive natural compounds as potential modulators of neuroinflammation, oxidative stress and neuronal apoptosis - processes that play a central role in neurodegeneration. Of these, nobiletin (a polymethoxylated flavonoid found in citrus peels) has attracted particular attention thanks to its reported antioxidant, anti-inflammatory and neuroprotective properties in preclinical models.</p><p><strong>Objective: </strong>We discuss the potential therapeutic role of nobiletin in neurological diseases, examining the relevant molecular mechanisms, preclinical findings, and emerging clinical data.</p><p><strong>Methods: </strong>We searched the electronic databases PubMed, Scopus, and Embase to identify studies examining the therapeutic effects of nobiletin on neurological disorders published up to October 2025.</p><p><strong>Results: </strong>This review discusses the neuroprotective actions of nobiletin, with particular attention to its anti-inflammatory, anti-apoptotic, and antioxidant activities and their involvement in major intracellular signaling pathways. In addition, available preclinical findings and emerging clinical data are examined to assess the therapeutic relevance of nobiletin in experimental and clinical models of neurological disorders.</p><p><strong>Discussion: </strong>Experimental evidence suggests that nobiletin has neuroprotective properties that could reduce pathological processes associated with neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases. However, further well-designed studies are needed to clarify its mechanisms of action and determine whether these effects are beneficial in clinical practice, either as a standalone therapy or in combination with existing treatments.</p><p><strong>Conclusion: </strong>Overall, the available evidence indicates that nobiletin may have beneficial effects on a wide range of neurological conditions, such as Parkinson's disease, Alzheimer's disease, stroke, epilepsy, depression, schizophrenia, multiple sclerosis, glioma, and sciatic nerve injury.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating lncRNA Landscapes: Redefining Biomarker Discovery in Ovarian Cancer.","authors":"Lidia Lorenzo-Catoira, Ángel Vizoso-Vázquez, Aida Barreiro-Alonso, María Esperanza Cerdán, Esther Rodríguez Belmonte, Monica Lamas-Maceiras","doi":"10.2174/0109298673492387260806065240","DOIUrl":"https://doi.org/10.2174/0109298673492387260806065240","url":null,"abstract":"<p><p>Ovarian cancer (OC) is an aggressive disease with nonspecific clinical manifestations that is frequently diagnosed at advanced stages, drastically reducing the 5- year survival rate, due in part to the absence of specific biomarkers. Owing to its high sensitivity and reproducibility, low cost, and minimal invasiveness, liquid biopsy is a promising technique for OC. Although proteins, ctDNA, and miRNAs have been widely studied as biomarkers, lncRNAs are more advantageous due to their cell- and tissue-specific expression and high stability. Several lncRNAs with potential as liquid biomarkers in OC have been characterized, but none are currently used clinically. The study has analysed 662 lncRNAs deregulated in OC to determine their ability to be detected in biofluids. Twenty-three have been identified in blood samples, four in ascites, and twenty- seven in extracellular vesicles isolated from biofluids. Most of these lncRNAs have an oncogenic role and have been associated with poor prognosis, primarily overall survival. Regarding their diagnostic value, some have even been positively associated with FIGO stages, but only one, included in the panel RP5-837J1.2/miR-361-3p/PELI3, allows differentiation between patients in early stages and healthy women. Information on lncRNAs detected in biofluids related to cancer hallmarks has also been included to identify gaps in the field and to serve as a guide for future research.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the Mechanisms of Panax Notoginseng in Accelerating Postoperative Recovery after Lung Surgery: A Comprehensive Study.","authors":"Zhe Chen, Chi Wang, Yixing Li, Yilong Zhao, Xiao Xiao, Heng Zhao, Bin He, Haotian Bai, Rui Zhao, Guangjian Zhang, Jinteng Feng","doi":"10.2174/0109298673467455260805093422","DOIUrl":"https://doi.org/10.2174/0109298673467455260805093422","url":null,"abstract":"<p><strong>Background: </strong>Enhanced recovery after lung surgery is important as it impacts patient outcomes. Among Traditional Chinese Medicine (TCM) herbs, Panax Notoginseng (PN) has been studied for its remarkable properties, making it a promising candidate for accelerating postoperative healing. However, the mechanisms of PN in enhancing recovery after lung surgery remain incompletely understood.</p><p><strong>Methods: </strong>First, animal experiments were conducted to validate the efficacy of PN in postoperative recovery following lung surgery. Then, herb-component-target network and Protein-Protein Interaction (PPI) network were constructed to identify the bioactive components of PN and key protein targets. Molecular docking was employed to validate the interactions between the active components and candidate recovery targets.</p><p><strong>Results: </strong>Animal experiments demonstrated that PN significantly improved postoperative recovery by enhancing collagen deposition and reducing pulmonary edema around the wound. Eight active components from PN and 251 targets associated with its therapeutic effects were revealed; 650 targets were linked to postoperative recovery after lung surgery. Key protein targets, including SRC, PIK3R1, and EGFR, were identified, with Quercetin, Liquiritigenin, and Mandenol emerging as the core active ingredients. Molecular docking demonstrated that the core components exhibited favorable binding energies with target proteins. KEGG and GO enrichment analyses highlighted the PI3KAKT signaling pathway and epithelial cell proliferation as critical pathways and biological processes underlying PN's efficacy.</p><p><strong>Discussion: </strong>PN may offer a novel strategy to enhance postoperative lung repair, as it may activate the PI3K/AKT pathway, which links traditional Chinese medicine with postoperative recovery. In this work, PN contributes to ERAS protocols in thoracic surgery, bridging molecular insights with clinical outcomes.</p><p><strong>Conclusion: </strong>The active components of PN, including Quercetin, Liquiritigenin, and Mandenol, can accelerate postoperative recovery after lung surgery by potentially activating the PI3K-AKT pathway and promoting collagen deposition processes.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Cell Sequencing Combined with Mendelian Randomization to Explore Potential Diagnostic Biomarkers and Therapeutic Targets for Rheumatoid Arthritis.","authors":"Shikai Chen, Hanyu Wang, Cheng Wang, Yubo Shao, Hao Xu, Jinman Chen, Qianqian Liang, Ning Li","doi":"10.2174/0109298673448346260805114910","DOIUrl":"https://doi.org/10.2174/0109298673448346260805114910","url":null,"abstract":"<p><strong>Background: </strong>Rheumatoid Arthritis (RA) is a common autoimmune disease with complex pathogenesis and high prevalence, severely affecting patients' quality of life. Multi-omics analysis has emerged as a powerful tool in RA research, providing insights into cell heterogeneity, genetic mechanisms, and immune microenvironment characteristics. This research looks into important genes linked to rheumatoid arthritis(RA) using single-cell data and Mendelian randomization analysis, while also uncovering the characteristics of the immune microenvironment and its mechanisms linking to these key genes.</p><p><strong>Methods: </strong>Gene expression, eQTL, and GWAS data were collected. Analyses included single-cell data processing (quality control, dimensionality reduction, clustering, cell annotation, and cell subset contribution assessment), subgroup non-negative matrix factorization, Mendelian randomization, co-localization analysis, immune infiltration analysis, and GSEA/GSVA.</p><p><strong>Results: </strong>This study analyzed 95,036 single-cell samples and found that alterations in B cells are closely associated with disease progression. Further analysis identified seven distinct B cell subpopulations, with immune responses and the tumor microenvironment exerting significant influence on their dynamics. Mendelian randomization analysis revealed key genes, CD83 and CRIP2, that are linked to the risk of RA. Subsequent investigation demonstrated strong associations between these genes and immune cell populations. GSEA and GSVA analyses showed that CD83 is involved in pathways related to allograft rejection and antigen processing, while CRIP2 is associated with interactions of extracellular matrix receptors and the IL-17 signaling pathway. Additionally, immunometabolism pathway analysis highlighted potential therapeutic targets and underlying mechanisms.</p><p><strong>Discussion: </strong>The findings suggest that B cells play a major role in the RA immune microenvironment and identify CD83 and CRIP2 as potential biomarkers and therapeutic targets. CD83 may contribute to RA through immune regulation, antigen presentation, and inflammatory signaling, whereas CRIP2 may be involved in metal ion homeostasis, cellular stress responses, and immune-related pathological processes. Immune infiltration analyses further indicate that these genes are closely associated with immune-cell activity in RA. Overall, the study provides new insight into RA pathogenesis and supports the potential clinical relevance of CD83 and CRIP2, although further experimental and clinical validation is required.</p><p><strong>Conclusion: </strong>This study offers valuable understanding about RA pathogenesis and identifies probable diagnostic biomarkers as well as therapeutic targets (CD83 and CRIP2), which could improve our awareness of the illness and help with formulating more successful care plans.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Biological Evaluation of Glutathione-Responsive 2-Alkoxycarbonyl Allyl Niclosamide Prodrugs as Anticancer Agents.","authors":"Anuj K Singh, Zachary S Gardner, Greeshma P Kumpati, Mathew Jacob, Conor T Ronayne, Venkatram R Mereddy","doi":"10.2174/0109298673440168260809163531","DOIUrl":"https://doi.org/10.2174/0109298673440168260809163531","url":null,"abstract":"<p><strong>Introduction: </strong>Reprogrammed mitochondrial metabolism is recognized as an important target for anticancer therapy. Niclosamide, an FDA-approved anthelmintic agent with mitochondrial uncoupling activity, has shown promise as an anticancer agent. However, off-target mitochondrial toxicity can limit its utility at clinically effective doses.</p><p><strong>Methods: </strong>This study synthesized a variety of prodrugs based on the niclosamide template via the Baylis-Hillman (BH) reaction, with the hypothesis that niclosamide would be released upon reaction with cellular nucleophiles, including thiols.</p><p><strong>Results and discussion: </strong>Consistent with this hypothesis, BH-prodrugs release the parent niclosamide in the presence of cysteine and glutathione. The lead candidates exhibit cancer cell proliferation inhibitory properties comparable to those of the parent compound, niclosamide. Mitochondrial respiration assays demonstrated that niclosamide acutely uncouples mitochondria, whereas the lead BH-prodrug 6b does not, providing evidence for this prodrug strategy in mitigating off-target toxicities. In a dose-escalation study, lead compound 6b was well tolerated in healthy mice up to 30 mg/kg, with no mortality and no abnormal changes in grooming behavior or body weight. In a 67NR syngeneic breast cancer model, 6b produced 54% tumor growth inhibition by volume, compared with 19% for niclosamide.</p><p><strong>Conclusion: </strong>The studies herein provide a novel methodology for the application of BH prodrugs on the niclosamide template and anticancer applications.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacovigilance Insights into Route-Stratified Adverse Events of Platinum-Based Drugs.","authors":"Xiaoqun Lv, Xibing Zhuang, Qi Zhang, Shu Wang, YanYan Zhu, Qing Zhai","doi":"10.2174/0109298673484441260806093741","DOIUrl":"https://doi.org/10.2174/0109298673484441260806093741","url":null,"abstract":"<p><strong>Introduction: </strong>Platinum-based drugs, including cisplatin, carboplatin, and oxaliplatin, are widely used in the treatment of various malignancies. However, the route-stratified adverse-event reporting patterns have not been fully characterized. This study aims to describe and characterize the patterns and time-to-onset distributions of adverse events (AEs) for platinum drugs across intravenous (IV), intraperitoneal (IP), and intraarterial (IA) routes.</p><p><strong>Methods: </strong>Data covering the period from 2004Q1 to 2024Q4 were collected from the Food and Drug Administration Adverse Event Reporting System (FAERS) database. Disproportionality analyses were conducted to identify potential safety signals by platinum agent and route. The identified signals were then classified according to clinical priority, a categorization based on clinical relevance, reporting rate, fatality rate, and signal stability. Furthermore, time-to-onset profiles were analyzed using Kaplan-Meier analysis, the log-rank test, and Weibull shape parameter modeling.</p><p><strong>Results: </strong>The study identified AE reports associated with cisplatin (5,783 IV, 193 IP, 135 IA), carboplatin (17,091 IV, 115 IP, 171 IA), and oxaliplatin (18,845 IV, 170 IP, 108 IA). IP reports were more frequently submitted for female patients, whereas IA reports were more frequently submitted for male patients, likely reflecting route-associated clinical indications. AE reporting profiles differed by platinum agent and route, with partial overlap. Among the identified AEs, twelve AEs were classified as high clinical priority. Of these, hepatic failure was the most frequently reported high-priority AE for both IV cisplatin and IV oxaliplatin. Notably, all IV platinum agents exhibited early failure- type patterns. The cumulative reporting distributions following IV administration differed significantly by drug. Patients treated with cisplatin showed shorter time to onset, with a median of 16 days (IQR: 7-46 days).</p><p><strong>Discussion: </strong>Through a comprehensive analysis of FAERS data, this study has identified and characterized the AE signals for platinum drugs across IV, IP, and IA routes, assessed clinical priorities, and elucidated temporal characteristics. These findings should be interpreted as exploratory pharmacovigilance signals because FAERS does not support incidence estimation, comparative risk assessment, or causal inference. Therefore, large-scale prospective studies are warranted to validate and extend these results.</p><p><strong>Conclusion: </strong>This study identified differences in AE reporting profiles and time-to-onset patterns stratified by platinum agent and administration route. This underscores the importance of pharmacovigilance and the integration of safety monitoring systems to facilitate timely identification and management of AEs in clinical practice.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Shared Associated Genes and Potential Molecular Mechanisms Between Psoriasis and Ischemic Stroke Based on Bioinformatics, Machine Learning, and Molecular Dynamics Simulation.","authors":"Mengyao Bi, Xinmin Li, Jing Wang, Fangjie Yang, Pengxue Guo, Chunlin Ren, Zhenfei Duan, Yuting Kong, Hanxue Li, Mengmeng Ma, Yasu Zhang","doi":"10.2174/0109298673490100260812043453","DOIUrl":"https://doi.org/10.2174/0109298673490100260812043453","url":null,"abstract":"<p><strong>Introduction/objective: </strong>Psoriasis is associated with an increased risk of Ischemic Stroke (IS), but the underlying mechanisms remain unclear. This study aims to identify shared associated genes and explore potential mechanisms underlying psoriasis and IS.</p><p><strong>Methods: </strong>Gene expression datasets from the GEO database were analyzed to identify common Differentially Expressed Genes (co-DEGs). Integrative bioinformatics analyses, machine-learning algorithms, single-cell RNA sequencing, molecular docking, and molecular dynamics simulations were employed to identify candidate shared genes and investigate the potential molecular mechanisms.</p><p><strong>Results: </strong>We identified 57 co-DEGs shared between psoriasis and IS. Enrichment analyses indicated that these genes were mainly associated with immune and inflammatory pathways, including NET formation, NF-κB, TLR, and IL-17 signaling pathways. TLR2 and TNFSF10 were identified as shared associated genes and remained significant across leave-one-out sensitivity analyses, demonstrating the robustness of their differential expression. Single-cell analysis revealed that TLR2 and TNFSF10 were mainly expressed in macrophages, NK cells, and smooth muscle cells. Epigallocatechin gallate was identified as a candidate compound for further investigation.</p><p><strong>Discussion: </strong>Our integrative analysis highlights TLR2 and TNFSF10 as potential mechanistic candidates associated with persistent immune activation, endothelial dysfunction, and vascular injury. These genes may participate in interconnected inflammatory processes involving TLR, IL-17, NF-κB, and NET-related pathways, providing a potential molecular link between psoriasis and IS.</p><p><strong>Conclusion: </strong>Chronic inflammation and immune dysregulation may contribute to psoriasis and IS comorbidity. TLR2 and TNFSF10 were identified as shared associated genes. These findings provide exploratory insights into the immunoinflammatory mechanistic association between psoriasis and IS.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148886567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}