Current medicinal chemistry最新文献

{"title":"CD47-SIRPα: A Pivotal Signaling Pathway for Targeting Immunotherapy in Non-Small Cell Lung Cancer.","authors":"Luying Zhang, Xueqin Wu, Mingyue Zhu, Yuli Zhou, Kun Liu, Bo Lin, Mengsen Li","doi":"10.2174/0109298673383976250911101532","DOIUrl":"https://doi.org/10.2174/0109298673383976250911101532","url":null,"abstract":"<p><p>Non-Small Cell Lung Cancer (NSCLC) remains a major oncologic challenge with high mortality. The CD47-SIRPα pathway is critical for tumor immune escape by mediating \"don't eat me\" signaling. Despite progress, the specific mechanism of action of this pathway in NSCLC remains unclear, and the specific role of the CD47-signal in regulating immune escape needs to be further explored. This paper comprehensively analyzes the latest research progress on the CD47-SIRPα signaling pathway in NSCLC, as well as the challenges of CD47-SIRPα as a potential therapeutic target.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic Insights into the Ferroptosis-Regulating Effects of EF in the Treatment of Chronic Renal Failure.","authors":"Qian Zhang, Xinran Xv, Wanchuan Zhang, Xiang Yang, Jincai Li, Tiejun Li","doi":"10.2174/0109298673409766250729110405","DOIUrl":"https://doi.org/10.2174/0109298673409766250729110405","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic Renal Failure (CRF) is a progressive disease that severely affects patients' quality of life, but its current treatment options remain limited. This study explores the potential mechanism of Eriobotryae Folium (EF) in treating CRF by targeting ferroptosis.</p><p><strong>Methods: </strong>Active compounds and targets of EF were identified through multiple databases (TCMSP, SwissTargetPrediction, UniProt, GeneCards, DrugBank). Using Cytoscape and STRING, both a compound-target network and a PPI network were generated. GO and KEGG analyses were conducted to explore relevant biological functions and pathways. The binding affinity and stability between critical compounds and target proteins were investigated through molecular docking and Molecular Dynamics (MD) simulations.</p><p><strong>Results: </strong>Eighteen active compounds and 366 targets of EF were identified, along with 1,267 CRF-related and 1,673 ferroptosis-related targets, with 40 overlapping genes. PPI analysis highlighted AKT1, EGFR, HIF1A, SRC, and ESR1 as key targets. The KEGG analysis indicated MAPK and HIF-1 pathways as major regulatory pathways. Molecular docking suggested quercetin, ellagic acid, and oleanolic acid as potential active compounds, with EGFR and SRC as promising targets. MD simulations confirmed strong and stable binding, especially for EGFR-ellagic acid (-21.38 kcal/mol) and EGFRoleanolic acid (-24.02 kcal/mol).</p><p><strong>Discussion: </strong>This study suggests that EF treats CRF by targeting ferroptosis-related pathways and key proteins, such as EGFR and AKT1. MAPK and HIF-1 signaling pathways further substantiate its significant role in disease regulation.</p><p><strong>Conclusion: </strong>EF may regulate ferroptosis through multiple targets and pathways, offering potential therapeutic benefits for CRF. The findings offer foundational insights for subsequent research and therapeutic development.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Matricellular Proteins (MCPs) in Rheumatoid Arthritis.","authors":"Asiya Kurmanova, Dieter Riethmacher","doi":"10.2174/0109298673382498250919112316","DOIUrl":"https://doi.org/10.2174/0109298673382498250919112316","url":null,"abstract":"<p><p>Rheumatoid arthritis is a chronic autoimmune disorder affecting approximately 230 per 100,000 people worldwide. It typically affects joints and bones but may involve other tissues and internal organs as well. Rheumatoid arthritis is twice as common in females compared to males and causes a significant psychological burden on patients and an economic burden on society. During the development of the disease, multiple cellular processes are involved, including the activation of JAK-STAT, MAPK, PI3KAKT, and Wnt signaling pathways, the subsequent production of cytokines, interleukins, and matrix metalloproteinases, and the stimulation of immune cells, osteoclasts, and fibroblast-like synoviocytes. Matricellular proteins typically support the stability of the extracellular matrix and oversee cellular interactions within it. They are also thought to be involved in several pathological processes, including cancer, diabetes, immune cell recruitment, and cardiovascular diseases. Recent research evidence suggests that matricellular proteins can play both pro- and anti-inflammatory roles in rheumatoid arthritis and may also affect other processes relevant to disease propagation. In conclusion, this review highlights published research that sheds light on the roles matricellular proteins may play in rheumatoid arthritis, as well as their potential as diagnostic and therapeutic targets for the disease.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Pan-cancer analysis of Pyroglutamylated RFamide Peptide Receptor: Its Potential Biological Functions and Associations with Prognosis and Immunity.","authors":"Quanxin Huang, Boyuan Qiu, Tiantian Lu, Mocan Qiu, Daizheng Huang","doi":"10.2174/0109298673386201250806154911","DOIUrl":"https://doi.org/10.2174/0109298673386201250806154911","url":null,"abstract":"<p><strong>Introduction: </strong>The receptor for pyroglutamylated RF amide peptide (QRFPR) is a G protein-coupled receptor that plays a role in various physiological and pathological processes. However, a gap remains in our understanding of QRFPR's pan-cancer properties.</p><p><strong>Methods: </strong>This study performs an extensive pan-cancer analysis of QRFPR utilizing large-scale genomic datasets, including The Cancer Genome Atlas (TCGA). We evaluated QRFPR expression levels in multiple malignancies and examined their correlations with clinical outcomes. Additionally, we investigated associations between QRFPR expression and immune cell infiltration using bioinformatics tools.</p><p><strong>Results: </strong>Our results reveal significant alterations in QRFPR expression across several cancer types, particularly breast, colorectal, and prostate cancers. Elevated levels of QRFPR are linked to poor prognosis in certain malignancies, such as uterine corpus endometrial carcinoma (UCEC) and mesothelioma (MESO), and correlate with increased infiltration of immune cells, especially T cells and macrophages. Pathway enrichment analyses suggest that QRFPR may impact critical signaling pathways associated with cell growth, apoptosis, and immune regulation.</p><p><strong>Discussion: </strong>The observed variations in QRFPR expression across cancer types suggest its diverse roles in tumor biology. Its association with unfavorable clinical outcomes in specific cancers, as well as its link to immune cell infiltration, highlights its multifaceted impact on tumor progression and microenvironment modulation.</p><p><strong>Conclusion: </strong>Our findings underscore the potential of QRFPR as a prognostic biomarker and therapeutic target in cancer biology. Further investigations into its functional mechanisms could pave the way for precision medicine approaches in oncology.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Potential of Nuciferine in Diabetes Management via PTGS2 Pathway Targeting by Network Analysis and in Silico Modeling Approach.","authors":"N Sridevi, Thirumal Margesan","doi":"10.2174/0109298673382481250908210052","DOIUrl":"https://doi.org/10.2174/0109298673382481250908210052","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetes mellitus, a chronic metabolic disorder characterized by elevated blood glucose levels, has emerged as a significant global health burden. Chronic inflammation and insulin resistance are central to the pathogenesis of non-insulin- dependent (type 2) diabetes mellitus. PTGS2 (prostaglandin-endoperoxide synthase 2) has been implicated in inflammatory pathways associated with diabetic complications, making it a potential therapeutic target.</p><p><strong>Methods: </strong>Advanced computational methodologies were employed to identify potential natural compounds with anti-diabetic activity. Techniques included network pharmacology to establish compound-target-pathway relationships and in silico molecular docking to evaluate binding affinity and interaction profiles of selected phytochemicals with PTGS2.</p><p><strong>Results: </strong>PTGS2 and its downstream prostaglandin pathways were strongly associated with diabetic inflammation and insulin resistance. Molecular docking identified Corytuberine and Nuciferine as having high binding affinities with PTGS2. Network pharmacology analysis confirmed Nuciferine's connection to PTGS2, supporting its role as a bioactive agent targeting diabetes-related inflammatory processes.</p><p><strong>Discussion: </strong>The findings suggest that PTGS2 contributes to the progression of insulin resistance and chronic inflammation in type 2 diabetes. Targeting this enzyme with bioactive compounds such as Nuciferine may offer therapeutic benefits. However, translational studies and clinical trials are essential to validate these computational predictions and assess safety and efficacy in vivo.</p><p><strong>Conclusion: </strong>Nuciferine exhibits promising potential in modulating PTGS2 activity and improving insulin sensitivity. Continued research and clinical validation are needed to confirm its efficacy and support the development of novel anti-diabetic therapies targeting inflammatory pathways.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Unified Model of Consciousness: Glycoprotein Patterns in Memory Processes and Quantum Entanglement.","authors":"Atta-Ur-Rahman","doi":"10.2174/0109298673442402250922113756","DOIUrl":"https://doi.org/10.2174/0109298673442402250922113756","url":null,"abstract":"<p><p>The author had previously proposed that memory could be encoded as patterns of hydrogen-bonded \"frozen\" conformers of neuronal glycoproteins. These stabilised molecular patterns represent an ideal template for information storage in the human brain because of the large number of asymmetric centres present in sugar molecules with attached hydroxyl groups. Hydrogen bonding of hydroxyl groups present on sugar molecules with other hydroxyl or amino groups on nearby sugar or nucleic acid units, through intramolecular or intermolecular hydrogen bonding, can result in the formation of memory patterns comprising such \"frozen conformers\". This mechanism can be involved in learning, information storage, and its recall. Penrose and Hameroff's orchestrated objective reduction (Orch OR) theory proposes that quantum superpositions and entanglement within neuronal microtubules are orchestrated by cellular processes and periodically undergo objective reduction, yielding discrete moments of conscious awareness. Recent developments in quantum biology and protein photophysics have significantly narrowed the gap between these perspectives. Most notably, Babcock et al. (2024) demonstrated that ultraviolet super radiance can occur in tryptophan- containing protein networks, including tubulin assemblies, indicating that protein architectures can support collective excitonic states (and associated subradiant \"dark\" manifolds) under physiological conditions. These findings can potentially address decoherence objections and provide a tangible mechanism by which aromatic amino-acid networks could mediate coherent energy/information transfer in living cells. We present here a possible unified model combining these concepts: Microtubules are proposed to function as quantum information processors that may bind and route distributed information through excitonic or entanglement dynamics, while glycoprotein conformational patterns could serve as a molecular register for memory storage. The convergent evidence from spectroscopy, anesthetic pharmacology, and glycosylation biology are reviewed in this context. The combination of these concepts can offer a mechanistic bridge between quantum events and cognitive function.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Emerging Role of N-Acetylcysteine in Psychiatry: A Narrative Review of Available Data.","authors":"Donatella Marazziti, Valerio Caruso, Gabriele Cappellato, Ilaria Chiarantini, Riccardo Gurrieri, Paola Perrone, Miriam Violi, Nicola Schulz Bizzozzero Crivelli, Francesco Weiss, Giulio Perugi","doi":"10.2174/0109298673365458250901115725","DOIUrl":"https://doi.org/10.2174/0109298673365458250901115725","url":null,"abstract":"<p><p>N-acetylcysteine (NAC), a cysteine derivative with a reactive thiol group, possesses antioxidant and anti-inflammatory properties. Its redox activity plays a central role in scavenging reactive oxygen and nitrogen species and modulating cellular signaling pathways. Recent research highlights its potential role in psychiatric disorders through the modulation of oxidative stress and inflammatory pathways. This narrative review examines the efficacy of NAC in treating psychiatric conditions, including mood disorders, schizophrenia, anxiety disorders, post-traumatic stress disorder (PTSD), obsessive- compulsive disorder (OCD), substance use disorders (SUDs), and neurodevelopmental disorders. A comprehensive search of PubMed, Scopus, Embase, PsycINFO, and Google Scholar databases was conducted for studies published between March 1, 2007, and December 30, 2024. The search utilized keywords related to NAC and psychiatric disorders. Data were critically analyzed to evaluate NAC's therapeutic potential. Preclinical studies demonstrate NAC's benefits in reducing oxidative stress, inflammation, and modulating neurotransmitter systems. Animal models of depression, schizophrenia, and OCD show symptom reduction through glutamatergic and antioxidant mechanisms. Clinical trials reveal NAC's efficacy as an adjunct in treating major depressive disorder, bipolar disorder, and schizophrenia, particularly for negative and cognitive symptoms. Evidence for anxiety disorders, PTSD, and OCD is limited but suggests anxiolytic and anti-obsessive effects. In SUDs, NAC shows promise in reducing cravings and substance- seeking behavior, while preliminary findings in autism suggest improvements in irritability and hyperactivity. NAC exhibits potential as an adjunctive treatment for various psychiatric disorders due to its safety profile, low cost, and broad mechanisms of action. However, clinical results are mixed, highlighting the need for larger, well-designed trials to confirm its efficacy and define optimal dosing strategies.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Notice to Single-cell RNA-sequencing Analysis Reveals the Promoting Role of the Hedgehog Pathway in Epithelial Cells during Cervical Cancer Progression.","authors":"Chen Ji, Yiyi Wang, Yingchun Jiang, Yan Wang","doi":"10.2174/0929867332999250923165204","DOIUrl":"https://doi.org/10.2174/0929867332999250923165204","url":null,"abstract":"<p><p>This article titled \"Single-cell RNA-sequencing Analysis Reveals the Promoting Role of the Hedgehog Pathway in Epithelial Cells during Cervical Cancer Progression\", published in Volume 32, Issue 33, 2025 of Current Medicinal Chemistry (10.2174/0109298673333784240819063118). The authors have requested the retraction of this article due to insufficient rigor in the data analysis, which prevented the conclusions from being reliably supported. Specifically, the study lacked adequate validation, omitted essential clinical correlation, and was affected by potential technical biases. The authors sincerely apologize to the editors and readers for this oversight. The Bentham Editorial Policy on Retraction can be found at https://benthamscience.com/editorial-policies-main.php. BENTHAM SCIENCE DISCLAIMER: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure, or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication, the authors agree that the publishers have the legal right to take appropriate action against the authors if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing Vitamin C: Unveiling Its Potential in Cancer Prevention and Treatment.","authors":"Antara Roy, Dilip K Maiti, Bimal Krishna Banik","doi":"10.2174/0109298673411854250808061949","DOIUrl":"https://doi.org/10.2174/0109298673411854250808061949","url":null,"abstract":"<p><p>The strong antioxidant vitamin C has been researched for its potential use in the prevention and treatment of cancer. Scavenging free radicals and lowering oxidative stress, which is essential in carcinogenesis, helps to protect cells. Excessive levels of vitamin C can produce hydrogen peroxide and selectively kill cancer cells in the tumor microenvironment by exerting pro-oxidant effects. Normal cells might be spared, indicating a possible window for treatment. Additionally, vitamin C affects important cellular functions that contribute to the development of tumors, including angiogenesis, inflammation, immune response modulation, and epigenetic regulation. Sensitizing tumor cells or shielding healthy tissue from harm caused by treatment may increase the effectiveness of traditional cancer treatments. Recent clinical investigations have revisited the use of high-dose intravenous vitamin C in both monotherapy and combination regimens. While some trials report improvements in quality of life, reduced chemotherapy side effects, and extended survival in specific cancer types, robust evidence of a consistent anticancer effect remains lacking due to variability in study design, cancer type, dosing protocols, and patient populations. Nonetheless, these studies have renewed interest in understanding the pharmacodynamics and clinical utility of vitamin C in oncology. Vitamin C should be considered an investigational approach rather than a standard component of cancer therapy. This review provides a comprehensive overview of the biochemical properties of Vitamin C, its anticancer mechanisms, experimental evidence, clinical data, controversies, and future directions.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer Stem Cell-targeted Antibody-drug Conjugates for Cancer Immunotherapy.","authors":"Gyas Khan, Ali Hanbashi, Wedad Mawkili, Faroq Kamli, Md Sajid Ali, Sarfaraz Ahmad, Amani Khardali, Nawazish Alam, Prawez Alam, Md Sadique Hussain","doi":"10.2174/0109298673393449250818052754","DOIUrl":"https://doi.org/10.2174/0109298673393449250818052754","url":null,"abstract":"<p><p>Cancer stem cells (CSCs) participate in cancer initiation, metastasis, and therapy tolerance, presenting a formidable challenge in cancer treatment. Antibody-drug conjugates (ADCs) have been established as a potential strategy for selectively targeting and eradicating CSCs, thereby overcoming resistance mechanisms and preventing tumor recurrence. ADCs integrate a monoclonal antibody specific to CSC surface markers, such as CD44, CD133, EpCAM, and ALDH1, with a potent cytotoxic payload linked by a stable chemical linker. Upon antigen binding, ADCs undergo receptor-mediated internalization, leading to intracellular payload release and CSC apoptosis. Recent advances in ADC technology have enhanced selectivity and efficacy while minimizing off-target toxicity. Preclinical studies demonstrate that CSC-targeted ADCs, including CD133- and CD44-directed therapies, effectively deplete CSC populations in glioblastoma, breast, colorectal, and lung cancers. EpCAM-targeted ADCs have also shown efficacy in epithelial tumors with potential synergy in combination immunotherapies. Moreover, emerging approaches, such as bispecific antibodies and optimized linker chemistry, further refine CSC-targeted ADCs for clinical applications. Despite these advancements, challenges remain, including CSC heterogeneity, immune evasion, and limitations in biomarker specificity. Addressing these hurdles requires continued innovation in ADC engineering, novel payloads, and combinatory strategies with immune checkpoint inhibitors or CAR-T cell therapies. While clinical evaluations are still in the early phases, preliminary trials underscore the potential of CSC-targeted ADCs in revolutionizing precision oncology. This review explores the mechanisms, recent developments, and prospects of CSC-targeted ADCs, highlighting their transformative potential in cancer immunotherapy.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}